Gene Gene information from NCBI Gene database.
Entrez ID 83716
Gene name Cysteine rich secretory protein LCCL domain containing 2
Gene symbol CRISPLD2
Synonyms (NCBI Gene)
CRISP11LCRISP2LGL1
Chromosome 16
Chromosome location 16q24.1
miRNA miRNA information provided by mirtarbase database.
1157
miRTarBase ID miRNA Experiments Reference
MIRT016863 hsa-miR-335-5p Microarray 18185580
MIRT719620 hsa-miR-300 HITS-CLIP 19536157
MIRT719619 hsa-miR-381-3p HITS-CLIP 19536157
MIRT719618 hsa-miR-6515-3p HITS-CLIP 19536157
MIRT719617 hsa-miR-642a-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0005539 Function Glycosaminoglycan binding IBA
GO:0005539 Function Glycosaminoglycan binding IEA
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612434 25248 ENSG00000103196
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9H0B8
Protein name Cysteine-rich secretory protein LCCL domain-containing 2 (Cysteine-rich secretory protein 11) (CRISP-11) (LCCL domain-containing cysteine-rich secretory protein 2)
Protein function Promotes matrix assembly.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00188 CAP 60 200 Cysteine-rich secretory protein family Domain
PF03815 LCCL 288 379 LCCL domain Domain
PF03815 LCCL 389 488 LCCL domain Domain
Sequence
Sequence length 497
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neutrophil degranulation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
41
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign rs7194957 RCV005904947
Cervical cancer Benign rs7194957 RCV005904948
Clear cell carcinoma of kidney Benign rs7194957 RCV005904949
CRISPLD2-related disorder Likely benign; Uncertain significance; Benign rs149615348, rs750062740, rs544311455, rs762791289, rs147872508, rs2646128, rs34582606, rs140729826, rs147475865, rs138518275, rs550003217, rs140214661, rs150433030, rs140282295, rs111425745
View all (14 more)
RCV003938942
RCV003897011
RCV003921673
RCV003901933
RCV003912138
RCV003973929
RCV003909631
RCV003939872
RCV003952127
RCV003961569
RCV003947329
RCV003939763
RCV003932324
RCV003941358
RCV003937093
RCV003946801
RCV003956828
RCV003954338
RCV003944678
RCV003969399
RCV003969172
RCV003935880
RCV003905799
RCV003916077
RCV003905884
RCV003930566
RCV003940748
RCV003950700
RCV003978166
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Asthma Associate 24926665, 31557467
Bone Diseases Associate 37021796
Cleft Lip Associate 20815724
Cleft Palate Associate 20815724, 27369588
Diabetes Mellitus Associate 40640313
Facial Pain Associate 21254358
Gaucher Disease Associate 30988500
Inflammation Associate 24926665
Neurodegenerative Diseases Inhibit 31219803
Orofacial Cleft 1 Associate 20815724