Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8366
Gene name Gene Name - the full gene name approved by the HGNC.
H4 clustered histone 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
H4C2
Synonyms (NCBI Gene) Gene synonyms aliases
H4-16, H4/I, H4C1, H4C11, H4C12, H4C13, H4C14, H4C15, H4C16, H4C3, H4C4, H4C5, H4C6, H4C8, H4C9, H4FI, HIST1H4B
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p22.2
Summary Summary of gene provided in NCBI Entrez Gene.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000183 Process RDNA heterochromatin assembly TAS
GO:0000228 Component Nuclear chromosome IDA 14718166
GO:0000781 Component Chromosome, telomeric region HDA 19135898
GO:0000786 Component Nucleosome IDA 20498094, 21636898, 24699735, 25615412
GO:0000786 Component Nucleosome TAS 3035717
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602829 4789 ENSG00000278705
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Neutrophil extracellular trap formation
Alcoholism
Viral carcinogenesis
Systemic lupus erythematosus
  Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Packaging Of Telomere Ends
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
PKMTs methylate histone lysines
HDMs demethylate histones
HATs acetylate histones
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
SUMOylation of chromatin organization proteins
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Estrogen-dependent gene expression
HCMV Early Events
HCMV Late Events
Amyloid fiber formation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Mental retardation Profound Mental Retardation, Mental deficiency, Intellectual Disability rs5742905, rs267607136, rs267607137, rs2131714307, rs267607038, rs267607042, rs80338685, rs137853127, rs80338815, rs28940893, rs387906309, rs121908096, rs121908099, rs587784365, rs121918315
View all (1024 more)
21937992
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Unknown
Disease term Disease name Evidence References Source
Neurodevelopmental Disorders neurodevelopmental disorder GenCC
Associations from Text Mining
Disease Name Relationship Type References
Acute Disease Associate 24335474
Cardiomyopathies Associate 32196466
Choriocarcinoma Associate 16177192
Polycystic Ovary Syndrome Associate 33964924