H4C8 (H4 clustered histone 8)

Gene

• Entrez ID: 8365
• Gene name: H4 clustered histone 8
• Gene symbol: H4C8
• Synonyms (NCBI Gene): H4-16, H4/h, H4C1, H4C11, H4C12, H4C13, H4C14, H4C15, H4C16, H4C2, H4C3, H4C4, H4C5, H4C6, H4C9, H4FH, HIST1H4H
• Chromosome: 6
• Chromosome location: 6p22.2
• Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000781	Component	Chromosome, telomeric region	HDA	19135898
GO:0000786	Component	Nucleosome	IDA	14718166, 20498094, 21636898, 24699735, 25615412
GO:0000786	Component	Nucleosome	IEA
GO:0000786	Component	Nucleosome	IPI	20498094, 21812398, 24311584, 26694698
GO:0000786	Component	Nucleosome	TAS	3035717
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	TAS	3035717
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	9540062, 10220385, 14585971, 15161933, 15933069, 16415788, 16917504, 17540172, 18404153, 18408754, 18474616, 18571423, 19410544, 19494831, 19498464, 19710015, 19862764, 20000738, 20224553, 20498094, 20618440, 20709061, 20739937, 20951943, 21085121, 21478274, 21596426, 21743476, 2188
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	14585971
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0006325	Process	Chromatin organization	NAS	31790919
GO:0006334	Process	Nucleosome assembly	IBA
GO:0006334	Process	Nucleosome assembly	IDA	14718166, 20498094, 21636898, 24699735, 25615412
GO:0016020	Component	Membrane	HDA	19946888
GO:0030527	Function	Structural constituent of chromatin	IBA
GO:0030527	Function	Structural constituent of chromatin	IDA	14718166
GO:0030527	Function	Structural constituent of chromatin	IEA
GO:0032200	Process	Telomere organization	TAS	17675446
GO:0032991	Component	Protein-containing complex	IDA	14718166
GO:0043505	Component	CENP-A containing nucleosome	IPI	21743476
GO:0045653	Process	Negative regulation of megakaryocyte differentiation	IDA	18474616
GO:0046982	Function	Protein heterodimerization activity	IEA
GO:0061644	Process	Protein localization to CENP-A containing chromatin	NAS	21743476
GO:0070062	Component	Extracellular exosome	HDA	19199708, 20458337, 23533145

Other IDs

• MIM: 602828
• HGNC: 4788
• e!Ensembl: ENSG00000158406

Interactions View interactions

Pathways

KEGG:

Neutrophil extracellular trap formation
Alcoholism
Viral carcinogenesis
Systemic lupus erythematosus

Reactome:

Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Packaging Of Telomere Ends
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
PKMTs methylate histone lysines
HDMs demethylate histones
HATs acetylate histones
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
SUMOylation of chromatin organization proteins
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Estrogen-dependent gene expression
HCMV Early Events
HCMV Late Events
Amyloid fiber formation