Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
836
Gene name Gene Name - the full gene name approved by the HGNC.
Caspase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CASP3
Synonyms (NCBI Gene) Gene synonyms aliases
CPP32, CPP32B, SCA-1
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q35.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulat
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003574 hsa-miR-98-5p Review 19815577
MIRT005292 hsa-let-7a-5p Luciferase reporter assay, Western blot 18758960
MIRT005292 hsa-let-7a-5p Luciferase reporter assay, Western blot 18758960
MIRT006240 hsa-miR-30d-5p Luciferase reporter assay, Western blot 22058146
MIRT006240 hsa-miR-30d-5p Luciferase reporter assay, Western blot 22058146
Transcription factors
Transcription factor Regulation Reference
ING1 Activation 15662138
ING4 Activation 19895734
NFKB1 Unknown 20056115
PHF10 Unknown 20530714
PML Activation 16253165
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001554 Process Luteolysis IEA
GO:0001666 Process Response to hypoxia IEA
GO:0001782 Process B cell homeostasis IEA
GO:0002020 Function Protease binding IEA
GO:0004190 Function Aspartic-type endopeptidase activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600636 1504 ENSG00000164305
Protein
UniProt ID P42574
Protein name Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
Protein function Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis (PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:35338844, PubMed:35446120, PubMed:7596430). Following cleavage and activation by initiat
PDB 1CP3 , 1GFW , 1I3O , 1NME , 1NMQ , 1NMS , 1PAU , 1QX3 , 1RE1 , 1RHJ , 1RHK , 1RHM , 1RHQ , 1RHR , 1RHU , 2C1E , 2C2K , 2C2M , 2C2O , 2CDR , 2CJX , 2CJY , 2CNK , 2CNL , 2CNN , 2CNO , 2DKO , 2H5I , 2H5J , 2H65 , 2J30 , 2J31 , 2J32 , 2J33 , 2XYG , 2XYH , 2XYP , 2XZD , 2XZT , 2Y0B , 3DEH , 3DEI , 3DEJ , 3DEK , 3EDQ , 3GJQ , 3GJR , 3GJS , 3GJT , 3H0E , 3ITN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00656 Peptidase_C14 45 275 Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system. {ECO:0000269|PubMed:7983002}.
Sequence
Sequence length 277
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Platinum drug resistance
MAPK signaling pathway
p53 signaling pathway
Efferocytosis
Apoptosis
Apoptosis - multiple species
Cytosolic DNA-sensing pathway
Natural killer cell mediated cytotoxicity
IL-17 signaling pathway
TNF signaling pathway
Serotonergic synapse
Non-alcoholic fatty liver disease
AGE-RAGE signaling pathway in diabetic complications
Alcoholic liver disease
Alzheimer disease
Parkinson disease
Amyotrophic lateral sclerosis
Huntington disease
Prion disease
Pathways of neurodegeneration - multiple diseases
Epithelial cell signaling in Helicobacter pylori infection
Pathogenic Escherichia coli infection
Salmonella infection
Pertussis
Legionellosis
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis C
Hepatitis B
Measles
Human cytomegalovirus infection
Influenza A
Human papillomavirus infection
Kaposi sarcoma-associated herpesvirus infection
Herpes simplex virus 1 infection
Epstein-Barr virus infection
Human immunodeficiency virus 1 infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Small cell lung cancer
Viral myocarditis
Lipid and atherosclerosis
  Activation of caspases through apoptosome-mediated cleavage
Apoptotic cleavage of cellular proteins
SMAC, XIAP-regulated apoptotic response
Apoptosis induced DNA fragmentation
Signaling by Hippo
NADE modulates death signalling
Caspase-mediated cleavage of cytoskeletal proteins
Apoptotic cleavage of cell adhesion proteins
Caspase activation via Dependence Receptors in the absence of ligand
Other interleukin signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Alzheimer disease Familial Alzheimer Disease (FAD), Alzheimer Disease, Late Onset, Alzheimer Disease, Early Onset, Alzheimer`s Disease, Alzheimer`s Disease, Focal Onset rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039
View all (65 more)
18077176
Cryptorchidism Cryptorchidism, Bilateral Cryptorchidism, Unilateral Cryptorchidism, Abdominal Cryptorchidism rs121912555, rs104894697, rs104894698, rs398122886 26050606
Diabetes mellitus Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
15531508
Retinal detachment Retinal Detachment rs1555976049, rs1592230091 18497877
Unknown
Disease term Disease name Evidence References Source
Myocardial infarction Myocardial Infarction 25450231 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Abortion Spontaneous Associate 23218678
Acquired ichthyosis Associate 28402449
Acquired Immunodeficiency Syndrome Associate 11861282
Acrocephalosyndactylia Stimulate 23330016, 23404329
Acute Coronary Syndrome Associate 29962384
Adenocarcinoma Associate 15163235, 20076902, 27723786, 35986318
Adenocarcinoma of Lung Associate 12576296, 20150439, 20885442, 22471490, 24972691, 27706758, 38182570
Adenoma Stimulate 34762658
Adenoma Pleomorphic Associate 25230790
Adrenocortical Carcinoma Associate 35848940