Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	836
Gene name	Caspase 3
Gene symbol	CASP3
Synonyms (NCBI Gene)	CPP32CPP32BSCA-1
Chromosome	4
Chromosome location	4q35.1
Summary	The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulat

360

Show/Hide all (360)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003574	hsa-miR-98-5p	Review	19815577
MIRT005292	hsa-let-7a-5p	Luciferase reporter assayWestern blot	18758960
MIRT005292	hsa-let-7a-5p	Luciferase reporter assayWestern blot	18758960
MIRT006240	hsa-miR-30d-5p	Luciferase reporter assayWestern blot	22058146
MIRT006240	hsa-miR-30d-5p	Luciferase reporter assayWestern blot	22058146
MIRT006240	hsa-miR-30d-5p	Luciferase reporter assayWestern blot	22058146
MIRT006864	hsa-miR-138-5p	Luciferase reporter assay	22921398
MIRT019884	hsa-miR-375	qRT-PCR;Microarray	20584986
MIRT021992	hsa-miR-128-3p	Sequencing	20371350
MIRT024157	hsa-miR-221-3p	Sequencing	20371350
MIRT029617	hsa-miR-26b-5p	Microarray	19088304
MIRT048249	hsa-miR-196a-5p	CLASH	23622248
MIRT054129	hsa-miR-421	qRT-PCRWestern blot	25041019
MIRT438878	hsa-miR-885-5p	Luciferase reporter assay	23271051
MIRT438878	hsa-miR-885-5p	Luciferase reporter assay	23271051
MIRT438878	hsa-miR-885-5p	Luciferase reporter assay	23271051
MIRT438730	hsa-miR-363-3p	and NCH441"	24805821
MIRT438730	hsa-miR-363-3p	and NCH441"	24805821
MIRT438729	hsa-miR-582-5p	and NCH441"	24805821
MIRT438729	hsa-miR-582-5p	and NCH441"	24805821
MIRT438878	hsa-miR-885-5p	Luciferase reporter assay	23271051
MIRT438878	hsa-miR-885-5p	Luciferase reporter assay	23271051
MIRT438878	hsa-miR-885-5p	Luciferase reporter assay	23271051
MIRT438730	hsa-miR-363-3p	and NCH441"	24805821
MIRT438730	hsa-miR-363-3p	and NCH441"	24805821
MIRT438729	hsa-miR-582-5p	and NCH441"	24805821
MIRT438729	hsa-miR-582-5p	and NCH441"	24805821
MIRT487458	hsa-miR-548n	PAR-CLIP	23592263
MIRT164579	hsa-miR-651-3p	PAR-CLIP	23592263
MIRT487457	hsa-miR-562	PAR-CLIP	23592263
MIRT487456	hsa-miR-888-5p	PAR-CLIP	23592263
MIRT487455	hsa-miR-6076	PAR-CLIP	23592263
MIRT487454	hsa-miR-6797-3p	PAR-CLIP	23592263
MIRT164595	hsa-miR-6124	PAR-CLIP	23592263
MIRT487453	hsa-miR-5011-3p	PAR-CLIP	23592263
MIRT487452	hsa-miR-4666b	PAR-CLIP	23592263
MIRT487451	hsa-miR-3680-3p	PAR-CLIP	23592263
MIRT441002	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT441003	hsa-miR-382-5p	HITS-CLIP	24374217
MIRT728049	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT728050	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT437365	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT006240	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT728048	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT441002	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT441003	hsa-miR-382-5p	HITS-CLIP	24374217
MIRT003574	hsa-miR-98-5p	Luciferase reporter assayqRT-PCRWestern blot	26367177
MIRT054129	hsa-miR-421	Luciferase reporter assay	27016414
MIRT054129	hsa-miR-421	Luciferase reporter assay	27016414
MIRT728048	hsa-miR-30e-5p	Luciferase reporter assay	26895377
MIRT728048	hsa-miR-30e-5p	Luciferase reporter assay	26895377
MIRT356254	hsa-let-7b-3p	ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	26296645
MIRT732067	hsa-miR-224-5p	Luciferase reporter assayWestern blot	26307684
MIRT732067	hsa-miR-224-5p	Luciferase reporter assayWestern blot	26307684
MIRT054129	hsa-miR-421	ImmunofluorescenceImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	27016414
MIRT054129	hsa-miR-421	ImmunofluorescenceImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	27016414
MIRT732590	hsa-miR-133a-3p	ImmunofluorescenceqRT-PCRWestern blotting	33639970
MIRT734060	hsa-miR-612	qRT-PCR	33564285
MIRT006864	hsa-miR-138-5p	Luciferase reporter assayWestern blottingqRT-PCRFlow cytometry	33856081
MIRT734992	hsa-let-7e-3p	qRT-PCR	33066614
MIRT735171	hsa-miR-7-5p	MicroarrayqRT-PCR	33468167
MIRT735254	hsa-miR-30d-3p	MicroarrayqRT-PCR	32407273
MIRT006864	hsa-miR-138-5p	Western blottingqRT-PCR	32388607
MIRT006864	hsa-miR-138-5p	Western blottingqRT-PCR	32388607
MIRT487458	hsa-miR-548n	PAR-CLIP	23592263
MIRT164579	hsa-miR-651-3p	PAR-CLIP	23592263
MIRT487457	hsa-miR-562	PAR-CLIP	23592263
MIRT487456	hsa-miR-888-5p	PAR-CLIP	23592263
MIRT487455	hsa-miR-6076	PAR-CLIP	23592263
MIRT487454	hsa-miR-6797-3p	PAR-CLIP	23592263
MIRT164595	hsa-miR-6124	PAR-CLIP	23592263
MIRT487453	hsa-miR-5011-3p	PAR-CLIP	23592263
MIRT487452	hsa-miR-4666b	PAR-CLIP	23592263
MIRT487451	hsa-miR-3680-3p	PAR-CLIP	23592263
MIRT755542	hsa-miR-181c-5p	Western blottingqRT-PCR	36676955
MIRT755862	hsa-miR-107	Luciferase reporter assayWestern blottingqRT-PCRFlow cytometryELISA	38828010
MIRT755862	hsa-miR-107	Immunoprecipitaion (IP)	36816358
MIRT756319	hsa-miR-29b-1-5p	Western blottingImmunofluorescence	38934067
MIRT756379	hsa-miR-139-5p	Western blotting	37794118
MIRT864029	hsa-miR-1304	CLIP-seq
MIRT864030	hsa-miR-137	CLIP-seq
MIRT864031	hsa-miR-1825	CLIP-seq
MIRT864032	hsa-miR-197	CLIP-seq
MIRT864033	hsa-miR-3152-5p	CLIP-seq
MIRT864034	hsa-miR-4760-3p	CLIP-seq
MIRT864035	hsa-miR-4789-3p	CLIP-seq
MIRT864036	hsa-miR-891b	CLIP-seq
MIRT864037	hsa-miR-103a	CLIP-seq
MIRT755862	hsa-miR-107	CLIP-seq
MIRT864038	hsa-miR-1184	CLIP-seq
MIRT864039	hsa-miR-1205	CLIP-seq
MIRT864040	hsa-miR-1287	CLIP-seq
MIRT864030	hsa-miR-137	CLIP-seq
MIRT864032	hsa-miR-197	CLIP-seq
MIRT864041	hsa-miR-24	CLIP-seq
MIRT864033	hsa-miR-3152-5p	CLIP-seq
MIRT864042	hsa-miR-3158-5p	CLIP-seq
MIRT864043	hsa-miR-3176	CLIP-seq
MIRT864044	hsa-miR-3202	CLIP-seq
MIRT864045	hsa-miR-3616-3p	CLIP-seq
MIRT864046	hsa-miR-3652	CLIP-seq
MIRT864047	hsa-miR-3658	CLIP-seq
MIRT864048	hsa-miR-3662	CLIP-seq
MIRT864049	hsa-miR-376c	CLIP-seq
MIRT864050	hsa-miR-3922-3p	CLIP-seq
MIRT864051	hsa-miR-4430	CLIP-seq
MIRT864052	hsa-miR-4437	CLIP-seq
MIRT864053	hsa-miR-4533	CLIP-seq
MIRT864054	hsa-miR-455-5p	CLIP-seq
MIRT864055	hsa-miR-4662a-3p	CLIP-seq
MIRT864056	hsa-miR-4693-3p	CLIP-seq
MIRT864057	hsa-miR-4698	CLIP-seq
MIRT864058	hsa-miR-4712-3p	CLIP-seq
MIRT864059	hsa-miR-4721	CLIP-seq
MIRT864060	hsa-miR-4757-5p	CLIP-seq
MIRT864061	hsa-miR-4773	CLIP-seq
MIRT864062	hsa-miR-518d-5p	CLIP-seq
MIRT864063	hsa-miR-519b-5p	CLIP-seq
MIRT864064	hsa-miR-519c-5p	CLIP-seq
MIRT864065	hsa-miR-520c-5p	CLIP-seq
MIRT864066	hsa-miR-526a	CLIP-seq
MIRT864067	hsa-miR-548a-5p	CLIP-seq
MIRT864068	hsa-miR-548ab	CLIP-seq
MIRT864069	hsa-miR-548ak	CLIP-seq
MIRT864070	hsa-miR-548b-5p	CLIP-seq
MIRT864071	hsa-miR-548c-5p	CLIP-seq
MIRT864072	hsa-miR-548d-5p	CLIP-seq
MIRT864073	hsa-miR-548h	CLIP-seq
MIRT864074	hsa-miR-548i	CLIP-seq
MIRT864075	hsa-miR-548j	CLIP-seq
MIRT864076	hsa-miR-548k	CLIP-seq
MIRT864077	hsa-miR-548l	CLIP-seq
MIRT864078	hsa-miR-548w	CLIP-seq
MIRT864079	hsa-miR-548y	CLIP-seq
MIRT864080	hsa-miR-559	CLIP-seq
MIRT864081	hsa-miR-603	CLIP-seq
MIRT864082	hsa-miR-654-3p	CLIP-seq
MIRT1546174	hsa-let-7a	CLIP-seq
MIRT1546175	hsa-let-7b	CLIP-seq
MIRT1546176	hsa-let-7c	CLIP-seq
MIRT1546177	hsa-let-7d	CLIP-seq
MIRT1546178	hsa-let-7e	CLIP-seq
MIRT1546179	hsa-let-7f	CLIP-seq
MIRT1546180	hsa-let-7g	CLIP-seq
MIRT1546181	hsa-let-7i	CLIP-seq
MIRT864029	hsa-miR-1304	CLIP-seq
MIRT1546182	hsa-miR-138	CLIP-seq
MIRT1546183	hsa-miR-140-5p	CLIP-seq
MIRT1546184	hsa-miR-202	CLIP-seq
MIRT1546185	hsa-miR-3545-5p	CLIP-seq
MIRT1546186	hsa-miR-376a	CLIP-seq
MIRT1546187	hsa-miR-376b	CLIP-seq
MIRT1546188	hsa-miR-4458	CLIP-seq
MIRT1546189	hsa-miR-4460	CLIP-seq
MIRT1546190	hsa-miR-4500	CLIP-seq
MIRT1546191	hsa-miR-98	CLIP-seq
MIRT1556132	hsa-miR-369-3p	CLIP-seq
MIRT1556133	hsa-miR-374a	CLIP-seq
MIRT1556134	hsa-miR-374b	CLIP-seq
MIRT1556135	hsa-miR-3942-3p	CLIP-seq
MIRT1556136	hsa-miR-410	CLIP-seq
MIRT756379	hsa-miR-139-5p	CLIP-seq
MIRT864047	hsa-miR-3658	CLIP-seq
MIRT864055	hsa-miR-4662a-3p	CLIP-seq
MIRT1956145	hsa-miR-4666-5p	CLIP-seq
MIRT1956146	hsa-miR-4795-3p	CLIP-seq
MIRT1956147	hsa-miR-5095	CLIP-seq
MIRT1956148	hsa-miR-514	CLIP-seq
MIRT1956149	hsa-miR-514b-3p	CLIP-seq
MIRT1956150	hsa-miR-601	CLIP-seq
MIRT864081	hsa-miR-603	CLIP-seq
MIRT1546182	hsa-miR-138	CLIP-seq
MIRT864034	hsa-miR-4760-3p	CLIP-seq
MIRT864037	hsa-miR-103a	CLIP-seq
MIRT755862	hsa-miR-107	CLIP-seq
MIRT2193795	hsa-miR-1229	CLIP-seq
MIRT2193796	hsa-miR-203	CLIP-seq
MIRT2193797	hsa-miR-2277-3p	CLIP-seq
MIRT2193798	hsa-miR-3614-5p	CLIP-seq
MIRT2193799	hsa-miR-3660	CLIP-seq
MIRT2193800	hsa-miR-3672	CLIP-seq
MIRT2193801	hsa-miR-3977	CLIP-seq
MIRT2193802	hsa-miR-4526	CLIP-seq
MIRT2193803	hsa-miR-4642	CLIP-seq
MIRT2193804	hsa-miR-4676-5p	CLIP-seq
MIRT864058	hsa-miR-4712-3p	CLIP-seq
MIRT864034	hsa-miR-4760-3p	CLIP-seq
MIRT2193805	hsa-miR-550b	CLIP-seq
MIRT2193806	hsa-miR-566	CLIP-seq
MIRT2193807	hsa-miR-575	CLIP-seq
MIRT2193808	hsa-miR-652	CLIP-seq
MIRT864082	hsa-miR-654-3p	CLIP-seq
MIRT2193809	hsa-miR-885-3p	CLIP-seq
MIRT2193810	hsa-miR-890	CLIP-seq
MIRT2193811	hsa-miR-942	CLIP-seq
MIRT2385555	hsa-miR-513b	CLIP-seq
MIRT2427045	hsa-miR-23a	CLIP-seq
MIRT2427046	hsa-miR-23b	CLIP-seq
MIRT2427047	hsa-miR-23c	CLIP-seq
MIRT2427048	hsa-miR-323-3p	CLIP-seq
MIRT2427049	hsa-miR-337-3p	CLIP-seq
MIRT2427050	hsa-miR-382	CLIP-seq
MIRT2427051	hsa-miR-4326	CLIP-seq
MIRT2427052	hsa-miR-4709-5p	CLIP-seq
MIRT2427053	hsa-miR-4794	CLIP-seq
MIRT2427054	hsa-miR-619	CLIP-seq
MIRT2446205	hsa-miR-144	CLIP-seq
MIRT2446206	hsa-miR-30a	CLIP-seq
MIRT2446207	hsa-miR-30b	CLIP-seq
MIRT2446208	hsa-miR-30c	CLIP-seq
MIRT2446209	hsa-miR-30d	CLIP-seq
MIRT2446210	hsa-miR-30e	CLIP-seq
MIRT2496952	hsa-miR-1254	CLIP-seq
MIRT2496953	hsa-miR-1256	CLIP-seq
MIRT2496954	hsa-miR-1283	CLIP-seq
MIRT864040	hsa-miR-1287	CLIP-seq
MIRT1546182	hsa-miR-138	CLIP-seq
MIRT2446205	hsa-miR-144	CLIP-seq
MIRT2496955	hsa-miR-153	CLIP-seq
MIRT2496956	hsa-miR-190	CLIP-seq
MIRT2496957	hsa-miR-190b	CLIP-seq
MIRT2496958	hsa-miR-221	CLIP-seq
MIRT2496959	hsa-miR-222	CLIP-seq
MIRT2193797	hsa-miR-2277-3p	CLIP-seq
MIRT864041	hsa-miR-24	CLIP-seq
MIRT2496960	hsa-miR-29a	CLIP-seq
MIRT2496961	hsa-miR-29b	CLIP-seq
MIRT2496962	hsa-miR-29c	CLIP-seq
MIRT2446206	hsa-miR-30a	CLIP-seq
MIRT2446207	hsa-miR-30b	CLIP-seq
MIRT2446208	hsa-miR-30c	CLIP-seq
MIRT2446209	hsa-miR-30d	CLIP-seq
MIRT2446210	hsa-miR-30e	CLIP-seq
MIRT2496963	hsa-miR-3116	CLIP-seq
MIRT2496964	hsa-miR-3145-3p	CLIP-seq
MIRT864033	hsa-miR-3152-5p	CLIP-seq
MIRT2496965	hsa-miR-3163	CLIP-seq
MIRT864043	hsa-miR-3176	CLIP-seq
MIRT2496966	hsa-miR-320a	CLIP-seq
MIRT2496967	hsa-miR-320b	CLIP-seq
MIRT2496968	hsa-miR-320c	CLIP-seq
MIRT2496969	hsa-miR-320d	CLIP-seq
MIRT2496970	hsa-miR-342-3p	CLIP-seq
MIRT2496971	hsa-miR-3529	CLIP-seq
MIRT2496972	hsa-miR-3607-3p	CLIP-seq
MIRT2496973	hsa-miR-3614-3p	CLIP-seq
MIRT864045	hsa-miR-3616-3p	CLIP-seq
MIRT864046	hsa-miR-3652	CLIP-seq
MIRT2193800	hsa-miR-3672	CLIP-seq
MIRT2496974	hsa-miR-370	CLIP-seq
MIRT2496975	hsa-miR-379	CLIP-seq
MIRT864050	hsa-miR-3922-3p	CLIP-seq
MIRT2496976	hsa-miR-4254	CLIP-seq
MIRT2496977	hsa-miR-4317	CLIP-seq
MIRT2496978	hsa-miR-4429	CLIP-seq
MIRT864051	hsa-miR-4430	CLIP-seq
MIRT864052	hsa-miR-4437	CLIP-seq
MIRT2496979	hsa-miR-4451	CLIP-seq
MIRT2496980	hsa-miR-4532	CLIP-seq
MIRT864054	hsa-miR-455-5p	CLIP-seq
MIRT2496981	hsa-miR-4639-5p	CLIP-seq
MIRT2496982	hsa-miR-4649-3p	CLIP-seq
MIRT2496983	hsa-miR-4650-3p	CLIP-seq
MIRT2496984	hsa-miR-4656	CLIP-seq
MIRT2496985	hsa-miR-4663	CLIP-seq
MIRT2193804	hsa-miR-4676-5p	CLIP-seq
MIRT2496986	hsa-miR-4685-5p	CLIP-seq
MIRT2496987	hsa-miR-4688	CLIP-seq
MIRT864059	hsa-miR-4721	CLIP-seq
MIRT2496988	hsa-miR-4728-3p	CLIP-seq
MIRT864060	hsa-miR-4757-5p	CLIP-seq
MIRT2496989	hsa-miR-4763-5p	CLIP-seq
MIRT2496990	hsa-miR-4768-5p	CLIP-seq
MIRT1956146	hsa-miR-4795-3p	CLIP-seq
MIRT2496991	hsa-miR-491-3p	CLIP-seq
MIRT2496992	hsa-miR-513c	CLIP-seq
MIRT2496993	hsa-miR-514b-5p	CLIP-seq
MIRT864062	hsa-miR-518d-5p	CLIP-seq
MIRT864063	hsa-miR-519b-5p	CLIP-seq
MIRT864064	hsa-miR-519c-5p	CLIP-seq
MIRT864065	hsa-miR-520c-5p	CLIP-seq
MIRT2496994	hsa-miR-520d-5p	CLIP-seq
MIRT2496995	hsa-miR-524-5p	CLIP-seq
MIRT864066	hsa-miR-526a	CLIP-seq
MIRT2496996	hsa-miR-548a-3p	CLIP-seq
MIRT2496997	hsa-miR-548e	CLIP-seq
MIRT2496998	hsa-miR-548f	CLIP-seq
MIRT2496999	hsa-miR-548t	CLIP-seq
MIRT2497000	hsa-miR-548v	CLIP-seq
MIRT2193807	hsa-miR-575	CLIP-seq
MIRT2497001	hsa-miR-586	CLIP-seq
MIRT2497002	hsa-miR-596	CLIP-seq
MIRT2497003	hsa-miR-600	CLIP-seq
MIRT2496952	hsa-miR-1254	CLIP-seq
MIRT2496953	hsa-miR-1256	CLIP-seq
MIRT864040	hsa-miR-1287	CLIP-seq
MIRT1546182	hsa-miR-138	CLIP-seq
MIRT2496955	hsa-miR-153	CLIP-seq
MIRT2496956	hsa-miR-190	CLIP-seq
MIRT2496957	hsa-miR-190b	CLIP-seq
MIRT2193797	hsa-miR-2277-3p	CLIP-seq
MIRT864041	hsa-miR-24	CLIP-seq
MIRT2496960	hsa-miR-29a	CLIP-seq
MIRT2496961	hsa-miR-29b	CLIP-seq
MIRT2496962	hsa-miR-29c	CLIP-seq
MIRT2496963	hsa-miR-3116	CLIP-seq
MIRT2496964	hsa-miR-3145-3p	CLIP-seq
MIRT2496965	hsa-miR-3163	CLIP-seq
MIRT864043	hsa-miR-3176	CLIP-seq
MIRT2496966	hsa-miR-320a	CLIP-seq
MIRT2496967	hsa-miR-320b	CLIP-seq
MIRT2496968	hsa-miR-320c	CLIP-seq
MIRT2496969	hsa-miR-320d	CLIP-seq
MIRT2496970	hsa-miR-342-3p	CLIP-seq
MIRT2496971	hsa-miR-3529	CLIP-seq
MIRT2496972	hsa-miR-3607-3p	CLIP-seq
MIRT2496973	hsa-miR-3614-3p	CLIP-seq
MIRT864045	hsa-miR-3616-3p	CLIP-seq
MIRT864046	hsa-miR-3652	CLIP-seq
MIRT2193800	hsa-miR-3672	CLIP-seq
MIRT2496974	hsa-miR-370	CLIP-seq
MIRT2496975	hsa-miR-379	CLIP-seq
MIRT864050	hsa-miR-3922-3p	CLIP-seq
MIRT2496976	hsa-miR-4254	CLIP-seq
MIRT2496977	hsa-miR-4317	CLIP-seq
MIRT2496978	hsa-miR-4429	CLIP-seq
MIRT864051	hsa-miR-4430	CLIP-seq
MIRT864052	hsa-miR-4437	CLIP-seq
MIRT2496979	hsa-miR-4451	CLIP-seq
MIRT2496980	hsa-miR-4532	CLIP-seq
MIRT864054	hsa-miR-455-5p	CLIP-seq
MIRT2496981	hsa-miR-4639-5p	CLIP-seq
MIRT2496982	hsa-miR-4649-3p	CLIP-seq
MIRT2496983	hsa-miR-4650-3p	CLIP-seq
MIRT2496984	hsa-miR-4656	CLIP-seq
MIRT2496985	hsa-miR-4663	CLIP-seq
MIRT2193804	hsa-miR-4676-5p	CLIP-seq
MIRT2496986	hsa-miR-4685-5p	CLIP-seq
MIRT2496987	hsa-miR-4688	CLIP-seq
MIRT864059	hsa-miR-4721	CLIP-seq
MIRT2496988	hsa-miR-4728-3p	CLIP-seq
MIRT864060	hsa-miR-4757-5p	CLIP-seq
MIRT2496989	hsa-miR-4763-5p	CLIP-seq
MIRT2496990	hsa-miR-4768-5p	CLIP-seq
MIRT1956146	hsa-miR-4795-3p	CLIP-seq
MIRT2496991	hsa-miR-491-3p	CLIP-seq
MIRT2496992	hsa-miR-513c	CLIP-seq
MIRT2496993	hsa-miR-514b-5p	CLIP-seq
MIRT864062	hsa-miR-518d-5p	CLIP-seq
MIRT864063	hsa-miR-519b-5p	CLIP-seq
MIRT864064	hsa-miR-519c-5p	CLIP-seq
MIRT864065	hsa-miR-520c-5p	CLIP-seq
MIRT864066	hsa-miR-526a	CLIP-seq
MIRT2496996	hsa-miR-548a-3p	CLIP-seq
MIRT2496997	hsa-miR-548e	CLIP-seq
MIRT2496998	hsa-miR-548f	CLIP-seq
MIRT2193807	hsa-miR-575	CLIP-seq
MIRT2497001	hsa-miR-586	CLIP-seq
MIRT2497002	hsa-miR-596	CLIP-seq
MIRT2497003	hsa-miR-600	CLIP-seq

Show/Hide all (10)

Transcription factor	Regulation	Reference
ING1	Activation	15662138
ING4	Activation	19895734
NFKB1	Unknown	20056115
PHF10	Unknown	20530714
PML	Activation	16253165
RELA	Unknown	20056115
RUNX3	Activation	15930301;19290488
SIM2	Activation	21729534
SP1	Unknown	11773055
TP53	Unknown	21859835

119

Show/Hide all (119)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001554	Process	Luteolysis	IEA
GO:0001666	Process	Response to hypoxia	IEA
GO:0001782	Process	B cell homeostasis	IEA
GO:0001818	Process	Negative regulation of cytokine production	IMP	36002459
GO:0002020	Function	Protease binding	IEA
GO:0004175	Function	Endopeptidase activity	IEA
GO:0004190	Function	Aspartic-type endopeptidase activity	IEA
GO:0004197	Function	Cysteine-type endopeptidase activity	IBA
GO:0004197	Function	Cysteine-type endopeptidase activity	IDA	9334240, 16374543, 16920334, 17823127, 18723680, 19240112, 20566630, 21726810, 23650375, 23729654, 24904167, 28459430, 30878284, 33725486, 33852854, 35594856, 36002459, 37327784
GO:0004197	Function	Cysteine-type endopeptidase activity	IEA
GO:0004197	Function	Cysteine-type endopeptidase activity	IMP	10921886, 17559062, 21980415, 22253444
GO:0004197	Function	Cysteine-type endopeptidase activity	TAS	10942389
GO:0004861	Function	Cyclin-dependent protein serine/threonine kinase inhibitor activity	IEA
GO:0005123	Function	Death receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	7596430, 9208847, 9736630, 11257232, 15246877, 16227597, 16501604, 16530191, 17167422, 17544405, 17606900, 17823127, 18723680, 19273858, 21726810, 23150525, 25241761, 28514442, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IDA	16374543
GO:0005634	Component	Nucleus	IDA	17167422
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	17167422
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	17167422, 17823127, 22253444
GO:0005829	Component	Cytosol	TAS
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IDA	12888622, 17553422
GO:0006508	Process	Proteolysis	IEA
GO:0006915	Process	Apoptotic process	IBA
GO:0006915	Process	Apoptotic process	IDA	34480022
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	IMP	15565177
GO:0006915	Process	Apoptotic process	TAS	7983002
GO:0006974	Process	DNA damage response	IEA
GO:0007413	Process	Axonal fasciculation	IEA
GO:0007507	Process	Heart development	IEA
GO:0007605	Process	Sensory perception of sound	IEA
GO:0007611	Process	Learning or memory	IEA
GO:0008047	Function	Enzyme activator activity	IBA
GO:0008233	Function	Peptidase activity	IDA	9353287, 17167422, 19740745
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0008627	Process	Intrinsic apoptotic signaling pathway in response to osmotic stress	IEA
GO:0009410	Process	Response to xenobiotic stimulus	IEA
GO:0009411	Process	Response to UV	IEA
GO:0009611	Process	Response to wounding	IEA
GO:0009749	Process	Response to glucose	IEA
GO:0010038	Process	Response to metal ion	IEA
GO:0010165	Process	Response to X-ray	IEA
GO:0014069	Component	Postsynaptic density	IEA
GO:0016005	Function	Phospholipase A2 activator activity	IEA
GO:0016241	Process	Regulation of macroautophagy	TAS	19549685
GO:0016485	Process	Protein processing	IDA	9334240
GO:0016485	Process	Protein processing	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0021766	Process	Hippocampus development	IEA
GO:0030163	Process	Protein catabolic process	IDA	16374543
GO:0030163	Process	Protein catabolic process	IEA
GO:0030182	Process	Neuron differentiation	IBA
GO:0030182	Process	Neuron differentiation	IEA
GO:0030216	Process	Keratinocyte differentiation	IBA
GO:0030216	Process	Keratinocyte differentiation	IEA
GO:0030218	Process	Erythrocyte differentiation	IBA
GO:0030218	Process	Erythrocyte differentiation	IDA	17167422
GO:0030218	Process	Erythrocyte differentiation	TAS	18309324
GO:0030220	Process	Platelet formation	TAS	18309324
GO:0030889	Process	Negative regulation of B cell proliferation	IEA
GO:0031264	Component	Death-inducing signaling complex	IBA
GO:0031264	Component	Death-inducing signaling complex	IEA
GO:0031647	Process	Regulation of protein stability	IDA	17553422
GO:0031647	Process	Regulation of protein stability	IEA
GO:0032025	Process	Response to cobalt ion	IEA
GO:0032355	Process	Response to estradiol	IEA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0034349	Process	Glial cell apoptotic process	IEA
GO:0034349	Process	Glial cell apoptotic process	IEA
GO:0034612	Process	Response to tumor necrosis factor	TAS	10521396
GO:0035094	Process	Response to nicotine	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0035655	Process	Interleukin-18-mediated signaling pathway	IDA	14528293
GO:0042542	Process	Response to hydrogen peroxide	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043029	Process	T cell homeostasis	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043200	Process	Response to amino acid	IEA
GO:0043525	Process	Positive regulation of neuron apoptotic process	IBA
GO:0043525	Process	Positive regulation of neuron apoptotic process	IEA
GO:0044346	Process	Fibroblast apoptotic process	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045165	Process	Cell fate commitment	IEA
GO:0045786	Process	Negative regulation of cell cycle	IEA
GO:0046007	Process	Negative regulation of activated T cell proliferation	IEA
GO:0048011	Process	Neurotrophin TRK receptor signaling pathway	IDA	23954828
GO:0051146	Process	Striated muscle cell differentiation	IEA
GO:0051384	Process	Response to glucocorticoid	IEA
GO:0051402	Process	Neuron apoptotic process	IEA
GO:0051604	Process	Protein maturation	IDA	28459430, 33852854, 35594856
GO:0051604	Process	Protein maturation	IEA
GO:0061713	Process	Anterior neural tube closure	IEA
GO:0070212	Process	Protein poly-ADP-ribosylation	IDA	33186521
GO:0070269	Process	Pyroptotic inflammatory response	IDA	28459430, 33852854, 35594856
GO:0070269	Process	Pyroptotic inflammatory response	IDA	36426955
GO:0071887	Process	Leukocyte apoptotic process	IEA
GO:0072347	Process	Response to anesthetic	IEA
GO:0072734	Process	Cellular response to staurosporine	IEA
GO:0072734	Process	Cellular response to staurosporine	IMP	22253444
GO:0097190	Process	Apoptotic signaling pathway	TAS	10521396
GO:0097193	Process	Intrinsic apoptotic signaling pathway	IMP	15565177
GO:0097194	Process	Execution phase of apoptosis	IBA
GO:0097194	Process	Execution phase of apoptosis	IDA	8689682, 16374543
GO:0097194	Process	Execution phase of apoptosis	IEA
GO:0097194	Process	Execution phase of apoptosis	IGI	12107093
GO:0097194	Process	Execution phase of apoptosis	IMP	11350920
GO:0098693	Process	Regulation of synaptic vesicle cycle	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0140639	Process	Positive regulation of pyroptotic inflammatory response	IDA	28459430, 33852854, 35594856
GO:1902004	Process	Positive regulation of amyloid-beta formation	IDA	17553422
GO:1902004	Process	Positive regulation of amyloid-beta formation	IEA
GO:1904019	Process	Epithelial cell apoptotic process	IEA

MIM	HGNC	e!Ensembl
600636	1504	ENSG00000164305

P42574

Protein name

Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]

Protein function

Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis (PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:35338844, PubMed:35446120, PubMed:7596430). Following cleavage and activation by initiat

PDB

1CP3 , 1GFW , 1I3O , 1NME , 1NMQ , 1NMS , 1PAU , 1QX3 , 1RE1 , 1RHJ , 1RHK , 1RHM , 1RHQ , 1RHR , 1RHU , 2C1E , 2C2K , 2C2M , 2C2O , 2CDR , 2CJX , 2CJY , 2CNK , 2CNL , 2CNN , 2CNO , 2DKO , 2H5I , 2H5J , 2H65 , 2J30 , 2J31 , 2J32 , 2J33 , 2XYG , 2XYH , 2XYP , 2XZD , 2XZT , 2Y0B , 3DEH , 3DEI , 3DEJ , 3DEK , 3EDQ , 3GJQ , 3GJR , 3GJS , 3GJT , 3H0E , 3ITN

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00656	Peptidase_C14	45 → 275		Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system. {ECO:0000269|PubMed:7983002}.

Sequence

MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH

Sequence length

277

Interactions

View interactions

	KEGG		Reactome
	Platinum drug resistance MAPK signaling pathway p53 signaling pathway Efferocytosis Apoptosis Apoptosis - multiple species Cytosolic DNA-sensing pathway Natural killer cell mediated cytotoxicity IL-17 signaling pathway TNF signaling pathway Serotonergic synapse Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Epithelial cell signaling in Helicobacter pylori infection Pathogenic Escherichia coli infection Salmonella infection Pertussis Legionellosis Toxoplasmosis Amoebiasis Tuberculosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Colorectal cancer Small cell lung cancer Viral myocarditis Lipid and atherosclerosis		Activation of caspases through apoptosome-mediated cleavage Apoptotic cleavage of cellular proteins SMAC, XIAP-regulated apoptotic response Apoptosis induced DNA fragmentation Signaling by Hippo NADE modulates death signalling Caspase-mediated cleavage of cytoskeletal proteins Apoptotic cleavage of cell adhesion proteins Caspase activation via Dependence Receptors in the absence of ligand Other interleukin signaling

CASP3 (caspase 3)