Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene Gene ontology Other IDs Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8359
Gene name Gene Name - the full gene name approved by the HGNC.	H4 clustered histone 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	H4C1
Synonyms (NCBI Gene) Gene synonyms aliases	H4-16, H4C11, H4C12, H4C13, H4C14, H4C15, H4C16, H4C2, H4C3, H4C4, H4C5, H4C6, H4C8, H4C9, H4FA, HIST1H4A
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p22.2
Summary Summary of gene provided in NCBI Entrez Gene.	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA

Show/Hide all(32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000183	Process	RDNA heterochromatin assembly	TAS
GO:0000228	Component	Nuclear chromosome	IDA	14718166
GO:0000781	Component	Chromosome, telomeric region	HDA	19135898
GO:0000786	Component	Nucleosome	IDA	20498094, 21636898, 24699735, 25615412
GO:0000786	Component	Nucleosome	TAS	3035717
GO:0003677	Function	DNA binding	IBA	21873635
GO:0003677	Function	DNA binding	TAS	3035717
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	9540062, 10220385, 14585971, 15161933, 15933069, 16415788, 16917504, 17540172, 18404153, 18408754, 18474616, 18571423, 19410544, 19494831, 19498464, 19710015, 19862764, 20000738, 20224553, 20498094, 20618440, 20709061, 20739937, 20951943, 21085121, 21478274, 21596426, 21743476, 2188
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IDA	14585971
GO:0005654	Component	Nucleoplasm	TAS
GO:0006303	Process	Double-strand break repair via nonhomologous end joining	TAS
GO:0006334	Process	Nucleosome assembly	IBA	21873635
GO:0006334	Process	Nucleosome assembly	IDA	20498094, 21636898, 24699735, 25615412
GO:0006335	Process	DNA replication-dependent nucleosome assembly	IDA	14718166
GO:0006336	Process	DNA replication-independent nucleosome assembly	IDA	14718166
GO:0006352	Process	DNA-templated transcription, initiation	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016233	Process	Telomere capping	TAS
GO:0019904	Function	Protein domain specific binding	IPI	22368283
GO:0032200	Process	Telomere organization	TAS	17675446
GO:0032991	Component	Protein-containing complex	IDA	14718166
GO:0034080	Process	CENP-A containing nucleosome assembly	TAS
GO:0044267	Process	Cellular protein metabolic process	TAS
GO:0045652	Process	Regulation of megakaryocyte differentiation	TAS
GO:0045653	Process	Negative regulation of megakaryocyte differentiation	IDA	18474616
GO:0045814	Process	Negative regulation of gene expression, epigenetic	TAS
GO:0046982	Function	Protein heterodimerization activity	IEA
GO:0060964	Process	Regulation of gene silencing by miRNA	TAS
GO:0070062	Component	Extracellular exosome	HDA	19199708, 20458337, 23533145

MIM	HGNC	e!Ensembl
602822	4781	ENSG00000278637

	KEGG		Reactome
	Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis Systemic lupus erythematosus		Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Packaging Of Telomere Ends Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Estrogen-dependent gene expression HCMV Early Events HCMV Late Events Amyloid fiber formation

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Insomnia	Insomnia			GWAS

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining
Abortion Habitual	Inhibit	27929073
Cardiomyopathies	Associate	32196466
Leukocyte adhesion deficiency type 1	Associate	31201998
Polycystic Ovary Syndrome	Stimulate	37854181

H4C1 (H4 clustered histone 1)