Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene Gene ontology Other IDs Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8358
Gene name Gene Name - the full gene name approved by the HGNC.	H3 clustered histone 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	H3C2
Synonyms (NCBI Gene) Gene synonyms aliases	H3/l, H3C1, H3C10, H3C11, H3C12, H3C3, H3C4, H3C6, H3C7, H3C8, H3FL, HIST1H3B
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p22.2
Summary Summary of gene provided in NCBI Entrez Gene.	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the f

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000786	Component	Nucleosome	IDA	14718166, 20498094, 21636898, 24699735, 25615412, 30867594
GO:0000786	Component	Nucleosome	IEA
GO:0000786	Component	Nucleosome	IPI	21812398, 24311584
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IDA	30867594
GO:0005515	Function	Protein binding	IPI	10949293, 10975519, 12540855, 16189514, 16246723, 16415788, 16603238, 16946699, 17157298, 18292755, 18418070, 19410544, 19498464, 19766566, 20080577, 20498094, 20541251, 20739937, 20871592, 21685874, 22720776, 23142979, 23275563, 24590075, 24606918, 24788516, 24981860, 25281560, 254
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IDA	21636898, 22720776
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0006325	Process	Chromatin organization	NAS	31790919
GO:0006334	Process	Nucleosome assembly	IDA	14718166, 20498094, 21636898, 24699735
GO:0006334	Process	Nucleosome assembly	IMP	25615412
GO:0010467	Process	Gene expression	IDA	30867594
GO:0016020	Component	Membrane	HDA	19946888
GO:0030527	Function	Structural constituent of chromatin	IEA
GO:0032200	Process	Telomere organization	TAS	17675446
GO:0032991	Component	Protein-containing complex	IDA	14718166
GO:0040029	Process	Epigenetic regulation of gene expression	IDA	16267050
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0046982	Function	Protein heterodimerization activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337

MIM	HGNC	e!Ensembl
602819	4776	ENSG00000286522

	KEGG		Reactome
	Neutrophil extracellular trap formation Alcoholism Shigellosis Transcriptional misregulation in cancer Systemic lupus erythematosus		Interleukin-7 signaling Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones RMTs methylate histone arginines Chromatin modifying enzymes SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Estrogen-dependent gene expression HCMV Early Events HCMV Late Events Amyloid fiber formation Factors involved in megakaryocyte development and platelet production

H3C2 (H3 clustered histone 2)