H3C2 (H3 clustered histone 2)

Gene Gene information from NCBI Gene database.
Gene Gene ontology Other IDs Pathways Associated diseases
Entrez ID 8358
Gene name H3 clustered histone 2
Gene symbol H3C2
Synonyms (NCBI Gene)
H3/lH3C1H3C10H3C11H3C12H3C3H3C4H3C6H3C7H3C8H3FLHIST1H3B
Chromosome 6
Chromosome location 6p22.2
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the f
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26
Gene Gene ontology Other IDs Pathways Associated diseases
Show/Hide all (26)
GO ID Ontology Definition Evidence Reference
GO:0000786 Component Nucleosome IDA 14718166, 20498094, 21636898, 24699735, 25615412, 30867594
GO:0000786 Component Nucleosome IEA
GO:0000786 Component Nucleosome IPI 21812398, 24311584
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IDA 30867594
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene Gene ontology Other IDs Pathways Associated diseases
MIM HGNC e!Ensembl
602819 4776 ENSG00000286522
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Pathways Associated diseases
  KEGG  Reactome
  Neutrophil extracellular trap formation
Alcoholism
Shigellosis
Transcriptional misregulation in cancer
Systemic lupus erythematosus 		  Interleukin-7 signaling
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
HDACs deacetylate histones
PKMTs methylate histone lysines
HDMs demethylate histones
HATs acetylate histones
RMTs methylate histone arginines
Chromatin modifying enzymes
SIRT1 negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Estrogen-dependent gene expression
HCMV Early Events
HCMV Late Events
Amyloid fiber formation
Factors involved in megakaryocyte development and platelet production
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
3
Gene Gene ontology Other IDs Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Squamous cell lung carcinoma Uncertain significance; Benign rs184952244, rs34966100, rs2213284 RCV001250935
RCV001250952
RCV001250934
Show/Hide Text Mining Associations (12)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Bloom Syndrome Associate 22286216
Carcinoma Hepatocellular Associate 28377632
Diffuse Intrinsic Pontine Glioma Associate 22286216, 24297113, 26399631, 27251074, 29746225, 30861105, 32381545, 34114629
Disease Associate 31645348
Gastrointestinal Stromal Tumors Associate 28377632
Glioblastoma Associate 23907119, 27251074
Glioma Associate 26517431, 27251074, 27577993, 31348837, 33435779, 34812950
Hydrocephalus Associate 33435779
Infections Associate 37434783
Infratentorial Neoplasms Associate 36104744