H3C2 (H3 clustered histone 2)

Gene
Gene Gene ontology Other IDs Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8358
Gene name Gene Name - the full gene name approved by the HGNC.
H3 clustered histone 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
H3C2
Synonyms (NCBI Gene) Gene synonyms aliases
H3/l, H3C1, H3C10, H3C11, H3C12, H3C3, H3C4, H3C6, H3C7, H3C8, H3FL, HIST1H3B
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p22.2
Summary Summary of gene provided in NCBI Entrez Gene.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the f
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Pathways Associated diseases
Show/Hide all(26)
GO ID Ontology Definition Evidence Reference
GO:0000183 Process RDNA heterochromatin assembly TAS
GO:0000228 Component Nuclear chromosome IDA 14718166
GO:0000786 Component Nucleosome IDA 20498094, 21636898, 24699735, 25615412
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 10949293, 10975519, 12489984, 12540855, 16189514, 16246723, 16415788, 16603238, 16946699, 17157298, 18292755, 18418070, 19410544, 19498464, 19766566, 20080577, 20498094, 20541251, 20739937, 20871592, 21685874, 22720776, 23142979, 23275563, 24590075, 24606918, 24788516, 24981860, 254
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Pathways Associated diseases
MIM HGNC e!Ensembl
602819 4776 ENSG00000286522
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Pathways Associated diseases
  KEGG   Reactome
  Neutrophil extracellular trap formation
Alcoholism
Shigellosis
Transcriptional misregulation in cancer
Systemic lupus erythematosus 		  Interleukin-7 signaling
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
HDACs deacetylate histones
PKMTs methylate histone lysines
HDMs demethylate histones
HATs acetylate histones
RMTs methylate histone arginines
Chromatin modifying enzymes
SIRT1 negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Estrogen-dependent gene expression
HCMV Early Events
HCMV Late Events
Amyloid fiber formation
Factors involved in megakaryocyte development and platelet production
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal
Disease term Disease name dbSNP ID References
Glioblastoma Glioblastoma, Glioblastoma Multiforme rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888 22286216
Glioma Glioma, mixed gliomas, Malignant Glioma rs121909219, rs121909224, rs587776667, rs587776671, rs121909239, rs121909241, rs28933368, rs121913500, rs55863639, rs786201995, rs786202517, rs786201044, rs398123317, rs1057518425, rs121913499
View all (13 more)		 22286216
Show/Hide Text Mining Associations (12)
Associations from Text Mining
Disease Name Relationship Type References
Bloom Syndrome Associate 22286216
Carcinoma Hepatocellular Associate 28377632
Diffuse Intrinsic Pontine Glioma Associate 22286216, 24297113, 26399631, 27251074, 29746225, 30861105, 32381545, 34114629
Disease Associate 31645348
Gastrointestinal Stromal Tumors Associate 28377632
Glioblastoma Associate 23907119, 27251074
Glioma Associate 26517431, 27251074, 27577993, 31348837, 33435779, 34812950
Hydrocephalus Associate 33435779
Infections Associate 37434783
Infratentorial Neoplasms Associate 36104744