Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	83546
Gene name	Retbindin
Gene symbol	RTBDN
Synonyms (NCBI Gene)	-
Chromosome	19
Chromosome location	19p13.13
Summary	This gene was first identified in a study of human eye tissues. The protein encoded by this gene is preferentially expressed in the retina and may play a role in binding retinoids and other carotenoids as it shares homology with riboflavin binding protein

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018579	hsa-miR-335-5p	Microarray	18185580
MIRT485975	hsa-miR-6793-3p	PAR-CLIP	23592263
MIRT485974	hsa-miR-361-3p	PAR-CLIP	23592263
MIRT485973	hsa-miR-637	PAR-CLIP	23592263
MIRT485972	hsa-miR-4731-5p	PAR-CLIP	23592263
MIRT485971	hsa-miR-4505	PAR-CLIP	23592263
MIRT485969	hsa-miR-5787	PAR-CLIP	23592263
MIRT485970	hsa-miR-4492	PAR-CLIP	23592263
MIRT485968	hsa-miR-4498	PAR-CLIP	23592263
MIRT485967	hsa-miR-5001-5p	PAR-CLIP	23592263
MIRT485966	hsa-miR-762	PAR-CLIP	23592263
MIRT485965	hsa-miR-4271	PAR-CLIP	23592263
MIRT485963	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT485964	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT485962	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT485961	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT485960	hsa-miR-5698	PAR-CLIP	23592263
MIRT485959	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT485957	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT485958	hsa-miR-4525	PAR-CLIP	23592263
MIRT485956	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT485955	hsa-miR-1275	PAR-CLIP	23592263
MIRT485954	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT485953	hsa-miR-6085	PAR-CLIP	23592263
MIRT485975	hsa-miR-6793-3p	PAR-CLIP	23592263
MIRT485974	hsa-miR-361-3p	PAR-CLIP	23592263
MIRT485973	hsa-miR-637	PAR-CLIP	23592263
MIRT485972	hsa-miR-4731-5p	PAR-CLIP	23592263
MIRT485971	hsa-miR-4505	PAR-CLIP	23592263
MIRT485969	hsa-miR-5787	PAR-CLIP	23592263
MIRT485970	hsa-miR-4492	PAR-CLIP	23592263
MIRT485968	hsa-miR-4498	PAR-CLIP	23592263
MIRT485967	hsa-miR-5001-5p	PAR-CLIP	23592263
MIRT485966	hsa-miR-762	PAR-CLIP	23592263
MIRT485965	hsa-miR-4271	PAR-CLIP	23592263
MIRT485963	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT485964	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT485962	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT485961	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT485960	hsa-miR-5698	PAR-CLIP	23592263
MIRT485959	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT485957	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT485958	hsa-miR-4525	PAR-CLIP	23592263
MIRT485956	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT485955	hsa-miR-1275	PAR-CLIP	23592263
MIRT485954	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT485953	hsa-miR-6085	PAR-CLIP	23592263
MIRT1321570	hsa-miR-1908	CLIP-seq
MIRT1321571	hsa-miR-3180	CLIP-seq
MIRT1321572	hsa-miR-3180-3p	CLIP-seq
MIRT1321573	hsa-miR-3184	CLIP-seq
MIRT1321574	hsa-miR-3196	CLIP-seq
MIRT1321575	hsa-miR-3202	CLIP-seq
MIRT1321576	hsa-miR-423-5p	CLIP-seq
MIRT1321577	hsa-miR-4508	CLIP-seq
MIRT1321578	hsa-miR-4747-5p	CLIP-seq
MIRT1321579	hsa-miR-625	CLIP-seq
MIRT1321580	hsa-miR-663	CLIP-seq
MIRT1321581	hsa-miR-744	CLIP-seq
MIRT2319870	hsa-miR-3170	CLIP-seq
MIRT2319871	hsa-miR-4314	CLIP-seq
MIRT2319872	hsa-miR-4651	CLIP-seq
MIRT2319873	hsa-miR-608	CLIP-seq

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GO ID	Ontology	Definition	Evidence
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0009897	Component	External side of plasma membrane	IBA
GO:0009897	Component	External side of plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0032217	Function	Riboflavin transmembrane transporter activity	IBA
GO:0032218	Process	Riboflavin transport	IEA
GO:0033165	Component	Interphotoreceptor matrix	IEA
GO:0038023	Function	Signaling receptor activity	IBA
GO:1902444	Function	Riboflavin binding	IBA
GO:1902444	Function	Riboflavin binding	IEA

MIM	HGNC	e!Ensembl
609553	30310	ENSG00000132026

Q9BSG5

Protein name

Retbindin

Protein function

Riboflavin-binding protein which might have a role in retinal flavin transport.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03024	Folate_rec	27 → 183	Folate receptor family	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in peripheral retina (at protein level). {ECO:0000269|PubMed:25542898}.

Sequence

MDCRVHMRPIGLTWVLQLTLAWILLEACGGSRPLQARSQQHHGLAADLGKGKLHLAGPCC
PSEMDTTETSGPGNHPERCGVPSPECESFLEHLQRALRSRFRLRLLGVRQAQPLCEELCQ
AWFANCEDDITCGPTWLPLSEKRGCEPSCLTYGQTFADGTDLCRSALGHALPVAAPGARH
CFNISISAVPRPRPGRRGREAPSRRSRSPRTSILDAAGSGSGSGSGSGP

Sequence length

229

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

RTBDN (retbindin)