APH1B (aph-1B gamma-secretase subunit)

Gene

• Entrez ID: 83464
• Gene name: Aph-1B gamma-secretase subunit
• Gene symbol: APH1B
• Synonyms (NCBI Gene): APH-1B, PRO1328, PSFL, TAAV688, aph-1beta
• Chromosome: 15
• Chromosome location: 15q22.2
• Summary: This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex.

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019680	hsa-miR-375	Microarray	20215506
MIRT789230	hsa-miR-105	CLIP-seq
MIRT789231	hsa-miR-1226	CLIP-seq
MIRT789232	hsa-miR-124	CLIP-seq
MIRT789233	hsa-miR-1253	CLIP-seq
MIRT789234	hsa-miR-1257	CLIP-seq
MIRT789235	hsa-miR-1290	CLIP-seq
MIRT789236	hsa-miR-1292	CLIP-seq
MIRT789237	hsa-miR-129-3p	CLIP-seq
MIRT789238	hsa-miR-134	CLIP-seq
MIRT789239	hsa-miR-137	CLIP-seq
MIRT789240	hsa-miR-139-5p	CLIP-seq
MIRT789241	hsa-miR-141	CLIP-seq
MIRT789242	hsa-miR-147	CLIP-seq
MIRT789243	hsa-miR-15a	CLIP-seq
MIRT789244	hsa-miR-15b	CLIP-seq
MIRT789245	hsa-miR-16	CLIP-seq
MIRT789246	hsa-miR-1909	CLIP-seq
MIRT789247	hsa-miR-195	CLIP-seq
MIRT789248	hsa-miR-200a	CLIP-seq
MIRT789249	hsa-miR-21	CLIP-seq
MIRT789250	hsa-miR-2113	CLIP-seq
MIRT789251	hsa-miR-2117	CLIP-seq
MIRT789252	hsa-miR-2278	CLIP-seq
MIRT789253	hsa-miR-23a	CLIP-seq
MIRT789254	hsa-miR-23b	CLIP-seq
MIRT789255	hsa-miR-23c	CLIP-seq
MIRT789256	hsa-miR-24	CLIP-seq
MIRT789257	hsa-miR-25	CLIP-seq
MIRT789258	hsa-miR-28-3p	CLIP-seq
MIRT789259	hsa-miR-2964a-3p	CLIP-seq
MIRT789260	hsa-miR-3074-3p	CLIP-seq
MIRT789261	hsa-miR-3118	CLIP-seq
MIRT789262	hsa-miR-3120-3p	CLIP-seq
MIRT789263	hsa-miR-3127-5p	CLIP-seq
MIRT789264	hsa-miR-3164	CLIP-seq
MIRT789265	hsa-miR-32	CLIP-seq
MIRT789266	hsa-miR-33a	CLIP-seq
MIRT789267	hsa-miR-33b	CLIP-seq
MIRT789268	hsa-miR-342-3p	CLIP-seq
MIRT789269	hsa-miR-3613-3p	CLIP-seq
MIRT789270	hsa-miR-361-5p	CLIP-seq
MIRT789271	hsa-miR-3617	CLIP-seq
MIRT789272	hsa-miR-3622a-3p	CLIP-seq
MIRT789273	hsa-miR-3622a-5p	CLIP-seq
MIRT789274	hsa-miR-3622b-3p	CLIP-seq
MIRT789275	hsa-miR-363	CLIP-seq
MIRT789276	hsa-miR-3646	CLIP-seq
MIRT789277	hsa-miR-3651	CLIP-seq
MIRT789278	hsa-miR-367	CLIP-seq
MIRT789279	hsa-miR-3671	CLIP-seq
MIRT789280	hsa-miR-3913-3p	CLIP-seq
MIRT789281	hsa-miR-3918	CLIP-seq
MIRT789282	hsa-miR-3942-3p	CLIP-seq
MIRT789283	hsa-miR-424	CLIP-seq
MIRT789284	hsa-miR-4263	CLIP-seq
MIRT789285	hsa-miR-4267	CLIP-seq
MIRT789286	hsa-miR-4272	CLIP-seq
MIRT789287	hsa-miR-4273	CLIP-seq
MIRT789288	hsa-miR-4279	CLIP-seq
MIRT789289	hsa-miR-4310	CLIP-seq
MIRT789290	hsa-miR-4426	CLIP-seq
MIRT789291	hsa-miR-4437	CLIP-seq
MIRT789292	hsa-miR-4461	CLIP-seq
MIRT789293	hsa-miR-4468	CLIP-seq
MIRT789294	hsa-miR-4471	CLIP-seq
MIRT789295	hsa-miR-4480	CLIP-seq
MIRT789296	hsa-miR-4484	CLIP-seq
MIRT789297	hsa-miR-4494	CLIP-seq
MIRT789298	hsa-miR-452	CLIP-seq
MIRT789299	hsa-miR-4528	CLIP-seq
MIRT789300	hsa-miR-4646-5p	CLIP-seq
MIRT789301	hsa-miR-4647	CLIP-seq
MIRT789302	hsa-miR-4659a-3p	CLIP-seq
MIRT789303	hsa-miR-4659b-3p	CLIP-seq
MIRT789304	hsa-miR-4662b	CLIP-seq
MIRT789305	hsa-miR-4676-3p	CLIP-seq
MIRT789306	hsa-miR-4687-5p	CLIP-seq
MIRT789307	hsa-miR-4698	CLIP-seq
MIRT789308	hsa-miR-4714-3p	CLIP-seq
MIRT789309	hsa-miR-4717-3p	CLIP-seq
MIRT789310	hsa-miR-4722-3p	CLIP-seq
MIRT789311	hsa-miR-4760-3p	CLIP-seq
MIRT789312	hsa-miR-4764-3p	CLIP-seq
MIRT789313	hsa-miR-4778-3p	CLIP-seq
MIRT789314	hsa-miR-4790-3p	CLIP-seq
MIRT789315	hsa-miR-4794	CLIP-seq
MIRT789316	hsa-miR-4795-3p	CLIP-seq
MIRT789317	hsa-miR-4797-5p	CLIP-seq
MIRT789318	hsa-miR-4800-3p	CLIP-seq
MIRT789319	hsa-miR-497	CLIP-seq
MIRT789320	hsa-miR-499a-5p	CLIP-seq
MIRT789321	hsa-miR-506	CLIP-seq
MIRT789322	hsa-miR-513c	CLIP-seq
MIRT789323	hsa-miR-514b-5p	CLIP-seq
MIRT789324	hsa-miR-545	CLIP-seq
MIRT789325	hsa-miR-548an	CLIP-seq
MIRT789326	hsa-miR-548p	CLIP-seq
MIRT789327	hsa-miR-568	CLIP-seq
MIRT789328	hsa-miR-576-5p	CLIP-seq
MIRT789329	hsa-miR-577	CLIP-seq
MIRT789330	hsa-miR-580	CLIP-seq
MIRT789331	hsa-miR-590-5p	CLIP-seq
MIRT789332	hsa-miR-604	CLIP-seq
MIRT789333	hsa-miR-607	CLIP-seq
MIRT789334	hsa-miR-617	CLIP-seq
MIRT789335	hsa-miR-633	CLIP-seq
MIRT789336	hsa-miR-641	CLIP-seq
MIRT789337	hsa-miR-647	CLIP-seq
MIRT789338	hsa-miR-758	CLIP-seq
MIRT789339	hsa-miR-889	CLIP-seq
MIRT789340	hsa-miR-892b	CLIP-seq
MIRT789341	hsa-miR-92a	CLIP-seq
MIRT789342	hsa-miR-92b	CLIP-seq
MIRT789343	hsa-miR-122	CLIP-seq
MIRT789344	hsa-miR-1258	CLIP-seq
MIRT789242	hsa-miR-147	CLIP-seq
MIRT789345	hsa-miR-181a	CLIP-seq
MIRT789346	hsa-miR-181b	CLIP-seq
MIRT789347	hsa-miR-181c	CLIP-seq
MIRT789348	hsa-miR-181d	CLIP-seq
MIRT789249	hsa-miR-21	CLIP-seq
MIRT789349	hsa-miR-219-1-3p	CLIP-seq
MIRT789256	hsa-miR-24	CLIP-seq
MIRT789258	hsa-miR-28-3p	CLIP-seq
MIRT789260	hsa-miR-3074-3p	CLIP-seq
MIRT789263	hsa-miR-3127-5p	CLIP-seq
MIRT789350	hsa-miR-3140-5p	CLIP-seq
MIRT789351	hsa-miR-3165	CLIP-seq
MIRT789352	hsa-miR-3202	CLIP-seq
MIRT789268	hsa-miR-342-3p	CLIP-seq
MIRT789353	hsa-miR-3618	CLIP-seq
MIRT789354	hsa-miR-3655	CLIP-seq
MIRT789355	hsa-miR-3675-3p	CLIP-seq
MIRT789280	hsa-miR-3913-3p	CLIP-seq
MIRT789281	hsa-miR-3918	CLIP-seq
MIRT789356	hsa-miR-3919	CLIP-seq
MIRT789282	hsa-miR-3942-3p	CLIP-seq
MIRT789357	hsa-miR-4254	CLIP-seq
MIRT789358	hsa-miR-4262	CLIP-seq
MIRT789359	hsa-miR-4266	CLIP-seq
MIRT789360	hsa-miR-4420	CLIP-seq
MIRT789361	hsa-miR-4424	CLIP-seq
MIRT789291	hsa-miR-4437	CLIP-seq
MIRT789362	hsa-miR-4504	CLIP-seq
MIRT789363	hsa-miR-4533	CLIP-seq
MIRT789364	hsa-miR-4653-3p	CLIP-seq
MIRT789365	hsa-miR-4668-3p	CLIP-seq
MIRT789366	hsa-miR-4756-3p	CLIP-seq
MIRT789312	hsa-miR-4764-3p	CLIP-seq
MIRT789314	hsa-miR-4790-3p	CLIP-seq
MIRT789367	hsa-miR-489	CLIP-seq
MIRT789368	hsa-miR-514	CLIP-seq
MIRT789369	hsa-miR-514b-3p	CLIP-seq
MIRT789370	hsa-miR-542-3p	CLIP-seq
MIRT789371	hsa-miR-543	CLIP-seq
MIRT789327	hsa-miR-568	CLIP-seq
MIRT789372	hsa-miR-570	CLIP-seq
MIRT789328	hsa-miR-576-5p	CLIP-seq
MIRT789331	hsa-miR-590-5p	CLIP-seq
MIRT789373	hsa-miR-619	CLIP-seq
MIRT789374	hsa-miR-767-3p	CLIP-seq
MIRT789339	hsa-miR-889	CLIP-seq
MIRT789375	hsa-miR-934	CLIP-seq
MIRT789256	hsa-miR-24	CLIP-seq
MIRT789260	hsa-miR-3074-3p	CLIP-seq
MIRT789263	hsa-miR-3127-5p	CLIP-seq
MIRT789281	hsa-miR-3918	CLIP-seq
MIRT789291	hsa-miR-4437	CLIP-seq
MIRT789339	hsa-miR-889	CLIP-seq
MIRT1932818	hsa-miR-3664-3p	CLIP-seq
MIRT1932819	hsa-miR-145	CLIP-seq
MIRT789242	hsa-miR-147	CLIP-seq
MIRT789345	hsa-miR-181a	CLIP-seq
MIRT789346	hsa-miR-181b	CLIP-seq
MIRT789347	hsa-miR-181c	CLIP-seq
MIRT789348	hsa-miR-181d	CLIP-seq
MIRT789252	hsa-miR-2278	CLIP-seq
MIRT789256	hsa-miR-24	CLIP-seq
MIRT789260	hsa-miR-3074-3p	CLIP-seq
MIRT789263	hsa-miR-3127-5p	CLIP-seq
MIRT1932820	hsa-miR-3189-3p	CLIP-seq
MIRT1932821	hsa-miR-338-5p	CLIP-seq
MIRT789268	hsa-miR-342-3p	CLIP-seq
MIRT789270	hsa-miR-361-5p	CLIP-seq
MIRT789272	hsa-miR-3622a-3p	CLIP-seq
MIRT789274	hsa-miR-3622b-3p	CLIP-seq
MIRT789281	hsa-miR-3918	CLIP-seq
MIRT789282	hsa-miR-3942-3p	CLIP-seq
MIRT789358	hsa-miR-4262	CLIP-seq
MIRT789291	hsa-miR-4437	CLIP-seq
MIRT789299	hsa-miR-4528	CLIP-seq
MIRT789300	hsa-miR-4646-5p	CLIP-seq
MIRT789302	hsa-miR-4659a-3p	CLIP-seq
MIRT789303	hsa-miR-4659b-3p	CLIP-seq
MIRT1932822	hsa-miR-4686	CLIP-seq
MIRT1932823	hsa-miR-4747-5p	CLIP-seq
MIRT789312	hsa-miR-4764-3p	CLIP-seq
MIRT1932824	hsa-miR-486-5p	CLIP-seq
MIRT789367	hsa-miR-489	CLIP-seq
MIRT1932825	hsa-miR-495	CLIP-seq
MIRT789368	hsa-miR-514	CLIP-seq
MIRT789369	hsa-miR-514b-3p	CLIP-seq
MIRT789339	hsa-miR-889	CLIP-seq
MIRT1932826	hsa-miR-942	CLIP-seq
MIRT2172992	hsa-miR-1208	CLIP-seq
MIRT2172993	hsa-miR-1236	CLIP-seq
MIRT789344	hsa-miR-1258	CLIP-seq
MIRT789239	hsa-miR-137	CLIP-seq
MIRT789253	hsa-miR-23a	CLIP-seq
MIRT789254	hsa-miR-23b	CLIP-seq
MIRT789255	hsa-miR-23c	CLIP-seq
MIRT789256	hsa-miR-24	CLIP-seq
MIRT789257	hsa-miR-25	CLIP-seq
MIRT789258	hsa-miR-28-3p	CLIP-seq
MIRT789259	hsa-miR-2964a-3p	CLIP-seq
MIRT789260	hsa-miR-3074-3p	CLIP-seq
MIRT789262	hsa-miR-3120-3p	CLIP-seq
MIRT789263	hsa-miR-3127-5p	CLIP-seq
MIRT789265	hsa-miR-32	CLIP-seq
MIRT789352	hsa-miR-3202	CLIP-seq
MIRT1932821	hsa-miR-338-5p	CLIP-seq
MIRT789266	hsa-miR-33a	CLIP-seq
MIRT789267	hsa-miR-33b	CLIP-seq
MIRT789268	hsa-miR-342-3p	CLIP-seq
MIRT2172994	hsa-miR-3613-5p	CLIP-seq
MIRT789270	hsa-miR-361-5p	CLIP-seq
MIRT789271	hsa-miR-3617	CLIP-seq
MIRT789353	hsa-miR-3618	CLIP-seq
MIRT2172995	hsa-miR-362-5p	CLIP-seq
MIRT789275	hsa-miR-363	CLIP-seq
MIRT789354	hsa-miR-3655	CLIP-seq
MIRT789278	hsa-miR-367	CLIP-seq
MIRT789280	hsa-miR-3913-3p	CLIP-seq
MIRT789281	hsa-miR-3918	CLIP-seq
MIRT789357	hsa-miR-4254	CLIP-seq
MIRT789285	hsa-miR-4267	CLIP-seq
MIRT2172996	hsa-miR-4269	CLIP-seq
MIRT789286	hsa-miR-4272	CLIP-seq
MIRT789289	hsa-miR-4310	CLIP-seq
MIRT789360	hsa-miR-4420	CLIP-seq
MIRT789291	hsa-miR-4437	CLIP-seq
MIRT789297	hsa-miR-4494	CLIP-seq
MIRT2172997	hsa-miR-4514	CLIP-seq
MIRT789298	hsa-miR-452	CLIP-seq
MIRT2172998	hsa-miR-4522	CLIP-seq
MIRT789299	hsa-miR-4528	CLIP-seq
MIRT789363	hsa-miR-4533	CLIP-seq
MIRT789364	hsa-miR-4653-3p	CLIP-seq
MIRT789305	hsa-miR-4676-3p	CLIP-seq
MIRT2172999	hsa-miR-4676-5p	CLIP-seq
MIRT2173000	hsa-miR-4692	CLIP-seq
MIRT789309	hsa-miR-4717-3p	CLIP-seq
MIRT2173001	hsa-miR-4724-3p	CLIP-seq
MIRT2173002	hsa-miR-4742-5p	CLIP-seq
MIRT789312	hsa-miR-4764-3p	CLIP-seq
MIRT2173003	hsa-miR-4789-5p	CLIP-seq
MIRT789314	hsa-miR-4790-3p	CLIP-seq
MIRT789316	hsa-miR-4795-3p	CLIP-seq
MIRT789320	hsa-miR-499a-5p	CLIP-seq
MIRT2173004	hsa-miR-500b	CLIP-seq
MIRT2173005	hsa-miR-501-5p	CLIP-seq
MIRT789327	hsa-miR-568	CLIP-seq
MIRT2173006	hsa-miR-575	CLIP-seq
MIRT789373	hsa-miR-619	CLIP-seq
MIRT2173007	hsa-miR-627	CLIP-seq
MIRT789336	hsa-miR-641	CLIP-seq
MIRT2173008	hsa-miR-668	CLIP-seq
MIRT789339	hsa-miR-889	CLIP-seq
MIRT2173009	hsa-miR-924	CLIP-seq
MIRT789341	hsa-miR-92a	CLIP-seq
MIRT789342	hsa-miR-92b	CLIP-seq
MIRT789375	hsa-miR-934	CLIP-seq
MIRT789344	hsa-miR-1258	CLIP-seq
MIRT789353	hsa-miR-3618	CLIP-seq
MIRT789354	hsa-miR-3655	CLIP-seq
MIRT789357	hsa-miR-4254	CLIP-seq
MIRT789364	hsa-miR-4653-3p	CLIP-seq
MIRT789373	hsa-miR-619	CLIP-seq
MIRT789375	hsa-miR-934	CLIP-seq
MIRT789230	hsa-miR-105	CLIP-seq
MIRT1932819	hsa-miR-145	CLIP-seq
MIRT789269	hsa-miR-3613-3p	CLIP-seq
MIRT789276	hsa-miR-3646	CLIP-seq
MIRT789279	hsa-miR-3671	CLIP-seq
MIRT2426371	hsa-miR-3923	CLIP-seq
MIRT2426372	hsa-miR-3925-3p	CLIP-seq
MIRT2426373	hsa-miR-4282	CLIP-seq
MIRT789311	hsa-miR-4760-3p	CLIP-seq
MIRT2426374	hsa-miR-4799-5p	CLIP-seq
MIRT1932825	hsa-miR-495	CLIP-seq
MIRT2426375	hsa-miR-513a-3p	CLIP-seq
MIRT2426376	hsa-miR-515-5p	CLIP-seq
MIRT789333	hsa-miR-607	CLIP-seq
MIRT2426377	hsa-miR-628-3p	CLIP-seq
MIRT2426378	hsa-miR-766	CLIP-seq
MIRT2476209	hsa-miR-1184	CLIP-seq
MIRT789231	hsa-miR-1226	CLIP-seq
MIRT789232	hsa-miR-124	CLIP-seq
MIRT2476210	hsa-miR-1245b-3p	CLIP-seq
MIRT789235	hsa-miR-1290	CLIP-seq
MIRT2476211	hsa-miR-1298	CLIP-seq
MIRT2476212	hsa-miR-1299	CLIP-seq
MIRT2476213	hsa-miR-153	CLIP-seq
MIRT2476214	hsa-miR-1825	CLIP-seq
MIRT2476215	hsa-miR-1915	CLIP-seq
MIRT2476216	hsa-miR-199a-5p	CLIP-seq
MIRT2476217	hsa-miR-199b-5p	CLIP-seq
MIRT2476218	hsa-miR-203	CLIP-seq
MIRT2476219	hsa-miR-205	CLIP-seq
MIRT2476220	hsa-miR-218	CLIP-seq
MIRT789256	hsa-miR-24	CLIP-seq
MIRT2476221	hsa-miR-27a	CLIP-seq
MIRT2476222	hsa-miR-27b	CLIP-seq
MIRT2476223	hsa-miR-3159	CLIP-seq
MIRT1932820	hsa-miR-3189-3p	CLIP-seq
MIRT789266	hsa-miR-33a	CLIP-seq
MIRT789267	hsa-miR-33b	CLIP-seq
MIRT2476224	hsa-miR-361-3p	CLIP-seq
MIRT1932818	hsa-miR-3664-3p	CLIP-seq
MIRT2476225	hsa-miR-3912	CLIP-seq
MIRT789280	hsa-miR-3913-3p	CLIP-seq
MIRT2426372	hsa-miR-3925-3p	CLIP-seq
MIRT789282	hsa-miR-3942-3p	CLIP-seq
MIRT2476226	hsa-miR-3978	CLIP-seq
MIRT2476227	hsa-miR-4252	CLIP-seq
MIRT2476228	hsa-miR-4260	CLIP-seq
MIRT789285	hsa-miR-4267	CLIP-seq
MIRT2476229	hsa-miR-4284	CLIP-seq
MIRT2476230	hsa-miR-4307	CLIP-seq
MIRT2476231	hsa-miR-4330	CLIP-seq
MIRT2476232	hsa-miR-4477a	CLIP-seq
MIRT2476233	hsa-miR-4485	CLIP-seq
MIRT2172998	hsa-miR-4522	CLIP-seq
MIRT2476234	hsa-miR-4639-3p	CLIP-seq
MIRT2476235	hsa-miR-4641	CLIP-seq
MIRT2476236	hsa-miR-4685-5p	CLIP-seq
MIRT1932822	hsa-miR-4686	CLIP-seq
MIRT2476237	hsa-miR-4715-3p	CLIP-seq
MIRT2476238	hsa-miR-4726-3p	CLIP-seq
MIRT2476239	hsa-miR-4744	CLIP-seq
MIRT2476240	hsa-miR-4749-3p	CLIP-seq
MIRT2476241	hsa-miR-4786-3p	CLIP-seq
MIRT2476242	hsa-miR-483-3p	CLIP-seq
MIRT2476243	hsa-miR-486-3p	CLIP-seq
MIRT1932825	hsa-miR-495	CLIP-seq
MIRT2476244	hsa-miR-499-3p	CLIP-seq
MIRT2476245	hsa-miR-499a-3p	CLIP-seq
MIRT2476246	hsa-miR-502-5p	CLIP-seq
MIRT789321	hsa-miR-506	CLIP-seq
MIRT2476247	hsa-miR-513a-5p	CLIP-seq
MIRT789322	hsa-miR-513c	CLIP-seq
MIRT789323	hsa-miR-514b-5p	CLIP-seq
MIRT2476248	hsa-miR-520d-5p	CLIP-seq
MIRT2476249	hsa-miR-524-5p	CLIP-seq
MIRT789325	hsa-miR-548an	CLIP-seq
MIRT2476250	hsa-miR-579	CLIP-seq
MIRT2476251	hsa-miR-636	CLIP-seq
MIRT2173008	hsa-miR-668	CLIP-seq
MIRT2476252	hsa-miR-875-3p	CLIP-seq
MIRT2476209	hsa-miR-1184	CLIP-seq
MIRT2675133	hsa-miR-1200	CLIP-seq
MIRT789231	hsa-miR-1226	CLIP-seq
MIRT2476210	hsa-miR-1245b-3p	CLIP-seq
MIRT789236	hsa-miR-1292	CLIP-seq
MIRT2476211	hsa-miR-1298	CLIP-seq
MIRT2476212	hsa-miR-1299	CLIP-seq
MIRT2675134	hsa-miR-1470	CLIP-seq
MIRT2476213	hsa-miR-153	CLIP-seq
MIRT2476214	hsa-miR-1825	CLIP-seq
MIRT2476215	hsa-miR-1915	CLIP-seq
MIRT2476216	hsa-miR-199a-5p	CLIP-seq
MIRT2476217	hsa-miR-199b-5p	CLIP-seq
MIRT2476219	hsa-miR-205	CLIP-seq
MIRT2476220	hsa-miR-218	CLIP-seq
MIRT789256	hsa-miR-24	CLIP-seq
MIRT2476221	hsa-miR-27a	CLIP-seq
MIRT2476222	hsa-miR-27b	CLIP-seq
MIRT2675135	hsa-miR-3074-5p	CLIP-seq
MIRT789350	hsa-miR-3140-5p	CLIP-seq
MIRT2476223	hsa-miR-3159	CLIP-seq
MIRT1932820	hsa-miR-3189-3p	CLIP-seq
MIRT789266	hsa-miR-33a	CLIP-seq
MIRT789267	hsa-miR-33b	CLIP-seq
MIRT789271	hsa-miR-3617	CLIP-seq
MIRT2675136	hsa-miR-3688-3p	CLIP-seq
MIRT2476225	hsa-miR-3912	CLIP-seq
MIRT789280	hsa-miR-3913-3p	CLIP-seq
MIRT2426372	hsa-miR-3925-3p	CLIP-seq
MIRT2675137	hsa-miR-3974	CLIP-seq
MIRT2476226	hsa-miR-3978	CLIP-seq
MIRT2476228	hsa-miR-4260	CLIP-seq
MIRT789284	hsa-miR-4263	CLIP-seq
MIRT789285	hsa-miR-4267	CLIP-seq
MIRT2476229	hsa-miR-4284	CLIP-seq
MIRT2476230	hsa-miR-4307	CLIP-seq
MIRT2476231	hsa-miR-4330	CLIP-seq
MIRT2675138	hsa-miR-4438	CLIP-seq
MIRT2675139	hsa-miR-4446-5p	CLIP-seq
MIRT789294	hsa-miR-4471	CLIP-seq
MIRT2476232	hsa-miR-4477a	CLIP-seq
MIRT2476233	hsa-miR-4485	CLIP-seq
MIRT2675140	hsa-miR-4521	CLIP-seq
MIRT2172998	hsa-miR-4522	CLIP-seq
MIRT2675141	hsa-miR-4539	CLIP-seq
MIRT2476235	hsa-miR-4641	CLIP-seq
MIRT789300	hsa-miR-4646-5p	CLIP-seq
MIRT2675142	hsa-miR-4667-3p	CLIP-seq
MIRT2476236	hsa-miR-4685-5p	CLIP-seq
MIRT1932822	hsa-miR-4686	CLIP-seq
MIRT2476237	hsa-miR-4715-3p	CLIP-seq
MIRT2476238	hsa-miR-4726-3p	CLIP-seq
MIRT2675143	hsa-miR-4755-5p	CLIP-seq
MIRT2476241	hsa-miR-4786-3p	CLIP-seq
MIRT2476243	hsa-miR-486-3p	CLIP-seq
MIRT1932825	hsa-miR-495	CLIP-seq
MIRT2476244	hsa-miR-499-3p	CLIP-seq
MIRT2476245	hsa-miR-499a-3p	CLIP-seq
MIRT2476246	hsa-miR-502-5p	CLIP-seq
MIRT2675144	hsa-miR-505	CLIP-seq
MIRT2476247	hsa-miR-513a-5p	CLIP-seq
MIRT789322	hsa-miR-513c	CLIP-seq
MIRT789323	hsa-miR-514b-5p	CLIP-seq
MIRT2476248	hsa-miR-520d-5p	CLIP-seq
MIRT2476249	hsa-miR-524-5p	CLIP-seq
MIRT789328	hsa-miR-576-5p	CLIP-seq
MIRT2476250	hsa-miR-579	CLIP-seq
MIRT2476251	hsa-miR-636	CLIP-seq
MIRT789336	hsa-miR-641	CLIP-seq
MIRT2675145	hsa-miR-642a	CLIP-seq
MIRT2476252	hsa-miR-875-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	NAS	15274632
GO:0005515	Function	Protein binding	IPI	12297508, 32296183, 32814053
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	NAS	15274632
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0007219	Process	Notch signaling pathway	IBA
GO:0007219	Process	Notch signaling pathway	IEA
GO:0007220	Process	Notch receptor processing	IBA
GO:0007220	Process	Notch receptor processing	IDA	27608597
GO:0007220	Process	Notch receptor processing	NAS	10206645
GO:0010008	Component	Endosome membrane	TAS
GO:0016020	Component	Membrane	IDA	12297508
GO:0016020	Component	Membrane	IEA
GO:0016485	Process	Protein processing	IBA
GO:0016485	Process	Protein processing	IDA	12297508
GO:0016485	Process	Protein processing	IDA	27608597
GO:0016485	Process	Protein processing	IEA
GO:0016485	Process	Protein processing	IGI	12763021
GO:0030133	Component	Transport vesicle	IDA
GO:0030674	Function	Protein-macromolecule adaptor activity	IBA
GO:0030674	Function	Protein-macromolecule adaptor activity	IMP	12297508
GO:0031293	Process	Membrane protein intracellular domain proteolysis	ISS
GO:0034205	Process	Amyloid-beta formation	IDA	27608597
GO:0034205	Process	Amyloid-beta formation	IGI	12763021
GO:0042987	Process	Amyloid precursor protein catabolic process	IDA	27608597
GO:0042987	Process	Amyloid precursor protein catabolic process	IGI	12763021
GO:0042987	Process	Amyloid precursor protein catabolic process	ISS
GO:0061133	Function	Endopeptidase activator activity	IGI	12763021
GO:0061133	Function	Endopeptidase activator activity	IMP	12297508
GO:0070765	Component	Gamma-secretase complex	IBA
GO:0070765	Component	Gamma-secretase complex	IDA	12297508
GO:0070765	Component	Gamma-secretase complex	IEA
GO:0070765	Component	Gamma-secretase complex	IGI	12763021
GO:0070765	Component	Gamma-secretase complex	ISS

Other IDs

• MIM: 607630
• HGNC: 24080
• e!Ensembl: ENSG00000138613

Protein

• UniProt ID: Q8WW43
• Protein name: Gamma-secretase subunit APH-1B (APH-1b) (Aph-1beta) (Presenilin-stabilization factor-like)
• Protein function: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofact
• PDB: 8OQY, 8OQZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06105	Aph-1	2 → 238	Aph-1 protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain. {ECO:0000269|PubMed:12740439}.
• Sequence:

  MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
  DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVS
  GLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDG
  CEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKL
  CLLCQDKNFLLYNQRSR

• Sequence length: 257

Pathways

KEGG:

Notch signaling pathway
Alzheimer disease

Reactome:

Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
EPH-ephrin mediated repulsion of cells
NOTCH3 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
Amyloid fiber formation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ALZHEIMERS DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTROCYTOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC ISCHEMIC HEART DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERIOSCLEROSIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY HEART DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Alzheimer Disease	Associate	33152005	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Alzheimer Disease	Stimulate	34732252	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Atherosclerosis	Associate	27573188	★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Associate	33152005	★☆☆☆☆ Found in Text Mining only
Frontotemporal Dementia	Associate	33152005	★☆☆☆☆ Found in Text Mining only
Inflammation	Associate	24341743	★☆☆☆☆ Found in Text Mining only
Microphthalmia Syndromic 10	Associate	34732252	★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Associate	37512088	★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Associate	25808939	★☆☆☆☆ Found in Text Mining only