Gene Gene information from NCBI Gene database.
Entrez ID 8324
Gene name Frizzled class receptor 7
Gene symbol FZD7
Synonyms (NCBI Gene)
FzE3
Chromosome 2
Chromosome location 2q33.1
Summary Members of the `frizzled` gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of
miRNA miRNA information provided by mirtarbase database.
138
miRTarBase ID miRNA Experiments Reference
MIRT005690 hsa-miR-145-5p Luciferase reporter assay 20737575
MIRT024428 hsa-miR-215-5p Microarray 19074876
MIRT026887 hsa-miR-192-5p Microarray 19074876
MIRT036603 hsa-miR-940 CLASH 23622248
MIRT438813 hsa-miR-1-3p Luciferase reporter assayqRT-PCRWestern blot 23939491
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
57
GO ID Ontology Definition Evidence Reference
GO:0004888 Function Transmembrane signaling receptor activity IEA
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0005109 Function Frizzled binding IPI 19188438
GO:0005515 Function Protein binding IPI 16189514, 18256285, 18313787, 21314951, 26126266, 27386966, 27680706, 28298427, 31515488, 32296183
GO:0005546 Function Phosphatidylinositol-4,5-bisphosphate binding IDA 27386966
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603410 4045 ENSG00000155760
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75084
Protein name Frizzled-7 (Fz-7) (hFz7) (FzE3)
Protein function Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation
PDB 4Z33 , 5T44 , 5URV , 5WBS , 6NE2 , 6NE4 , 6O3A , 6O3B , 8QEO , 8YY8 , 9EPO , 9EW2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01392 Fz 49 156 Fz domain Domain
PF01534 Frizzled 244 564 Frizzled/Smoothened family membrane region Family
Tissue specificity TISSUE SPECIFICITY: High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas.
Sequence
Sequence length 574
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  mTOR signaling pathway
Wnt signaling pathway
Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells
Melanogenesis
Cushing syndrome
Alzheimer disease
Pathways of neurodegeneration - multiple diseases
Human papillomavirus infection
Pathways in cancer
Proteoglycans in cancer
Basal cell carcinoma
Breast cancer
Hepatocellular carcinoma
Gastric cancer
  PCP/CE pathway
Asymmetric localization of PCP proteins
WNT5:FZD7-mediated leishmania damping
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BONE FRACTURE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PARTIAL EPILEPSY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma Associate 30841855
★☆☆☆☆
Found in Text Mining only
Adenomatous Polyposis Coli Inhibit 9707618
★☆☆☆☆
Found in Text Mining only
Anophthalmia with pulmonary hypoplasia Associate 33934523
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Associate 10688908
★☆☆☆☆
Found in Text Mining only
Barrett Esophagus Associate 30841855
★☆☆☆☆
Found in Text Mining only
Bipolar Disorder Stimulate 29507296
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 24897117, 27323693, 31436297, 34055036
★☆☆☆☆
Found in Text Mining only
Calcinosis Cutis Stimulate 26808375
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Inhibit 29487190
★☆☆☆☆
Found in Text Mining only
Carcinoma Adenoid Cystic Associate 12368205
★☆☆☆☆
Found in Text Mining only