FZD6 (frizzled class receptor 6)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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8323 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Frizzled class receptor 6 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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FZD6 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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FZ-6, FZ6, HFZ6, NDNC1, NDNC10 |
Disease Acronyms (UniProt)
Disease acronyms from UniProt database
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NDNC1 |
Chromosome
Chromosome number
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8 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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8q22.3 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene represents a member of the `frizzled` gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-t |
SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | ||||||||||||||||
UniProt ID | O60353 | |||||||||||||||
Protein name | Frizzled-6 (Fz-6) (hFz6) | |||||||||||||||
Protein function | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activat | |||||||||||||||
PDB | 8JH7 , 8JHB | |||||||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney. | |||||||||||||||
Sequence |
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Sequence length | 706 | |||||||||||||||
Interactions | View interactions |
Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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