Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
829
Gene name Gene Name - the full gene name approved by the HGNC.
Capping actin protein of muscle Z-line subunit alpha 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CAPZA1
Synonyms (NCBI Gene) Gene synonyms aliases
CAPPA1, CAPZ, CAZ1
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p13.2
Summary Summary of gene provided in NCBI Entrez Gene.
CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments.
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004060 hsa-miR-7-5p Microarray 19073608
MIRT021466 hsa-miR-9-5p Microarray 17612493
MIRT021670 hsa-miR-140-3p Sequencing 20371350
MIRT004060 hsa-miR-7-5p Microarray 17612493
MIRT004060 hsa-miR-7-5p Microarray;Other 19073608
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding TAS 7665558
GO:0005515 Function Protein binding IPI 22891260, 23178720, 28514442, 30361697, 31837246, 31980649
GO:0005576 Component Extracellular region TAS
GO:0005829 Component Cytosol TAS
GO:0005856 Component Cytoskeleton TAS 16130169
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601580 1488 ENSG00000116489
Protein
UniProt ID P52907
Protein name F-actin-capping protein subunit alpha-1 (CapZ alpha-1)
Protein function F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these pr
PDB 1MQ1 , 1MWN , 7T5Q , 8F8Q
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01267 F-actin_cap_A 17 284 F-actin capping protein alpha subunit Family
Sequence
Sequence length 286
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Endocytosis
Motor proteins
Cytoskeleton in muscle cells
  MHC class II antigen presentation
HSP90 chaperone cycle for steroid hormone receptors (SHR)
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Advanced glycosylation endproduct receptor signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Factors involved in megakaryocyte development and platelet production
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Esophagus neoplasm Squamous cell carcinoma of esophagus rs28934578, rs121918714, rs1567556006, rs1575166666 21517111
Hypertension Hypertensive disease rs13306026 25249183, 30487518
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Rheumatoid Associate 17125526
Breast Neoplasms Associate 24098497
Carcinogenesis Associate 30176157
Colorectal Neoplasms Associate 35909892
Death Associate 23545944
Neoplasms Inhibit 23545944
Pre Eclampsia Associate 36421809
Stomach Neoplasms Associate 23545944, 36643863