Gene Gene information from NCBI Gene database.
Entrez ID 829
Gene name Capping actin protein of muscle Z-line subunit alpha 1
Gene symbol CAPZA1
Synonyms (NCBI Gene)
CAPPA1CAPZCAZ1
Chromosome 1
Chromosome location 1p13.2
Summary CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments.
miRNA miRNA information provided by mirtarbase database.
1320
miRTarBase ID miRNA Experiments Reference
MIRT004060 hsa-miR-7-5p Microarray 19073608
MIRT021466 hsa-miR-9-5p Microarray 17612493
MIRT021670 hsa-miR-140-3p Sequencing 20371350
MIRT004060 hsa-miR-7-5p Microarray 17612493
MIRT004060 hsa-miR-7-5p Microarray;Other 19073608
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
24
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding IEA
GO:0003779 Function Actin binding TAS 7665558
GO:0005515 Function Protein binding IPI 22891260, 23178720, 28514442, 30021884, 30361697, 31837246, 31980649, 33961781, 35271311
GO:0005576 Component Extracellular region TAS
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601580 1488 ENSG00000116489
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P52907
Protein name F-actin-capping protein subunit alpha-1 (CapZ alpha-1)
Protein function F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these pr
PDB 1MQ1 , 1MWN , 7T5Q , 8F8Q
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01267 F-actin_cap_A 17 284 F-actin capping protein alpha subunit Family
Sequence
Sequence length 286
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Endocytosis
Motor proteins
Cytoskeleton in muscle cells
  MHC class II antigen presentation
HSP90 chaperone cycle for steroid hormone receptors (SHR)
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Advanced glycosylation endproduct receptor signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Factors involved in megakaryocyte development and platelet production