Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8288
Gene name Gene Name - the full gene name approved by the HGNC.	Eosinophil peroxidase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	EPX
Synonyms (NCBI Gene) Gene synonyms aliases	EPO, EPP, EPX-PEN, EPXD
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q22
Summary Summary of gene provided in NCBI Entrez Gene.	This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzym

Show/Hide all(3)

SNP ID	Visualize variation	Clinical significance	Consequence
rs121434566	G>A	Affects	Coding sequence variant, missense variant
rs141055426	G>A	Affects	Coding sequence variant, missense variant
rs397518446	->G	Affects	Splice acceptor variant, coding sequence variant

Show/Hide all(156)

miRTarBase ID	miRNA	Experiments	Reference
MIRT612223	hsa-miR-3127-3p	HITS-CLIP	19536157
MIRT612222	hsa-miR-6756-3p	HITS-CLIP	19536157
MIRT612221	hsa-miR-6780b-3p	HITS-CLIP	19536157
MIRT612220	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT612219	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT612218	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT612217	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT612223	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT612222	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT612221	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT612220	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT612219	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT612218	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT612217	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT612223	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT612222	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT612221	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT612220	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT612219	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT612218	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT639796	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT612217	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT612223	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT612222	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT612221	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT612220	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT612219	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT612218	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT612217	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT612223	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT612222	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT612221	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT612220	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT612219	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT612218	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT612217	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT612223	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT612222	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT612221	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT612220	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT612219	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT612218	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT612217	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT612223	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT612222	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT612221	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT612220	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT612219	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT612218	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT612217	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT612223	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT612222	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT612221	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT612220	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT612219	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT612218	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT612217	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT612223	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT612222	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT612221	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT612220	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT612219	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT612218	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT612217	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT612223	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT612222	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT612221	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT612220	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT612219	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT612218	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT612217	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT612223	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT612222	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT612221	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT612220	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT612219	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT612218	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT612217	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT612223	hsa-miR-3127-3p	HITS-CLIP	19536157
MIRT612222	hsa-miR-6756-3p	HITS-CLIP	19536157
MIRT612221	hsa-miR-6780b-3p	HITS-CLIP	19536157
MIRT612220	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT612219	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT612218	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT612217	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT612223	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT612222	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT612221	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT612220	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT612219	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT612218	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT612217	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT612223	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT612222	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT612221	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT612220	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT612219	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT612218	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT639796	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT612217	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT612223	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT612222	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT612221	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT612220	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT612219	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT612218	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT612217	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT612223	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT612222	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT612221	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT612220	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT612219	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT612218	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT612217	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT612223	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT612222	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT612221	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT612220	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT612219	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT612218	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT612217	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT612223	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT612222	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT612221	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT612220	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT612219	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT612218	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT612217	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT612223	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT612222	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT612221	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT612220	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT612219	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT612218	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT612217	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT612223	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT612222	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT612221	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT612220	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT612219	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT612218	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT612217	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT612223	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT612222	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT612221	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT612220	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT612219	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT612218	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT612217	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT612223	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT612222	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT612221	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT612220	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT612219	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT612218	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT612217	hsa-miR-1236-3p	HITS-CLIP	23824327

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002215	Process	Defense response to nematode	IEA
GO:0004601	Function	Peroxidase activity	IBA
GO:0004601	Function	Peroxidase activity	IEA
GO:0004601	Function	Peroxidase activity	TAS	10386597
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0006979	Process	Response to oxidative stress	IEA
GO:0010936	Process	Negative regulation of macrophage cytokine production	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0020037	Function	Heme binding	IEA
GO:0032693	Process	Negative regulation of interleukin-10 production	IEA
GO:0032714	Process	Negative regulation of interleukin-5 production	IEA
GO:0032753	Process	Positive regulation of interleukin-4 production	IEA
GO:0034774	Component	Secretory granule lumen	TAS
GO:0042742	Process	Defense response to bacterium	IBA
GO:0042744	Process	Hydrogen peroxide catabolic process	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0072677	Process	Eosinophil migration	IEA
GO:0098869	Process	Cellular oxidant detoxification	IEA
GO:0140825	Function	Lactoperoxidase activity	IEA

MIM	HGNC	e!Ensembl
131399	3423	ENSG00000121053

Protein

UniProt ID

P11678

Protein name

Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain]

Protein function

Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis. {ECO:0000269|PubMed:12540536,

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03098	An_peroxidase	145 → 689	Animal haem peroxidase	Domain

Sequence

MHLLPALAGVLATLVLAQPCEGTDPASPGAVETSVLRDCIAEAKLLVDAAYNWTQKSIKQ
RLRSGSASPMDLLSYFKQPVAATRTVVRAADYMHVALGLLEEKLQPQRSGPFNVTDVLTE
PQLRLLSQASGCALRDQAERCSDKYRTITGRCNNKRRPLLGASNQALARWLPAEYEDGLS
LPFGWTPSRRRNGFLLPLVRAVSNQIVRFPNERLTSDRGRALMFMQWGQFIDHDLDFSPE
SPARVAFTAGVDCERTCAQLPPCFPIKIPPNDPRIKNQRDCIPFFRSAPSCPQNKNRVRN
QINALTSFVDASMVYGSEVSLSLRLRNRTNYLGLLAINQRFQDNGRALLPFDNLHDDPCL
LTNRSARIPCFLAGDTRSTETPKLAAMHTLFMREHNRLATELRRLNPRWNGDKLYNEARK
IMGAMVQIITYRDFLPLVLGKARARRTLGHYRGYCSNVDPRVANVFTLAFRFGHTMLQPF
MFRLDSQYRASAPNSHVPLSSAFFASWRIVYEGGIDPILRGLMATPAKLNRQDAMLVDEL
RDRLFRQVRRIGLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLAR
KFLNLYGTPDNIDIWIGAIAEPLLPGARVGPLLACLFENQFRRARDGDRFWWQKRGVFTK
RQRKALSRISLSRIICDNTGITTVSRDIFRANIYPRGFVNCSRIPRLNLSAWRGT

Sequence length

715

Interactions

View interactions

	KEGG		Reactome
	Asthma		Neutrophil degranulation

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
eosinophil peroxidase deficiency	Eosinophil peroxidase deficiency	N/A	N/A	ClinVar

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Asthma	Associate	29692868, 30876376, 31300640, 38551536
Colitis Ulcerative	Associate	39891110
Colorectal Neoplasms	Associate	22531693
Deglutition Disorders	Associate	26051952
Diabetic Nephropathies	Associate	34545296
Eosinophilia	Associate	2541222, 31300640
Eosinophilic Esophagitis	Associate	39343172
Inflammatory Bowel Diseases	Associate	23197886
Presentey Anomaly	Associate	10848988
Rectal Neoplasms	Associate	22531693
Status Asthmaticus	Associate	24295867

EPX (eosinophil peroxidase)