Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	827
Gene name	Calpain 6
Gene symbol	CAPN6
Synonyms (NCBI Gene)	CANPXCAPNXCalpMDJ914P14.1
Chromosome	X
Chromosome location	Xq23
Summary	Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, an

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miRTarBase ID	miRNA	Experiments	Reference
MIRT725610	hsa-miR-670-3p	HITS-CLIP	19536157
MIRT725609	hsa-miR-4687-5p	HITS-CLIP	19536157
MIRT725608	hsa-miR-4690-3p	HITS-CLIP	19536157
MIRT725607	hsa-miR-5685	HITS-CLIP	19536157
MIRT725606	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT725605	hsa-miR-5193	HITS-CLIP	19536157
MIRT725604	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT725603	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT725602	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT725601	hsa-miR-383-5p	HITS-CLIP	19536157
MIRT725600	hsa-miR-4772-5p	HITS-CLIP	19536157
MIRT725599	hsa-miR-4290	HITS-CLIP	19536157
MIRT659896	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT659895	hsa-miR-6870-3p	HITS-CLIP	23824327
MIRT659894	hsa-miR-6744-5p	HITS-CLIP	23824327
MIRT659893	hsa-miR-1255a	HITS-CLIP	23824327
MIRT659892	hsa-miR-1255b-5p	HITS-CLIP	23824327
MIRT659891	hsa-miR-6800-5p	HITS-CLIP	23824327
MIRT659890	hsa-miR-6802-5p	HITS-CLIP	23824327
MIRT659889	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT659887	hsa-miR-4452	HITS-CLIP	23824327
MIRT659888	hsa-miR-6509-5p	HITS-CLIP	23824327
MIRT659886	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT659885	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT659896	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT659895	hsa-miR-6870-3p	HITS-CLIP	23824327
MIRT659894	hsa-miR-6744-5p	HITS-CLIP	23824327
MIRT659893	hsa-miR-1255a	HITS-CLIP	23824327
MIRT659892	hsa-miR-1255b-5p	HITS-CLIP	23824327
MIRT659891	hsa-miR-6800-5p	HITS-CLIP	23824327
MIRT659890	hsa-miR-6802-5p	HITS-CLIP	23824327
MIRT659889	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT659887	hsa-miR-4452	HITS-CLIP	23824327
MIRT659888	hsa-miR-6509-5p	HITS-CLIP	23824327
MIRT659886	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT659885	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT862001	hsa-miR-1184	CLIP-seq
MIRT862002	hsa-miR-124	CLIP-seq
MIRT862003	hsa-miR-1301	CLIP-seq
MIRT862004	hsa-miR-299-5p	CLIP-seq
MIRT862005	hsa-miR-3160-5p	CLIP-seq
MIRT862006	hsa-miR-324-5p	CLIP-seq
MIRT862007	hsa-miR-361-3p	CLIP-seq
MIRT862008	hsa-miR-3714	CLIP-seq
MIRT862009	hsa-miR-380	CLIP-seq
MIRT862010	hsa-miR-3910	CLIP-seq
MIRT862011	hsa-miR-3924	CLIP-seq
MIRT862012	hsa-miR-4282	CLIP-seq
MIRT862013	hsa-miR-4418	CLIP-seq
MIRT862014	hsa-miR-4436b-5p	CLIP-seq
MIRT862015	hsa-miR-4495	CLIP-seq
MIRT862016	hsa-miR-4660	CLIP-seq
MIRT862017	hsa-miR-4733-5p	CLIP-seq
MIRT862018	hsa-miR-4778-3p	CLIP-seq
MIRT862019	hsa-miR-493	CLIP-seq
MIRT862020	hsa-miR-5047	CLIP-seq
MIRT862021	hsa-miR-506	CLIP-seq
MIRT862022	hsa-miR-509-3-5p	CLIP-seq
MIRT862023	hsa-miR-509-5p	CLIP-seq
MIRT862024	hsa-miR-513c	CLIP-seq
MIRT862025	hsa-miR-514b-5p	CLIP-seq
MIRT862026	hsa-miR-548ag	CLIP-seq
MIRT862027	hsa-miR-548ai	CLIP-seq
MIRT862028	hsa-miR-659	CLIP-seq
MIRT1955750	hsa-miR-1287	CLIP-seq
MIRT1955751	hsa-miR-198	CLIP-seq
MIRT1955752	hsa-miR-203	CLIP-seq
MIRT1955753	hsa-miR-3074-3p	CLIP-seq
MIRT1955754	hsa-miR-3135b	CLIP-seq
MIRT1955755	hsa-miR-3650	CLIP-seq
MIRT1955756	hsa-miR-3689d	CLIP-seq
MIRT1955757	hsa-miR-4267	CLIP-seq
MIRT2193394	hsa-miR-1285	CLIP-seq
MIRT2193395	hsa-miR-1587	CLIP-seq
MIRT2193396	hsa-miR-3187-5p	CLIP-seq
MIRT2193397	hsa-miR-3649	CLIP-seq
MIRT2193398	hsa-miR-378g	CLIP-seq
MIRT2193399	hsa-miR-4294	CLIP-seq
MIRT2193400	hsa-miR-4486	CLIP-seq
MIRT2193401	hsa-miR-4492	CLIP-seq
MIRT2193402	hsa-miR-4498	CLIP-seq
MIRT2193403	hsa-miR-4505	CLIP-seq
MIRT2193404	hsa-miR-4656	CLIP-seq
MIRT2193405	hsa-miR-4675	CLIP-seq
MIRT2193406	hsa-miR-4741	CLIP-seq
MIRT2193407	hsa-miR-612	CLIP-seq
MIRT2193408	hsa-miR-762	CLIP-seq
MIRT2385530	hsa-miR-1273g	CLIP-seq
MIRT2385531	hsa-miR-323-5p	CLIP-seq
MIRT1955755	hsa-miR-3650	CLIP-seq
MIRT2385532	hsa-miR-503	CLIP-seq
MIRT2385533	hsa-miR-876-3p	CLIP-seq
MIRT2496474	hsa-miR-1231	CLIP-seq
MIRT2496475	hsa-miR-1255b	CLIP-seq
MIRT2496476	hsa-miR-4782-5p	CLIP-seq
MIRT2496477	hsa-miR-654-3p	CLIP-seq
MIRT2496474	hsa-miR-1231	CLIP-seq
MIRT2496475	hsa-miR-1255b	CLIP-seq
MIRT2496476	hsa-miR-4782-5p	CLIP-seq
MIRT2496477	hsa-miR-654-3p	CLIP-seq

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Transcription factor	Regulation	Reference
FOXD3	Unknown	21255642
POU2F1	Unknown	21255642

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001578	Process	Microtubule bundle formation	IEA
GO:0001578	Process	Microtubule bundle formation	ISS
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	IBA
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	TAS	9503024
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005819	Component	Spindle	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0005876	Component	Spindle microtubule	IDA	17210638
GO:0006508	Process	Proteolysis	IBA
GO:0008017	Function	Microtubule binding	IEA
GO:0008017	Function	Microtubule binding	ISS
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	17210638
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0051493	Process	Regulation of cytoskeleton organization	IEA
GO:0051493	Process	Regulation of cytoskeleton organization	ISS

MIM	HGNC	e!Ensembl
300146	1483	ENSG00000077274

Q9Y6Q1

Protein name

Calpain-6 (Calpain-like protease X-linked) (Calpamodulin) (CalpM)

Protein function

Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mo

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00648	Peptidase_C2	27 → 341	Calpain family cysteine protease	Family
PF01067	Calpain_III	358 → 487	Calpain large subunit, domain III	Domain
PF00168	C2	516 → 614	C2 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed only in placenta.

Sequence

MGPPLKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDD
PHLIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGI
FHFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGL
TITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQ
EVETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISE
EWQQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVLGCW
TVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPEDGHKVIMSLQQKDLRTYRRMGRPDNYI
IGFELFKVEMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQHGRTS
EFLLRIFSEVPVQLRELTLDMPKMSCWNLARGYPKVVTQITVHSAEDLEKKYANETVNPY
LVIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPIIVQVWNSRKFCDQFLGQVTLDA
DPSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDLTEL

Sequence length

641

Interactions

View interactions

	Reactome
			Degradation of the extracellular matrix

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Prostate cancer	Uncertain significance	rs193921059	RCV000149209

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	33176622
Carcinosarcoma	Associate	17291261
Leiomyosarcoma	Associate	17291261
Neoplasms	Associate	33176622
Sarcoma	Associate	17291261
Thyroid Neoplasms	Associate	36930113

CAPN6 (calpain 6)