Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
826
Gene name Gene Name - the full gene name approved by the HGNC.
Calpain small subunit 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CAPNS1
Synonyms (NCBI Gene) Gene synonyms aliases
CALPAIN4, CANP, CANPS, CAPN4, CDPS, CSS1, PPH6
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.12
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subun
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023039 hsa-miR-124-3p Microarray 18668037
MIRT048635 hsa-miR-99a-5p CLASH 23622248
MIRT048473 hsa-miR-100-5p CLASH 23622248
MIRT047067 hsa-miR-183-5p CLASH 23622248
MIRT047067 hsa-miR-183-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
NRF1 Activation 18234454
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004198 Function Calcium-dependent cysteine-type endopeptidase activity IDA 17646163
GO:0004198 Function Calcium-dependent cysteine-type endopeptidase activity IEA
GO:0004198 Function Calcium-dependent cysteine-type endopeptidase activity TAS 8702541
GO:0005509 Function Calcium ion binding IEA
GO:0005515 Function Protein binding IPI 10639123, 18519038, 18761085, 25416956, 27173435, 28319173, 33961781
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
114170 1481 ENSG00000126247
Protein
UniProt ID P04632
Protein name Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit)
Protein function Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development (By similarity). {ECO:000
PDB 1KFU , 1KFX , 4PHJ , 4PHK , 4PHM , 4WQ2 , 4WQ3 , 5D69 , 6QLB
Family and domains
Sequence
MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMR
ILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATEL
MNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQ
FDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMF
RAFKSLDKDGTGQIQVNIQEWLQLTMYS
Sequence length 268
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Shigellosis   Degradation of the extracellular matrix
Formation of the cornified envelope
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
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