Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
821
Gene name Gene Name - the full gene name approved by the HGNC.
Calnexin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CANX
Synonyms (NCBI Gene) Gene synonyms aliases
CNX, IP90, P90
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q35.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating prote
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT050869 hsa-miR-17-5p CLASH 23622248
MIRT050692 hsa-miR-18a-5p CLASH 23622248
MIRT048231 hsa-miR-196a-5p CLASH 23622248
MIRT046689 hsa-miR-222-3p CLASH 23622248
MIRT045334 hsa-miR-185-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0005509 Function Calcium ion binding IBA
GO:0005509 Function Calcium ion binding IEA
GO:0005509 Function Calcium ion binding TAS 8136357
GO:0005515 Function Protein binding IPI 16361248, 16546175, 17110338, 17220478, 17380188, 20528919, 21205830, 22190034, 22314232, 22872700, 23826168, 24764305, 25170080, 26496610, 26618866, 28514442, 29568061, 29765154, 29924966, 30021884, 31324722, 31735293, 32783947, 32814053, 33961781, 35271311, 36012204
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
114217 1473 ENSG00000127022
Protein
UniProt ID P27824
Protein name Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90)
Protein function Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems t
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00262 Calreticulin 71 440 Calreticulin family Family
Sequence
Sequence length 592
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Protein processing in endoplasmic reticulum
Phagosome
Antigen processing and presentation
Thyroid hormone synthesis
Human T-cell leukemia virus 1 infection
  Assembly of Viral Components at the Budding Site
MHC class II antigen presentation
Interleukin-35 Signalling
Calnexin/calreticulin cycle
Interleukin-27 signaling
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Alzheimer disease Alzheimer's disease or family history of Alzheimer's disease N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenoma Inhibit 12480915
Alzheimer Disease Associate 29725981
Aortic Aneurysm Abdominal Associate 31885343
Breast Neoplasms Associate 22355776, 31422285
Carcinoma Squamous Cell Associate 23024775
Charcot Marie Tooth Disease Associate 15537650
Colorectal Neoplasms Associate 27369741
Diabetes Mellitus Type 1 Associate 36099092
Distal myopathy Nonaka type Associate 23472144
Endometriosis Associate 35124383