HYI (hydroxypyruvate isomerase (putative))

Gene

• Entrez ID: 81888
• Gene name: Hydroxypyruvate isomerase (putative)
• Gene symbol: HYI
• Synonyms (NCBI Gene): HT036
• Chromosome: 1
• Chromosome location: 1p34.2
• Summary: This gene encodes a putative hydroxypyruvate isomerase, which likely catalyzes the conversion of hydroxypyruvate to 2-hydroxy-3-oxopropanoate, and may be involved in carbohydrate transport and metabolism. Alternatively spliced transcript variants encoding

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023937	hsa-miR-1-3p	Proteomics	18668040
MIRT1057824	hsa-miR-1231	CLIP-seq
MIRT1057825	hsa-miR-1293	CLIP-seq
MIRT1057826	hsa-miR-3120-5p	CLIP-seq
MIRT1057827	hsa-miR-3612	CLIP-seq
MIRT1057828	hsa-miR-3622a-5p	CLIP-seq
MIRT1057829	hsa-miR-4443	CLIP-seq
MIRT1057830	hsa-miR-4483	CLIP-seq
MIRT1057831	hsa-miR-516b	CLIP-seq
MIRT1057832	hsa-miR-626	CLIP-seq
MIRT1057833	hsa-miR-650	CLIP-seq
MIRT1057834	hsa-miR-720	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 25416956, 33961781
GO:0008903	Function	Hydroxypyruvate isomerase activity	IBA
GO:0008903	Function	Hydroxypyruvate isomerase activity	IEA
GO:0016853	Function	Isomerase activity	IEA
GO:0046487	Process	Glyoxylate metabolic process	IBA

Other IDs

• MIM: 619128
• HGNC: 26948
• e!Ensembl: ENSG00000178922

Protein

• UniProt ID: Q5T013
• Protein name: Putative hydroxypyruvate isomerase (EC 5.3.1.22) (Endothelial cell apoptosis protein E-CE1)
• Protein function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01261	AP_endonuc_2	24 → 266	Xylose isomerase-like TIM barrel	Domain

• Sequence:

  MAPLRFSANLSWLFPELSGLPARVRAAGSSGFEAVEVAWPYAETPEALARAAREAGLRLV
  LINTPPGDQEKGEMGLGAVPGRQAAFREGLEQAVRYAKALGCPRIHLMAGRVPQGADRIA
  VKAEMEAVFLENLRHAAGVLAQEDLVGLLEPINTRITDPQYFLDTPQQAAAILQKVGRPN
  LQLQMDIFHWQIMDGNLTGNIREFLPIVGHVQVAQVPGRGEPSSPGELNFPYLFQLLEDE
  GYKGFVGCEYQPRGDTVEGLSWLRSYWDRRGHPEAGQ

• Sequence length: 277

Pathways

KEGG:

Glyoxylate and dicarboxylate metabolism
Metabolic pathways

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Acute myeloid leukemia	Benign	rs79439514	RCV005913120
Adrenocortical carcinoma, hereditary	Benign	rs79439514	RCV005913124
Cervical cancer	Likely benign; Benign	rs111686948, rs79439514	RCV005901040 RCV005913125
Clear cell carcinoma of kidney	Likely benign; Benign	rs111686948, rs79439514	RCV005901041 RCV005913127
Colon adenocarcinoma	Likely benign; Benign	rs111686948, rs79439514	RCV005901036 RCV005913119
Gastric cancer	Likely benign; Benign	rs111686948, rs79439514	RCV005901043 RCV005913129
Hepatocellular carcinoma	Likely benign; Benign	rs111686948, rs79439514	RCV005901037 RCV005913121
Lung cancer	Likely benign; Benign	rs111686948, rs79439514	RCV005901048 RCV005913134
Malignant tumor of esophagus	Likely benign; Benign	rs111686948, rs79439514	RCV005901038 RCV005913122
Melanoma	Likely benign; Benign	rs111686948, rs79439514	RCV005901047 RCV005913133
Nonpapillary renal cell carcinoma	Likely benign; Benign	rs111686948, rs79439514	RCV005901039 RCV005913123
Ovarian cancer	Benign	rs79439514	RCV005913126
Ovarian serous cystadenocarcinoma	Likely benign; Benign	rs111686948, rs79439514	RCV005901044 RCV005913130
Sarcoma	Likely benign; Benign	rs111686948, rs79439514	RCV005901042 RCV005913128
Thymoma	Likely benign	rs111686948	RCV005901045
Thyroid cancer, nonmedullary, 1	Likely benign; Benign	rs111686948, rs79439514	RCV005901046 RCV005913132
Uterine carcinosarcoma	Benign	rs79439514	RCV005913131
Uterine corpus endometrial carcinoma	Likely benign; Benign	rs111686948, rs79439514	RCV005901049 RCV005913135

Associations from Text Mining
Disease Name	Relationship Type	References
Carcinoma Hepatocellular	Associate	38022651
Endometrial Neoplasms	Associate	35937391