ST6GALNAC5 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5)

Gene

• Entrez ID: 81849
• Gene name: ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
• Gene symbol: ST6GALNAC5
• Synonyms (NCBI Gene): SIAT7-E, SIAT7E, ST6GalNAcV
• Chromosome: 1
• Chromosome location: 1p31.1
• Summary: The protein encoded by this gene is a Golgi type II transmembrane glycosyltransferase. The encoded protein catalyzes the transfer of sialic acid to cell surface proteins to modulate cell-cell interactions. Several transcript variants encoding different is

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019483	hsa-miR-148b-3p	Microarray	17612493
MIRT725137	hsa-miR-377-3p	HITS-CLIP	19536157
MIRT725136	hsa-miR-3688-3p	HITS-CLIP	19536157
MIRT725135	hsa-miR-5093	HITS-CLIP	19536157
MIRT725137	hsa-miR-377-3p	HITS-CLIP	19536157
MIRT725136	hsa-miR-3688-3p	HITS-CLIP	19536157
MIRT725135	hsa-miR-5093	HITS-CLIP	19536157
MIRT1393771	hsa-miR-1276	CLIP-seq
MIRT1393772	hsa-miR-219-2-3p	CLIP-seq
MIRT1393773	hsa-miR-2278	CLIP-seq
MIRT1393774	hsa-miR-2964a-3p	CLIP-seq
MIRT1393775	hsa-miR-3130-3p	CLIP-seq
MIRT1393776	hsa-miR-4328	CLIP-seq
MIRT1393777	hsa-miR-4680-3p	CLIP-seq
MIRT1393778	hsa-miR-4793-3p	CLIP-seq
MIRT1393779	hsa-miR-520d-5p	CLIP-seq
MIRT1393780	hsa-miR-524-5p	CLIP-seq
MIRT1393781	hsa-miR-544	CLIP-seq
MIRT2118218	hsa-miR-576-3p	CLIP-seq
MIRT2340200	hsa-miR-3140-3p	CLIP-seq
MIRT2340201	hsa-miR-377	CLIP-seq
MIRT2340202	hsa-miR-4789-3p	CLIP-seq
MIRT1393779	hsa-miR-520d-5p	CLIP-seq
MIRT1393780	hsa-miR-524-5p	CLIP-seq
MIRT1393781	hsa-miR-544	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0001574	Process	Ganglioside biosynthetic process	IBA
GO:0001665	Function	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	IBA
GO:0001665	Function	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	ISS
GO:0001665	Function	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	TAS
GO:0005794	Component	Golgi apparatus	IEA
GO:0006486	Process	Protein glycosylation	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006688	Process	Glycosphingolipid biosynthetic process	ISS
GO:0006688	Process	Glycosphingolipid biosynthetic process	TAS
GO:0008373	Function	Sialyltransferase activity	IEA
GO:0008373	Function	Sialyltransferase activity	ISS	12668675
GO:0009311	Process	Oligosaccharide metabolic process	IBA
GO:0009312	Process	Oligosaccharide biosynthetic process	ISS	12668675
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA

Other IDs

• MIM: 610134
• HGNC: 19342
• e!Ensembl: ENSG00000117069

Protein

• UniProt ID: Q9BVH7
• Protein name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (EC 2.4.99.-) (GD1 alpha synthase) (GalNAc alpha-2,6-sialyltransferase V) (ST6GalNAc V) (ST6GalNAcV) (Sialyltransferase 7E) (SIAT7-E)
• Protein function: Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transferring the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequen
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00777	Glyco_transf_29	79 → 317	Glycosyltransferase family 29 (sialyltransferase)	Family

• Sequence:

  MKTLMRHGLAVCLALTTMCTSLLLVYSSLGGQKERPPQQQQQQQQQQQQASATGSSQPAA
  ESSTQQRPGVPAGPRPLDGYLGVADHKPLKMHCRDCALVTSSGHLLHSRQGSQIDQTECV
  IRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRNRHDLLNVSQGTVFIFWGPSSYMRRD
  GKGQVYNNLHLLSQVLPRLKAFMITRHKMLQFDELFKQETGKDRKISNTWLSTGWFTMTI
  ALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPFGPDECTMYLSHERGRKGSHHRFITE
  KRVFKNWARTFNIHFFQPDWKPESLAINHPENKPVF

• Sequence length: 336

Pathways

KEGG:

Glycosphingolipid biosynthesis - ganglio series
Metabolic pathways

Reactome:

Sialic acid metabolism

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