Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8178
Gene name Gene Name - the full gene name approved by the HGNC.
Elongation factor for RNA polymerase II
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ELL
Synonyms (NCBI Gene) Gene synonyms aliases
C19orf17, ELL1, MEN, PPP1R68
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.11
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT039101 hsa-miR-769-3p CLASH 23622248
MIRT960708 hsa-miR-1207-5p CLIP-seq
MIRT960709 hsa-miR-1238 CLIP-seq
MIRT960710 hsa-miR-1252 CLIP-seq
MIRT960711 hsa-miR-1269 CLIP-seq
Transcription factors
Transcription factor Regulation Reference
EAF1 Activation 16006523
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001701 Process In utero embryonic development IEA
GO:0005515 Function Protein binding IPI 19389623, 19819239, 22195968, 23932780, 24413172
GO:0005654 Component Nucleoplasm IDA
GO:0005654 Component Nucleoplasm TAS
GO:0005829 Component Cytosol IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600284 23114 ENSG00000105656
Protein
UniProt ID P55199
Protein name RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein)
Protein function Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongatio
PDB 2DOA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10390 ELL 6 292 RNA polymerase II elongation factor ELL Family
PF07303 Occludin_ELL 513 614 Occludin homology domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes.
Sequence
Sequence length 621
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Viral life cycle - HIV-1   Formation of RNA Pol II elongation complex
RNA Polymerase II Pre-transcription Events
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
23535729
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
29059683, 25751625, 23535729
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537 29212778
Unknown
Disease term Disease name Evidence References Source
Metabolic Syndrome Metabolic Syndrome GWAS
Crohn Disease Crohn Disease GWAS
Psoriasis Psoriasis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 23593120, 25227710
Leukemia Associate 11238904, 12686606
Leukemia Myeloid Acute Associate 10419521, 10882741, 11238904, 17044034, 21900057, 36543308, 7991593, 8639852, 9268387
Neoplasms Associate 11238904, 27058417, 36543308
Neoplasms Inhibit 12773566
Prostatic Neoplasms Associate 27058417
Sarcoma Myeloid Associate 30922345