CAMK2B (calcium/calmodulin dependent protein kinase II beta)

Gene

• Entrez ID: 816
• Gene name: Calcium/calmodulin dependent protein kinase II beta
• Gene symbol: CAMK2B
• Synonyms (NCBI Gene): CAM2, CAMK2, CAMKB, CaMKIIbeta, MRD54
• Chromosome: 7
• Chromosome location: 7p13
• Summary: The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, t

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1554385102	C>T	Likely-pathogenic, uncertain-significance	Splice donor variant
rs1554385111	T>C	Pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs1554385203	T>A	Pathogenic	Coding sequence variant, missense variant
rs1554385305	C>T	Pathogenic	Splice acceptor variant
rs1554386687	C>T	Pathogenic	Coding sequence variant, missense variant
rs1554387293	G>A	Pathogenic	Coding sequence variant, missense variant
rs1554389088	G>A	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs1554402092	C>T	Pathogenic	5 prime UTR variant, coding sequence variant, missense variant
rs1554434435	G>A	Pathogenic, likely-pathogenic	5 prime UTR variant, coding sequence variant, stop gained

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT045124	hsa-miR-186-5p	CLASH	23622248
MIRT860136	hsa-miR-1228	CLIP-seq
MIRT860137	hsa-miR-129-3p	CLIP-seq
MIRT860138	hsa-miR-129-5p	CLIP-seq
MIRT860139	hsa-miR-147	CLIP-seq
MIRT860140	hsa-miR-3065-3p	CLIP-seq
MIRT860141	hsa-miR-3127-5p	CLIP-seq
MIRT860142	hsa-miR-3151	CLIP-seq
MIRT860143	hsa-miR-3202	CLIP-seq
MIRT860144	hsa-miR-3591-3p	CLIP-seq
MIRT860145	hsa-miR-3616-3p	CLIP-seq
MIRT860146	hsa-miR-3650	CLIP-seq
MIRT860147	hsa-miR-3911	CLIP-seq
MIRT860148	hsa-miR-3944-3p	CLIP-seq
MIRT860149	hsa-miR-4291	CLIP-seq
MIRT860150	hsa-miR-4436b-3p	CLIP-seq
MIRT860151	hsa-miR-4447	CLIP-seq
MIRT860152	hsa-miR-4450	CLIP-seq
MIRT860153	hsa-miR-4455	CLIP-seq
MIRT860154	hsa-miR-4472	CLIP-seq
MIRT860155	hsa-miR-4476	CLIP-seq
MIRT860156	hsa-miR-4655-5p	CLIP-seq
MIRT860157	hsa-miR-4687-5p	CLIP-seq
MIRT860158	hsa-miR-4690-3p	CLIP-seq
MIRT860159	hsa-miR-4695-5p	CLIP-seq
MIRT860160	hsa-miR-4731-5p	CLIP-seq
MIRT860161	hsa-miR-4747-5p	CLIP-seq
MIRT860162	hsa-miR-4775	CLIP-seq
MIRT860163	hsa-miR-488	CLIP-seq
MIRT860164	hsa-miR-491-5p	CLIP-seq
MIRT860165	hsa-miR-495	CLIP-seq
MIRT860166	hsa-miR-564	CLIP-seq
MIRT860167	hsa-miR-590-3p	CLIP-seq
MIRT860168	hsa-miR-609	CLIP-seq
MIRT860169	hsa-miR-644	CLIP-seq
MIRT860170	hsa-miR-765	CLIP-seq
MIRT860171	hsa-miR-1307	CLIP-seq
MIRT860172	hsa-miR-1323	CLIP-seq
MIRT860173	hsa-miR-3136-3p	CLIP-seq
MIRT860174	hsa-miR-3154	CLIP-seq
MIRT860175	hsa-miR-320e	CLIP-seq
MIRT860176	hsa-miR-3919	CLIP-seq
MIRT860177	hsa-miR-423-3p	CLIP-seq
MIRT860178	hsa-miR-4285	CLIP-seq
MIRT860179	hsa-miR-4475	CLIP-seq
MIRT860158	hsa-miR-4690-3p	CLIP-seq
MIRT860180	hsa-miR-512-3p	CLIP-seq
MIRT860181	hsa-miR-548o	CLIP-seq
MIRT860182	hsa-miR-593	CLIP-seq
MIRT860183	hsa-miR-626	CLIP-seq
MIRT860184	hsa-miR-922	CLIP-seq
MIRT860185	hsa-miR-1184	CLIP-seq
MIRT860186	hsa-miR-1205	CLIP-seq
MIRT860187	hsa-miR-3158-5p	CLIP-seq
MIRT860188	hsa-miR-3166	CLIP-seq
MIRT860189	hsa-miR-3663-5p	CLIP-seq
MIRT860190	hsa-miR-4269	CLIP-seq
MIRT860191	hsa-miR-4733-3p	CLIP-seq
MIRT860192	hsa-miR-4771	CLIP-seq
MIRT860193	hsa-miR-544	CLIP-seq
MIRT860138	hsa-miR-129-5p	CLIP-seq
MIRT1922653	hsa-miR-579	CLIP-seq
MIRT1955260	hsa-miR-624	CLIP-seq
MIRT860145	hsa-miR-3616-3p	CLIP-seq
MIRT860148	hsa-miR-3944-3p	CLIP-seq
MIRT860150	hsa-miR-4436b-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003779	Function	Actin binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004683	Function	Calcium/calmodulin-dependent protein kinase activity	IBA
GO:0004683	Function	Calcium/calmodulin-dependent protein kinase activity	IDA	31930741
GO:0004683	Function	Calcium/calmodulin-dependent protein kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	20668654, 25416956, 26871637, 27173435, 29426014, 32296183, 32707033, 33961781
GO:0005516	Function	Calmodulin binding	IBA
GO:0005516	Function	Calmodulin binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005954	Component	Calcium- and calmodulin-dependent protein kinase complex	IDA	20668654
GO:0005954	Component	Calcium- and calmodulin-dependent protein kinase complex	IEA
GO:0006468	Process	Protein phosphorylation	TAS	9060999
GO:0007165	Process	Signal transduction	TAS	9060999
GO:0007399	Process	Nervous system development	IEA
GO:0010976	Process	Positive regulation of neuron projection development	ISS
GO:0014069	Component	Postsynaptic density	IBA
GO:0014733	Process	Regulation of skeletal muscle adaptation	TAS	15294044
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016529	Component	Sarcoplasmic reticulum	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030666	Component	Endocytic vesicle membrane	IEA
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0033017	Component	Sarcoplasmic reticulum membrane	IEA
GO:0042802	Function	Identical protein binding	IPI	20668654, 25416956
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0042803	Function	Protein homodimerization activity	IPI	20668654
GO:0043005	Component	Neuron projection	IBA
GO:0045202	Component	Synapse	IEA
GO:0046777	Process	Protein autophosphorylation	IDA	18817731
GO:0048168	Process	Regulation of neuronal synaptic plasticity	IBA
GO:0048169	Process	Regulation of long-term neuronal synaptic plasticity	TAS	18817731
GO:0051823	Process	Regulation of synapse structural plasticity	TAS	18817731
GO:0051924	Process	Regulation of calcium ion transport	TAS	15294044
GO:0060291	Process	Long-term synaptic potentiation	IEA
GO:0060291	Process	Long-term synaptic potentiation	TAS	20668654
GO:0060998	Process	Regulation of dendritic spine development	TAS	18817731
GO:0061003	Process	Positive regulation of dendritic spine morphogenesis	ISS
GO:0090129	Process	Positive regulation of synapse maturation	ISS
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1903076	Process	Regulation of protein localization to plasma membrane	IBA
GO:2001222	Process	Regulation of neuron migration	IMP	29100089

Other IDs

• MIM: 607707
• HGNC: 1461
• e!Ensembl: ENSG00000058404

Protein

• UniProt ID: Q13554
• Protein name: Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)
• Protein function: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticul
• PDB: 3BHH, 7URW, 7URY, 7URZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	14 → 272	Protein kinase domain	Domain
  PF08332	CaMKII_AD	534 → 661	Calcium/calmodulin dependent protein kinase II association domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle. {ECO:0000269|PubMed:16690701}.
• Sequence:

  MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLER
  EARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQI
  LEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
  LSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDT
  VTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKL
  KGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADGVKPQTNSTK
  NSAAATSPKGTLPPAALEPQTTVIHNPVDGIKESSDSANTTIEDEDAKAPRVPDILSSVR
  RGSGAPEAEGPLPCPSPAPFSPLPAPSPRISDILNSVRRGSGTPEAEGPLSAGPPPCLSP
  ALLGPLSSPSPRISDILNSVRRGSGTPEAEGPSPVGPPPCPSPTIPGPLPTPSRKQEIIK
  TTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHT
  TILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGA
  PVAPLQ

• Sequence length: 666

Pathways

KEGG:

ErbB signaling pathway
Calcium signaling pathway
cAMP signaling pathway
HIF-1 signaling pathway
Oocyte meiosis
Efferocytosis
Necroptosis
Adrenergic signaling in cardiomyocytes
Wnt signaling pathway
Axon guidance
Circadian entrainment
Long-term potentiation
Neurotrophin signaling pathway
Cholinergic synapse
Dopaminergic synapse
Olfactory transduction
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Melanogenesis
Oxytocin signaling pathway
Glucagon signaling pathway
Aldosterone synthesis and secretion
Cushing syndrome
Gastric acid secretion
Parkinson disease
Pathways of neurodegeneration - multiple diseases
Amphetamine addiction
Tuberculosis
Pathways in cancer
Proteoglycans in cancer
Glioma
Diabetic cardiomyopathy
Lipid and atherosclerosis

Reactome:

HSF1-dependent transactivation
Trafficking of AMPA receptors
Unblocking of NMDA receptors, glutamate binding and activation
Phase 0 - rapid depolarisation
Ion homeostasis
RAF activation
RAF/MAP kinase cascade
Signaling by moderate kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Interferon gamma signaling
Ion transport by P-type ATPases
Signaling downstream of RAS mutants

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Abnormality of the nervous system	Likely pathogenic; Pathogenic	rs1554389088	RCV001814167
Intellectual disability	Likely pathogenic; Pathogenic	rs2128963917, rs1554385102, rs1554385111, rs1554385305, rs1554386687, rs1554389088, rs1554402092, rs1554434435, rs2096680726	RCV005622120 RCV000577913 RCV000577892 RCV000577873 RCV000577912 RCV000577890 RCV000577922 RCV000577898 RCV001260651
Intellectual disability, autosomal dominant 54	Likely pathogenic; Pathogenic	rs2486084284, rs1554385111, rs1554386687, rs1554389088, rs1554402092, rs1554434435, rs1554387293, rs1554385203	RCV003236654 RCV000516162 RCV000516159 RCV000516163 RCV000516161 RCV000516157 RCV000678219 RCV000678220

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Autism spectrum disorder	Uncertain significance; Conflicting classifications of pathogenicity	rs35452727, rs1584086882	RCV003128072 RCV003128073
CAMK2B-related disorder	Benign; Likely benign; Uncertain significance	rs1127065, rs369973326, rs371901503, rs773750991, rs149091142, rs202187533, rs550135870, rs367731329, rs200389446, rs201188394, rs372486674, rs770287814, rs575970166, rs564835679, rs200866892, rs200808092, rs2128857849, rs2096547723, rs2096701433, rs2483954422, rs2486009114, rs565318645, rs77158048	RCV003983976 RCV003976110 RCV003958472 RCV003407996 RCV003968675 RCV003895914 RCV003958615 RCV003923776 RCV003913623 RCV003971143 RCV003948882 RCV003978558 RCV003896069 RCV003913595 RCV003951132 RCV003971030 RCV003403727 RCV003898464 RCV003400212 RCV003397533 RCV003971857 RCV003962651 RCV003935992
Developmental disorder	Uncertain significance	rs2486097918	RCV003128014
Dystonia, early-onset, and/or spastic paraplegia	Benign; Likely benign	rs367731329	RCV005626606
Hereditary ataxia	Conflicting classifications of pathogenicity	rs555460132	RCV005626482
Intellectual disability, autosomal dominant 40	Conflicting classifications of pathogenicity	rs755427879	RCV005361979
Neurodevelopmental abnormality	Uncertain significance	rs2485518014	RCV003149163
Neurodevelopmental disorder	Uncertain significance	rs2128968013	RCV001780002
Ovarian serous cystadenocarcinoma	Uncertain significance	rs1408614185	RCV005931565

Associations from Text Mining
Disease Name	Relationship Type	References
Abortion Spontaneous	Associate	37625567
Abruptio Placentae	Associate	30194050
Anxiety	Associate	33082841
Atrial Fibrillation	Associate	37597360
Breast Neoplasms	Associate	21871176, 27605043
Coronary Artery Disease	Associate	35151267
Diabetes Mellitus Type 2	Associate	40141237
Drug Resistant Epilepsy	Associate	40646440
Epilepsy	Associate	35805192
Epilepsy rolandic with paroxysmal exercise induced dystonia and writer's cramp	Associate	40646440
Glioblastoma	Associate	30816530
Glioma	Associate	30816530
Intellectual Disability	Associate	37625567
Mental Retardation Autosomal Recessive 7	Associate	37625567
Metabolic Syndrome	Associate	37612641
Neoplasm Metastasis	Stimulate	27605043
Neoplasms	Associate	21871176
Nerve Degeneration	Associate	33767277
Neurologic Manifestations	Associate	29784083
Neurotoxicity Syndromes	Associate	37906427
Prediabetic State	Associate	40141237
Sleep Disorders Circadian Rhythm	Associate	33536559