Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
81567
Gene name Gene Name - the full gene name approved by the HGNC.
Thioredoxin domain containing 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TXNDC5
Synonyms (NCBI Gene) Gene synonyms aliases
ENDOPDI, ERP46, HCC-2, HCC2, PDIA15, STRF8, UNQ364
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p24.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequ
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT049868 hsa-miR-31-5p CLASH 23622248
MIRT042668 hsa-miR-196b-5p CLASH 23622248
MIRT037960 hsa-miR-505-5p CLASH 23622248
MIRT451852 hsa-miR-3120-3p PAR-CLIP 23592263
MIRT451851 hsa-miR-503-5p PAR-CLIP 23592263
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003756 Function Protein disulfide isomerase activity IBA
GO:0003756 Function Protein disulfide isomerase activity IEA
GO:0003756 Function Protein disulfide isomerase activity ISS
GO:0005515 Function Protein binding IPI 21057456, 24462249, 32296183
GO:0005576 Component Extracellular region TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
616412 21073 ENSG00000239264
Protein
UniProt ID Q8NBS9
Protein name Thioredoxin domain-containing protein 5 (EC 1.8.4.-) (EC 5.3.4.1) (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Thioredoxin-like protein p46)
Protein function Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds.
PDB 2DIZ , 3UJ1 , 3UVT , 3WGD , 3WGE , 3WGX , 8EKY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00085 Thioredoxin 62 166 Thioredoxin Domain
PF00085 Thioredoxin 190 292 Thioredoxin Domain
PF00085 Thioredoxin 323 426 Thioredoxin Domain
Sequence
Sequence length 432
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Protein processing in endoplasmic reticulum   Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Neutrophil degranulation
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Coronary artery disease Coronary artery disease N/A N/A GWAS
Pelvic Organ Prolapse Pelvic organ prolapse N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Arthritis Rheumatoid Associate 21801346, 28603283, 29131315
Arthritis Rheumatoid Stimulate 21801346, 26166764
Ataxia Telangiectasia Stimulate 35296659
Attention Deficit Disorder with Hyperactivity Associate 19694819
Carcinogenesis Associate 26810069, 29749460
Carcinogenesis Stimulate 29749460
Carcinoma Hepatocellular Associate 34606982
Carcinoma Renal Cell Stimulate 26810069
Colorectal Neoplasms Stimulate 17895523, 29749460
Colorectal Neoplasms Associate 39275334