Gene Gene information from NCBI Gene database.
Entrez ID 81567
Gene name Thioredoxin domain containing 5
Gene symbol TXNDC5
Synonyms (NCBI Gene)
ENDOPDIERP46HCC-2HCC2PDIA15STRF8UNQ364
Chromosome 6
Chromosome location 6p24.3
Summary This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequ
miRNA miRNA information provided by mirtarbase database.
675
miRTarBase ID miRNA Experiments Reference
MIRT049868 hsa-miR-31-5p CLASH 23622248
MIRT042668 hsa-miR-196b-5p CLASH 23622248
MIRT037960 hsa-miR-505-5p CLASH 23622248
MIRT451852 hsa-miR-3120-3p PAR-CLIP 23592263
MIRT451851 hsa-miR-503-5p PAR-CLIP 23592263
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22
GO ID Ontology Definition Evidence Reference
GO:0003756 Function Protein disulfide isomerase activity IBA
GO:0003756 Function Protein disulfide isomerase activity IEA
GO:0003756 Function Protein disulfide isomerase activity ISS
GO:0005515 Function Protein binding IPI 21057456, 24462249, 32296183
GO:0005576 Component Extracellular region TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616412 21073 ENSG00000239264
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NBS9
Protein name Thioredoxin domain-containing protein 5 (EC 1.8.4.-) (EC 5.3.4.1) (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Thioredoxin-like protein p46)
Protein function Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds.
PDB 2DIZ , 3UJ1 , 3UVT , 3WGD , 3WGE , 3WGX , 8EKY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00085 Thioredoxin 62 166 Thioredoxin Domain
PF00085 Thioredoxin 190 292 Thioredoxin Domain
PF00085 Thioredoxin 323 426 Thioredoxin Domain
Sequence
Sequence length 432
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Protein processing in endoplasmic reticulum   Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Neutrophil degranulation