Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	81543
Gene name Gene Name - the full gene name approved by the HGNC.	Leucine rich repeat containing 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	LRRC3
Synonyms (NCBI Gene) Gene synonyms aliases	C21orf102, C21orf30, LRRC3DN
Chromosome Chromosome number	21
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	21q22.3

Show/Hide all(118)

miRTarBase ID	miRNA	Experiments
MIRT1119506	hsa-miR-1299	CLIP-seq
MIRT1119507	hsa-miR-1304	CLIP-seq
MIRT1119508	hsa-miR-2355-5p	CLIP-seq
MIRT1119509	hsa-miR-24	CLIP-seq
MIRT1119510	hsa-miR-3122	CLIP-seq
MIRT1119511	hsa-miR-3140-5p	CLIP-seq
MIRT1119512	hsa-miR-3178	CLIP-seq
MIRT1119513	hsa-miR-3194-3p	CLIP-seq
MIRT1119514	hsa-miR-3197	CLIP-seq
MIRT1119515	hsa-miR-3611	CLIP-seq
MIRT1119516	hsa-miR-3614-5p	CLIP-seq
MIRT1119517	hsa-miR-3689a-3p	CLIP-seq
MIRT1119518	hsa-miR-3689c	CLIP-seq
MIRT1119519	hsa-miR-3689d	CLIP-seq
MIRT1119520	hsa-miR-3913-5p	CLIP-seq
MIRT1119521	hsa-miR-3929	CLIP-seq
MIRT1119522	hsa-miR-4261	CLIP-seq
MIRT1119523	hsa-miR-4284	CLIP-seq
MIRT1119524	hsa-miR-4419b	CLIP-seq
MIRT1119525	hsa-miR-4478	CLIP-seq
MIRT1119526	hsa-miR-4649-3p	CLIP-seq
MIRT1119527	hsa-miR-4662a-5p	CLIP-seq
MIRT1119528	hsa-miR-4676-5p	CLIP-seq
MIRT1119529	hsa-miR-4712-5p	CLIP-seq
MIRT1119530	hsa-miR-4728-5p	CLIP-seq
MIRT1119531	hsa-miR-4755-3p	CLIP-seq
MIRT1119532	hsa-miR-4767	CLIP-seq
MIRT1119533	hsa-miR-485-5p	CLIP-seq
MIRT1119534	hsa-miR-487a	CLIP-seq
MIRT1119535	hsa-miR-490-3p	CLIP-seq
MIRT1119536	hsa-miR-575	CLIP-seq
MIRT1119537	hsa-miR-593	CLIP-seq
MIRT1119538	hsa-miR-649	CLIP-seq
MIRT1119539	hsa-miR-770-5p	CLIP-seq
MIRT1119540	hsa-miR-875-3p	CLIP-seq
MIRT2033767	hsa-miR-1271	CLIP-seq
MIRT2033768	hsa-miR-1321	CLIP-seq
MIRT2033769	hsa-miR-1323	CLIP-seq
MIRT2033770	hsa-miR-182	CLIP-seq
MIRT2033771	hsa-miR-1827	CLIP-seq
MIRT1119509	hsa-miR-24	CLIP-seq
MIRT2033772	hsa-miR-3162-5p	CLIP-seq
MIRT1119514	hsa-miR-3197	CLIP-seq
MIRT1119517	hsa-miR-3689a-3p	CLIP-seq
MIRT1119518	hsa-miR-3689c	CLIP-seq
MIRT2033773	hsa-miR-371b-5p	CLIP-seq
MIRT1119521	hsa-miR-3929	CLIP-seq
MIRT2033774	hsa-miR-4267	CLIP-seq
MIRT1119523	hsa-miR-4284	CLIP-seq
MIRT1119524	hsa-miR-4419b	CLIP-seq
MIRT1119525	hsa-miR-4478	CLIP-seq
MIRT1119526	hsa-miR-4649-3p	CLIP-seq
MIRT1119527	hsa-miR-4662a-5p	CLIP-seq
MIRT1119528	hsa-miR-4676-5p	CLIP-seq
MIRT2033775	hsa-miR-4726-3p	CLIP-seq
MIRT1119530	hsa-miR-4728-5p	CLIP-seq
MIRT2033776	hsa-miR-4729	CLIP-seq
MIRT2033777	hsa-miR-4739	CLIP-seq
MIRT1119531	hsa-miR-4755-3p	CLIP-seq
MIRT2033778	hsa-miR-4756-5p	CLIP-seq
MIRT1119533	hsa-miR-485-5p	CLIP-seq
MIRT2033779	hsa-miR-495	CLIP-seq
MIRT2033780	hsa-miR-548o	CLIP-seq
MIRT1119536	hsa-miR-575	CLIP-seq
MIRT2033781	hsa-miR-580	CLIP-seq
MIRT2033782	hsa-miR-888	CLIP-seq
MIRT2033783	hsa-miR-96	CLIP-seq
MIRT2264203	hsa-miR-4325	CLIP-seq
MIRT1119507	hsa-miR-1304	CLIP-seq
MIRT2390340	hsa-miR-4709-5p	CLIP-seq
MIRT2453351	hsa-miR-1205	CLIP-seq
MIRT2453352	hsa-miR-1909	CLIP-seq
MIRT2453353	hsa-miR-448	CLIP-seq
MIRT1119527	hsa-miR-4662a-5p	CLIP-seq
MIRT1119528	hsa-miR-4676-5p	CLIP-seq
MIRT2453354	hsa-miR-4684-5p	CLIP-seq
MIRT1119531	hsa-miR-4755-3p	CLIP-seq
MIRT2453355	hsa-miR-548c-3p	CLIP-seq
MIRT1119536	hsa-miR-575	CLIP-seq
MIRT2453356	hsa-miR-596	CLIP-seq
MIRT1119507	hsa-miR-1304	CLIP-seq
MIRT2563320	hsa-miR-1910	CLIP-seq
MIRT1119509	hsa-miR-24	CLIP-seq
MIRT1119510	hsa-miR-3122	CLIP-seq
MIRT1119514	hsa-miR-3197	CLIP-seq
MIRT1119516	hsa-miR-3614-5p	CLIP-seq
MIRT1119517	hsa-miR-3689a-3p	CLIP-seq
MIRT1119518	hsa-miR-3689c	CLIP-seq
MIRT1119520	hsa-miR-3913-5p	CLIP-seq
MIRT1119521	hsa-miR-3929	CLIP-seq
MIRT2033774	hsa-miR-4267	CLIP-seq
MIRT1119523	hsa-miR-4284	CLIP-seq
MIRT1119524	hsa-miR-4419b	CLIP-seq
MIRT1119525	hsa-miR-4478	CLIP-seq
MIRT2563321	hsa-miR-455-3p	CLIP-seq
MIRT1119526	hsa-miR-4649-3p	CLIP-seq
MIRT2453354	hsa-miR-4684-5p	CLIP-seq
MIRT1119530	hsa-miR-4728-5p	CLIP-seq
MIRT1119532	hsa-miR-4767	CLIP-seq
MIRT1119533	hsa-miR-485-5p	CLIP-seq
MIRT2453355	hsa-miR-548c-3p	CLIP-seq
MIRT1119507	hsa-miR-1304	CLIP-seq
MIRT1119510	hsa-miR-3122	CLIP-seq
MIRT1119514	hsa-miR-3197	CLIP-seq
MIRT1119516	hsa-miR-3614-5p	CLIP-seq
MIRT1119517	hsa-miR-3689a-3p	CLIP-seq
MIRT1119518	hsa-miR-3689c	CLIP-seq
MIRT1119520	hsa-miR-3913-5p	CLIP-seq
MIRT1119521	hsa-miR-3929	CLIP-seq
MIRT1119524	hsa-miR-4419b	CLIP-seq
MIRT1119525	hsa-miR-4478	CLIP-seq
MIRT1119526	hsa-miR-4649-3p	CLIP-seq
MIRT1119527	hsa-miR-4662a-5p	CLIP-seq
MIRT2453354	hsa-miR-4684-5p	CLIP-seq
MIRT1119530	hsa-miR-4728-5p	CLIP-seq
MIRT1119532	hsa-miR-4767	CLIP-seq
MIRT1119533	hsa-miR-485-5p	CLIP-seq
MIRT2453355	hsa-miR-548c-3p	CLIP-seq

Show/Hide all(2)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17474147
GO:0016021	Component	Integral component of membrane	IEA

MIM	HGNC	e!Ensembl
617620	14965	ENSG00000160233

Protein

UniProt ID

Q9BY71

Protein name

Leucine-rich repeat-containing protein 3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01462	LRRNT	32 → 63	Leucine rich repeat N-terminal domain	Family
PF13855	LRR_8	65 → 113	Leucine rich repeat	Repeat
PF00560	LRR_1	114 → 136	Leucine Rich Repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Widely expressed; detected in testis, lung, small intestine, breast, brain, heart, bone marrow, placenta, colon, fetal brain, liver, fetal liver, thymus, salivary gland, spinal cord, spleen, trachea and adrenal gland.

Sequence

MGTVRPPRPSLLLVSTRESCLFLLFCLHLGAACPQPCRCPDHAGAVAVFCSLRGLQEVPE
DIPANTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDL
SYNRIQRIPKDALGKLSAKIRLSHNPLHCECALQEALWELKLDPDSVDEIACHTSVQEEF
VGKPLVQALDAGASLCSVPHRTTDVAMLVTMFGWFAMVIAYVVYYVRHNQEDARRHLEYL
KSLPSAPASKDPIGPGP

Sequence length

257

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Intracranial aneurysm	Intracranial Aneurysm	rs1594095223	30823506

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Evidence	Source
Unknown
Intracranial Aneurysm	Intracranial Aneurysm		GWAS
Colorectal Cancer	Colorectal Cancer	In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1.	GWAS, CBGDA

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining
Polycythemia Vera	Associate	28427458

LRRC3 (leucine rich repeat containing 3)