Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8148
Gene name	TATA-box binding protein associated factor 15
Gene symbol	TAF15
Synonyms (NCBI Gene)	Npl3RBP56TAF2NTAFII68
Chromosome	17
Chromosome location	17q12
Summary	This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocat

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021732	hsa-miR-132-3p	Microarray	17612493
MIRT025067	hsa-miR-181a-5p	Microarray	17612493
MIRT030412	hsa-miR-24-3p	Microarray	19748357
MIRT031463	hsa-miR-16-5p	Proteomics	18668040
MIRT048160	hsa-miR-196a-5p	CLASH	23622248
MIRT047604	hsa-miR-10a-5p	CLASH	23622248
MIRT046039	hsa-miR-125b-5p	CLASH	23622248
MIRT044517	hsa-miR-320a	CLASH	23622248
MIRT041143	hsa-miR-501-5p	CLASH	23622248
MIRT040091	hsa-miR-615-3p	CLASH	23622248
MIRT040091	hsa-miR-615-3p	CLASH	23622248
MIRT040091	hsa-miR-615-3p	CLASH	23622248
MIRT037061	hsa-miR-877-3p	CLASH	23622248
MIRT1409126	hsa-miR-1246	CLIP-seq
MIRT1409127	hsa-miR-1271	CLIP-seq
MIRT1409128	hsa-miR-132	CLIP-seq
MIRT1409129	hsa-miR-1323	CLIP-seq
MIRT1409130	hsa-miR-137	CLIP-seq
MIRT1409131	hsa-miR-15a	CLIP-seq
MIRT1409132	hsa-miR-15b	CLIP-seq
MIRT1409133	hsa-miR-16	CLIP-seq
MIRT1409134	hsa-miR-181a	CLIP-seq
MIRT1409135	hsa-miR-181b	CLIP-seq
MIRT1409136	hsa-miR-181c	CLIP-seq
MIRT1409137	hsa-miR-181d	CLIP-seq
MIRT1409138	hsa-miR-182	CLIP-seq
MIRT1409139	hsa-miR-195	CLIP-seq
MIRT1409140	hsa-miR-2110	CLIP-seq
MIRT1409141	hsa-miR-212	CLIP-seq
MIRT1409142	hsa-miR-214	CLIP-seq
MIRT1409143	hsa-miR-216a	CLIP-seq
MIRT1409144	hsa-miR-25	CLIP-seq
MIRT1409145	hsa-miR-296-3p	CLIP-seq
MIRT1409146	hsa-miR-3128	CLIP-seq
MIRT1409147	hsa-miR-3150a-3p	CLIP-seq
MIRT1409148	hsa-miR-3175	CLIP-seq
MIRT1409149	hsa-miR-32	CLIP-seq
MIRT1409150	hsa-miR-3619-5p	CLIP-seq
MIRT1409151	hsa-miR-363	CLIP-seq
MIRT1409152	hsa-miR-367	CLIP-seq
MIRT1409153	hsa-miR-3912	CLIP-seq
MIRT1409154	hsa-miR-3919	CLIP-seq
MIRT1409155	hsa-miR-3978	CLIP-seq
MIRT1409156	hsa-miR-424	CLIP-seq
MIRT1409157	hsa-miR-4261	CLIP-seq
MIRT1409158	hsa-miR-4262	CLIP-seq
MIRT1409159	hsa-miR-4434	CLIP-seq
MIRT1409160	hsa-miR-4509	CLIP-seq
MIRT1409161	hsa-miR-4516	CLIP-seq
MIRT1409162	hsa-miR-4668-3p	CLIP-seq
MIRT1409163	hsa-miR-4690-5p	CLIP-seq
MIRT1409164	hsa-miR-4716-3p	CLIP-seq
MIRT1409165	hsa-miR-4717-5p	CLIP-seq
MIRT1409166	hsa-miR-4720-5p	CLIP-seq
MIRT1409167	hsa-miR-4742-5p	CLIP-seq
MIRT1409168	hsa-miR-4756-3p	CLIP-seq
MIRT1409169	hsa-miR-4775	CLIP-seq
MIRT1409170	hsa-miR-4799-3p	CLIP-seq
MIRT1409171	hsa-miR-497	CLIP-seq
MIRT1409172	hsa-miR-520d-5p	CLIP-seq
MIRT1409173	hsa-miR-524-5p	CLIP-seq
MIRT1409174	hsa-miR-543	CLIP-seq
MIRT1409175	hsa-miR-548c-3p	CLIP-seq
MIRT1409176	hsa-miR-548o	CLIP-seq
MIRT1409177	hsa-miR-579	CLIP-seq
MIRT1409178	hsa-miR-625	CLIP-seq
MIRT1409179	hsa-miR-668	CLIP-seq
MIRT1409180	hsa-miR-761	CLIP-seq
MIRT1409181	hsa-miR-92a	CLIP-seq
MIRT1409182	hsa-miR-92b	CLIP-seq
MIRT1409183	hsa-miR-939	CLIP-seq
MIRT1409184	hsa-miR-96	CLIP-seq
MIRT1409129	hsa-miR-1323	CLIP-seq
MIRT1409131	hsa-miR-15a	CLIP-seq
MIRT1409132	hsa-miR-15b	CLIP-seq
MIRT1409133	hsa-miR-16	CLIP-seq
MIRT1409139	hsa-miR-195	CLIP-seq
MIRT1409142	hsa-miR-214	CLIP-seq
MIRT1409143	hsa-miR-216a	CLIP-seq
MIRT1409150	hsa-miR-3619-5p	CLIP-seq
MIRT1409156	hsa-miR-424	CLIP-seq
MIRT1409162	hsa-miR-4668-3p	CLIP-seq
MIRT1409163	hsa-miR-4690-5p	CLIP-seq
MIRT1409165	hsa-miR-4717-5p	CLIP-seq
MIRT1409167	hsa-miR-4742-5p	CLIP-seq
MIRT1409169	hsa-miR-4775	CLIP-seq
MIRT2122704	hsa-miR-4777-5p	CLIP-seq
MIRT1409171	hsa-miR-497	CLIP-seq
MIRT2122705	hsa-miR-518d-5p	CLIP-seq
MIRT2122706	hsa-miR-519b-5p	CLIP-seq
MIRT2122707	hsa-miR-519c-5p	CLIP-seq
MIRT2122708	hsa-miR-520c-5p	CLIP-seq
MIRT2122709	hsa-miR-526a	CLIP-seq
MIRT1409175	hsa-miR-548c-3p	CLIP-seq
MIRT1409176	hsa-miR-548o	CLIP-seq
MIRT1409179	hsa-miR-668	CLIP-seq
MIRT1409180	hsa-miR-761	CLIP-seq
MIRT1409126	hsa-miR-1246	CLIP-seq
MIRT1409127	hsa-miR-1271	CLIP-seq
MIRT1409129	hsa-miR-1323	CLIP-seq
MIRT1409131	hsa-miR-15a	CLIP-seq
MIRT1409132	hsa-miR-15b	CLIP-seq
MIRT1409133	hsa-miR-16	CLIP-seq
MIRT1409134	hsa-miR-181a	CLIP-seq
MIRT1409135	hsa-miR-181b	CLIP-seq
MIRT1409136	hsa-miR-181c	CLIP-seq
MIRT1409137	hsa-miR-181d	CLIP-seq
MIRT1409138	hsa-miR-182	CLIP-seq
MIRT1409139	hsa-miR-195	CLIP-seq
MIRT1409142	hsa-miR-214	CLIP-seq
MIRT1409146	hsa-miR-3128	CLIP-seq
MIRT1409150	hsa-miR-3619-5p	CLIP-seq
MIRT1409153	hsa-miR-3912	CLIP-seq
MIRT1409154	hsa-miR-3919	CLIP-seq
MIRT1409156	hsa-miR-424	CLIP-seq
MIRT1409158	hsa-miR-4262	CLIP-seq
MIRT1409162	hsa-miR-4668-3p	CLIP-seq
MIRT1409163	hsa-miR-4690-5p	CLIP-seq
MIRT1409165	hsa-miR-4717-5p	CLIP-seq
MIRT1409166	hsa-miR-4720-5p	CLIP-seq
MIRT1409167	hsa-miR-4742-5p	CLIP-seq
MIRT1409168	hsa-miR-4756-3p	CLIP-seq
MIRT1409169	hsa-miR-4775	CLIP-seq
MIRT1409170	hsa-miR-4799-3p	CLIP-seq
MIRT1409171	hsa-miR-497	CLIP-seq
MIRT1409172	hsa-miR-520d-5p	CLIP-seq
MIRT1409173	hsa-miR-524-5p	CLIP-seq
MIRT1409174	hsa-miR-543	CLIP-seq
MIRT1409175	hsa-miR-548c-3p	CLIP-seq
MIRT1409176	hsa-miR-548o	CLIP-seq
MIRT1409177	hsa-miR-579	CLIP-seq
MIRT1409179	hsa-miR-668	CLIP-seq
MIRT1409180	hsa-miR-761	CLIP-seq
MIRT1409184	hsa-miR-96	CLIP-seq

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003712	Function	Transcription coregulator activity	IBA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IDA	27378374
GO:0003723	Function	RNA binding	IEA
GO:0003730	Function	MRNA 3'-UTR binding	IEA
GO:0005515	Function	Protein binding	IPI	18509338, 19124016, 21988832, 23975937, 27460707, 35271311
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	19124016
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	19124016
GO:0005737	Component	Cytoplasm	IDA	19124016
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0010467	Process	Gene expression	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	TAS	19124016
GO:0046872	Function	Metal ion binding	IEA
GO:0048255	Process	MRNA stabilization	IDA	27378374

MIM	HGNC	e!Ensembl
601574	11547	ENSG00000270647

Q92804

Protein name

TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56)

Protein function

RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Can enter the preinitiation complex together with

PDB

2MMY , 8ONS

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00076	RRM_1	236 → 314	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF00641	zf-RanBP	354 → 385	Zn-finger in Ran binding protein and others	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Observed in all fetal and adult tissues.

Sequence

MSDSGSYGQSGGEQQSYSTYGNPGSQGYGQASQSYSGYGQTTDSSYGQNYSGYSSYGQSQ
SGYSQSYGGYENQKQSSYSQQPYNNQGQQQNMESSGSQGGRAPSYDQPDYGQQDSYDQQS
GYDQHQGSYDEQSNYDQQHDSYSQNQQSYHSQRENYSHHTQDDRRDVSRYGEDNRGYGGS
QGGGRGRGGYDKDGRGPMTGSSGGDRGGFKNFGGHRDYGPRTDADSESDNSDNNTIFVQG
LGEGVSTDQVGEFFKQIGIIKTNKKTGKPMINLYTDKDTGKPKGEATVSFDDPPSAKAAI
DWFDGKEFHGNIIKVSFATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWVC
PNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGG
DRSGGGYGGDRSSGGGYSGDRSGGGYGGDRSGGGYGGDRGGGYGGDRGGGYGGDRGGGYG
GDRGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRSRGGYGGDRGGGSG
YGGDRSGGYGGDRSGGGYGGDRGGGYGGDRGGYGGKMGGRNDYRNDQRNRPY

Sequence length

592

Interactions

View interactions

	KEGG		Reactome
	Basal transcription factors Transcriptional misregulation in cancer		RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance

Show/Hide Unknown Diseases (14)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs9894083	RCV005915181
Cholangiocarcinoma	Benign	rs9894083, rs4251785	RCV005915186 RCV005924617
Colon adenocarcinoma	Likely benign	rs201942273	RCV005933490
Colorectal cancer	Benign	rs4251785	RCV005924615
Gastric cancer	Benign	rs9894083	RCV005915183
Hepatocellular carcinoma	Benign	rs9894083	RCV005915182
Lung cancer	Uncertain significance	rs71381481	RCV005932759
Malignant lymphoma, large B-cell, diffuse	Benign	rs4251785	RCV005924614
Melanoma	Uncertain significance	rs774779964	RCV005930894
Nonpapillary renal cell carcinoma	Benign	rs4251785	RCV005924612
TAF15-related disorder	Likely benign; Benign; Uncertain significance; Conflicting classifications of pathogenicity	rs779360454, rs762946549, rs760281454, rs750774088, rs560923327, rs138790468, rs140268553, rs1321826060, rs745996982, rs4251786, rs4251785, rs150034643, rs768749438, rs777993379, rs1440860624 View all (45 more)	RCV003921216 RCV003956251 RCV003966194 RCV003910911 RCV004743554 RCV003956286 RCV003941049 RCV003948648 RCV003968411 RCV003931256 RCV003975802 RCV003975943 RCV003921345 RCV003941118 RCV003401674 RCV003948706 RCV003404139 RCV003410213 RCV003412046 RCV003412084 RCV003419245 RCV003410714 RCV003419254 RCV003414505 RCV003410645 RCV003414178 RCV003404407 RCV003402665 RCV003901050 RCV003896977 RCV003894558 RCV003923995 RCV003904603 RCV003899880 RCV003913873 RCV003939825 RCV003951883 RCV003951981 RCV003952144 RCV003947353 RCV003964136 RCV003951600 RCV003951735 RCV003949798 RCV003944509 RCV003949343 RCV003944752 RCV003942171 RCV003946764 RCV003946783 RCV003974750 RCV003967159 RCV003967179 RCV003948034 RCV004743232 RCV003916254 RCV003916255 RCV003918470 RCV003962913 RCV003905950 RCV003930789 RCV003940753 RCV003950649 RCV003910702 RCV003950630 RCV003923081 RCV003950779 RCV003970602 RCV003960465
Thymoma	Benign	rs9894083	RCV005915185
Uterine carcinosarcoma	Benign	rs9894083, rs4251785	RCV005915184 RCV005924616
Uveal melanoma	Benign	rs4251785	RCV005924613

Show/Hide Text Mining Associations (28)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
AA amyloidosis	Associate	35643629
Adenocarcinoma of Lung	Associate	36261009
Amyotrophic Lateral Sclerosis	Associate	23755159, 26004182, 35643629, 37722062, 38492239
Bipolar Disorder	Associate	28291257
Breast Neoplasms	Associate	34908514, 36895010
Carcinogenesis	Associate	22081015
Carcinoma Squamous Cell	Associate	32871048
Cell Transformation Neoplastic	Stimulate	31020999
Chondrosarcoma	Associate	31020999
Chondrosarcoma Extraskeletal Myxoid	Associate	24508382, 31020999, 36948401
Frontotemporal Lobar Degeneration	Associate	23049996, 30755280
Heredodegenerative Disorders Nervous System	Associate	23049996
Leukemia	Associate	18620564
Leukemia T Cell	Associate	35182012
Liver Neoplasms	Associate	30398641
Malformations of Cortical Development Group I	Associate	28381165
Motor Neuron Disease	Associate	22081015
Nasopharyngeal Carcinoma	Associate	37257820
Neoplasm Metastasis	Associate	23874428, 36261009, 36948401
Neoplasms	Associate	18620564, 23049996, 24267890, 28945358, 31020999, 33674598
Neoplasms	Stimulate	37037864
Neurodegenerative Diseases	Associate	25375143, 35643629, 38492239
Osteoporosis	Associate	39953608
Prion Diseases	Associate	35643629
Psychological Distress	Associate	39953608
Sarcoma	Associate	18620564, 35182012
Sarcoma Ewing	Associate	38492239
Stomach Neoplasms	Stimulate	37037864

TAF15 (TATA-box binding protein associated factor 15)