SLC7A5 (solute carrier family 7 member 5)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8140
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 7 member 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC7A5
Synonyms (NCBI Gene) Gene synonyms aliases
4F2LC, CD98, D16S469E, E16, LAT1, MPE16
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q24.2
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1922)
miRTarBase ID miRNA Experiments Reference
MIRT004528 hsa-miR-7-5p Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot, Immunoprecipitation 19892711
MIRT004144 hsa-miR-626 Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot, Immunoprecipitation 19892711
MIRT006088 hsa-miR-663a Microarray, qRT-PCR 21378144
MIRT006088 hsa-miR-663a Microarray, qRT-PCR 21378144
MIRT006088 hsa-miR-663a Microarray, qRT-PCR 21378144
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
SP1 Unknown 17023546
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(90)
GO ID Ontology Definition Evidence Reference
GO:0002720 Process Positive regulation of cytokine production involved in immune response TAS 24038088
GO:0003333 Process Amino acid transmembrane transport IBA
GO:0005515 Function Protein binding IPI 25998567, 30867591, 30996345, 31160781, 35271311
GO:0005764 Component Lysosome IEA
GO:0005765 Component Lysosomal membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600182 11063 ENSG00000103257
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q01650
Protein name Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid t
Protein function The heterodimer with SLC3A2 functions as a sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, leucine, histidine, methionine, tryptophan, valine, isoleucine and alanin
PDB 6IRS , 6IRT , 6JMQ , 7DSK , 7DSL , 7DSN , 7DSQ , 8IDA , 8J8L , 8J8M , 8KDD , 8KDF , 8KDG , 8KDH , 8KDI , 8KDJ , 8KDN , 8KDO , 8KDP , 8X0W , 8XPU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13520 AA_permease_2 50 → 476 Amino acid permease Family
Tissue specificity TISSUE SPECIFICITY: Detected in placenta, in the syncytiotrophoblast layer (at protein level) (PubMed:11389679). Expressed abundantly in adult lung, liver, brain, skeletal muscle, placenta, bone marrow, testis, resting lymphocytes and monocytes, and in fe
Sequence
Sequence length 507
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  mTOR signaling pathway
Central carbon metabolism in cancer 		  Basigin interactions
Amino acid transport across the plasma membrane
Tryptophan catabolism
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (5)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Asthma Asthma (childhood onset) N/A N/A GWAS
Diabetes Type 2 diabetes N/A N/A GWAS
Insomnia Insomnia N/A N/A GWAS
Metabolic Syndrome Metabolic syndrome N/A N/A GWAS
Show/Hide Text Mining Associations (119)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 24694899, 25835180
Adenocarcinoma of Lung Associate 40179422, 40682067
Arthritis Rheumatoid Stimulate 29422900
Arthritis Rheumatoid Associate 32867828
Astrocytoma Associate 17329830
Atrophy Associate 38284122
Autism Spectrum Disorder Associate 31701662, 39428051
Autistic Disorder Associate 34579098
Bacterial Infections Associate 25701737
Bile Duct Neoplasms Associate 24890221