Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	814
Gene name Gene Name - the full gene name approved by the HGNC.	Calcium/calmodulin dependent protein kinase IV
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CAMK4
Synonyms (NCBI Gene) Gene synonyms aliases	CaMK IV, CaMK-GR, CaMKIV, caMK
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q22.1
Summary Summary of gene provided in NCBI Entrez Gene.	The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has be

Show/Hide all(1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs1561515242	G>A	Uncertain-significance, likely-pathogenic	Splice donor variant

Show/Hide all(238)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024679	hsa-miR-215-5p	Microarray	19074876
MIRT026869	hsa-miR-192-5p	Microarray	19074876
MIRT030257	hsa-miR-26b-5p	Microarray	19088304
MIRT437481	hsa-miR-185-5p	Luciferase reporter assay, qRT-PCR, Western blot	24014023
MIRT719226	hsa-miR-5197-3p	HITS-CLIP	19536157
MIRT719225	hsa-miR-329-5p	HITS-CLIP	19536157
MIRT719224	hsa-miR-4301	HITS-CLIP	19536157
MIRT719223	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT719222	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT719221	hsa-miR-2116-3p	HITS-CLIP	19536157
MIRT719220	hsa-miR-1253	HITS-CLIP	19536157
MIRT719219	hsa-miR-6770-5p	HITS-CLIP	19536157
MIRT719218	hsa-miR-3605-5p	HITS-CLIP	19536157
MIRT719217	hsa-miR-1255a	HITS-CLIP	19536157
MIRT719216	hsa-miR-1255b-5p	HITS-CLIP	19536157
MIRT719215	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT719214	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT719213	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT719212	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT628369	hsa-miR-622	HITS-CLIP	23824327
MIRT628367	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT628366	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT628365	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT628364	hsa-miR-4455	HITS-CLIP	23824327
MIRT628363	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT628369	hsa-miR-622	HITS-CLIP	23824327
MIRT628368	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT628367	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT628366	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT628365	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT628364	hsa-miR-4455	HITS-CLIP	23824327
MIRT628363	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT628369	hsa-miR-622	HITS-CLIP	23824327
MIRT628368	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT628367	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT628366	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT628365	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT628364	hsa-miR-4455	HITS-CLIP	23824327
MIRT628363	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT460337	hsa-miR-181a-2-3p	PAR-CLIP	20371350
MIRT460336	hsa-miR-1273g-3p	PAR-CLIP	20371350
MIRT460335	hsa-miR-4746-5p	PAR-CLIP	20371350
MIRT460334	hsa-miR-3128	PAR-CLIP	20371350
MIRT460333	hsa-miR-196a-3p	PAR-CLIP	20371350
MIRT460332	hsa-miR-6509-3p	PAR-CLIP	20371350
MIRT460331	hsa-miR-4691-5p	PAR-CLIP	20371350
MIRT460330	hsa-miR-6792-3p	PAR-CLIP	20371350
MIRT460337	hsa-miR-181a-2-3p	PAR-CLIP	22012620
MIRT460336	hsa-miR-1273g-3p	PAR-CLIP	22012620
MIRT460335	hsa-miR-4746-5p	PAR-CLIP	22012620
MIRT460334	hsa-miR-3128	PAR-CLIP	22012620
MIRT460333	hsa-miR-196a-3p	PAR-CLIP	22012620
MIRT460332	hsa-miR-6509-3p	PAR-CLIP	22012620
MIRT460331	hsa-miR-4691-5p	PAR-CLIP	22012620
MIRT460330	hsa-miR-6792-3p	PAR-CLIP	22012620
MIRT496934	hsa-miR-1245b-3p	PAR-CLIP	22291592
MIRT496933	hsa-miR-922	PAR-CLIP	22291592
MIRT496932	hsa-miR-6807-5p	PAR-CLIP	22291592
MIRT460337	hsa-miR-181a-2-3p	PAR-CLIP	23592263
MIRT460336	hsa-miR-1273g-3p	PAR-CLIP	23592263
MIRT460335	hsa-miR-4746-5p	PAR-CLIP	23592263
MIRT460334	hsa-miR-3128	PAR-CLIP	23592263
MIRT460333	hsa-miR-196a-3p	PAR-CLIP	23592263
MIRT460332	hsa-miR-6509-3p	PAR-CLIP	23592263
MIRT460331	hsa-miR-4691-5p	PAR-CLIP	23592263
MIRT460330	hsa-miR-6792-3p	PAR-CLIP	23592263
MIRT460336	hsa-miR-1273g-3p	PAR-CLIP	26701625
MIRT460336	hsa-miR-1273g-3p	PAR-CLIP	26701625
MIRT460336	hsa-miR-1273g-3p	PAR-CLIP	26701625
MIRT460336	hsa-miR-1273g-3p	PAR-CLIP	26701625
MIRT460336	hsa-miR-1273g-3p	PAR-CLIP	26701625
MIRT460336	hsa-miR-1273g-3p	PAR-CLIP	26701625
MIRT460336	hsa-miR-1273g-3p	PAR-CLIP	26701625
MIRT460337	hsa-miR-181a-2-3p	PAR-CLIP	26701625
MIRT460337	hsa-miR-181a-2-3p	PAR-CLIP	26701625
MIRT460337	hsa-miR-181a-2-3p	PAR-CLIP	26701625
MIRT460337	hsa-miR-181a-2-3p	PAR-CLIP	26701625
MIRT460337	hsa-miR-181a-2-3p	PAR-CLIP	26701625
MIRT460337	hsa-miR-181a-2-3p	PAR-CLIP	26701625
MIRT460337	hsa-miR-181a-2-3p	PAR-CLIP	26701625
MIRT460333	hsa-miR-196a-3p	PAR-CLIP	26701625
MIRT460333	hsa-miR-196a-3p	PAR-CLIP	26701625
MIRT460333	hsa-miR-196a-3p	PAR-CLIP	26701625
MIRT460333	hsa-miR-196a-3p	PAR-CLIP	26701625
MIRT460333	hsa-miR-196a-3p	PAR-CLIP	26701625
MIRT460333	hsa-miR-196a-3p	PAR-CLIP	26701625
MIRT460333	hsa-miR-196a-3p	PAR-CLIP	26701625
MIRT460334	hsa-miR-3128	PAR-CLIP	26701625
MIRT460334	hsa-miR-3128	PAR-CLIP	26701625
MIRT460334	hsa-miR-3128	PAR-CLIP	26701625
MIRT460334	hsa-miR-3128	PAR-CLIP	26701625
MIRT460334	hsa-miR-3128	PAR-CLIP	26701625
MIRT460334	hsa-miR-3128	PAR-CLIP	26701625
MIRT460334	hsa-miR-3128	PAR-CLIP	26701625
MIRT460331	hsa-miR-4691-5p	PAR-CLIP	26701625
MIRT460331	hsa-miR-4691-5p	PAR-CLIP	26701625
MIRT460331	hsa-miR-4691-5p	PAR-CLIP	26701625
MIRT460331	hsa-miR-4691-5p	PAR-CLIP	26701625
MIRT460331	hsa-miR-4691-5p	PAR-CLIP	26701625
MIRT460331	hsa-miR-4691-5p	PAR-CLIP	26701625
MIRT460331	hsa-miR-4691-5p	PAR-CLIP	26701625
MIRT460335	hsa-miR-4746-5p	PAR-CLIP	26701625
MIRT460335	hsa-miR-4746-5p	PAR-CLIP	26701625
MIRT460335	hsa-miR-4746-5p	PAR-CLIP	26701625
MIRT460335	hsa-miR-4746-5p	PAR-CLIP	26701625
MIRT460335	hsa-miR-4746-5p	PAR-CLIP	26701625
MIRT460335	hsa-miR-4746-5p	PAR-CLIP	26701625
MIRT460335	hsa-miR-4746-5p	PAR-CLIP	26701625
MIRT460332	hsa-miR-6509-3p	PAR-CLIP	26701625
MIRT460332	hsa-miR-6509-3p	PAR-CLIP	26701625
MIRT460332	hsa-miR-6509-3p	PAR-CLIP	26701625
MIRT460332	hsa-miR-6509-3p	PAR-CLIP	26701625
MIRT460332	hsa-miR-6509-3p	PAR-CLIP	26701625
MIRT460332	hsa-miR-6509-3p	PAR-CLIP	26701625
MIRT460332	hsa-miR-6509-3p	PAR-CLIP	26701625
MIRT460330	hsa-miR-6792-3p	PAR-CLIP	26701625
MIRT460330	hsa-miR-6792-3p	PAR-CLIP	26701625
MIRT460330	hsa-miR-6792-3p	PAR-CLIP	26701625
MIRT460330	hsa-miR-6792-3p	PAR-CLIP	26701625
MIRT460330	hsa-miR-6792-3p	PAR-CLIP	26701625
MIRT460330	hsa-miR-6792-3p	PAR-CLIP	26701625
MIRT460330	hsa-miR-6792-3p	PAR-CLIP	26701625
MIRT460336	hsa-miR-1273g-3p	PAR-CLIP	27292025
MIRT460336	hsa-miR-1273g-3p	PAR-CLIP	27292025
MIRT460336	hsa-miR-1273g-3p	PAR-CLIP	27292025
MIRT460336	hsa-miR-1273g-3p	PAR-CLIP	27292025
MIRT460337	hsa-miR-181a-2-3p	PAR-CLIP	27292025
MIRT460337	hsa-miR-181a-2-3p	PAR-CLIP	27292025
MIRT460337	hsa-miR-181a-2-3p	PAR-CLIP	27292025
MIRT460337	hsa-miR-181a-2-3p	PAR-CLIP	27292025
MIRT460333	hsa-miR-196a-3p	PAR-CLIP	27292025
MIRT460333	hsa-miR-196a-3p	PAR-CLIP	27292025
MIRT460333	hsa-miR-196a-3p	PAR-CLIP	27292025
MIRT460333	hsa-miR-196a-3p	PAR-CLIP	27292025
MIRT460334	hsa-miR-3128	PAR-CLIP	27292025
MIRT460334	hsa-miR-3128	PAR-CLIP	27292025
MIRT460334	hsa-miR-3128	PAR-CLIP	27292025
MIRT460334	hsa-miR-3128	PAR-CLIP	27292025
MIRT460331	hsa-miR-4691-5p	PAR-CLIP	27292025
MIRT460331	hsa-miR-4691-5p	PAR-CLIP	27292025
MIRT460331	hsa-miR-4691-5p	PAR-CLIP	27292025
MIRT460331	hsa-miR-4691-5p	PAR-CLIP	27292025
MIRT460335	hsa-miR-4746-5p	PAR-CLIP	27292025
MIRT460335	hsa-miR-4746-5p	PAR-CLIP	27292025
MIRT460335	hsa-miR-4746-5p	PAR-CLIP	27292025
MIRT460335	hsa-miR-4746-5p	PAR-CLIP	27292025
MIRT460332	hsa-miR-6509-3p	PAR-CLIP	27292025
MIRT460332	hsa-miR-6509-3p	PAR-CLIP	27292025
MIRT460332	hsa-miR-6509-3p	PAR-CLIP	27292025
MIRT460332	hsa-miR-6509-3p	PAR-CLIP	27292025
MIRT460330	hsa-miR-6792-3p	PAR-CLIP	27292025
MIRT460330	hsa-miR-6792-3p	PAR-CLIP	27292025
MIRT460330	hsa-miR-6792-3p	PAR-CLIP	27292025
MIRT460330	hsa-miR-6792-3p	PAR-CLIP	27292025
MIRT628367	hsa-miR-30a-3p	HITS-CLIP	27418678
MIRT628366	hsa-miR-30d-3p	HITS-CLIP	27418678
MIRT628365	hsa-miR-30e-3p	HITS-CLIP	27418678
MIRT628364	hsa-miR-4455	HITS-CLIP	27418678
MIRT628364	hsa-miR-4455	HITS-CLIP	27418678
MIRT628363	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT628363	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT628369	hsa-miR-622	HITS-CLIP	27418678
MIRT628368	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT628368	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT719226	hsa-miR-5197-3p	HITS-CLIP	19536157
MIRT719225	hsa-miR-329-5p	HITS-CLIP	19536157
MIRT719224	hsa-miR-4301	HITS-CLIP	19536157
MIRT719223	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT719222	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT719221	hsa-miR-2116-3p	HITS-CLIP	19536157
MIRT719220	hsa-miR-1253	HITS-CLIP	19536157
MIRT719219	hsa-miR-6770-5p	HITS-CLIP	19536157
MIRT719218	hsa-miR-3605-5p	HITS-CLIP	19536157
MIRT719217	hsa-miR-1255a	HITS-CLIP	19536157
MIRT719216	hsa-miR-1255b-5p	HITS-CLIP	19536157
MIRT719215	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT719214	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT719213	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT719212	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT628369	hsa-miR-622	HITS-CLIP	23824327
MIRT628367	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT628366	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT628365	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT628364	hsa-miR-4455	HITS-CLIP	23824327
MIRT628363	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT628369	hsa-miR-622	HITS-CLIP	23824327
MIRT628368	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT628367	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT628366	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT628365	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT628364	hsa-miR-4455	HITS-CLIP	23824327
MIRT628363	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT628369	hsa-miR-622	HITS-CLIP	23824327
MIRT628368	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT628367	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT628366	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT628365	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT628364	hsa-miR-4455	HITS-CLIP	23824327
MIRT628363	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT460337	hsa-miR-181a-2-3p	PAR-CLIP	20371350
MIRT460336	hsa-miR-1273g-3p	PAR-CLIP	20371350
MIRT460335	hsa-miR-4746-5p	PAR-CLIP	20371350
MIRT460334	hsa-miR-3128	PAR-CLIP	20371350
MIRT460333	hsa-miR-196a-3p	PAR-CLIP	20371350
MIRT460332	hsa-miR-6509-3p	PAR-CLIP	20371350
MIRT460331	hsa-miR-4691-5p	PAR-CLIP	20371350
MIRT460330	hsa-miR-6792-3p	PAR-CLIP	20371350
MIRT460337	hsa-miR-181a-2-3p	PAR-CLIP	22012620
MIRT460336	hsa-miR-1273g-3p	PAR-CLIP	22012620
MIRT460335	hsa-miR-4746-5p	PAR-CLIP	22012620
MIRT460334	hsa-miR-3128	PAR-CLIP	22012620
MIRT460333	hsa-miR-196a-3p	PAR-CLIP	22012620
MIRT460332	hsa-miR-6509-3p	PAR-CLIP	22012620
MIRT460331	hsa-miR-4691-5p	PAR-CLIP	22012620
MIRT460330	hsa-miR-6792-3p	PAR-CLIP	22012620
MIRT496934	hsa-miR-1245b-3p	PAR-CLIP	22291592
MIRT496933	hsa-miR-922	PAR-CLIP	22291592
MIRT496932	hsa-miR-6807-5p	PAR-CLIP	22291592
MIRT460337	hsa-miR-181a-2-3p	PAR-CLIP	23592263
MIRT460336	hsa-miR-1273g-3p	PAR-CLIP	23592263
MIRT460335	hsa-miR-4746-5p	PAR-CLIP	23592263
MIRT460334	hsa-miR-3128	PAR-CLIP	23592263
MIRT460333	hsa-miR-196a-3p	PAR-CLIP	23592263
MIRT460332	hsa-miR-6509-3p	PAR-CLIP	23592263
MIRT460331	hsa-miR-4691-5p	PAR-CLIP	23592263
MIRT460330	hsa-miR-6792-3p	PAR-CLIP	23592263
MIRT860404	hsa-miR-1252	CLIP-seq
MIRT860405	hsa-miR-2115	CLIP-seq
MIRT860406	hsa-miR-3180-5p	CLIP-seq
MIRT860407	hsa-miR-3185	CLIP-seq
MIRT860408	hsa-miR-3611	CLIP-seq
MIRT860409	hsa-miR-4312	CLIP-seq
MIRT860410	hsa-miR-4477b	CLIP-seq
MIRT860411	hsa-miR-520a-5p	CLIP-seq
MIRT860412	hsa-miR-525-5p	CLIP-seq
MIRT1955331	hsa-miR-607	CLIP-seq
MIRT2193077	hsa-miR-34b	CLIP-seq
MIRT2193078	hsa-miR-34c-3p	CLIP-seq

Show/Hide all(26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001650	Component	Fibrillar center	IDA
GO:0002250	Process	Adaptive immune response	IEA
GO:0002372	Process	Myeloid dendritic cell cytokine production	IMP	17909078
GO:0004683	Function	Calmodulin-dependent protein kinase activity	IBA	21873635
GO:0004683	Function	Calmodulin-dependent protein kinase activity	IDA	8107230
GO:0005516	Function	Calmodulin binding	IBA	21873635
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0006468	Process	Protein phosphorylation	TAS	8089075
GO:0006954	Process	Inflammatory response	IEA
GO:0007165	Process	Signal transduction	TAS	8089075
GO:0007616	Process	Long-term memory	IGI	18829949
GO:0009931	Function	Calcium-dependent protein serine/threonine kinase activity	IBA	21873635
GO:0018105	Process	Peptidyl-serine phosphorylation	IBA	21873635
GO:0033081	Process	Regulation of T cell differentiation in thymus	TAS	18930438
GO:0035556	Process	Intracellular signal transduction	IBA	21873635
GO:0043011	Process	Myeloid dendritic cell differentiation	IMP	17909078
GO:0045670	Process	Regulation of osteoclast differentiation	TAS	18930438
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IDA	8855261
GO:0046777	Process	Protein autophosphorylation	IBA	21873635
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0098794	Component	Postsynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA

MIM	HGNC	e!Ensembl
114080	1464	ENSG00000152495

Protein

UniProt ID

Q16566

Protein name

Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR)

Protein function

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, whic

PDB

2W4O

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	46 → 300	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue. {ECO:0000269|PubMed:12065094, ECO:0000269|PubMed:7961813, ECO:0000269|PubMed:8397199}.

Sequence

MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIV
YRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLEL
VTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAP
LKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEP
FYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV
TGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGSIQESHKASRDPS
PIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKA
VEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQDVILPEY

Sequence length

473

Interactions

View interactions

	KEGG		Reactome
	Calcium signaling pathway cAMP signaling pathway Longevity regulating pathway Apelin signaling pathway Osteoclast differentiation Long-term potentiation Neurotrophin signaling pathway Cholinergic synapse Oxytocin signaling pathway Aldosterone synthesis and secretion Amphetamine addiction Alcoholism Glioma		CaMK IV-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID	References
Causal
Autoimmune diseases	Autoimmune Diseases, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2	rs869025224	30595370
Hypothyroidism	Hypothyroidism	rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912 View all (22 more)	30595370
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370 View all (5 more)
Lung carcinoma	Large cell carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355 View all (44 more)

Show/Hide Unknown Diseases (4)

Disease term	Disease name	Evidence	References	Source
Unknown
Asthma	Asthma		31619474	ClinVar, GWAS
Neurodevelopmental Disorders	complex neurodevelopmental disorder			GenCC
Colorectal Cancer	Colorectal Cancer	In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1.		GWAS, CBGDA
Insomnia	Insomnia			GWAS

Show/Hide Text Mining Associations (18)

Disease Name	Relationship Type	References
Associations from Text Mining
Autistic Disorder	Associate	30262571
Coronary Disease	Associate	35958279
COVID 19	Associate	34252574
Dystonia	Associate	30262571
Heredodegenerative Disorders Nervous System	Associate	30262571
Hypercalcemia	Associate	18249060
Hyperkinesis	Associate	30262571
Hypertension	Associate	26909912
Intellectual Disability	Associate	30262571
Leukemia	Associate	25446257
Leukemia Myeloid Acute	Associate	25446257
Leukemia Myelomonocytic Acute	Inhibit	25446257
Neoplasm Metastasis	Associate	36516759
Neoplasms	Associate	32724490
Neuroblastoma	Associate	19633294
Neurodegenerative Diseases	Associate	32724490
Stomach Neoplasms	Associate	38035067
Temporomandibular Joint Disorders	Associate	22074755

CAMK4 (calcium/calmodulin dependent protein kinase IV)