Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
81033
Gene name Gene Name - the full gene name approved by the HGNC.
Potassium voltage-gated channel subfamily H member 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KCNH6
Synonyms (NCBI Gene) Gene synonyms aliases
ERG-2, ERG2, HERG2, Kv11.2, hERG-2
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q23.3
Summary Summary of gene provided in NCBI Entrez Gene.
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuro
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT657050 hsa-miR-4722-3p HITS-CLIP 23824327
MIRT657051 hsa-miR-6727-3p HITS-CLIP 23824327
MIRT657049 hsa-miR-6747-3p HITS-CLIP 23824327
MIRT657048 hsa-miR-3653-5p HITS-CLIP 23824327
MIRT657047 hsa-miR-1976 HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005249 Function Voltage-gated potassium channel activity IBA 21873635
GO:0005886 Component Plasma membrane TAS
GO:0005887 Component Integral component of plasma membrane IBA 21873635
GO:0034765 Process Regulation of ion transmembrane transport IEA
GO:0042391 Process Regulation of membrane potential IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608168 18862 ENSG00000173826
Protein
UniProt ID Q9H252
Protein name Voltage-gated inwardly rectifying potassium channel KCNH6 (Ether-a-go-go-related gene potassium channel 2) (ERG-2) (Eag-related protein 2) (Ether-a-go-go-related protein 2) (hERG-2) (hERG2) (Potassium voltage-gated channel subfamily H member 6) (Voltage-g
Protein function Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subseque
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13426 PAS_9 29 134 PAS domain Domain
PF00520 Ion_trans 256 523 Ion transport protein Family
PF00027 cNMP_binding 612 697 Cyclic nucleotide-binding domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in prolactin-secreting adenomas. {ECO:0000269|PubMed:12634931}.
Sequence
MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM
QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG
AVIMFILNFEDLAQ
LLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQ
IPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQ
APRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPL
TVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLI
FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWY
AIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFG
NVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA
RYHTQMLRVKEFIRFHQ
IPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGK
GCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEP
VSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMY
PAFAESFWSKLEVTFNLRDAAGG
LHSSPRQAPGSQDHQGFFLSDNQSGSPHELGPQFPSKGYSLLGPGSQNSMGAGPCAPGHP
DAAPPLSISDASGLWPELLQEMPPRHSPQSPQEDPDCWPLKLGSRLEQLQAQMNRLESRV
SSDLSRILQLLQKPMPQGHASYILEAPASNDLALVPIASETTSPGPRLPQGFLPPAQTPS
YGDLDDCSPKHRNSSPRMPHLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICG
PCFSSLPEHLGSVPKQLDFQRHGSDPGFAGSWGH
Sequence length 994
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Voltage gated Potassium channels
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
20507645
Associations from Text Mining
Disease Name Relationship Type References
Charcot Marie Tooth Disease Associate 30889162
Charcot Marie Tooth disease Type 1D Associate 30889162
Congenital Hyperinsulinism Associate 23869231
Osteoporosis Associate 23329517
Psychotic Disorders Associate 20507645