Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	81033
Gene name	Potassium voltage-gated channel subfamily H member 6
Gene symbol	KCNH6
Synonyms (NCBI Gene)	ERG-2ERG2HERG2Kv11.2hERG-2
Chromosome	17
Chromosome location	17q23.3
Summary	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT657050	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT657051	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT657049	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT657048	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT657047	hsa-miR-1976	HITS-CLIP	23824327
MIRT657046	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT657045	hsa-miR-1206	HITS-CLIP	23824327
MIRT657044	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT657043	hsa-miR-4279	HITS-CLIP	23824327
MIRT657050	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT657051	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT657049	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT657048	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT657047	hsa-miR-1976	HITS-CLIP	23824327
MIRT657046	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT657045	hsa-miR-1206	HITS-CLIP	23824327
MIRT657044	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT657043	hsa-miR-4279	HITS-CLIP	23824327
MIRT1081084	hsa-miR-1200	CLIP-seq
MIRT1081085	hsa-miR-1273f	CLIP-seq
MIRT1081086	hsa-miR-1289	CLIP-seq
MIRT1081087	hsa-miR-1297	CLIP-seq
MIRT1081088	hsa-miR-1307	CLIP-seq
MIRT1081089	hsa-miR-143	CLIP-seq
MIRT1081090	hsa-miR-26a	CLIP-seq
MIRT1081091	hsa-miR-26b	CLIP-seq
MIRT1081092	hsa-miR-2909	CLIP-seq
MIRT1081093	hsa-miR-296-3p	CLIP-seq
MIRT1081094	hsa-miR-3157-5p	CLIP-seq
MIRT1081095	hsa-miR-3198	CLIP-seq
MIRT1081096	hsa-miR-3664-5p	CLIP-seq
MIRT1081097	hsa-miR-3977	CLIP-seq
MIRT1081098	hsa-miR-4258	CLIP-seq
MIRT1081099	hsa-miR-4284	CLIP-seq
MIRT1081100	hsa-miR-4294	CLIP-seq
MIRT1081101	hsa-miR-4309	CLIP-seq
MIRT1081102	hsa-miR-4324	CLIP-seq
MIRT1081103	hsa-miR-4438	CLIP-seq
MIRT1081104	hsa-miR-4465	CLIP-seq
MIRT1081105	hsa-miR-4509	CLIP-seq
MIRT1081106	hsa-miR-4534	CLIP-seq
MIRT1081107	hsa-miR-4638-5p	CLIP-seq
MIRT1081108	hsa-miR-4639-3p	CLIP-seq
MIRT1081109	hsa-miR-4707-3p	CLIP-seq
MIRT1081110	hsa-miR-4708-5p	CLIP-seq
MIRT1081111	hsa-miR-4770	CLIP-seq
MIRT1081112	hsa-miR-4772-3p	CLIP-seq
MIRT1081113	hsa-miR-5095	CLIP-seq
MIRT1081114	hsa-miR-544b	CLIP-seq
MIRT1081098	hsa-miR-4258	CLIP-seq
MIRT1081103	hsa-miR-4438	CLIP-seq
MIRT1081109	hsa-miR-4707-3p	CLIP-seq
MIRT1081113	hsa-miR-5095	CLIP-seq
MIRT2251908	hsa-miR-130a	CLIP-seq
MIRT2251909	hsa-miR-130b	CLIP-seq
MIRT2251910	hsa-miR-301a	CLIP-seq
MIRT2251911	hsa-miR-301b	CLIP-seq
MIRT2251912	hsa-miR-3666	CLIP-seq
MIRT1081098	hsa-miR-4258	CLIP-seq
MIRT2251913	hsa-miR-4295	CLIP-seq
MIRT1081103	hsa-miR-4438	CLIP-seq
MIRT2251914	hsa-miR-454	CLIP-seq
MIRT2251915	hsa-miR-4671-3p	CLIP-seq
MIRT1081109	hsa-miR-4707-3p	CLIP-seq
MIRT1081113	hsa-miR-5095	CLIP-seq
MIRT1081096	hsa-miR-3664-5p	CLIP-seq
MIRT1081098	hsa-miR-4258	CLIP-seq
MIRT1081100	hsa-miR-4294	CLIP-seq
MIRT1081105	hsa-miR-4509	CLIP-seq
MIRT1081108	hsa-miR-4639-3p	CLIP-seq
MIRT2452182	hsa-miR-4675	CLIP-seq
MIRT1081109	hsa-miR-4707-3p	CLIP-seq
MIRT2452183	hsa-miR-4741	CLIP-seq
MIRT1081098	hsa-miR-4258	CLIP-seq
MIRT1081103	hsa-miR-4438	CLIP-seq
MIRT1081105	hsa-miR-4509	CLIP-seq
MIRT1081109	hsa-miR-4707-3p	CLIP-seq
MIRT1081113	hsa-miR-5095	CLIP-seq
MIRT1081098	hsa-miR-4258	CLIP-seq
MIRT1081103	hsa-miR-4438	CLIP-seq
MIRT1081105	hsa-miR-4509	CLIP-seq
MIRT1081109	hsa-miR-4707-3p	CLIP-seq
MIRT1081113	hsa-miR-5095	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005242	Function	Inward rectifier potassium channel activity	IBA
GO:0005249	Function	Voltage-gated potassium channel activity	IEA
GO:0005267	Function	Potassium channel activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006813	Process	Potassium ion transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034702	Component	Monoatomic ion channel complex	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0060307	Process	Regulation of ventricular cardiac muscle cell membrane repolarization	IBA
GO:0071805	Process	Potassium ion transmembrane transport	IBA
GO:0071805	Process	Potassium ion transmembrane transport	IEA
GO:0086013	Process	Membrane repolarization during cardiac muscle cell action potential	IBA
GO:0086091	Process	Regulation of heart rate by cardiac conduction	IBA

MIM	HGNC	e!Ensembl
608168	18862	ENSG00000173826

Q9H252

Protein name

Voltage-gated inwardly rectifying potassium channel KCNH6 (Ether-a-go-go-related gene potassium channel 2) (ERG-2) (Eag-related protein 2) (Ether-a-go-go-related protein 2) (hERG-2) (hERG2) (Potassium voltage-gated channel subfamily H member 6) (Voltage-g

Protein function

Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subseque

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13426	PAS_9	29 → 134	PAS domain	Domain
PF00520	Ion_trans	256 → 523	Ion transport protein	Family
PF00027	cNMP_binding	612 → 697	Cyclic nucleotide-binding domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in prolactin-secreting adenomas. {ECO:0000269|PubMed:12634931}.

Sequence

MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM
QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG
AVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQ
IPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQ
APRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPL
TVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLI
FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWY
AIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFG
NVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQ
IPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGK
GCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEP
VSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAGG
LHSSPRQAPGSQDHQGFFLSDNQSGSPHELGPQFPSKGYSLLGPGSQNSMGAGPCAPGHP
DAAPPLSISDASGLWPELLQEMPPRHSPQSPQEDPDCWPLKLGSRLEQLQAQMNRLESRV
SSDLSRILQLLQKPMPQGHASYILEAPASNDLALVPIASETTSPGPRLPQGFLPPAQTPS
YGDLDDCSPKHRNSSPRMPHLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICG
PCFSSLPEHLGSVPKQLDFQRHGSDPGFAGSWGH

Sequence length

994

Interactions

View interactions

	Reactome
			Voltage gated Potassium channels

KCNH6 (potassium voltage-gated channel subfamily H member 6)