Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	81029
Gene name Gene Name - the full gene name approved by the HGNC.	Wnt family member 5B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	WNT5B
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12p13.33
Summary Summary of gene provided in NCBI Entrez Gene.	The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryog

Show/Hide all(148)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022886	hsa-miR-124-3p	Microarray	18668037
MIRT045371	hsa-miR-185-5p	CLASH	23622248
MIRT1493833	hsa-miR-1275	CLIP-seq
MIRT1493834	hsa-miR-1324	CLIP-seq
MIRT1493835	hsa-miR-144	CLIP-seq
MIRT1493836	hsa-miR-1910	CLIP-seq
MIRT1493837	hsa-miR-2682	CLIP-seq
MIRT1493838	hsa-miR-3124-3p	CLIP-seq
MIRT1493839	hsa-miR-3138	CLIP-seq
MIRT1493840	hsa-miR-3165	CLIP-seq
MIRT1493841	hsa-miR-3185	CLIP-seq
MIRT1493842	hsa-miR-3605-5p	CLIP-seq
MIRT1493843	hsa-miR-3909	CLIP-seq
MIRT1493844	hsa-miR-4271	CLIP-seq
MIRT1493845	hsa-miR-4447	CLIP-seq
MIRT1493846	hsa-miR-4472	CLIP-seq
MIRT1493847	hsa-miR-449c	CLIP-seq
MIRT1493848	hsa-miR-4514	CLIP-seq
MIRT1493849	hsa-miR-4520a-3p	CLIP-seq
MIRT1493850	hsa-miR-4525	CLIP-seq
MIRT1493851	hsa-miR-4532	CLIP-seq
MIRT1493852	hsa-miR-4645-3p	CLIP-seq
MIRT1493853	hsa-miR-4651	CLIP-seq
MIRT1493854	hsa-miR-4665-5p	CLIP-seq
MIRT1493855	hsa-miR-4692	CLIP-seq
MIRT1493856	hsa-miR-4723-5p	CLIP-seq
MIRT1493857	hsa-miR-4725-3p	CLIP-seq
MIRT1493858	hsa-miR-4787-5p	CLIP-seq
MIRT1493859	hsa-miR-513a-5p	CLIP-seq
MIRT1493860	hsa-miR-568	CLIP-seq
MIRT1493861	hsa-miR-587	CLIP-seq
MIRT1493862	hsa-miR-608	CLIP-seq
MIRT1493863	hsa-miR-625	CLIP-seq
MIRT1493864	hsa-miR-7	CLIP-seq
MIRT1493865	hsa-miR-765	CLIP-seq
MIRT1493866	hsa-miR-1224-3p	CLIP-seq
MIRT1493867	hsa-miR-1260	CLIP-seq
MIRT1493868	hsa-miR-1260b	CLIP-seq
MIRT1493833	hsa-miR-1275	CLIP-seq
MIRT1493869	hsa-miR-1280	CLIP-seq
MIRT1493870	hsa-miR-146b-3p	CLIP-seq
MIRT1493871	hsa-miR-150	CLIP-seq
MIRT1493872	hsa-miR-339-5p	CLIP-seq
MIRT1493844	hsa-miR-4271	CLIP-seq
MIRT1493873	hsa-miR-4421	CLIP-seq
MIRT1493845	hsa-miR-4447	CLIP-seq
MIRT1493846	hsa-miR-4472	CLIP-seq
MIRT1493850	hsa-miR-4525	CLIP-seq
MIRT1493851	hsa-miR-4532	CLIP-seq
MIRT1493852	hsa-miR-4645-3p	CLIP-seq
MIRT1493853	hsa-miR-4651	CLIP-seq
MIRT1493854	hsa-miR-4665-5p	CLIP-seq
MIRT1493874	hsa-miR-4707-5p	CLIP-seq
MIRT1493875	hsa-miR-4713-5p	CLIP-seq
MIRT1493856	hsa-miR-4723-5p	CLIP-seq
MIRT1493857	hsa-miR-4725-3p	CLIP-seq
MIRT1493858	hsa-miR-4787-5p	CLIP-seq
MIRT1493876	hsa-miR-532-3p	CLIP-seq
MIRT1493862	hsa-miR-608	CLIP-seq
MIRT1493863	hsa-miR-625	CLIP-seq
MIRT1493864	hsa-miR-7	CLIP-seq
MIRT2369219	hsa-miR-3689d	CLIP-seq
MIRT2369220	hsa-miR-4497	CLIP-seq
MIRT2397027	hsa-miR-4756-3p	CLIP-seq
MIRT2434841	hsa-miR-300	CLIP-seq
MIRT2434842	hsa-miR-3121-3p	CLIP-seq
MIRT2434843	hsa-miR-3163	CLIP-seq
MIRT2434844	hsa-miR-381	CLIP-seq
MIRT2434845	hsa-miR-4666-3p	CLIP-seq
MIRT2434846	hsa-miR-4789-5p	CLIP-seq
MIRT2463553	hsa-miR-1272	CLIP-seq
MIRT2463554	hsa-miR-143	CLIP-seq
MIRT2434841	hsa-miR-300	CLIP-seq
MIRT2434842	hsa-miR-3121-3p	CLIP-seq
MIRT2434843	hsa-miR-3163	CLIP-seq
MIRT2463555	hsa-miR-3663-3p	CLIP-seq
MIRT2434844	hsa-miR-381	CLIP-seq
MIRT2434845	hsa-miR-4666-3p	CLIP-seq
MIRT2397027	hsa-miR-4756-3p	CLIP-seq
MIRT2463556	hsa-miR-4770	CLIP-seq
MIRT2434846	hsa-miR-4789-5p	CLIP-seq
MIRT2463557	hsa-miR-486-3p	CLIP-seq
MIRT2463553	hsa-miR-1272	CLIP-seq
MIRT2463554	hsa-miR-143	CLIP-seq
MIRT2463555	hsa-miR-3663-3p	CLIP-seq
MIRT2397027	hsa-miR-4756-3p	CLIP-seq
MIRT2463556	hsa-miR-4770	CLIP-seq
MIRT2463557	hsa-miR-486-3p	CLIP-seq
MIRT2662907	hsa-miR-105	CLIP-seq
MIRT2662908	hsa-miR-1238	CLIP-seq
MIRT1493833	hsa-miR-1275	CLIP-seq
MIRT1493835	hsa-miR-144	CLIP-seq
MIRT2662909	hsa-miR-15a	CLIP-seq
MIRT2662910	hsa-miR-15b	CLIP-seq
MIRT2662911	hsa-miR-16	CLIP-seq
MIRT2662912	hsa-miR-195	CLIP-seq
MIRT2662913	hsa-miR-2277-3p	CLIP-seq
MIRT2662914	hsa-miR-28-5p	CLIP-seq
MIRT1493838	hsa-miR-3124-3p	CLIP-seq
MIRT2662915	hsa-miR-3139	CLIP-seq
MIRT2662916	hsa-miR-3606	CLIP-seq
MIRT2662917	hsa-miR-424	CLIP-seq
MIRT1493844	hsa-miR-4271	CLIP-seq
MIRT2662918	hsa-miR-4313	CLIP-seq
MIRT1493845	hsa-miR-4447	CLIP-seq
MIRT1493846	hsa-miR-4472	CLIP-seq
MIRT1493850	hsa-miR-4525	CLIP-seq
MIRT1493851	hsa-miR-4532	CLIP-seq
MIRT2662919	hsa-miR-4633-3p	CLIP-seq
MIRT1493852	hsa-miR-4645-3p	CLIP-seq
MIRT1493853	hsa-miR-4651	CLIP-seq
MIRT2662920	hsa-miR-4660	CLIP-seq
MIRT1493854	hsa-miR-4665-5p	CLIP-seq
MIRT1493874	hsa-miR-4707-5p	CLIP-seq
MIRT1493856	hsa-miR-4723-5p	CLIP-seq
MIRT1493857	hsa-miR-4725-3p	CLIP-seq
MIRT1493858	hsa-miR-4787-5p	CLIP-seq
MIRT2662921	hsa-miR-497	CLIP-seq
MIRT1493862	hsa-miR-608	CLIP-seq
MIRT1493863	hsa-miR-625	CLIP-seq
MIRT2662922	hsa-miR-646	CLIP-seq
MIRT1493864	hsa-miR-7	CLIP-seq
MIRT2662923	hsa-miR-708	CLIP-seq
MIRT1493865	hsa-miR-765	CLIP-seq
MIRT2662907	hsa-miR-105	CLIP-seq
MIRT2662908	hsa-miR-1238	CLIP-seq
MIRT2662909	hsa-miR-15a	CLIP-seq
MIRT2662910	hsa-miR-15b	CLIP-seq
MIRT2662911	hsa-miR-16	CLIP-seq
MIRT2662912	hsa-miR-195	CLIP-seq
MIRT2695296	hsa-miR-2114	CLIP-seq
MIRT2662913	hsa-miR-2277-3p	CLIP-seq
MIRT2662914	hsa-miR-28-5p	CLIP-seq
MIRT1493838	hsa-miR-3124-3p	CLIP-seq
MIRT2662915	hsa-miR-3139	CLIP-seq
MIRT2695297	hsa-miR-3162-3p	CLIP-seq
MIRT2662916	hsa-miR-3606	CLIP-seq
MIRT2695298	hsa-miR-3691-3p	CLIP-seq
MIRT2662917	hsa-miR-424	CLIP-seq
MIRT2662918	hsa-miR-4313	CLIP-seq
MIRT2662919	hsa-miR-4633-3p	CLIP-seq
MIRT1493852	hsa-miR-4645-3p	CLIP-seq
MIRT2662920	hsa-miR-4660	CLIP-seq
MIRT2695299	hsa-miR-4793-5p	CLIP-seq
MIRT2662921	hsa-miR-497	CLIP-seq
MIRT2662922	hsa-miR-646	CLIP-seq
MIRT2662923	hsa-miR-708	CLIP-seq
MIRT1493865	hsa-miR-765	CLIP-seq

Show/Hide all(32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002062	Process	Chondrocyte differentiation	IEP	15135146
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005102	Function	Signaling receptor binding	IPI	19486338
GO:0005109	Function	Frizzled binding	IBA
GO:0005125	Function	Cytokine activity	IBA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	NAS	15135146
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005796	Component	Golgi lumen	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0009986	Component	Cell surface	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0030182	Process	Neuron differentiation	IBA
GO:0030182	Process	Neuron differentiation	ISS
GO:0030335	Process	Positive regulation of cell migration	IDA	19486338
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0031012	Component	Extracellular matrix	HDA	28327460
GO:0031012	Component	Extracellular matrix	IEA
GO:0042692	Process	Muscle cell differentiation	ISS
GO:0045165	Process	Cell fate commitment	IBA
GO:0045444	Process	Fat cell differentiation	NAS	19577541
GO:0045600	Process	Positive regulation of fat cell differentiation	IEA
GO:0060070	Process	Canonical Wnt signaling pathway	IBA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070062	Component	Extracellular exosome	TAS
GO:0070307	Process	Lens fiber cell development	ISS	16258938
GO:0071300	Process	Cellular response to retinoic acid	ISS
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IEA
GO:1904105	Process	Positive regulation of convergent extension involved in gastrulation	ISS
GO:2000052	Process	Positive regulation of non-canonical Wnt signaling pathway	ISS

MIM	HGNC	e!Ensembl
606361	16265	ENSG00000111186

Protein

UniProt ID

Q9H1J7

Protein name

Protein Wnt-5b

Protein function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameter

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00110	wnt	50 → 359	wnt family	Family

Sequence

MPSLLLLFTAALLSSWAQLLTDANSWWSLALNPVQRPEMFIIGAQPVCSQLPGLSPGQRK
LCQLYQEHMAYIGEGAKTGIKECQHQFRQRRWNCSTADNASVFGRVMQIGSRETAFTHAV
SAAGVVNAISRACREGELSTCGCSRTARPKDLPRDWLWGGCGDNVEYGYRFAKEFVDARE
REKNFAKGSEEQGRVLMNLQNNEAGRRAVYKMADVACKCHGVSGSCSLKTCWLQLAEFRK
VGDRLKEKYDSAAAMRVTRKGRLELVNSRFTQPTPEDLVYVDPSPDYCLRNESTGSLGTQ
GRLCNKTSEGMDGCELMCCGRGYNQFKSVQVERCHCKFHWCCFVRCKKCTEIVDQYICK

Sequence length

359

Interactions

View interactions

	KEGG		Reactome
	mTOR signaling pathway Wnt signaling pathway Axon guidance Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells Melanogenesis Cushing syndrome Alzheimer disease Pathways of neurodegeneration - multiple diseases Human papillomavirus infection Pathways in cancer Proteoglycans in cancer Basal cell carcinoma Breast cancer Hepatocellular carcinoma Gastric cancer		WNT ligand biogenesis and trafficking PCP/CE pathway

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Gout	Gout	N/A	N/A	GWAS

Show/Hide Text Mining Associations (26)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Airway Remodeling	Associate	27126693
Bone Diseases	Associate	17900349
Breast Neoplasms	Associate	29847788, 31462314
Carcinoma Hepatocellular	Associate	19849855, 24944491
Carcinoma Non Small Cell Lung	Associate	24980784
Carcinoma Renal Cell	Associate	33804101
Cleft Palate	Associate	25663376
Fibrosis	Associate	24040439
Inflammation	Associate	24040439
Inflammation	Stimulate	27036869
Leukemia Lymphocytic Chronic B Cell	Associate	14973184, 26240275
Leukemia Myelogenous Chronic BCR ABL Positive	Stimulate	35176183
Neoplasm Metastasis	Associate	24564888
Neoplasms	Stimulate	24564888
Neoplasms	Associate	35176183
Obesity	Associate	32561739
Osteoarthritis	Associate	17900349, 22820497
Osteoporosis	Associate	17295923
Plasmablastic Lymphoma	Associate	37105495
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Inhibit	22426169
Pulmonary Disease Chronic Obstructive	Associate	21980461, 27036869, 27126693
Scleroderma Systemic	Associate	37587067
Squamous Cell Carcinoma of Head and Neck	Associate	21998657, 26861993
Triple Negative Breast Neoplasms	Stimulate	24564888
Typical Teratoid Rhabdoid Tumor	Stimulate	25246426
Ventricular Remodeling	Stimulate	27126693

WNT5B (Wnt family member 5B)