Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	80975
Gene name Gene Name - the full gene name approved by the HGNC.	Transmembrane serine protease 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TMPRSS5
Synonyms (NCBI Gene) Gene synonyms aliases	SPINESIN
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q23.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein that belongs to the serine protease family. Serine proteases are known to be involved in many physiological and pathological processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014

Show/Hide all(162)

miRTarBase ID	miRNA	Experiments	Reference
MIRT716023	hsa-miR-6800-3p	HITS-CLIP	19536157
MIRT716022	hsa-miR-6736-3p	HITS-CLIP	19536157
MIRT716021	hsa-miR-4267	HITS-CLIP	19536157
MIRT716020	hsa-miR-3183	HITS-CLIP	19536157
MIRT716019	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT716018	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT716017	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT716016	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT716015	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT716014	hsa-miR-4279	HITS-CLIP	19536157
MIRT451969	hsa-miR-1321	PAR-CLIP	23592263
MIRT451968	hsa-miR-4739	PAR-CLIP	23592263
MIRT451967	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT451966	hsa-miR-4436b-3p	PAR-CLIP	23592263
MIRT451965	hsa-miR-4632-5p	PAR-CLIP	23592263
MIRT451964	hsa-miR-6735-5p	PAR-CLIP	23592263
MIRT451963	hsa-miR-6879-5p	PAR-CLIP	23592263
MIRT451961	hsa-miR-7843-5p	PAR-CLIP	23592263
MIRT451962	hsa-miR-4688	PAR-CLIP	23592263
MIRT451960	hsa-miR-6743-5p	PAR-CLIP	23592263
MIRT451959	hsa-miR-4270	PAR-CLIP	23592263
MIRT451958	hsa-miR-4441	PAR-CLIP	23592263
MIRT451957	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT451956	hsa-miR-3616-3p	PAR-CLIP	23592263
MIRT451955	hsa-miR-298	PAR-CLIP	23592263
MIRT451954	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT451953	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT451952	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT451951	hsa-miR-8085	PAR-CLIP	23592263
MIRT451950	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT451949	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT451948	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT451947	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT451945	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT451946	hsa-miR-3175	PAR-CLIP	23592263
MIRT451944	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT451943	hsa-miR-4773	PAR-CLIP	23592263
MIRT451942	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT451941	hsa-miR-4476	PAR-CLIP	23592263
MIRT451940	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT451939	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT451938	hsa-miR-3179	PAR-CLIP	23592263
MIRT451937	hsa-miR-589-5p	PAR-CLIP	23592263
MIRT451936	hsa-miR-146a-5p	PAR-CLIP	23592263
MIRT451935	hsa-miR-146b-5p	PAR-CLIP	23592263
MIRT451934	hsa-miR-7153-5p	PAR-CLIP	23592263
MIRT451933	hsa-miR-4693-3p	PAR-CLIP	23592263
MIRT451932	hsa-miR-4419a	PAR-CLIP	23592263
MIRT451931	hsa-miR-4510	PAR-CLIP	23592263
MIRT451930	hsa-miR-6127	PAR-CLIP	23592263
MIRT451929	hsa-miR-6129	PAR-CLIP	23592263
MIRT451928	hsa-miR-6130	PAR-CLIP	23592263
MIRT451927	hsa-miR-6133	PAR-CLIP	23592263
MIRT451926	hsa-miR-3202	PAR-CLIP	23592263
MIRT451925	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT451924	hsa-miR-4306	PAR-CLIP	23592263
MIRT451923	hsa-miR-4644	PAR-CLIP	23592263
MIRT451922	hsa-miR-5192	PAR-CLIP	23592263
MIRT716023	hsa-miR-6800-3p	HITS-CLIP	19536157
MIRT716022	hsa-miR-6736-3p	HITS-CLIP	19536157
MIRT716021	hsa-miR-4267	HITS-CLIP	19536157
MIRT716020	hsa-miR-3183	HITS-CLIP	19536157
MIRT716019	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT716018	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT716017	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT716016	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT716015	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT716014	hsa-miR-4279	HITS-CLIP	19536157
MIRT451969	hsa-miR-1321	PAR-CLIP	23592263
MIRT451968	hsa-miR-4739	PAR-CLIP	23592263
MIRT451967	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT451966	hsa-miR-4436b-3p	PAR-CLIP	23592263
MIRT451965	hsa-miR-4632-5p	PAR-CLIP	23592263
MIRT451964	hsa-miR-6735-5p	PAR-CLIP	23592263
MIRT451963	hsa-miR-6879-5p	PAR-CLIP	23592263
MIRT451961	hsa-miR-7843-5p	PAR-CLIP	23592263
MIRT451962	hsa-miR-4688	PAR-CLIP	23592263
MIRT451960	hsa-miR-6743-5p	PAR-CLIP	23592263
MIRT451959	hsa-miR-4270	PAR-CLIP	23592263
MIRT451958	hsa-miR-4441	PAR-CLIP	23592263
MIRT451957	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT451956	hsa-miR-3616-3p	PAR-CLIP	23592263
MIRT451955	hsa-miR-298	PAR-CLIP	23592263
MIRT451954	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT451953	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT451952	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT451951	hsa-miR-8085	PAR-CLIP	23592263
MIRT451950	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT451949	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT451948	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT451947	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT451945	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT451946	hsa-miR-3175	PAR-CLIP	23592263
MIRT451944	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT451943	hsa-miR-4773	PAR-CLIP	23592263
MIRT451942	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT451941	hsa-miR-4476	PAR-CLIP	23592263
MIRT451940	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT451939	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT451938	hsa-miR-3179	PAR-CLIP	23592263
MIRT451937	hsa-miR-589-5p	PAR-CLIP	23592263
MIRT451936	hsa-miR-146a-5p	PAR-CLIP	23592263
MIRT451935	hsa-miR-146b-5p	PAR-CLIP	23592263
MIRT451934	hsa-miR-7153-5p	PAR-CLIP	23592263
MIRT451933	hsa-miR-4693-3p	PAR-CLIP	23592263
MIRT451932	hsa-miR-4419a	PAR-CLIP	23592263
MIRT451931	hsa-miR-4510	PAR-CLIP	23592263
MIRT451930	hsa-miR-6127	PAR-CLIP	23592263
MIRT451929	hsa-miR-6129	PAR-CLIP	23592263
MIRT451928	hsa-miR-6130	PAR-CLIP	23592263
MIRT451927	hsa-miR-6133	PAR-CLIP	23592263
MIRT451926	hsa-miR-3202	PAR-CLIP	23592263
MIRT451925	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT451924	hsa-miR-4306	PAR-CLIP	23592263
MIRT451923	hsa-miR-4644	PAR-CLIP	23592263
MIRT451922	hsa-miR-5192	PAR-CLIP	23592263
MIRT1441161	hsa-miR-1287	CLIP-seq
MIRT1441162	hsa-miR-1289	CLIP-seq
MIRT1441163	hsa-miR-27a	CLIP-seq
MIRT1441164	hsa-miR-27b	CLIP-seq
MIRT1441165	hsa-miR-3135b	CLIP-seq
MIRT1441166	hsa-miR-3162-5p	CLIP-seq
MIRT1441167	hsa-miR-3189-3p	CLIP-seq
MIRT1441168	hsa-miR-3612	CLIP-seq
MIRT1441169	hsa-miR-3619-3p	CLIP-seq
MIRT1441170	hsa-miR-3909	CLIP-seq
MIRT1441171	hsa-miR-4443	CLIP-seq
MIRT1441172	hsa-miR-4535	CLIP-seq
MIRT1441173	hsa-miR-4776-5p	CLIP-seq
MIRT1441174	hsa-miR-513a-5p	CLIP-seq
MIRT1441175	hsa-miR-650	CLIP-seq
MIRT1920994	hsa-miR-140-3p	CLIP-seq
MIRT1920995	hsa-miR-545	CLIP-seq
MIRT1920994	hsa-miR-140-3p	CLIP-seq
MIRT1920995	hsa-miR-545	CLIP-seq
MIRT1441161	hsa-miR-1287	CLIP-seq
MIRT1441165	hsa-miR-3135b	CLIP-seq
MIRT1441168	hsa-miR-3612	CLIP-seq
MIRT1441171	hsa-miR-4443	CLIP-seq
MIRT2353189	hsa-miR-4633-3p	CLIP-seq
MIRT2353190	hsa-miR-558	CLIP-seq
MIRT1441175	hsa-miR-650	CLIP-seq
MIRT2462014	hsa-miR-125a-3p	CLIP-seq
MIRT2462015	hsa-miR-3194-5p	CLIP-seq
MIRT2462016	hsa-miR-3918	CLIP-seq
MIRT2462017	hsa-miR-4640-5p	CLIP-seq
MIRT2462018	hsa-miR-4691-3p	CLIP-seq
MIRT2462019	hsa-miR-4726-5p	CLIP-seq
MIRT1441161	hsa-miR-1287	CLIP-seq
MIRT1441165	hsa-miR-3135b	CLIP-seq
MIRT1441168	hsa-miR-3612	CLIP-seq
MIRT1441171	hsa-miR-4443	CLIP-seq
MIRT2353189	hsa-miR-4633-3p	CLIP-seq
MIRT2353190	hsa-miR-558	CLIP-seq
MIRT1441175	hsa-miR-650	CLIP-seq
MIRT1441161	hsa-miR-1287	CLIP-seq
MIRT1441165	hsa-miR-3135b	CLIP-seq
MIRT1441168	hsa-miR-3612	CLIP-seq
MIRT1441171	hsa-miR-4443	CLIP-seq
MIRT2353189	hsa-miR-4633-3p	CLIP-seq
MIRT2353190	hsa-miR-558	CLIP-seq
MIRT1441175	hsa-miR-650	CLIP-seq

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004252	Function	Serine-type endopeptidase activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	17918732
GO:0005886	Component	Plasma membrane	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	IMP	17918732
GO:0008233	Function	Peptidase activity	IEA
GO:0008233	Function	Peptidase activity	IMP	17918732
GO:0008236	Function	Serine-type peptidase activity	IBA
GO:0008236	Function	Serine-type peptidase activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0043025	Component	Neuronal cell body	IEA

MIM	HGNC	e!Ensembl
606751	14908	ENSG00000166682

Protein

UniProt ID

Q9H3S3

Protein name

Transmembrane protease serine 5 (EC 3.4.21.-) (Spinesin)

Protein function

May play a role in hearing.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15494	SRCR_2	116 → 213	Scavenger receptor cysteine-rich domain	Domain
PF00089	Trypsin	218 → 448	Trypsin	Domain

Tissue specificity

TISSUE SPECIFICITY: Brain-specific. Predominantly expressed in neurons, in their axons, and at the synapses of motoneurons in the spinal cord.

Sequence

MSLMLDDQPPMEAQYAEEGPGPGIFRAEPGDQQHPISQAVCWRSMRRGCAVLGALGLLAG
AGVGSWLLVLYLCPAASQPISGTLQDEEITLSCSEASAEEALLPALPKTVSFRINSEDFL
LEAQVRDQPRWLLVCHEGWSPALGLQICWSLGHLRLTHHKGVNLTDIKLNSSQEFAQLSP
RLGGFLEEAWQPRNNCTSGQVVSLRCSECGARPLASRIVGGQSVAPGRWPWQASVALGFR
HTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLY
SAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDM
LQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLV
GVVSWGRGCAEPNHPGVYAKVAEFLDWIHDTAQDSLL

Sequence length

457

Interactions

View interactions

Show/Hide Unknown Diseases (5)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Anxiety Disorder	Anxiety	N/A	N/A	GWAS
Lymphocytic Leukemia	Chronic lymphocytic leukemia	N/A	N/A	GWAS
Mental Depression	Major depressive disorder	N/A	N/A	GWAS
Neuroticism	Neuroticism	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Atrial Fibrillation	Associate	36253349, 40304040
Cerebral Infarction	Associate	40304040
Coronary Disease	Associate	33186364
Leukoencephalopathies	Associate	36253349
Stroke	Associate	36253349

TMPRSS5 (transmembrane serine protease 5)