KDM7A (lysine demethylase 7A)

Gene

• Entrez ID: 80853
• Gene name: Lysine demethylase 7A
• Gene symbol: KDM7A
• Synonyms (NCBI Gene): JHDM1D
• Chromosome: 7
• Chromosome location: 7q34

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT667800	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT667799	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT667798	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT667797	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT667796	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT667795	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT239629	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT667794	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT741698	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT741699	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT741700	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT741701	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT741702	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT741703	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT239629	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT741704	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT755330	hsa-miR-451a	Luciferase reporter assay, Western blotting, CLIP-seq	38943031

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003712	Function	Transcription coregulator activity	IBA
GO:0005506	Function	Iron ion binding	IDA	20023638
GO:0005506	Function	Iron ion binding	IEA
GO:0005506	Function	Iron ion binding	TAS	20194436
GO:0005634	Component	Nucleus	IC	20023638
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0006338	Process	Chromatin remodeling	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0007399	Process	Nervous system development	IEA
GO:0008270	Function	Zinc ion binding	IDA	20023638
GO:0008270	Function	Zinc ion binding	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016706	Function	2-oxoglutarate-dependent dioxygenase activity	IDA	20194436
GO:0030901	Process	Midbrain development	ISS
GO:0032452	Function	Histone demethylase activity	IBA
GO:0032452	Function	Histone demethylase activity	TAS
GO:0032454	Function	Histone H3K9 demethylase activity	IDA	20194436, 20622853
GO:0032454	Function	Histone H3K9 demethylase activity	IEA
GO:0035575	Function	Histone H4K20 demethylase activity	IDA	20622853
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051213	Function	Dioxygenase activity	IEA
GO:0051864	Function	Histone H3K36 demethylase activity	IDA	20622853
GO:0071558	Function	Histone H3K27me2/H3K27me3 demethylase activity	IDA	20023638, 20194436, 20622853
GO:0071558	Function	Histone H3K27me2/H3K27me3 demethylase activity	IEA
GO:0140683	Function	Histone H3K9me/H3K9me2 demethylase activity	IDA	20023638
GO:0140683	Function	Histone H3K9me/H3K9me2 demethylase activity	IEA

Other IDs

• MIM: 619640
• HGNC: 22224
• e!Ensembl: ENSG00000006459

Protein

• UniProt ID: Q6ZMT4
• Protein name: Lysine-specific demethylase 7A (JmjC domain-containing histone demethylation protein 1D) (Lysine-specific demethylase 7) ([histone H3]-dimethyl-L-lysine9 demethylase 7A) (EC 1.14.11.65)
• Protein function: Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereb
• PDB: 3KV5, 3KV6, 3KV9, 3KVA, 3KVB, 3U78
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00628	PHD	39 → 88	PHD-finger	Domain
  PF02373	JmjC	269 → 369	JmjC domain, hydroxylase	Domain
  PF17811	JHD	373 → 476	Jumonji helical domain	Domain

• Sequence:

  MAGAAAAVAAGAAAGAAAAAVSVAAPGRASAPPPPPPVYCVCRQPYDVNRFMIECDICKD
  WFHGSCVGVEEHHAVDIDLYHCPNCAVLHGSSLMKKRRNWHRHDYTEIDDGSKPVQAGTR
  TFIKELRSRVFPSADEIIIKMHGSQLTQRYLEKHGFDVPIMVPKLDDLGLRLPSPTFSVM
  DVERYVGGDKVIDVIDVARQADSKMTLHNYVKYFMNPNRPKVLNVISLEFSDTKMSELVE
  VPDIAKKLSWVENYWPDDSVFPKPFVQKYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKI
  FYLIKPTDENLARYESWSSSVTQSEVFFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQ
  DCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFEAICWFVAKNLLETLKELRED
  GFQPQTYLVQGVKALHTALKLWMKKELVSEHAFEIPDNVRPGHLIKELSKVIRAIEEENG
  KPVKSQGIPIVCPVSRSSNEATSPYHSRRKMRKLRDHNVRTPSNLDILELHTREVLKRLE
  MCPWEEDILSSKLNGKFNKHLQPSSTVPEWRAKDNDLRLLLTNGRIIKDERQPFADQSLY
  TADSENEEDKRRTKKAKMKIEESSGVEGVEHEESQKPLNGFFTRVKSELRSRSSGYSDIS
  ESEDSGPECTALKSIFTTEESESSGDEKKQEITSNFKEESNVMRNFLQKSQKPSRSEIPI
  KRECPTSTSTEEEAIQGMLSMAGLHYSTCLQRQIQSTDCSGERNSLQDPSSCHGSNHEVR
  QLYRYDKPVECGYHVKTEDPDLRTSSWIKQFDTSRFHPQDLSRSQKCIRKEGSSEISQRV
  QSRNYVDSSGSSLQNGKYMQNSNLTSGACQISNGSLSPERPVGETSFSVPLHPTKRPASN
  PPPISNQATKGKRPKKGMATAKQRLGKILKLNRNGHARFFV

• Sequence length: 941

Pathways

Reactome:

HDMs demethylate histones
Signaling by BRAF and RAF fusions

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