Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	80853
Gene name Gene Name - the full gene name approved by the HGNC.	Lysine demethylase 7A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	KDM7A
Synonyms (NCBI Gene) Gene synonyms aliases	JHDM1D
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q34

Show/Hide all(17)

miRTarBase ID	miRNA	Experiments	Reference
MIRT667800	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT667799	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT667798	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT667797	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT667796	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT667795	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT239629	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT667794	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT741698	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT741699	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT741700	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT741701	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT741702	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT741703	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT239629	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT741704	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT755330	hsa-miR-451a	Luciferase reporter assay, Western blotting, CLIP-seq	38943031

Show/Hide all(23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003712	Function	Transcription coregulator activity	IBA	21873635
GO:0005506	Function	Iron ion binding	IDA	20023638
GO:0005506	Function	Iron ion binding	TAS	20194436
GO:0005634	Component	Nucleus	IC	20023638
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006482	Process	Protein demethylation	IBA	21873635
GO:0008270	Function	Zinc ion binding	IDA	20023638
GO:0016706	Function	2-oxoglutarate-dependent dioxygenase activity	IDA	20023638, 20194436
GO:0030901	Process	Midbrain development	ISS
GO:0032452	Function	Histone demethylase activity	IBA	21873635
GO:0032454	Function	Histone demethylase activity (H3-K9 specific)	IDA	20023638, 20194436, 20622853
GO:0033169	Process	Histone H3-K9 demethylation	IDA	20023638, 20194436, 20622853
GO:0035064	Function	Methylated histone binding	IDA	20023638
GO:0035574	Process	Histone H4-K20 demethylation	IDA	20622853
GO:0035575	Function	Histone demethylase activity (H4-K20 specific)	IDA	20622853
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IEA
GO:0051864	Function	Histone demethylase activity (H3-K36 specific)	IDA	20622853
GO:0070544	Process	Histone H3-K36 demethylation	IDA	20622853
GO:0071557	Process	Histone H3-K27 demethylation	IDA	20023638, 20194436, 20622853
GO:0071558	Function	Histone demethylase activity (H3-K27 specific)	IDA	20023638, 20194436, 20622853

MIM	HGNC	e!Ensembl
619640	22224	ENSG00000006459

Protein

UniProt ID

Q6ZMT4

Protein name

Lysine-specific demethylase 7A (JmjC domain-containing histone demethylation protein 1D) (Lysine-specific demethylase 7) ([histone H3]-dimethyl-L-lysine9 demethylase 7A) (EC 1.14.11.65)

Protein function

Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereb

PDB

3KV5 , 3KV6 , 3KV9 , 3KVA , 3KVB , 3U78

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00628	PHD	39 → 88	PHD-finger	Domain
PF02373	JmjC	269 → 369	JmjC domain, hydroxylase	Domain
PF17811	JHD	373 → 476	Jumonji helical domain	Domain

Sequence

MAGAAAAVAAGAAAGAAAAAVSVAAPGRASAPPPPPPVYCVCRQPYDVNRFMIECDICKD
WFHGSCVGVEEHHAVDIDLYHCPNCAVLHGSSLMKKRRNWHRHDYTEIDDGSKPVQAGTR
TFIKELRSRVFPSADEIIIKMHGSQLTQRYLEKHGFDVPIMVPKLDDLGLRLPSPTFSVM
DVERYVGGDKVIDVIDVARQADSKMTLHNYVKYFMNPNRPKVLNVISLEFSDTKMSELVE
VPDIAKKLSWVENYWPDDSVFPKPFVQKYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKI
FYLIKPTDENLARYESWSSSVTQSEVFFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQ
DCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFEAICWFVAKNLLETLKELRED
GFQPQTYLVQGVKALHTALKLWMKKELVSEHAFEIPDNVRPGHLIKELSKVIRAIEEENG
KPVKSQGIPIVCPVSRSSNEATSPYHSRRKMRKLRDHNVRTPSNLDILELHTREVLKRLE
MCPWEEDILSSKLNGKFNKHLQPSSTVPEWRAKDNDLRLLLTNGRIIKDERQPFADQSLY
TADSENEEDKRRTKKAKMKIEESSGVEGVEHEESQKPLNGFFTRVKSELRSRSSGYSDIS
ESEDSGPECTALKSIFTTEESESSGDEKKQEITSNFKEESNVMRNFLQKSQKPSRSEIPI
KRECPTSTSTEEEAIQGMLSMAGLHYSTCLQRQIQSTDCSGERNSLQDPSSCHGSNHEVR
QLYRYDKPVECGYHVKTEDPDLRTSSWIKQFDTSRFHPQDLSRSQKCIRKEGSSEISQRV
QSRNYVDSSGSSLQNGKYMQNSNLTSGACQISNGSLSPERPVGETSFSVPLHPTKRPASN
PPPISNQATKGKRPKKGMATAKQRLGKILKLNRNGHARFFV

Sequence length

941

Interactions

View interactions

	Reactome
			HDMs demethylate histones Signaling by BRAF and RAF fusions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinoma Squamous Cell	Associate	33960436
DiGeorge Syndrome	Associate	26608785
Heart Defects Congenital	Associate	26608785
Neoplasms	Inhibit	26461474
Urinary Bladder Neoplasms	Associate	36903656

KDM7A (lysine demethylase 7A)