Gene Gene information from NCBI Gene database.
Entrez ID 80829
Gene name ZFP91 zinc finger protein, atypical E3 ubiquitin ligase
Gene symbol ZFP91
Synonyms (NCBI Gene)
DMS-8DSM-8DSM8FKSG11PZFZFP-91ZNF757
Chromosome 11
Chromosome location 11q12.1
Summary The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regul
miRNA miRNA information provided by mirtarbase database.
804
miRTarBase ID miRNA Experiments Reference
MIRT019693 hsa-miR-375 Microarray 20215506
MIRT027985 hsa-miR-93-5p Sequencing 20371350
MIRT049964 hsa-miR-29a-3p CLASH 23622248
MIRT181494 hsa-miR-595 HITS-CLIP 23313552
MIRT697421 hsa-miR-28-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0004842 Function Ubiquitin-protein transferase activity IDA 20682767
GO:0005515 Function Protein binding IPI 32296183
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
619289 14983 ENSG00000186660
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96JP5
Protein name E3 ubiquitin-protein ligase ZFP91 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZFP91) (Zinc finger protein 757) (Zinc finger protein 91 homolog) (Zfp-91)
Protein function Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an imp
PDB 2M9A
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00096 zf-C2H2 372 394 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 400 422 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 430 453 Zinc finger, C2H2 type Domain
Tissue specificity TISSUE SPECIFICITY: Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific.
Sequence
MPGETEEPRPPEQQDQEGGEAAKAAPEEPQQRPPEAVAAAPAGTTSSRVLRGGRDRGRAA
AAAAAAAVSRRRKAEYPRRRRSSPSARPPDVPGQQPQAAKSPSPVQGKKSPRLLCIEKVT
TDKDPKEEKEEEDDSALPQEVSIAASRPSRGWRSSRTSVSRHRDTENTRSSRSKTGSLQL
ICKSEPNTDQLDYDVGEEHQSPGGISSEEEEEEEEEMLISEEEIPFKDDPRDETYKPHLE
RETPKPRRKSGKVKEEKEKKEIKVEVEVEVKEEENEIREDEEPPRKRGRRRKDDKSPRLP
KRRKKPPIQYVRCEMEGCGTVLAHPRYLQHHIKYQHLLKKKYVCPHPSCGRLFRLQKQLL
RHAKHHTDQRDYICEYCARAFKSSHNLAVHRMIHTGEKPLQCEICGFTCRQKASLNWHMK
KH
DADSFYQFSCNICGKKFEKKDSVVAHKAKSHPEVLIAEALAANAGALITSTDILGTNP
ESLTQPSDGQGLPLLPEPLGNSTSGECLLLEAEGMSKSYCSGTERVSLMADGKIFVGSGS
SGGTEGLVMNSDILGATTEVLIEDSDSAGP
Sequence length 570
Interactions View interactions