Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
80829
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
ZFP91 zinc finger protein, atypical E3 ubiquitin ligase |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
ZFP91 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
DMS-8, DSM-8, DSM8, FKSG11, PZF, ZFP-91, ZNF757 |
Chromosome
Chromosome number
|
11 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
11q12.1 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regul |
UniProt ID |
Q96JP5
|
Protein name |
E3 ubiquitin-protein ligase ZFP91 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZFP91) (Zinc finger protein 757) (Zinc finger protein 91 homolog) (Zfp-91) |
Protein function |
Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an imp |
PDB |
2M9A
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00096
|
zf-C2H2 |
372 → 394 |
Zinc finger, C2H2 type |
Domain |
PF00096
|
zf-C2H2 |
400 → 422 |
Zinc finger, C2H2 type |
Domain |
PF00096
|
zf-C2H2 |
430 → 453 |
Zinc finger, C2H2 type |
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific. |
Sequence |
MPGETEEPRPPEQQDQEGGEAAKAAPEEPQQRPPEAVAAAPAGTTSSRVLRGGRDRGRAA AAAAAAAVSRRRKAEYPRRRRSSPSARPPDVPGQQPQAAKSPSPVQGKKSPRLLCIEKVT TDKDPKEEKEEEDDSALPQEVSIAASRPSRGWRSSRTSVSRHRDTENTRSSRSKTGSLQL ICKSEPNTDQLDYDVGEEHQSPGGISSEEEEEEEEEMLISEEEIPFKDDPRDETYKPHLE RETPKPRRKSGKVKEEKEKKEIKVEVEVEVKEEENEIREDEEPPRKRGRRRKDDKSPRLP KRRKKPPIQYVRCEMEGCGTVLAHPRYLQHHIKYQHLLKKKYVCPHPSCGRLFRLQKQLL RHAKHHTDQRDYICEYCARAFKSSHNLAVHRMIHTGEKPLQCEICGFTCRQKASLNWHMK KHDADSFYQFSCNICGKKFEKKDSVVAHKAKSHPEVLIAEALAANAGALITSTDILGTNP ESLTQPSDGQGLPLLPEPLGNSTSGECLLLEAEGMSKSYCSGTERVSLMADGKIFVGSGS SGGTEGLVMNSDILGATTEVLIEDSDSAGP
|
|
Sequence length |
570 |
Interactions |
View interactions
|