Gene Gene information from NCBI Gene database.
Entrez ID 80790
Gene name C-Maf inducing protein
Gene symbol CMIP
Synonyms (NCBI Gene)
TCMIP
Chromosome 16
Chromosome location 16q23.2-q23.3
Summary This gene encodes a c-Maf inducing protein that plays a role in T-cell signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
miRNA miRNA information provided by mirtarbase database.
301
miRTarBase ID miRNA Experiments Reference
MIRT028209 hsa-miR-33a-5p Sequencing 20371350
MIRT558688 hsa-miR-3121-3p PAR-CLIP 21572407
MIRT558687 hsa-miR-3529-3p PAR-CLIP 21572407
MIRT195826 hsa-miR-302a-5p PAR-CLIP 21572407
MIRT558686 hsa-miR-200c-5p PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
8
GO ID Ontology Definition Evidence Reference
GO:0001701 Process In utero embryonic development IEA
GO:0005515 Function Protein binding IPI 20018188, 32296183
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm IBA
GO:0005654 Component Nucleoplasm IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610112 24319 ENSG00000153815
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IY22
Protein name C-Maf-inducing protein (c-Mip) (Truncated c-Maf-inducing protein) (Tc-Mip)
Protein function Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 speci
Family and domains
Tissue specificity TISSUE SPECIFICITY: Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver. Expression is down-regulated in activated cells. Isoform 2 is expressed in lymphocyte precursors, however, expression shuts d
Sequence
MDVTSSSGGGGDPRQIEETKPLLGGDVSAPEGTKMGAVPCRRALLLCNGMRYKLLQEGDI
QVCVIRHPRTFLSKILTSKFLRRWEPHHLTLADNSLASATPTGYMENSVSYSAIEDVQLL
SWENAPKYCLQLTIPGGTVLLQAANSYLRDQWFHSLQWKKKIYKYKKVLSNPSRWEVVLK
EIRTLVDMALTSPLQDDSINQAPLEIVSKLLSENTNLTTQEHENIIVAIAPLLENNHPPP
DLCEFFCKHCRERPRSMVVIEVFTPVVQRILKHNMDFGKCPRLRLFTQEYILALNELNAG
MEVVKKFIQSMHGPTGHCPHPRVLPNLVAVCLAAIYSCYEEFINSRDNSPSLKEIRNGCQ
QPCDRKPTLPLRLLHPSPDLVSQEATLSEARLKSVVVASSEIHVEVERTSTAKPALTASA
GNDSEPNLIDCLMVSPACSTMSIELGPQADRTLGCYVEILKLLSDYDDWRPSLASLLQPI
PFPKEALAHEKFTKELKYVIQRFAEDPRQEVHSCLLSVRAGKDGWFQLYSPGGVACDDDG
ELFASMVHILMGSCYKTKKFLLSLAENKLGPCMLLALRGNQTMVEILCLMLEYNIIDNND
TQLQIISTLESTDVGKRMYEQLCDRQRELKELQRKGGPTRLTLPSKSTDADLARLLSSGS
FGNLENLSLAFTNVTSACAEHLIKLPSLKQLNLWSTQFGDAGLRLLSEHLTMLQVLNLCE
TPVTDAGLLALSSMKSLCSLNMNSTKLSADTYEDLKAKLPNLKEVDVRYTEAW
Sequence length 773
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
31
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign rs72831128 RCV005933549
Adrenocortical carcinoma, hereditary Benign rs72831128 RCV005933550
Cholangiocarcinoma Benign rs72831128 RCV005933555
CMIP-related disorder Uncertain significance; Likely benign; Benign rs2507849119, rs2507849217, rs770230656, rs754812064, rs376811403, rs377241916, rs560316334, rs544242568, rs545129438, rs375897973, rs1464550853, rs72831128, rs57603843, rs201681184, rs35429777
View all (6 more)
RCV003400252
RCV003404677
RCV003901840
RCV003903930
RCV003912202
RCV003907256
RCV003963893
RCV003919504
RCV003941474
RCV003942182
RCV003944676
RCV003981280
RCV003948330
RCV003910477
RCV003967971
RCV003948295
RCV003902883
RCV003912942
RCV003913062
RCV003942898
RCV003970747
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Diabetes Mellitus Type 2 Associate 24086726, 29597287, 29691896, 31145772
Glioma Associate 28744466
Glomerulonephritis IGA Associate 33112407
Glomerulonephritis Membranous Associate 23302718
Hematuria Associate 30439969
Immunoglobulin G4 Related Disease Associate 21457949
Kidney Diseases Stimulate 30439969
Language Disorders Associate 19646677, 21457949
Lupus Nephritis Associate 30439969
Malocclusion Angle Class I Stimulate 30439969