ZNF34 (zinc finger protein 34)

Gene

• Entrez ID: 80778
• Gene name: Zinc finger protein 34
• Gene symbol: ZNF34
• Synonyms (NCBI Gene): KOX32
• Chromosome: 8
• Chromosome location: 8q24.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT677060	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT677059	hsa-miR-1245a	HITS-CLIP	23824327
MIRT677058	hsa-miR-8079	HITS-CLIP	23824327
MIRT677057	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT677056	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT677055	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT677054	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT677052	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT677053	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT677051	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT677050	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT677049	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677047	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT677046	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT677045	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT677044	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT677043	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT677042	hsa-miR-640	HITS-CLIP	23824327
MIRT677041	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT677060	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT677059	hsa-miR-1245a	HITS-CLIP	23824327
MIRT677058	hsa-miR-8079	HITS-CLIP	23824327
MIRT677057	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT677056	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT677055	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT677054	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT677052	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT677053	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT677051	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT677050	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT677049	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677048	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT677047	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT677046	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT679251	hsa-miR-6131	HITS-CLIP	23824327
MIRT677045	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT677044	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT677043	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT677042	hsa-miR-640	HITS-CLIP	23824327
MIRT677041	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT677040	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT677039	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT677060	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT677059	hsa-miR-1245a	HITS-CLIP	23824327
MIRT677058	hsa-miR-8079	HITS-CLIP	23824327
MIRT677057	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT677056	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT677055	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT677054	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT677052	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT677053	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT677051	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT677050	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT677049	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677048	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT677047	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT677046	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT677045	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT677044	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT677043	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT677042	hsa-miR-640	HITS-CLIP	23824327
MIRT677041	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT677040	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT677039	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT496391	hsa-miR-4326	PAR-CLIP	22291592
MIRT496390	hsa-miR-5571-3p	PAR-CLIP	22291592
MIRT496389	hsa-miR-7975	PAR-CLIP	22291592
MIRT496388	hsa-miR-384	PAR-CLIP	22291592
MIRT457576	hsa-miR-3646	PAR-CLIP	23592263
MIRT457575	hsa-miR-634	PAR-CLIP	23592263
MIRT457574	hsa-miR-3154	PAR-CLIP	23592263
MIRT457573	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT457572	hsa-miR-1321	PAR-CLIP	23592263
MIRT457571	hsa-miR-4739	PAR-CLIP	23592263
MIRT457570	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT457569	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT457568	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT457567	hsa-miR-4530	PAR-CLIP	23592263
MIRT457566	hsa-miR-3179	PAR-CLIP	23592263
MIRT457565	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT457564	hsa-miR-5093	PAR-CLIP	23592263
MIRT457563	hsa-miR-4434	PAR-CLIP	23592263
MIRT457562	hsa-miR-4516	PAR-CLIP	23592263
MIRT457561	hsa-miR-5703	PAR-CLIP	23592263
MIRT457560	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT457559	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT457558	hsa-miR-3162-5p	PAR-CLIP	23592263
MIRT677060	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT677059	hsa-miR-1245a	HITS-CLIP	23824327
MIRT677058	hsa-miR-8079	HITS-CLIP	23824327
MIRT677057	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT677056	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT677055	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT677054	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT677052	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT677053	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT677051	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT677050	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT677049	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677047	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT677046	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT677045	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT677044	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT677043	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT677042	hsa-miR-640	HITS-CLIP	23824327
MIRT677041	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT677060	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT677059	hsa-miR-1245a	HITS-CLIP	23824327
MIRT677058	hsa-miR-8079	HITS-CLIP	23824327
MIRT677057	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT677056	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT677055	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT677054	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT677052	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT677053	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT677051	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT677050	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT677049	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677048	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT677047	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT677046	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT679251	hsa-miR-6131	HITS-CLIP	23824327
MIRT677045	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT677044	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT677043	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT677042	hsa-miR-640	HITS-CLIP	23824327
MIRT677041	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT677040	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT677039	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT677060	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT677059	hsa-miR-1245a	HITS-CLIP	23824327
MIRT677058	hsa-miR-8079	HITS-CLIP	23824327
MIRT677057	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT677056	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT677055	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT677054	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT677052	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT677053	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT677051	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT677050	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT677049	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677048	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT677047	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT677046	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT677045	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT677044	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT677043	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT677042	hsa-miR-640	HITS-CLIP	23824327
MIRT677041	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT677040	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT677039	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT496391	hsa-miR-4326	PAR-CLIP	22291592
MIRT496390	hsa-miR-5571-3p	PAR-CLIP	22291592
MIRT496389	hsa-miR-7975	PAR-CLIP	22291592
MIRT496388	hsa-miR-384	PAR-CLIP	22291592
MIRT457576	hsa-miR-3646	PAR-CLIP	23592263
MIRT457575	hsa-miR-634	PAR-CLIP	23592263
MIRT457574	hsa-miR-3154	PAR-CLIP	23592263
MIRT457573	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT457572	hsa-miR-1321	PAR-CLIP	23592263
MIRT457571	hsa-miR-4739	PAR-CLIP	23592263
MIRT457570	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT457569	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT457568	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT457567	hsa-miR-4530	PAR-CLIP	23592263
MIRT457566	hsa-miR-3179	PAR-CLIP	23592263
MIRT457565	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT457564	hsa-miR-5093	PAR-CLIP	23592263
MIRT457563	hsa-miR-4434	PAR-CLIP	23592263
MIRT457562	hsa-miR-4516	PAR-CLIP	23592263
MIRT457561	hsa-miR-5703	PAR-CLIP	23592263
MIRT457560	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT457559	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT457558	hsa-miR-3162-5p	PAR-CLIP	23592263

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0005515	Function	Protein binding	IPI	25416956, 29892012
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 194526
• HGNC: 13098
• e!Ensembl: ENSG00000196378

Protein

• UniProt ID: Q8IZ26
• Protein name: Zinc finger protein 34 (Zinc finger protein KOX32)
• Protein function: May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01352	KRAB	34 → 75	KRAB box	Family
  PF00096	zf-C2H2	195 → 217	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	251 → 273	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	279 → 301	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	307 → 329	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	335 → 357	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	363 → 385	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	391 → 413	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	419 → 441	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	447 → 469	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	475 → 498	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	503 → 525	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	531 → 553	Zinc finger, C2H2 type	Domain

• Sequence:

  MLLLLSDQLLLTALRKPNPQAMAALFLSAPPQAEVTFEDVAVYLSREEWGRLGPAQRGLY
  RDVMLETYGNLVSLGVGPAGPKPGVISQLERGDEPWVLDVQGTSGKEHLRVNSPALGTRT
  EYKELTSQETFGEEDPQGSEPVEACDHISKSEGSLEKLVEQRGPRAVTLTNGESSRESGG
  NLRLLSRPVPDQRPHKCDICEQSFEQRSYLNNHKRVHRSKKTNTVRNSGEIFSANLVVKE
  DQKIPTGKKLHYCSYCGKTFRYSANLVKHQRLHTEEKPYKCDECGKAFSQSCEFINHRRM
  HSGEIPYRCDECGKTFTRRPNLMKHQRIHTGEKPYKCGECGKHFSAYSSLIYHQRIHTGE
  KPYKCNDCGKAFSDGSILIRHRRTHTGEKPFECKECGKGFTQSSNLIQHQRIHTGEKPYK
  CNECEKAFIQKTKLVEHQRSHTGEKPYECNDCGKVFSQSTHLIQHQRIHTGEKPYKCSEC
  GKAFHNSSRLIHHQRLHHGEKPYRCSDCKKAFSQSTYLIQHRRIHTGEKPYKCSECGKAF
  RHSSNMCQHQRIHLREDFSM

• Sequence length: 560

Pathways

Reactome:

Generic Transcription Pathway

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs80356663, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs371977235, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	30054458

Unknown
Disease term	Disease name	Evidence	References	Source
Diabetes	Diabetes			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Asthma	Associate	35606283
Bipolar Disorder	Associate	26823146
Depressive Disorder Major	Associate	26823146
Mood Disorders	Associate	26823146