LIMD2 (LIM domain containing 2)

Gene

• Entrez ID: 80774
• Gene name: LIM domain containing 2
• Gene symbol: LIMD2
• Synonyms (NCBI Gene): -
• Chromosome: 17
• Chromosome location: 17q23.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020001	hsa-miR-375	Microarray	20215506
MIRT023120	hsa-miR-124-3p	Microarray	18668037
MIRT493329	hsa-let-7a-5p	PAR-CLIP	23592263
MIRT493328	hsa-miR-98-5p	PAR-CLIP	23592263
MIRT493327	hsa-let-7g-5p	PAR-CLIP	23592263
MIRT493326	hsa-let-7i-5p	PAR-CLIP	23592263
MIRT493325	hsa-miR-4458	PAR-CLIP	23592263
MIRT493324	hsa-let-7f-5p	PAR-CLIP	23592263
MIRT493323	hsa-let-7e-5p	PAR-CLIP	23592263
MIRT493322	hsa-let-7d-5p	PAR-CLIP	23592263
MIRT493320	hsa-miR-4500	PAR-CLIP	23592263
MIRT493321	hsa-let-7c-5p	PAR-CLIP	23592263
MIRT493319	hsa-let-7b-5p	PAR-CLIP	23592263
MIRT493317	hsa-miR-6863	PAR-CLIP	23592263
MIRT493318	hsa-miR-6755-5p	PAR-CLIP	23592263
MIRT493316	hsa-miR-3927-3p	PAR-CLIP	23592263
MIRT493315	hsa-miR-6831-5p	PAR-CLIP	23592263
MIRT493314	hsa-miR-139-3p	PAR-CLIP	23592263
MIRT493313	hsa-miR-3175	PAR-CLIP	23592263
MIRT493312	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT493311	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT493310	hsa-miR-197-5p	PAR-CLIP	23592263
MIRT493309	hsa-miR-3132	PAR-CLIP	23592263
MIRT493308	hsa-miR-4451	PAR-CLIP	23592263
MIRT493307	hsa-miR-6892-5p	PAR-CLIP	23592263
MIRT493306	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT493305	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT450500	hsa-miR-3145-5p	PAR-CLIP	22100165
MIRT450499	hsa-miR-5197-3p	PAR-CLIP	22100165
MIRT450498	hsa-miR-3925-5p	PAR-CLIP	22100165
MIRT450497	hsa-miR-146a-5p	PAR-CLIP	22100165
MIRT450496	hsa-miR-146b-5p	PAR-CLIP	22100165
MIRT450495	hsa-miR-7153-5p	PAR-CLIP	22100165
MIRT450494	hsa-miR-298	PAR-CLIP	22100165
MIRT450493	hsa-miR-498	PAR-CLIP	22100165
MIRT493329	hsa-let-7a-5p	PAR-CLIP	23592263
MIRT493328	hsa-miR-98-5p	PAR-CLIP	23592263
MIRT493327	hsa-let-7g-5p	PAR-CLIP	23592263
MIRT493326	hsa-let-7i-5p	PAR-CLIP	23592263
MIRT493325	hsa-miR-4458	PAR-CLIP	23592263
MIRT493324	hsa-let-7f-5p	PAR-CLIP	23592263
MIRT493323	hsa-let-7e-5p	PAR-CLIP	23592263
MIRT493322	hsa-let-7d-5p	PAR-CLIP	23592263
MIRT493320	hsa-miR-4500	PAR-CLIP	23592263
MIRT493321	hsa-let-7c-5p	PAR-CLIP	23592263
MIRT493319	hsa-let-7b-5p	PAR-CLIP	23592263
MIRT493317	hsa-miR-6863	PAR-CLIP	23592263
MIRT493318	hsa-miR-6755-5p	PAR-CLIP	23592263
MIRT493316	hsa-miR-3927-3p	PAR-CLIP	23592263
MIRT493315	hsa-miR-6831-5p	PAR-CLIP	23592263
MIRT493314	hsa-miR-139-3p	PAR-CLIP	23592263
MIRT493313	hsa-miR-3175	PAR-CLIP	23592263
MIRT493312	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT493311	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT493310	hsa-miR-197-5p	PAR-CLIP	23592263
MIRT493309	hsa-miR-3132	PAR-CLIP	23592263
MIRT493308	hsa-miR-4451	PAR-CLIP	23592263
MIRT493307	hsa-miR-6892-5p	PAR-CLIP	23592263
MIRT493306	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT493305	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT450500	hsa-miR-3145-5p	PAR-CLIP	22100165
MIRT450499	hsa-miR-5197-3p	PAR-CLIP	22100165
MIRT450498	hsa-miR-3925-5p	PAR-CLIP	22100165
MIRT450497	hsa-miR-146a-5p	PAR-CLIP	22100165
MIRT450496	hsa-miR-146b-5p	PAR-CLIP	22100165
MIRT450495	hsa-miR-7153-5p	PAR-CLIP	22100165
MIRT450494	hsa-miR-298	PAR-CLIP	22100165
MIRT450493	hsa-miR-498	PAR-CLIP	22100165
MIRT1109585	hsa-miR-1226	CLIP-seq
MIRT1109586	hsa-miR-1266	CLIP-seq
MIRT1109587	hsa-miR-1272	CLIP-seq
MIRT1109588	hsa-miR-1287	CLIP-seq
MIRT1109589	hsa-miR-1291	CLIP-seq
MIRT1109590	hsa-miR-1293	CLIP-seq
MIRT1109591	hsa-miR-1825	CLIP-seq
MIRT1109592	hsa-miR-1972	CLIP-seq
MIRT1109593	hsa-miR-2467-5p	CLIP-seq
MIRT1109594	hsa-miR-2682	CLIP-seq
MIRT1109595	hsa-miR-297	CLIP-seq
MIRT1109596	hsa-miR-3135b	CLIP-seq
MIRT1109597	hsa-miR-3149	CLIP-seq
MIRT1109598	hsa-miR-3151	CLIP-seq
MIRT1109599	hsa-miR-3188	CLIP-seq
MIRT1109600	hsa-miR-328	CLIP-seq
MIRT1109601	hsa-miR-342-5p	CLIP-seq
MIRT1109602	hsa-miR-345	CLIP-seq
MIRT1109603	hsa-miR-3664-3p	CLIP-seq
MIRT1109604	hsa-miR-3914	CLIP-seq
MIRT1109605	hsa-miR-3929	CLIP-seq
MIRT1109606	hsa-miR-3975	CLIP-seq
MIRT1109607	hsa-miR-412	CLIP-seq
MIRT1109608	hsa-miR-4269	CLIP-seq
MIRT1109609	hsa-miR-4277	CLIP-seq
MIRT1109610	hsa-miR-4290	CLIP-seq
MIRT1109611	hsa-miR-4318	CLIP-seq
MIRT1109612	hsa-miR-4419b	CLIP-seq
MIRT1109613	hsa-miR-4434	CLIP-seq
MIRT1109614	hsa-miR-4455	CLIP-seq
MIRT1109615	hsa-miR-4478	CLIP-seq
MIRT1109616	hsa-miR-4483	CLIP-seq
MIRT1109617	hsa-miR-449c	CLIP-seq
MIRT1109618	hsa-miR-4514	CLIP-seq
MIRT1109619	hsa-miR-4516	CLIP-seq
MIRT1109620	hsa-miR-4518	CLIP-seq
MIRT1109621	hsa-miR-4531	CLIP-seq
MIRT1109622	hsa-miR-4649-3p	CLIP-seq
MIRT1109623	hsa-miR-4650-5p	CLIP-seq
MIRT1109624	hsa-miR-4651	CLIP-seq
MIRT1109625	hsa-miR-4664-5p	CLIP-seq
MIRT1109626	hsa-miR-4692	CLIP-seq
MIRT1109627	hsa-miR-4722-3p	CLIP-seq
MIRT1109628	hsa-miR-4742-5p	CLIP-seq
MIRT1109629	hsa-miR-4757-5p	CLIP-seq
MIRT1109630	hsa-miR-485-5p	CLIP-seq
MIRT1109631	hsa-miR-502-5p	CLIP-seq
MIRT1109632	hsa-miR-510	CLIP-seq
MIRT1109633	hsa-miR-513b	CLIP-seq
MIRT1109634	hsa-miR-515-3p	CLIP-seq
MIRT1109635	hsa-miR-519e	CLIP-seq
MIRT1109636	hsa-miR-541	CLIP-seq
MIRT1109637	hsa-miR-544b	CLIP-seq
MIRT1109638	hsa-miR-548aa	CLIP-seq
MIRT1109639	hsa-miR-548an	CLIP-seq
MIRT1109640	hsa-miR-550a	CLIP-seq
MIRT1109641	hsa-miR-608	CLIP-seq
MIRT1109642	hsa-miR-609	CLIP-seq
MIRT1109643	hsa-miR-628-5p	CLIP-seq
MIRT1109644	hsa-miR-654-5p	CLIP-seq
MIRT1550753	hsa-miR-3173-5p	CLIP-seq
MIRT2030487	hsa-let-7a	CLIP-seq
MIRT2030488	hsa-let-7b	CLIP-seq
MIRT2030489	hsa-let-7c	CLIP-seq
MIRT2030490	hsa-let-7d	CLIP-seq
MIRT2030491	hsa-let-7e	CLIP-seq
MIRT2030492	hsa-let-7f	CLIP-seq
MIRT2030493	hsa-let-7g	CLIP-seq
MIRT2030494	hsa-let-7i	CLIP-seq
MIRT2030495	hsa-miR-1184	CLIP-seq
MIRT1109590	hsa-miR-1293	CLIP-seq
MIRT2030496	hsa-miR-1294	CLIP-seq
MIRT2030497	hsa-miR-1343	CLIP-seq
MIRT2030498	hsa-miR-2467-3p	CLIP-seq
MIRT1109593	hsa-miR-2467-5p	CLIP-seq
MIRT2030499	hsa-miR-3140-3p	CLIP-seq
MIRT2030500	hsa-miR-3144-5p	CLIP-seq
MIRT2030501	hsa-miR-3184	CLIP-seq
MIRT1109599	hsa-miR-3188	CLIP-seq
MIRT2030502	hsa-miR-3191	CLIP-seq
MIRT1109601	hsa-miR-342-5p	CLIP-seq
MIRT2030503	hsa-miR-377	CLIP-seq
MIRT2030504	hsa-miR-3919	CLIP-seq
MIRT1109606	hsa-miR-3975	CLIP-seq
MIRT2030505	hsa-miR-3977	CLIP-seq
MIRT2030506	hsa-miR-423-5p	CLIP-seq
MIRT2030507	hsa-miR-4289	CLIP-seq
MIRT2030508	hsa-miR-4300	CLIP-seq
MIRT2030509	hsa-miR-4446-3p	CLIP-seq
MIRT1109616	hsa-miR-4483	CLIP-seq
MIRT2030510	hsa-miR-4492	CLIP-seq
MIRT2030511	hsa-miR-4498	CLIP-seq
MIRT2030512	hsa-miR-4505	CLIP-seq
MIRT1109622	hsa-miR-4649-3p	CLIP-seq
MIRT1109624	hsa-miR-4651	CLIP-seq
MIRT2030513	hsa-miR-4652-5p	CLIP-seq
MIRT2030514	hsa-miR-4653-3p	CLIP-seq
MIRT1109625	hsa-miR-4664-5p	CLIP-seq
MIRT2030515	hsa-miR-4667-5p	CLIP-seq
MIRT2030516	hsa-miR-4700-5p	CLIP-seq
MIRT2030517	hsa-miR-4710	CLIP-seq
MIRT2030518	hsa-miR-4728-5p	CLIP-seq
MIRT2030519	hsa-miR-4731-5p	CLIP-seq
MIRT2030520	hsa-miR-4756-3p	CLIP-seq
MIRT1109630	hsa-miR-485-5p	CLIP-seq
MIRT1109634	hsa-miR-515-3p	CLIP-seq
MIRT1109635	hsa-miR-519e	CLIP-seq
MIRT2030521	hsa-miR-520f	CLIP-seq
MIRT1109640	hsa-miR-550a	CLIP-seq
MIRT1109641	hsa-miR-608	CLIP-seq
MIRT2030522	hsa-miR-762	CLIP-seq
MIRT2030523	hsa-miR-920	CLIP-seq
MIRT2030524	hsa-miR-939	CLIP-seq
MIRT2030525	hsa-miR-98	CLIP-seq
MIRT2030487	hsa-let-7a	CLIP-seq
MIRT2030488	hsa-let-7b	CLIP-seq
MIRT2030489	hsa-let-7c	CLIP-seq
MIRT2030490	hsa-let-7d	CLIP-seq
MIRT2030491	hsa-let-7e	CLIP-seq
MIRT2030492	hsa-let-7f	CLIP-seq
MIRT2030493	hsa-let-7g	CLIP-seq
MIRT2030494	hsa-let-7i	CLIP-seq
MIRT2030496	hsa-miR-1294	CLIP-seq
MIRT2261273	hsa-miR-3127-5p	CLIP-seq
MIRT1109598	hsa-miR-3151	CLIP-seq
MIRT2030501	hsa-miR-3184	CLIP-seq
MIRT2261274	hsa-miR-3918	CLIP-seq
MIRT2030506	hsa-miR-423-5p	CLIP-seq
MIRT2261275	hsa-miR-4279	CLIP-seq
MIRT2030510	hsa-miR-4492	CLIP-seq
MIRT2030511	hsa-miR-4498	CLIP-seq
MIRT2030514	hsa-miR-4653-3p	CLIP-seq
MIRT2261276	hsa-miR-4685-5p	CLIP-seq
MIRT2030517	hsa-miR-4710	CLIP-seq
MIRT1109627	hsa-miR-4722-3p	CLIP-seq
MIRT2030519	hsa-miR-4731-5p	CLIP-seq
MIRT2030522	hsa-miR-762	CLIP-seq
MIRT2030525	hsa-miR-98	CLIP-seq
MIRT2030496	hsa-miR-1294	CLIP-seq
MIRT2390150	hsa-miR-2355-5p	CLIP-seq
MIRT2030501	hsa-miR-3184	CLIP-seq
MIRT2390151	hsa-miR-361-3p	CLIP-seq
MIRT2030506	hsa-miR-423-5p	CLIP-seq
MIRT2261275	hsa-miR-4279	CLIP-seq
MIRT2030514	hsa-miR-4653-3p	CLIP-seq
MIRT2030517	hsa-miR-4710	CLIP-seq
MIRT2390152	hsa-miR-4781-5p	CLIP-seq
MIRT2453045	hsa-miR-1913	CLIP-seq
MIRT2453046	hsa-miR-1976	CLIP-seq
MIRT2453047	hsa-miR-3127-3p	CLIP-seq
MIRT2453048	hsa-miR-324-3p	CLIP-seq
MIRT2453049	hsa-miR-4267	CLIP-seq
MIRT2453050	hsa-miR-4667-3p	CLIP-seq
MIRT1109627	hsa-miR-4722-3p	CLIP-seq
MIRT2453051	hsa-miR-4749-3p	CLIP-seq
MIRT2453045	hsa-miR-1913	CLIP-seq
MIRT2453046	hsa-miR-1976	CLIP-seq
MIRT2561255	hsa-miR-219-2-3p	CLIP-seq
MIRT2561256	hsa-miR-2964a-3p	CLIP-seq
MIRT2453047	hsa-miR-3127-3p	CLIP-seq
MIRT2453048	hsa-miR-324-3p	CLIP-seq
MIRT2561257	hsa-miR-3691-5p	CLIP-seq
MIRT2561258	hsa-miR-3944-5p	CLIP-seq
MIRT2453049	hsa-miR-4267	CLIP-seq
MIRT2561259	hsa-miR-4427	CLIP-seq
MIRT2453050	hsa-miR-4667-3p	CLIP-seq
MIRT2561260	hsa-miR-4680-3p	CLIP-seq
MIRT2561261	hsa-miR-4711-3p	CLIP-seq
MIRT2561262	hsa-miR-4715-3p	CLIP-seq
MIRT1109627	hsa-miR-4722-3p	CLIP-seq
MIRT2453051	hsa-miR-4749-3p	CLIP-seq
MIRT2561263	hsa-miR-4752	CLIP-seq
MIRT2561264	hsa-miR-517a	CLIP-seq
MIRT2561265	hsa-miR-517b	CLIP-seq
MIRT2561266	hsa-miR-517c	CLIP-seq
MIRT2561267	hsa-miR-654-3p	CLIP-seq
MIRT2453045	hsa-miR-1913	CLIP-seq
MIRT2453046	hsa-miR-1976	CLIP-seq
MIRT2561255	hsa-miR-219-2-3p	CLIP-seq
MIRT2561256	hsa-miR-2964a-3p	CLIP-seq
MIRT2453047	hsa-miR-3127-3p	CLIP-seq
MIRT2453048	hsa-miR-324-3p	CLIP-seq
MIRT2561257	hsa-miR-3691-5p	CLIP-seq
MIRT2561258	hsa-miR-3944-5p	CLIP-seq
MIRT2453049	hsa-miR-4267	CLIP-seq
MIRT2561259	hsa-miR-4427	CLIP-seq
MIRT2453050	hsa-miR-4667-3p	CLIP-seq
MIRT2561260	hsa-miR-4680-3p	CLIP-seq
MIRT2561261	hsa-miR-4711-3p	CLIP-seq
MIRT2561262	hsa-miR-4715-3p	CLIP-seq
MIRT1109627	hsa-miR-4722-3p	CLIP-seq
MIRT2453051	hsa-miR-4749-3p	CLIP-seq
MIRT2561263	hsa-miR-4752	CLIP-seq
MIRT2561264	hsa-miR-517a	CLIP-seq
MIRT2561265	hsa-miR-517b	CLIP-seq
MIRT2561266	hsa-miR-517c	CLIP-seq
MIRT2561267	hsa-miR-654-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0015629	Component	Actin cytoskeleton	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0051015	Function	Actin filament binding	IBA
GO:0051017	Process	Actin filament bundle assembly	IBA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9BT23
• Protein name: LIM domain-containing protein 2
• Protein function: Acts as an activator of the protein-kinase ILK, thereby regulating cell motility (PubMed:24590809).
• PDB: 2LZU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00412	LIM	40 → 96	LIM domain	Domain

• Sequence:

  MFQAAGAAQATPSHDAKGGGSSTVQRSKSFSLRAQVKETCAACQKTVYPMERLVADKLIF
  HNSCFCCKHCHTKLSLGSYAALHGEFYCKPHFQQLFKSKGNYDEGFGRKQHKELWAHKEV
  DPGTKTA

• Sequence length: 127

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Sarcoma	Uncertain significance	rs200367312	RCV005926907

Associations from Text Mining
Disease Name	Relationship Type	References
Arthritis Rheumatoid	Associate	34713769
Breast Neoplasms	Associate	38116315
Inflammation	Associate	34713769
Neoplasm Metastasis	Associate	33238381
Neoplasms	Associate	17699795, 33238381
Obesity	Associate	27564309
Thyroid Cancer Papillary	Associate	17699795, 33238381