Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	80762
Gene name Gene Name - the full gene name approved by the HGNC.	Nedd4 family interacting protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NDFIP1
Synonyms (NCBI Gene) Gene synonyms aliases	N4WBP5
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q31.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of

Show/Hide all(239)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024174	hsa-miR-221-3p	Sequencing	20371350
MIRT028563	hsa-miR-30a-5p	Proteomics	18668040
MIRT048220	hsa-miR-196a-5p	CLASH	23622248
MIRT046433	hsa-miR-15b-5p	CLASH	23622248
MIRT043897	hsa-miR-378a-3p	CLASH	23622248
MIRT437541	hsa-miR-19b-3p	Immunoprecipitaion	22382630
MIRT1177954	hsa-miR-1178	CLIP-seq
MIRT1177955	hsa-miR-1267	CLIP-seq
MIRT1177956	hsa-miR-1284	CLIP-seq
MIRT1177957	hsa-miR-129-5p	CLIP-seq
MIRT1177958	hsa-miR-1305	CLIP-seq
MIRT1177959	hsa-miR-221	CLIP-seq
MIRT1177960	hsa-miR-222	CLIP-seq
MIRT1177961	hsa-miR-24	CLIP-seq
MIRT1177962	hsa-miR-3143	CLIP-seq
MIRT1177963	hsa-miR-3145-3p	CLIP-seq
MIRT1177964	hsa-miR-3162-3p	CLIP-seq
MIRT1177965	hsa-miR-335	CLIP-seq
MIRT1177966	hsa-miR-3613-5p	CLIP-seq
MIRT1177967	hsa-miR-3614-5p	CLIP-seq
MIRT1177968	hsa-miR-3657	CLIP-seq
MIRT1177969	hsa-miR-3662	CLIP-seq
MIRT1177970	hsa-miR-371-5p	CLIP-seq
MIRT1177971	hsa-miR-374c	CLIP-seq
MIRT1177972	hsa-miR-409-3p	CLIP-seq
MIRT1177973	hsa-miR-4272	CLIP-seq
MIRT1177974	hsa-miR-4284	CLIP-seq
MIRT1177975	hsa-miR-4313	CLIP-seq
MIRT1177976	hsa-miR-4325	CLIP-seq
MIRT1177977	hsa-miR-4328	CLIP-seq
MIRT1177978	hsa-miR-4477a	CLIP-seq
MIRT1177979	hsa-miR-450b-5p	CLIP-seq
MIRT1177980	hsa-miR-4652-3p	CLIP-seq
MIRT1177981	hsa-miR-4669	CLIP-seq
MIRT1177982	hsa-miR-4696	CLIP-seq
MIRT1177983	hsa-miR-4699-3p	CLIP-seq
MIRT1177984	hsa-miR-4700-3p	CLIP-seq
MIRT1177985	hsa-miR-4731-3p	CLIP-seq
MIRT1177986	hsa-miR-4801	CLIP-seq
MIRT1177987	hsa-miR-4803	CLIP-seq
MIRT1177988	hsa-miR-499-3p	CLIP-seq
MIRT1177989	hsa-miR-499a-3p	CLIP-seq
MIRT1177990	hsa-miR-499a-5p	CLIP-seq
MIRT1177991	hsa-miR-507	CLIP-seq
MIRT1177992	hsa-miR-513a-5p	CLIP-seq
MIRT1177993	hsa-miR-548p	CLIP-seq
MIRT1177994	hsa-miR-548v	CLIP-seq
MIRT1177995	hsa-miR-557	CLIP-seq
MIRT1177996	hsa-miR-582-5p	CLIP-seq
MIRT1177997	hsa-miR-607	CLIP-seq
MIRT1177998	hsa-miR-635	CLIP-seq
MIRT1177999	hsa-miR-655	CLIP-seq
MIRT1178000	hsa-miR-888	CLIP-seq
MIRT1177969	hsa-miR-3662	CLIP-seq
MIRT1551642	hsa-miR-4528	CLIP-seq
MIRT1551643	hsa-miR-544	CLIP-seq
MIRT1551644	hsa-miR-875-3p	CLIP-seq
MIRT1177967	hsa-miR-3614-5p	CLIP-seq
MIRT1177998	hsa-miR-635	CLIP-seq
MIRT1177971	hsa-miR-374c	CLIP-seq
MIRT1177978	hsa-miR-4477a	CLIP-seq
MIRT1177988	hsa-miR-499-3p	CLIP-seq
MIRT1177989	hsa-miR-499a-3p	CLIP-seq
MIRT1177990	hsa-miR-499a-5p	CLIP-seq
MIRT1177999	hsa-miR-655	CLIP-seq
MIRT1177971	hsa-miR-374c	CLIP-seq
MIRT1177978	hsa-miR-4477a	CLIP-seq
MIRT1177988	hsa-miR-499-3p	CLIP-seq
MIRT1177989	hsa-miR-499a-3p	CLIP-seq
MIRT1177990	hsa-miR-499a-5p	CLIP-seq
MIRT1177999	hsa-miR-655	CLIP-seq
MIRT1177971	hsa-miR-374c	CLIP-seq
MIRT1177978	hsa-miR-4477a	CLIP-seq
MIRT1177988	hsa-miR-499-3p	CLIP-seq
MIRT1177989	hsa-miR-499a-3p	CLIP-seq
MIRT1177990	hsa-miR-499a-5p	CLIP-seq
MIRT1177999	hsa-miR-655	CLIP-seq
MIRT2051494	hsa-miR-101	CLIP-seq
MIRT2051495	hsa-miR-1206	CLIP-seq
MIRT1177957	hsa-miR-129-5p	CLIP-seq
MIRT2051496	hsa-miR-2115	CLIP-seq
MIRT2051497	hsa-miR-338-3p	CLIP-seq
MIRT2051498	hsa-miR-338-5p	CLIP-seq
MIRT1177967	hsa-miR-3614-5p	CLIP-seq
MIRT2051499	hsa-miR-3658	CLIP-seq
MIRT1177969	hsa-miR-3662	CLIP-seq
MIRT2051500	hsa-miR-3934	CLIP-seq
MIRT2051501	hsa-miR-3977	CLIP-seq
MIRT2051502	hsa-miR-410	CLIP-seq
MIRT2051503	hsa-miR-4310	CLIP-seq
MIRT1177976	hsa-miR-4325	CLIP-seq
MIRT2051504	hsa-miR-4435	CLIP-seq
MIRT1177979	hsa-miR-450b-5p	CLIP-seq
MIRT1551642	hsa-miR-4528	CLIP-seq
MIRT2051505	hsa-miR-4789-5p	CLIP-seq
MIRT2051506	hsa-miR-485-3p	CLIP-seq
MIRT1177990	hsa-miR-499a-5p	CLIP-seq
MIRT1177991	hsa-miR-507	CLIP-seq
MIRT2051507	hsa-miR-516a-3p	CLIP-seq
MIRT1177993	hsa-miR-548p	CLIP-seq
MIRT1177995	hsa-miR-557	CLIP-seq
MIRT2051508	hsa-miR-590-3p	CLIP-seq
MIRT2051509	hsa-miR-600	CLIP-seq
MIRT1177998	hsa-miR-635	CLIP-seq
MIRT2051494	hsa-miR-101	CLIP-seq
MIRT2280556	hsa-miR-1228	CLIP-seq
MIRT1177957	hsa-miR-129-5p	CLIP-seq
MIRT2280557	hsa-miR-144	CLIP-seq
MIRT1177962	hsa-miR-3143	CLIP-seq
MIRT2280558	hsa-miR-3201	CLIP-seq
MIRT2051497	hsa-miR-338-3p	CLIP-seq
MIRT2051498	hsa-miR-338-5p	CLIP-seq
MIRT1177967	hsa-miR-3614-5p	CLIP-seq
MIRT1177969	hsa-miR-3662	CLIP-seq
MIRT2280559	hsa-miR-3691-3p	CLIP-seq
MIRT2051503	hsa-miR-4310	CLIP-seq
MIRT1177976	hsa-miR-4325	CLIP-seq
MIRT1177977	hsa-miR-4328	CLIP-seq
MIRT2051504	hsa-miR-4435	CLIP-seq
MIRT1177979	hsa-miR-450b-5p	CLIP-seq
MIRT1551642	hsa-miR-4528	CLIP-seq
MIRT1177983	hsa-miR-4699-3p	CLIP-seq
MIRT2051505	hsa-miR-4789-5p	CLIP-seq
MIRT2280560	hsa-miR-4791	CLIP-seq
MIRT1177987	hsa-miR-4803	CLIP-seq
MIRT1177990	hsa-miR-499a-5p	CLIP-seq
MIRT1177991	hsa-miR-507	CLIP-seq
MIRT2280561	hsa-miR-548g	CLIP-seq
MIRT1177993	hsa-miR-548p	CLIP-seq
MIRT1177995	hsa-miR-557	CLIP-seq
MIRT2280562	hsa-miR-567	CLIP-seq
MIRT2280563	hsa-miR-570	CLIP-seq
MIRT1177996	hsa-miR-582-5p	CLIP-seq
MIRT2051508	hsa-miR-590-3p	CLIP-seq
MIRT2051509	hsa-miR-600	CLIP-seq
MIRT1177998	hsa-miR-635	CLIP-seq
MIRT2454961	hsa-miR-155	CLIP-seq
MIRT2454962	hsa-miR-3163	CLIP-seq
MIRT2454963	hsa-miR-4795-3p	CLIP-seq
MIRT2051494	hsa-miR-101	CLIP-seq
MIRT2578995	hsa-miR-1226	CLIP-seq
MIRT2578996	hsa-miR-124	CLIP-seq
MIRT2578997	hsa-miR-1258	CLIP-seq
MIRT2578998	hsa-miR-1264	CLIP-seq
MIRT2578999	hsa-miR-1277	CLIP-seq
MIRT2579000	hsa-miR-1283	CLIP-seq
MIRT2579001	hsa-miR-141	CLIP-seq
MIRT2280557	hsa-miR-144	CLIP-seq
MIRT2454961	hsa-miR-155	CLIP-seq
MIRT2579002	hsa-miR-200a	CLIP-seq
MIRT1177961	hsa-miR-24	CLIP-seq
MIRT2579003	hsa-miR-300	CLIP-seq
MIRT2579004	hsa-miR-3140-5p	CLIP-seq
MIRT1177964	hsa-miR-3162-3p	CLIP-seq
MIRT2579005	hsa-miR-3162-5p	CLIP-seq
MIRT2579006	hsa-miR-3183	CLIP-seq
MIRT1177965	hsa-miR-335	CLIP-seq
MIRT2051498	hsa-miR-338-5p	CLIP-seq
MIRT2579007	hsa-miR-34b	CLIP-seq
MIRT2579008	hsa-miR-3619-3p	CLIP-seq
MIRT1177969	hsa-miR-3662	CLIP-seq
MIRT2579009	hsa-miR-3682-5p	CLIP-seq
MIRT2579010	hsa-miR-3714	CLIP-seq
MIRT1177970	hsa-miR-371-5p	CLIP-seq
MIRT2579011	hsa-miR-371b-5p	CLIP-seq
MIRT1177971	hsa-miR-374c	CLIP-seq
MIRT2579012	hsa-miR-381	CLIP-seq
MIRT2579013	hsa-miR-3910	CLIP-seq
MIRT2051502	hsa-miR-410	CLIP-seq
MIRT2579014	hsa-miR-4268	CLIP-seq
MIRT2579015	hsa-miR-4277	CLIP-seq
MIRT1177974	hsa-miR-4284	CLIP-seq
MIRT1177975	hsa-miR-4313	CLIP-seq
MIRT2579016	hsa-miR-4427	CLIP-seq
MIRT2579017	hsa-miR-4448	CLIP-seq
MIRT1177978	hsa-miR-4477a	CLIP-seq
MIRT2579018	hsa-miR-4666-3p	CLIP-seq
MIRT1177982	hsa-miR-4696	CLIP-seq
MIRT2579019	hsa-miR-4723-3p	CLIP-seq
MIRT2579020	hsa-miR-4733-3p	CLIP-seq
MIRT2579021	hsa-miR-4768-3p	CLIP-seq
MIRT2579022	hsa-miR-4776-5p	CLIP-seq
MIRT2579023	hsa-miR-4793-5p	CLIP-seq
MIRT1177988	hsa-miR-499-3p	CLIP-seq
MIRT1177989	hsa-miR-499a-3p	CLIP-seq
MIRT1177990	hsa-miR-499a-5p	CLIP-seq
MIRT2579024	hsa-miR-500a	CLIP-seq
MIRT2579025	hsa-miR-506	CLIP-seq
MIRT2579026	hsa-miR-548aa	CLIP-seq
MIRT2579027	hsa-miR-550b	CLIP-seq
MIRT2280562	hsa-miR-567	CLIP-seq
MIRT1177999	hsa-miR-655	CLIP-seq
MIRT2579028	hsa-miR-665	CLIP-seq
MIRT1551644	hsa-miR-875-3p	CLIP-seq
MIRT2051494	hsa-miR-101	CLIP-seq
MIRT2578995	hsa-miR-1226	CLIP-seq
MIRT2578996	hsa-miR-124	CLIP-seq
MIRT2578997	hsa-miR-1258	CLIP-seq
MIRT2578998	hsa-miR-1264	CLIP-seq
MIRT2578999	hsa-miR-1277	CLIP-seq
MIRT2579000	hsa-miR-1283	CLIP-seq
MIRT2280557	hsa-miR-144	CLIP-seq
MIRT2454961	hsa-miR-155	CLIP-seq
MIRT1177961	hsa-miR-24	CLIP-seq
MIRT2579004	hsa-miR-3140-5p	CLIP-seq
MIRT1177964	hsa-miR-3162-3p	CLIP-seq
MIRT2579005	hsa-miR-3162-5p	CLIP-seq
MIRT2579006	hsa-miR-3183	CLIP-seq
MIRT1177965	hsa-miR-335	CLIP-seq
MIRT2051498	hsa-miR-338-5p	CLIP-seq
MIRT2579007	hsa-miR-34b	CLIP-seq
MIRT2579008	hsa-miR-3619-3p	CLIP-seq
MIRT1177969	hsa-miR-3662	CLIP-seq
MIRT2579009	hsa-miR-3682-5p	CLIP-seq
MIRT2579010	hsa-miR-3714	CLIP-seq
MIRT1177970	hsa-miR-371-5p	CLIP-seq
MIRT2579011	hsa-miR-371b-5p	CLIP-seq
MIRT1177971	hsa-miR-374c	CLIP-seq
MIRT2579013	hsa-miR-3910	CLIP-seq
MIRT2051502	hsa-miR-410	CLIP-seq
MIRT2579014	hsa-miR-4268	CLIP-seq
MIRT1177974	hsa-miR-4284	CLIP-seq
MIRT1177975	hsa-miR-4313	CLIP-seq
MIRT2579016	hsa-miR-4427	CLIP-seq
MIRT2579017	hsa-miR-4448	CLIP-seq
MIRT1177978	hsa-miR-4477a	CLIP-seq
MIRT1177982	hsa-miR-4696	CLIP-seq
MIRT2579019	hsa-miR-4723-3p	CLIP-seq
MIRT2579020	hsa-miR-4733-3p	CLIP-seq
MIRT2579022	hsa-miR-4776-5p	CLIP-seq
MIRT2579023	hsa-miR-4793-5p	CLIP-seq
MIRT1177988	hsa-miR-499-3p	CLIP-seq
MIRT1177989	hsa-miR-499a-3p	CLIP-seq
MIRT1177990	hsa-miR-499a-5p	CLIP-seq
MIRT2579024	hsa-miR-500a	CLIP-seq
MIRT2579025	hsa-miR-506	CLIP-seq
MIRT2579027	hsa-miR-550b	CLIP-seq
MIRT2280562	hsa-miR-567	CLIP-seq
MIRT1177999	hsa-miR-655	CLIP-seq

Show/Hide all(33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0002761	Process	Regulation of myeloid leukocyte differentiation	IEA
GO:0002829	Process	Negative regulation of type 2 immune response	IEA
GO:0005515	Function	Protein binding	IPI	18776082, 19706893, 25631046, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0005794	Component	Golgi apparatus	IBA	21873635
GO:0005938	Component	Cell cortex	IEA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA	21873635
GO:0006879	Process	Cellular iron ion homeostasis	IMP	18776082
GO:0007034	Process	Vacuolar transport	IEA
GO:0010008	Component	Endosome membrane	IEA
GO:0010629	Process	Negative regulation of gene expression	IMP	18776082
GO:0016021	Component	Integral component of membrane	IEA
GO:0030001	Process	Metal ion transport	IBA	21873635
GO:0030425	Component	Dendrite	IEA
GO:0031398	Process	Positive regulation of protein ubiquitination	IBA	21873635
GO:0031398	Process	Positive regulation of protein ubiquitination	IDA	25631046
GO:0031398	Process	Positive regulation of protein ubiquitination	IMP	18776082
GO:0032410	Process	Negative regulation of transporter activity	IMP	18776082
GO:0032713	Process	Negative regulation of interleukin-4 production	IEA
GO:0042130	Process	Negative regulation of T cell proliferation	IEA
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	HMP	12761501
GO:0045202	Component	Synapse	IEA
GO:0045619	Process	Regulation of lymphocyte differentiation	IEA
GO:0045732	Process	Positive regulation of protein catabolic process	IEA
GO:0048294	Process	Negative regulation of isotype switching to IgE isotypes	IEA
GO:0048302	Process	Regulation of isotype switching to IgG isotypes	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IBA	21873635
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	18776082
GO:0050699	Function	WW domain binding	IBA	21873635
GO:0050728	Process	Negative regulation of inflammatory response	IEA
GO:0051224	Process	Negative regulation of protein transport	IMP	18776082

MIM	HGNC	e!Ensembl
612050	17592	ENSG00000131507

Protein

UniProt ID

Q9BT67

Protein name

NEDD4 family-interacting protein 1 (Breast cancer-associated protein SGA-1M) (NEDD4 WW domain-binding protein 5) (Putative MAPK-activating protein PM13) (Putative NF-kappa-B-activating protein 164) (Putative NFKB and MAPK-activating protein)

Protein function

Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cell-mediated inflammati

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10176	DUF2370	54 → 173	Protein of unknown function (DUF2370)	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney, liver, testis, salivary glands and placenta. Also expressed in fetal brain, kidney and lung. {ECO:0000269|PubMed:11748237}.

Sequence

MALALAALAAVEPACGSRYQQLQNEEESGEPEQAAGDAPPPYSSISAESAAYFDYKDESG
FPKPPSYNVATTLPSYDEAERTKAEATIPLVPGRDEDFVGRDDFDDADQLRIGNDGIFML
TFFMAFLFNWIGFFLSFCLTTSAAGRYGAISGFGLSLIKWILIVRFSTYFPGYFDGQYWL
WWVFLVLGFLLFLRGFINYAKVRKMPETFSNLPRTRVLFIY

Sequence length

221

Interactions

View interactions

Show/Hide Causal Diseases (3)

Disease term	Disease name	dbSNP ID	References
Causal
Inflammatory bowel disease	Inflammatory Bowel Diseases	rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468	26192919, 28067908, 23128233
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039 View all (4 more)	24076602
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	26974007

Show/Hide Unknown Diseases (12)

Disease term	Disease name	Evidence	References	Source
Unknown
Asthma	Asthma, Childhood asthma		30929738, 29273806, 27182965, 31036433	ClinVar, GWAS
Crohn disease	Crohn Disease		28067908, 26974007, 26192919	ClinVar
Eczema	Eczema			GWAS
Testicular Germ Cell Tumor	Testicular Germ Cell Tumor			GWAS
Crohn Disease	Crohn Disease			GWAS
Multiple Sclerosis	Multiple Sclerosis			GWAS
Inflammatory Bowel Disease	Inflammatory Bowel Disease			GWAS
Biliary Cholangitis	Biliary Cholangitis			GWAS
Ulcerative colitis	Ulcerative colitis			GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA
Dementia	Dementia			GWAS
Dermatitis	Dermatitis			GWAS

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining
Asthma	Associate	21907864, 25997986
Uveal melanoma	Associate	29333944

NDFIP1 (Nedd4 family interacting protein 1)