Gene Gene information from NCBI Gene database.
Entrez ID 80725
Gene name SRC kinase signaling inhibitor 1
Gene symbol SRCIN1
Synonyms (NCBI Gene)
P140SNIP
Chromosome 17
Chromosome location 17q12
miRNA miRNA information provided by mirtarbase database.
558
miRTarBase ID miRNA Experiments Reference
MIRT006067 hsa-miR-542-5p MicroarrayqRT-PCR 21310526
MIRT006067 hsa-miR-542-5p MicroarrayqRT-PCR 21310526
MIRT006067 hsa-miR-542-5p MicroarrayqRT-PCR 21310526
MIRT054263 hsa-miR-374a-5p ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 25554419
MIRT054263 hsa-miR-374a-5p ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 25554419
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
32
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 14657239, 17525734, 32814053
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IDA 19146815
GO:0005737 Component Cytoplasm IEA
GO:0005856 Component Cytoskeleton IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610786 29506 ENSG00000277363
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9C0H9
Protein name SRC kinase signaling inhibitor 1 (SNAP-25-interacting protein) (SNIP) (p130Cas-associated protein) (p140Cap)
Protein function Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May pla
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03915 AIP3 184 290 Actin interacting protein 3 Family
Tissue specificity TISSUE SPECIFICITY: Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue. {ECO:0000269|PubMed:18475297}.
Sequence
MGNAPSQDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRRFSNVGLVHTSERRHTVI
AAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQPNYWSFKTRSSR
HTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSP
GVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVF
YELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSP
TRRLNNLSPA
PHLASGSPPPGLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQG
VSPSPSAILERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAY
PGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLAD
VAAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPP
SELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEK
IEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNS
ASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERL
RYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHF
PGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNL
LSQSPKKVTAETDFNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKR
SVDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAP
TPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLT
TTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDED
DEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQA
TKPSKEMSGSNETSSPVSEKPSASRTSIPVLTSFGARNSSISF
Sequence length 1183
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CEREBRAL AMYLOID ANGIOPATHY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PERIPROSTHETIC OSTEOLYSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Acrogeria gottron type Stimulate 23877355
★☆☆☆☆
Found in Text Mining only
Amyopathic dermatomyositis Associate 30016492
★☆☆☆☆
Found in Text Mining only
Basal Laminar Drusen Stimulate 23877355
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 11359788, 18475297, 37169737
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Inhibit 17525734, 27513473, 28393242, 38123597
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 28550679
★☆☆☆☆
Found in Text Mining only
Carcinoma Non Small Cell Lung Inhibit 26277787
★☆☆☆☆
Found in Text Mining only
Carcinoma Non Small Cell Lung Associate 28891208, 30982489, 31432113, 32323798
★☆☆☆☆
Found in Text Mining only
Carcinoma Non Small Cell Lung Stimulate 32964035
★☆☆☆☆
Found in Text Mining only
Carcinoma Squamous Cell Inhibit 26408183
★☆☆☆☆
Found in Text Mining only