ACAD10 (acyl-CoA dehydrogenase family member 10)

Gene

• Entrez ID: 80724
• Gene name: Acyl-CoA dehydrogenase family member 10
• Gene symbol: ACAD10
• Synonyms (NCBI Gene): -
• Chromosome: 12
• Chromosome location: 12q24.12
• Summary: This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protei

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT761405	hsa-miR-1286	CLIP-seq
MIRT761406	hsa-miR-4276	CLIP-seq
MIRT761407	hsa-miR-4468	CLIP-seq
MIRT761408	hsa-miR-4663	CLIP-seq
MIRT761409	hsa-miR-4722-5p	CLIP-seq
MIRT761410	hsa-miR-542-3p	CLIP-seq
MIRT761411	hsa-miR-576-3p	CLIP-seq
MIRT1924508	hsa-miR-1184	CLIP-seq
MIRT1924509	hsa-miR-1343	CLIP-seq
MIRT1924510	hsa-miR-1915	CLIP-seq
MIRT1924511	hsa-miR-193a-5p	CLIP-seq
MIRT1924512	hsa-miR-4446-5p	CLIP-seq
MIRT1924513	hsa-miR-4726-3p	CLIP-seq
MIRT761407	hsa-miR-4468	CLIP-seq
MIRT761408	hsa-miR-4663	CLIP-seq
MIRT2468303	hsa-miR-558	CLIP-seq
MIRT761405	hsa-miR-1286	CLIP-seq
MIRT2674207	hsa-miR-4449	CLIP-seq
MIRT761407	hsa-miR-4468	CLIP-seq
MIRT2674208	hsa-miR-4532	CLIP-seq
MIRT761408	hsa-miR-4663	CLIP-seq
MIRT761409	hsa-miR-4722-5p	CLIP-seq
MIRT2468303	hsa-miR-558	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003995	Function	Acyl-CoA dehydrogenase activity	IBA
GO:0003995	Function	Acyl-CoA dehydrogenase activity	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	NAS	21237683
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006635	Process	Fatty acid beta-oxidation	IEA
GO:0006635	Process	Fatty acid beta-oxidation	TAS
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016627	Function	Oxidoreductase activity, acting on the CH-CH group of donors	IEA
GO:0033539	Process	Fatty acid beta-oxidation using acyl-CoA dehydrogenase	IBA
GO:0050660	Function	Flavin adenine dinucleotide binding	IEA

Other IDs

• MIM: 611181
• HGNC: 21597
• e!Ensembl: ENSG00000111271

Protein

• UniProt ID: Q6JQN1
• Protein name: Acyl-CoA dehydrogenase family member 10 (ACAD-10) (EC 1.3.99.-)
• Protein function: Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13419	HAD_2	117 → 231	Haloacid dehalogenase-like hydrolase	Family
  PF01636	APH	287 → 530	Phosphotransferase enzyme family	Family
  PF02771	Acyl-CoA_dh_N	660 → 787	Acyl-CoA dehydrogenase, N-terminal domain	Domain
  PF02770	Acyl-CoA_dh_M	791 → 892	Acyl-CoA dehydrogenase, middle domain	Domain
  PF00441	Acyl-CoA_dh_1	904 → 1055	Acyl-CoA dehydrogenase, C-terminal domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed with highest expression in fetal brain, followed by heart, muscle, kidney and adult brain. Expression levels varying from isoform to isoform. {ECO:0000269|PubMed:15560374, ECO:0000269|PubMed:21237683}.
• Sequence:

  MCVRSCFQSPRLQWVWRTAFLKHTQRRHQGSHRWTHLGGSTYRAVIFDMGGVLIPSPGRV
  AAEWEVQNRIPSGTILKALMEGGENGPWMRFMRAEITAEGFLREFGRLCSEMLKTSVPVD
  SFFSLLTSERVAKQFPVMTEAITQIRAKGLQTAVLSNNFYLPNQKSFLPLDRKQFDVIVE
  SCMEGICKPDPRIYKLCLEQLGLQPSESIFLDDLGTNLKEAARLGIHTIKVNDPETAVKE
  LEALLGFTLRVGVPNTRPVKKTMEIPKDSLQKYLKDLLGIQTTGPLELLQFDHGQSNPTY
  YIRLANRDLVLRKKPPGTLLPSAHAIEREFRIMKALANAGVPVPNVLDLCEDSSVIGTPF
  YVMEYCPGLIYKDPSLPGLEPSHRRAIYTAMNTVLCKIHSVDLQAVGLEDYGKQGDYIPR
  QVRTWVKQYRASETSTIPAMERLIEWLPLHLPRQQRTTVVHGDFRLDNLVFHPEEPEVLA
  VLDWELSTLGDPLADVAYSCLAHYLPSSFPVLRGINDCDLTQLGIPAAEEYFRMYCLQMG
  LPPTENWNFYMAFSFFRVAAILQGVYKRSLTGQASSTYAEQTGKLTEFVSNLAWDFAVKE
  GFRVFKEMPFTNPLTRSYHTWARPQSQWCPTGSRSYSSVPEASPAHTSRGGLVISPESLS
  PPVRELYHRLKHFMEQRVYPAEPELQSHQASAARWSPSPLIEDLKEKAKAEGLWNLFLPL
  EADPEKKYGAGLTNVEYAHLCELMGTSLYAPEVCNCSAPDTGNMELLVRYGTEAQKARWL
  IPLLEGKARSCFAMTEPQVASSDATNIEASIREEDSFYVINGHKWWITGILDPRCQLCVF
  MGKTDPHAPRHRQQSVLLVPMDTPGIKIIRPLTVYGLEDAPGGHGEVRFEHVRVPKENMV
  LGPGRGFEIAQGRLGPGRIHHCMRLIGFSERALALMKARVKSRLAFGKPLVEQGTVLADI
  AQSRVEIEQARLLVLRAAHLMDLAGNKAAALDIAMIKMVAPSMASRVIDRAIQAFGAAGL
  SSDYPLAQFFTWARALRFADGPDEVHRATVAKLELKHRI

• Sequence length: 1059

Pathways

Reactome:

Mitochondrial Fatty Acid Beta-Oxidation

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Acute myeloid leukemia	Uncertain significance	rs143276470	RCV005929070
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs765259177	RCV004558087
Malignant tumor of esophagus	Uncertain significance	rs747866176	RCV005929032
Melanoma	Uncertain significance	rs747866176	RCV005929034
Ovarian serous cystadenocarcinoma	Uncertain significance	rs747866176	RCV005929033

Associations from Text Mining
Disease Name	Relationship Type	References
Diabetes Mellitus Type 2	Associate	20390405, 32722627
Hypertension	Associate	28562329, 34828409
Insulin Resistance	Associate	20390405
Prediabetic State	Associate	32722627
Stroke	Associate	36958462