UBXN6 (UBX domain protein 6)

Gene

• Entrez ID: 80700
• Gene name: UBX domain protein 6
• Gene symbol: UBXN6
• Synonyms (NCBI Gene): UBXD1, UBXDC2
• Chromosome: 19
• Chromosome location: 19p13.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT045110	hsa-miR-186-5p	CLASH	23622248
MIRT040969	hsa-miR-18a-3p	CLASH	23622248
MIRT1472193	hsa-miR-1286	CLIP-seq
MIRT1472194	hsa-miR-324-5p	CLIP-seq
MIRT1472195	hsa-miR-338-3p	CLIP-seq
MIRT1472196	hsa-miR-3944-5p	CLIP-seq
MIRT1472197	hsa-miR-4476	CLIP-seq
MIRT1472198	hsa-miR-4493	CLIP-seq
MIRT1472199	hsa-miR-455-5p	CLIP-seq
MIRT1472200	hsa-miR-4722-5p	CLIP-seq
MIRT1472201	hsa-miR-4753-5p	CLIP-seq
MIRT1472202	hsa-miR-1205	CLIP-seq
MIRT1472193	hsa-miR-1286	CLIP-seq
MIRT1472203	hsa-miR-1587	CLIP-seq
MIRT1472204	hsa-miR-3665	CLIP-seq
MIRT1472196	hsa-miR-3944-5p	CLIP-seq
MIRT1472205	hsa-miR-4418	CLIP-seq
MIRT1472199	hsa-miR-455-5p	CLIP-seq
MIRT1472206	hsa-miR-4637	CLIP-seq
MIRT1472207	hsa-miR-4674	CLIP-seq
MIRT1472208	hsa-miR-4699-3p	CLIP-seq
MIRT1472200	hsa-miR-4722-5p	CLIP-seq
MIRT1472209	hsa-miR-509-3-5p	CLIP-seq
MIRT1472210	hsa-miR-509-5p	CLIP-seq
MIRT1472211	hsa-miR-657	CLIP-seq
MIRT2142222	hsa-miR-1976	CLIP-seq
MIRT2142223	hsa-miR-4722-3p	CLIP-seq
MIRT2362739	hsa-miR-2355-5p	CLIP-seq
MIRT2362740	hsa-miR-3657	CLIP-seq
MIRT2362741	hsa-miR-4270	CLIP-seq
MIRT2362742	hsa-miR-4441	CLIP-seq
MIRT2362743	hsa-miR-4650-5p	CLIP-seq
MIRT2362744	hsa-miR-4760-5p	CLIP-seq
MIRT1472203	hsa-miR-1587	CLIP-seq
MIRT2656757	hsa-miR-4272	CLIP-seq
MIRT1472207	hsa-miR-4674	CLIP-seq
MIRT2656758	hsa-miR-649	CLIP-seq
MIRT1472203	hsa-miR-1587	CLIP-seq
MIRT2656757	hsa-miR-4272	CLIP-seq
MIRT1472207	hsa-miR-4674	CLIP-seq
MIRT2656758	hsa-miR-649	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	18656546, 18775313, 19275885, 21822278, 22337587, 23349634, 25416956, 27753622, 29892012, 29997244, 31515488, 32296183, 32814053, 33961781, 35271311, 37776851
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	27753622
GO:0005737	Component	Cytoplasm	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IDA	21822278
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005768	Component	Endosome	IDA	26475856
GO:0005768	Component	Endosome	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005829	Component	Cytosol	IDA	19275885, 21822278
GO:0005829	Component	Cytosol	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0006950	Process	Response to stress	IEA
GO:0016020	Component	Membrane	IDA	19275885
GO:0016020	Component	Membrane	IEA
GO:0016236	Process	Macroautophagy	IMP	27753622
GO:0031901	Component	Early endosome membrane	IDA	21822278
GO:0031901	Component	Early endosome membrane	IEA
GO:0031902	Component	Late endosome membrane	IDA	21822278
GO:0031902	Component	Late endosome membrane	IEA
GO:0032510	Process	Endosome to lysosome transport via multivesicular body sorting pathway	IMP	21822278
GO:0032991	Component	Protein-containing complex	IDA	21822278
GO:0036503	Process	ERAD pathway	IMP	19275885
GO:0051117	Function	ATPase binding	IMP	26475856
GO:0070062	Component	Extracellular exosome	HDA	19056867

Other IDs

• MIM: 611946
• HGNC: 14928
• e!Ensembl: ENSG00000167671

Protein

• UniProt ID: Q9BZV1
• Protein name: UBX domain-containing protein 6 (UBX domain-containing protein 1)
• Protein function: May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes (PubMed:26475856). As a cofactor of VCP, it may play a role in the transport of
• PDB: 6SAP, 8FCL, 8FCM, 8FCN, 8FCO, 8FCP, 8FCQ, 8FCR, 8FCT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09409	PUB	168 → 255	PUB domain	Domain
  PF00789	UBX	332 → 410	UBX domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Enhanced expression in testis.
• Sequence:

  MKKFFQEFKADIKFKSAGPGQKLKESVGEKAHKEKPNQPAPRPPRQGPTNEAQMAAAAAL
  ARLEQKQSRAWGPTSQDTIRNQVRKELQAEATVSGSPEAPGTNVVSEPREEGSAHLAVPG
  VYFTCPLTGATLRKDQRDACIKEAILLHFSTDPVAASIMKIYTFNKDQDRVKLGVDTIAK
  YLDNIHLHPEEEKYRKIKLQNKVFQERINCLEGTHEFFEAIGFQKVLLPAQDQEDPEEFY
  VLSETTLAQPQSLERHKEQLLAAEPVRAKLDRQRRVFQPSPLASQFELPGDFFNLTAEEI
  KREQRLRSEAVERLSVLRTKAMREKEEQRGLRKYNYTLLRVRLPDGCLLQGTFYARERLG
  AVYGFVREALQSDWLPFELLASGGQKLSEDENLALNECGLVPSALLTFSWDMAVLEDIKA
  AGAEPDSILKPELLSAIEKLL

• Sequence length: 441

Pathways

KEGG:

Protein processing in endoplasmic reticulum