UBXN6 (UBX domain protein 6)

Gene

• Entrez ID: 80700
• Gene name: UBX domain protein 6
• Gene symbol: UBXN6
• Synonyms (NCBI Gene): UBXD1, UBXDC2
• Chromosome: 19
• Chromosome location: 19p13.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT045110	hsa-miR-186-5p	CLASH	23622248
MIRT040969	hsa-miR-18a-3p	CLASH	23622248
MIRT1472193	hsa-miR-1286	CLIP-seq
MIRT1472194	hsa-miR-324-5p	CLIP-seq
MIRT1472195	hsa-miR-338-3p	CLIP-seq
MIRT1472196	hsa-miR-3944-5p	CLIP-seq
MIRT1472197	hsa-miR-4476	CLIP-seq
MIRT1472198	hsa-miR-4493	CLIP-seq
MIRT1472199	hsa-miR-455-5p	CLIP-seq
MIRT1472200	hsa-miR-4722-5p	CLIP-seq
MIRT1472201	hsa-miR-4753-5p	CLIP-seq
MIRT1472202	hsa-miR-1205	CLIP-seq
MIRT1472193	hsa-miR-1286	CLIP-seq
MIRT1472203	hsa-miR-1587	CLIP-seq
MIRT1472204	hsa-miR-3665	CLIP-seq
MIRT1472196	hsa-miR-3944-5p	CLIP-seq
MIRT1472205	hsa-miR-4418	CLIP-seq
MIRT1472199	hsa-miR-455-5p	CLIP-seq
MIRT1472206	hsa-miR-4637	CLIP-seq
MIRT1472207	hsa-miR-4674	CLIP-seq
MIRT1472208	hsa-miR-4699-3p	CLIP-seq
MIRT1472200	hsa-miR-4722-5p	CLIP-seq
MIRT1472209	hsa-miR-509-3-5p	CLIP-seq
MIRT1472210	hsa-miR-509-5p	CLIP-seq
MIRT1472211	hsa-miR-657	CLIP-seq
MIRT2142222	hsa-miR-1976	CLIP-seq
MIRT2142223	hsa-miR-4722-3p	CLIP-seq
MIRT2362739	hsa-miR-2355-5p	CLIP-seq
MIRT2362740	hsa-miR-3657	CLIP-seq
MIRT2362741	hsa-miR-4270	CLIP-seq
MIRT2362742	hsa-miR-4441	CLIP-seq
MIRT2362743	hsa-miR-4650-5p	CLIP-seq
MIRT2362744	hsa-miR-4760-5p	CLIP-seq
MIRT1472203	hsa-miR-1587	CLIP-seq
MIRT2656757	hsa-miR-4272	CLIP-seq
MIRT1472207	hsa-miR-4674	CLIP-seq
MIRT2656758	hsa-miR-649	CLIP-seq
MIRT1472203	hsa-miR-1587	CLIP-seq
MIRT2656757	hsa-miR-4272	CLIP-seq
MIRT1472207	hsa-miR-4674	CLIP-seq
MIRT2656758	hsa-miR-649	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	18656546, 18775313, 19275885, 21822278, 22337587, 23349634, 25416956, 27753622, 29892012, 29997244, 31515488, 32296183, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	27753622
GO:0005765	Component	Lysosomal membrane	IDA	21822278
GO:0005768	Component	Endosome	IDA	26475856
GO:0005815	Component	Microtubule organizing center	IEA
GO:0005829	Component	Cytosol	IDA	19275885, 21822278
GO:0016236	Process	Macroautophagy	IMP	27753622
GO:0019898	Component	Extrinsic component of membrane	IDA	19275885
GO:0031901	Component	Early endosome membrane	IDA	21822278
GO:0031902	Component	Late endosome membrane	IDA	21822278
GO:0032510	Process	Endosome to lysosome transport via multivesicular body sorting pathway	IMP	21822278
GO:0032991	Component	Protein-containing complex	IDA	21822278
GO:0036503	Process	ERAD pathway	IMP	19275885
GO:0070062	Component	Extracellular exosome	HDA	19056867

Other IDs

• MIM: 611946
• HGNC: 14928
• e!Ensembl: ENSG00000167671

Protein

• UniProt ID: Q9BZV1
• Protein name: UBX domain-containing protein 6 (UBX domain-containing protein 1)
• Protein function: May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes (PubMed:26475856). As a cofactor of VCP, it may play a role in the transport of
• PDB: 6SAP, 8FCL, 8FCM, 8FCN, 8FCO, 8FCP, 8FCQ, 8FCR, 8FCT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09409	PUB	168 → 255	PUB domain	Domain
  PF00789	UBX	332 → 410	UBX domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Enhanced expression in testis.
• Sequence:

  MKKFFQEFKADIKFKSAGPGQKLKESVGEKAHKEKPNQPAPRPPRQGPTNEAQMAAAAAL
  ARLEQKQSRAWGPTSQDTIRNQVRKELQAEATVSGSPEAPGTNVVSEPREEGSAHLAVPG
  VYFTCPLTGATLRKDQRDACIKEAILLHFSTDPVAASIMKIYTFNKDQDRVKLGVDTIAK
  YLDNIHLHPEEEKYRKIKLQNKVFQERINCLEGTHEFFEAIGFQKVLLPAQDQEDPEEFY
  VLSETTLAQPQSLERHKEQLLAAEPVRAKLDRQRRVFQPSPLASQFELPGDFFNLTAEEI
  KREQRLRSEAVERLSVLRTKAMREKEEQRGLRKYNYTLLRVRLPDGCLLQGTFYARERLG
  AVYGFVREALQSDWLPFELLASGGQKLSEDENLALNECGLVPSALLTFSWDMAVLEDIKA
  AGAEPDSILKPELLSAIEKLL

• Sequence length: 441

Pathways

KEGG:

Protein processing in endoplasmic reticulum

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959

Unknown
Disease term	Disease name	Evidence	References	Source
Multiple Sclerosis	Multiple Sclerosis			GWAS
Alzheimer disease	Alzheimer disease			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Amyotrophic Lateral Sclerosis	Associate	26475856
Frontotemporal Dementia	Associate	26475856