Gene Gene information from NCBI Gene database.
Entrez ID 8065
Gene name Cullin 5
Gene symbol CUL5
Synonyms (NCBI Gene)
CUL-5VACM-1VACM1
Chromosome 11
Chromosome location 11q22.3
miRNA miRNA information provided by mirtarbase database.
405
miRTarBase ID miRNA Experiments Reference
MIRT004846 hsa-miR-192-5p Luciferase reporter assayqRT-PCRWestern blot 19074876
MIRT006475 hsa-miR-19a-3p qRT-PCRWestern blot 22561557
MIRT006475 hsa-miR-19a-3p qRT-PCRWestern blot 22561557
MIRT006475 hsa-miR-19a-3p qRT-PCRWestern blot 22561557
MIRT006476 hsa-miR-19b-3p qRT-PCRWestern blot 22561557
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
57
GO ID Ontology Definition Evidence Reference
GO:0000082 Process G1/S transition of mitotic cell cycle TAS 8681378
GO:0001837 Process Epithelial to mesenchymal transition IDA 16096638
GO:0004842 Function Ubiquitin-protein transferase activity TAS
GO:0005262 Function Calcium channel activity TAS 9581826
GO:0005515 Function Protein binding IPI 12504025, 16325183, 17500595, 18805092, 18826954, 19322197, 19933325, 21119685, 21145461, 21199876, 21516116, 21778237, 22190034, 24076655, 24402281, 25416956, 26906416, 28292928, 28514442, 29997244, 30833792, 31515488, 32296183, 32814053, 33961781, 35512830
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601741 2556 ENSG00000166266
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q93034
Protein name Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Protein function Core component of multiple cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes, also named CRL5 complexes), which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11384984, PubMed:156018
PDB 3DPL , 3DQV , 4JGH , 4N9F , 6V9I , 7ONI , 8EI2 , 8FVI , 8FVJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00888 Cullin 19 672 Cullin family Family
PF10557 Cullin_Nedd8 710 772 Cullin protein neddylation domain Domain
Sequence
Sequence length 780
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Ubiquitin mediated proteolysis
Human immunodeficiency virus 1 infection
  Vif-mediated degradation of APOBEC3G
Downregulation of ERBB2 signaling
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation