Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8065
Gene name Gene Name - the full gene name approved by the HGNC.
Cullin 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CUL5
Synonyms (NCBI Gene) Gene synonyms aliases
CUL-5, VACM-1, VACM1
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q22.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004846 hsa-miR-192-5p Luciferase reporter assay, qRT-PCR, Western blot 19074876
MIRT006475 hsa-miR-19a-3p qRT-PCR, Western blot 22561557
MIRT006475 hsa-miR-19a-3p qRT-PCR, Western blot 22561557
MIRT006475 hsa-miR-19a-3p qRT-PCR, Western blot 22561557
MIRT006476 hsa-miR-19b-3p qRT-PCR, Western blot 22561557
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000082 Process G1/S transition of mitotic cell cycle TAS 8681378
GO:0004842 Function Ubiquitin-protein transferase activity IBA 21873635
GO:0004842 Function Ubiquitin-protein transferase activity TAS
GO:0005262 Function Calcium channel activity TAS 9581826
GO:0005515 Function Protein binding IPI 12504025, 16325183, 17500595, 18805092, 18826954, 19322197, 19933325, 21145461, 21199876, 21516116, 21778237, 22190034, 24076655, 24402281, 25416956, 26906416, 28292928, 28514442, 29997244, 30833792, 31515488, 32296183, 32814053
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601741 2556 ENSG00000166266
Protein
UniProt ID Q93034
Protein name Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Protein function Core component of multiple cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes, also named CRL5 complexes), which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11384984, PubMed:156018
PDB 3DPL , 3DQV , 4JGH , 4N9F , 6V9I , 7ONI , 8EI2 , 8FVI , 8FVJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00888 Cullin 19 672 Cullin family Family
PF10557 Cullin_Nedd8 710 772 Cullin protein neddylation domain Domain
Sequence
Sequence length 780
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Ubiquitin mediated proteolysis
Human immunodeficiency virus 1 infection
  Vif-mediated degradation of APOBEC3G
Downregulation of ERBB2 signaling
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
20949323
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
20949323
Marfan syndrome Mammary Carcinoma, Human rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465
View all (942 more)
20949323
Rheumatoid arthritis Rheumatoid Arthritis rs587776843 30423114
Unknown
Disease term Disease name Evidence References Source
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Uterine Fibroids Uterine Fibroids GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acquired Immunodeficiency Syndrome Associate 17257057
Breast Neoplasms Inhibit 14641918
Breast Neoplasms Associate 26847831, 30999048, 31374029, 31759986, 35293963
Carcinoma Endometrioid Inhibit 26847831
Carcinoma Hepatocellular Associate 24339204, 26512974
Colorectal Neoplasms Associate 33712558, 37087475
Drug Related Side Effects and Adverse Reactions Stimulate 30999048
Endometrial Neoplasms Associate 26847831
HIV Infections Associate 17257057
Hypertension Associate 35563538