Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
805
Gene name Gene Name - the full gene name approved by the HGNC.
Calmodulin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CALM2
Synonyms (NCBI Gene) Gene synonyms aliases
CALM, CALML2, CAM1, CAM3, CAMC, CAMII, CAMIII, LQT15, PHKD, PHKD2, caM
Disease Acronyms (UniProt) Disease acronyms from UniProt database
LQT15
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p21
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005904 hsa-miR-1-3p qRT-PCR 21169019
MIRT005904 hsa-miR-1-3p Proteomics 18668040
MIRT040483 hsa-miR-598-3p CLASH 23622248
MIRT507911 hsa-miR-130a-3p HITS-CLIP 21572407
MIRT507910 hsa-miR-3666 HITS-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000922 Component Spindle pole IDA 16760425
GO:0002027 Process Regulation of heart rate IMP 23040497
GO:0005509 Function Calcium ion binding IBA 21873635
GO:0005509 Function Calcium ion binding IDA 7607248, 8631777, 11807546, 23040497, 26164367, 26969752, 27516456
GO:0005513 Process Detection of calcium ion IMP 23040497
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
114182 1445 ENSG00000143933
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Phosphatidylinositol signaling system
Oocyte meiosis
Cellular senescence
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Apelin signaling pathway
C-type lectin receptor signaling pathway
Circadian entrainment
Long-term potentiation
Neurotrophin signaling pathway
Dopaminergic synapse
Olfactory transduction
Phototransduction
Inflammatory mediator regulation of TRP channels
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Oxytocin signaling pathway
Glucagon signaling pathway
Renin secretion
Aldosterone synthesis and secretion
Salivary secretion
Gastric acid secretion
Alzheimer disease
Parkinson disease
Pathways of neurodegeneration - multiple diseases
Amphetamine addiction
Alcoholism
Pertussis
Tuberculosis
Human cytomegalovirus infection
Kaposi sarcoma-associated herpesvirus infection
Human immunodeficiency virus 1 infection
Pathways in cancer
Glioma
Lipid and atherosclerosis
Fluid shear stress and atherosclerosis
  CaMK IV-mediated phosphorylation of CREB
Calmodulin induced events
Cam-PDE 1 activation
Platelet degranulation
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
PKA activation
Synthesis of IP3 and IP4 in the cytosol
Calcineurin activates NFAT
eNOS activation
Inactivation, recovery and regulation of the phototransduction cascade
Stimuli-sensing channels
FCERI mediated Ca+2 mobilization
Ca2+ pathway
Reduction of cytosolic Ca++ levels
Sodium/Calcium exchangers
Unblocking of NMDA receptors, glutamate binding and activation
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Smooth Muscle Contraction
Activation of Ca-permeable Kainate Receptor
Uptake and function of anthrax toxins
VEGFR2 mediated vascular permeability
Phase 0 - rapid depolarisation
Ion homeostasis
CLEC7A (Dectin-1) induces NFAT activation
RHO GTPases activate IQGAPs
RHO GTPases activate PAKs
RAF activation
RAF/MAP kinase cascade
Signaling by moderate kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Glycogen breakdown (glycogenolysis)
Protein methylation
Extra-nuclear estrogen signaling
Ion transport by P-type ATPases
Activation of RAC1 downstream of NMDARs
Long-term potentiation
Signaling downstream of RAS mutants
FCGR3A-mediated IL10 synthesis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Atrioventricular block First degree atrioventricular block rs766840243, rs763809932
Brugada syndrome Brugada Syndrome (disorder) rs104894718, rs397514252, rs397514446, rs137854613, rs137854601, rs397514449, rs137854604, rs28937318, rs137854611, rs137854612, rs137854615, rs137854618, rs137854620, rs72554632, rs121912776
View all (97 more)
27100291
Catecholaminergic polymorphic ventricular tachycardia VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder), Catecholaminergic polymorphic ventricular tachycardia rs121918597, rs121918598, rs121918599, rs121918600, rs121918601, rs121918602, rs121918603, rs121918604, rs121918605, rs121434549, rs786205106, rs121434550, rs267607276, rs267607277, rs397507555
View all (105 more)
24917665
Dysautonomia Dysautonomia rs111033171, rs137853022, rs28939712, rs754348901, rs749052963, rs1057517169, rs1057516865, rs763445509, rs767527819, rs781333644, rs1239081703, rs1554696574, rs539544212, rs1201626345, rs774890086
View all (27 more)
Unknown
Disease term Disease name Evidence References Source
Mental depression Mental Depression, Depressive disorder, Severe depression 17074061, 23314275, 24240473, 15905095, 23990563, 16247765 ClinVar
Torsades de pointes Torsades de Pointes ClinVar
Long QT Syndrome long QT syndrome 15, long QT syndrome GenCC
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 31984950
Arrhythmias Cardiac Associate 23388215, 24917665, 31170290, 37528649
Atrioventricular Block Associate 27374306
Bradycardia Associate 27374306
Breast Neoplasms Associate 26458823
Channelopathies Associate 35543671, 37622577
Death Associate 21546767, 27100291
Death Sudden Associate 31170290, 37380439
Death Sudden Cardiac Associate 27100291
Diabetes Mellitus Type 2 Associate 21546767