Gene Gene information from NCBI Gene database.
Entrez ID 805
Gene name Calmodulin 2
Gene symbol CALM2
Synonyms (NCBI Gene)
CALMCALML2CAM1CAM3CAMCCAMIICAMIIILQT15PHKDPHKD2caM
Chromosome 2
Chromosome location 2p21
Summary This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role
miRNA miRNA information provided by mirtarbase database.
696
miRTarBase ID miRNA Experiments Reference
MIRT005904 hsa-miR-1-3p qRT-PCR 21169019
MIRT005904 hsa-miR-1-3p Proteomics 18668040
MIRT040483 hsa-miR-598-3p CLASH 23622248
MIRT507911 hsa-miR-130a-3p HITS-CLIP 21572407
MIRT507910 hsa-miR-3666 HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
86
GO ID Ontology Definition Evidence Reference
GO:0000086 Process G2/M transition of mitotic cell cycle IEA
GO:0000922 Component Spindle pole IDA 16760425
GO:0000922 Component Spindle pole IEA
GO:0002027 Process Regulation of heart rate IEA
GO:0002027 Process Regulation of heart rate IMP 23040497
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
114182 1445 ENSG00000143933
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Phosphatidylinositol signaling system
Oocyte meiosis
Cellular senescence
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Apelin signaling pathway
C-type lectin receptor signaling pathway
Circadian entrainment
Long-term potentiation
Neurotrophin signaling pathway
Dopaminergic synapse
Olfactory transduction
Phototransduction
Inflammatory mediator regulation of TRP channels
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Oxytocin signaling pathway
Glucagon signaling pathway
Renin secretion
Aldosterone synthesis and secretion
Salivary secretion
Gastric acid secretion
Alzheimer disease
Parkinson disease
Pathways of neurodegeneration - multiple diseases
Amphetamine addiction
Alcoholism
Pertussis
Tuberculosis
Human cytomegalovirus infection
Kaposi sarcoma-associated herpesvirus infection
Human immunodeficiency virus 1 infection
Pathways in cancer
Glioma
Lipid and atherosclerosis
Fluid shear stress and atherosclerosis
  CaMK IV-mediated phosphorylation of CREB
Calmodulin induced events
Cam-PDE 1 activation
Platelet degranulation
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
PKA activation
Synthesis of IP3 and IP4 in the cytosol
Calcineurin activates NFAT
eNOS activation
Inactivation, recovery and regulation of the phototransduction cascade
Stimuli-sensing channels
FCERI mediated Ca+2 mobilization
Ca2+ pathway
Reduction of cytosolic Ca++ levels
Sodium/Calcium exchangers
Unblocking of NMDA receptors, glutamate binding and activation
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Smooth Muscle Contraction
Activation of Ca-permeable Kainate Receptor
Uptake and function of anthrax toxins
VEGFR2 mediated vascular permeability
Phase 0 - rapid depolarisation
Ion homeostasis
CLEC7A (Dectin-1) induces NFAT activation
RHO GTPases activate IQGAPs
RHO GTPases activate PAKs
RAF activation
RAF/MAP kinase cascade
Signaling by moderate kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Glycogen breakdown (glycogenolysis)
Protein methylation
Extra-nuclear estrogen signaling
Ion transport by P-type ATPases
Activation of RAC1 downstream of NMDARs
Long-term potentiation
Signaling downstream of RAS mutants
FCGR3A-mediated IL10 synthesis
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
183
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Cardiovascular phenotype Pathogenic rs398124647 RCV005532578
Long QT syndrome Pathogenic rs398124647 RCV003318349
Long QT syndrome 1 Pathogenic; Likely pathogenic rs398124647, rs398124648, rs398124650, rs398124649, rs2103823599, rs2103823638, rs2103823612, rs2103821507, rs730882254, rs2465708816, rs1558693760, rs1573214371, rs1573214163, rs1687164164 RCV000143836
RCV000143837
RCV000143838
RCV000143839
RCV000143840
RCV002242878
RCV001922668
RCV001972345
RCV001993477
RCV001850284
RCV003501689
RCV000698791
RCV002234248
RCV002236070
RCV002241435
Long QT syndrome 15 Pathogenic; Likely pathogenic rs398124647, rs398124648, rs398124650, rs398124649, rs730882254, rs2465707237, rs1553431702, rs1573214371, rs1573214163 RCV000162067
RCV000162068
RCV000162069
RCV000162066
RCV000162070
RCV000162065
RCV003224832
RCV000578313
RCV005231341
RCV001003503
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
CALM2-related disorder Uncertain significance; Benign; Likely benign rs2465709282, rs2103825224, rs377288714, rs780054532 RCV003391395
RCV003982609
RCV003924729
RCV003969590
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Associate 31984950
Arrhythmias Cardiac Associate 23388215, 24917665, 31170290, 37528649
Atrioventricular Block Associate 27374306
Bradycardia Associate 27374306
Breast Neoplasms Associate 26458823
Channelopathies Associate 35543671, 37622577
Death Associate 21546767, 27100291
Death Sudden Associate 31170290, 37380439
Death Sudden Cardiac Associate 27100291
Diabetes Mellitus Type 2 Associate 21546767