Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	80342
Gene name Gene Name - the full gene name approved by the HGNC.	TRAF3 interacting protein 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TRAF3IP3
Synonyms (NCBI Gene) Gene synonyms aliases	T3JAM
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q32.2
Summary Summary of gene provided in NCBI Entrez Gene.	The gene encodes a protein that mediates cell growth by modulating the c-Jun N-terminal kinase signal transduction pathway. The encoded protein may also interact with a large multi-protein assembly containing the phosphatase 2A catalytic subunit. Alternat

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miRTarBase ID	miRNA	Experiments	Reference
MIRT026450	hsa-miR-192-5p	Microarray	19074876
MIRT1450973	hsa-miR-1273e	CLIP-seq
MIRT1450974	hsa-miR-219-1-3p	CLIP-seq
MIRT1450975	hsa-miR-3920	CLIP-seq
MIRT1450976	hsa-miR-3977	CLIP-seq
MIRT1450977	hsa-miR-4327	CLIP-seq
MIRT1450978	hsa-miR-4682	CLIP-seq
MIRT1450979	hsa-miR-4762-3p	CLIP-seq
MIRT1450980	hsa-miR-571	CLIP-seq
MIRT1450981	hsa-miR-639	CLIP-seq
MIRT2356069	hsa-miR-5096	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0002753	Process	Cytoplasmic pattern recognition receptor signaling pathway	IBA
GO:0002753	Process	Cytoplasmic pattern recognition receptor signaling pathway	IDA	31390091
GO:0005515	Function	Protein binding	IPI	18782753, 25416956, 25910212, 31515488, 32226298, 32296183, 32814053, 33961781
GO:0005739	Component	Mitochondrion	IDA	31390091
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IDA	31390091
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0030674	Function	Protein-macromolecule adaptor activity	IDA	31390091
GO:0032481	Process	Positive regulation of type I interferon production	IDA	19898473
GO:0032481	Process	Positive regulation of type I interferon production	IDA	31390091
GO:0060090	Function	Molecular adaptor activity	IBA
GO:0060090	Function	Molecular adaptor activity	IDA	31390091

MIM	HGNC	e!Ensembl
608255	30766	ENSG00000009790

Protein

UniProt ID

Q9Y228

Protein name

TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3)

Protein function

Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development (PubMed:26195727). Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK

Family and domains

Sequence

MISPDPRPSPGLARWAESYEAKCERRQEIRESRRCRPNVTTCRQVGKTLRIQQREQLQRA
RLQQFFRRRNLELEEKGKAQHPQAREQGPSRRPGQVTVLKEPLSCARRISSPREQVTGTS
SEVFPAQHPPPSGICRDLSDHLSSQAGGLPPQDTPIKKPPKHHRGTQTKAEGPTIKNDAS
QQTNYGVAVLDKEIIQLSDYLKEALQRELVLKQKMVILQDLLSTLIQASDSSWKGQLNED
KLKGKLRSLENQLYTCTQKYSPWGMKKVLLEMEDQKNSYEQKAKESLQKVLEEKMNAEQQ
LQSTQRSLALAEQKCEEWRSQYEALKEDWRTLGTQHRELESQLHVLQSKLQGADSRDLQM
NQALRFLENEHQQLQAKIECLQGDRDLCSLDTQDLQDQLKRSEAEKLTLVTRVQQLQGLL
QNQSLQLQEQEKLLTKKDQALPVWSPKSFPNEVEPEGTGKEKDWDLRDQLQKKTLQLQAK
EKECRELHSELDNLSDEYLSCLRKLQHCREELNQSQQLPPRRQCGRWLPVLMVVIAAALA
VFLANKDNLMI

Sequence length

551

Interactions

View interactions

TRAF3IP3 (TRAF3 interacting protein 3)