Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	80339
Gene name Gene Name - the full gene name approved by the HGNC.	Patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PNPLA3
Synonyms (NCBI Gene) Gene synonyms aliases	ADPN, C22orf20, iPLA(2)epsilon
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q13.31
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided b

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SNP ID	Visualize variation	Clinical significance	Consequence
rs738409	C>G,T	Risk-factor, likely-benign, drug-response	Coding sequence variant, missense variant, synonymous variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016844	hsa-miR-335-5p	Microarray	18185580
MIRT686091	hsa-miR-4438	HITS-CLIP	23313552
MIRT686090	hsa-miR-4687-5p	HITS-CLIP	23313552
MIRT686089	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT686088	hsa-miR-130b-5p	HITS-CLIP	23313552
MIRT686087	hsa-miR-5095	HITS-CLIP	23313552
MIRT686086	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT686085	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT686084	hsa-miR-30a-3p	HITS-CLIP	23313552
MIRT686083	hsa-miR-30d-3p	HITS-CLIP	23313552
MIRT686082	hsa-miR-30e-3p	HITS-CLIP	23313552
MIRT686081	hsa-miR-4763-5p	HITS-CLIP	23313552
MIRT621429	hsa-miR-8062	HITS-CLIP	23824327
MIRT665151	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT621428	hsa-miR-4308	HITS-CLIP	23824327
MIRT621427	hsa-miR-4292	HITS-CLIP	23824327
MIRT621426	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT621425	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621424	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621423	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677806	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT677805	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT677804	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT621422	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT621421	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621420	hsa-miR-1976	HITS-CLIP	23824327
MIRT621419	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677803	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT677802	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT621418	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT677801	hsa-miR-1297	HITS-CLIP	23824327
MIRT677800	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT677799	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT677798	hsa-miR-4465	HITS-CLIP	23824327
MIRT677797	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT677796	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT621417	hsa-miR-4279	HITS-CLIP	23824327
MIRT621429	hsa-miR-8062	HITS-CLIP	23824327
MIRT665151	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT621428	hsa-miR-4308	HITS-CLIP	23824327
MIRT621427	hsa-miR-4292	HITS-CLIP	23824327
MIRT621426	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT621425	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621424	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621423	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621422	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT621421	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621420	hsa-miR-1976	HITS-CLIP	23824327
MIRT621419	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT650814	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT650813	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT621418	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT621417	hsa-miR-4279	HITS-CLIP	23824327
MIRT621429	hsa-miR-8062	HITS-CLIP	23824327
MIRT621428	hsa-miR-4308	HITS-CLIP	23824327
MIRT621427	hsa-miR-4292	HITS-CLIP	23824327
MIRT621426	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT621425	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621424	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621423	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621422	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT621421	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621420	hsa-miR-1976	HITS-CLIP	23824327
MIRT621419	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT650814	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT650813	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT621418	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT621417	hsa-miR-4279	HITS-CLIP	23824327
MIRT621429	hsa-miR-8062	HITS-CLIP	23824327
MIRT621428	hsa-miR-4308	HITS-CLIP	23824327
MIRT621427	hsa-miR-4292	HITS-CLIP	23824327
MIRT621426	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT621425	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621424	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621423	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621422	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT621421	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621420	hsa-miR-1976	HITS-CLIP	23824327
MIRT621419	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT621418	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT621417	hsa-miR-4279	HITS-CLIP	23824327
MIRT630117	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT630116	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT630115	hsa-miR-520h	HITS-CLIP	23824327
MIRT630114	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT630113	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT630112	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT630111	hsa-miR-4769-3p	HITS-CLIP	23824327
MIRT630110	hsa-miR-6817-5p	HITS-CLIP	23824327
MIRT630109	hsa-miR-5189-3p	HITS-CLIP	23824327
MIRT630108	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT630107	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT630106	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT630105	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT621429	hsa-miR-8062	HITS-CLIP	23824327
MIRT621428	hsa-miR-4308	HITS-CLIP	23824327
MIRT621427	hsa-miR-4292	HITS-CLIP	23824327
MIRT621426	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT621425	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621424	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621423	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621422	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT621421	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621420	hsa-miR-1976	HITS-CLIP	23824327
MIRT621419	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT621418	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT621417	hsa-miR-4279	HITS-CLIP	23824327
MIRT519493	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT519492	hsa-miR-4524b-3p	PAR-CLIP	23446348
MIRT519482	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT519491	hsa-miR-1228-3p	PAR-CLIP	23446348
MIRT519490	hsa-miR-6765-3p	PAR-CLIP	23446348
MIRT519489	hsa-miR-6823-5p	PAR-CLIP	23446348
MIRT519488	hsa-miR-4735-5p	PAR-CLIP	23446348
MIRT519487	hsa-miR-4794	PAR-CLIP	23446348
MIRT519486	hsa-miR-664a-5p	PAR-CLIP	23446348
MIRT519485	hsa-miR-4524a-3p	PAR-CLIP	23446348
MIRT519484	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT519483	hsa-miR-4775	PAR-CLIP	23446348
MIRT519482	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT519481	hsa-miR-197-3p	PAR-CLIP	23446348
MIRT519480	hsa-miR-5096	PAR-CLIP	23446348
MIRT519479	hsa-miR-2113	PAR-CLIP	23446348
MIRT519478	hsa-miR-5010-3p	PAR-CLIP	23446348
MIRT519477	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT686091	hsa-miR-4438	HITS-CLIP	23313552
MIRT686090	hsa-miR-4687-5p	HITS-CLIP	23313552
MIRT686089	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT686088	hsa-miR-130b-5p	HITS-CLIP	23313552
MIRT686087	hsa-miR-5095	HITS-CLIP	23313552
MIRT686086	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT686085	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT686084	hsa-miR-30a-3p	HITS-CLIP	23313552
MIRT686083	hsa-miR-30d-3p	HITS-CLIP	23313552
MIRT686082	hsa-miR-30e-3p	HITS-CLIP	23313552
MIRT686081	hsa-miR-4763-5p	HITS-CLIP	23313552
MIRT621429	hsa-miR-8062	HITS-CLIP	23824327
MIRT665151	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT621428	hsa-miR-4308	HITS-CLIP	23824327
MIRT621427	hsa-miR-4292	HITS-CLIP	23824327
MIRT621426	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT621425	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621424	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621423	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677806	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT677805	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT677804	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT621422	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT621421	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621420	hsa-miR-1976	HITS-CLIP	23824327
MIRT621419	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677803	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT677802	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT621418	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT677801	hsa-miR-1297	HITS-CLIP	23824327
MIRT677800	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT677799	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT677798	hsa-miR-4465	HITS-CLIP	23824327
MIRT677797	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT677796	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT621417	hsa-miR-4279	HITS-CLIP	23824327
MIRT621429	hsa-miR-8062	HITS-CLIP	23824327
MIRT665151	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT621428	hsa-miR-4308	HITS-CLIP	23824327
MIRT621427	hsa-miR-4292	HITS-CLIP	23824327
MIRT621426	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT621425	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621424	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621423	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621422	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT621421	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621420	hsa-miR-1976	HITS-CLIP	23824327
MIRT621419	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT650814	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT650813	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT621418	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT621417	hsa-miR-4279	HITS-CLIP	23824327
MIRT621429	hsa-miR-8062	HITS-CLIP	23824327
MIRT621428	hsa-miR-4308	HITS-CLIP	23824327
MIRT621427	hsa-miR-4292	HITS-CLIP	23824327
MIRT621426	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT621425	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621424	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621423	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621422	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT621421	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621420	hsa-miR-1976	HITS-CLIP	23824327
MIRT621419	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT650814	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT650813	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT621418	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT621417	hsa-miR-4279	HITS-CLIP	23824327
MIRT621429	hsa-miR-8062	HITS-CLIP	23824327
MIRT621428	hsa-miR-4308	HITS-CLIP	23824327
MIRT621427	hsa-miR-4292	HITS-CLIP	23824327
MIRT621426	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT621425	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621424	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621423	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621422	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT621421	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621420	hsa-miR-1976	HITS-CLIP	23824327
MIRT621419	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT621418	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT621417	hsa-miR-4279	HITS-CLIP	23824327
MIRT630117	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT630116	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT630115	hsa-miR-520h	HITS-CLIP	23824327
MIRT630114	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT630113	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT630112	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT630111	hsa-miR-4769-3p	HITS-CLIP	23824327
MIRT630110	hsa-miR-6817-5p	HITS-CLIP	23824327
MIRT630109	hsa-miR-5189-3p	HITS-CLIP	23824327
MIRT630108	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT630107	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT630106	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT630105	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT621429	hsa-miR-8062	HITS-CLIP	23824327
MIRT621428	hsa-miR-4308	HITS-CLIP	23824327
MIRT621427	hsa-miR-4292	HITS-CLIP	23824327
MIRT621426	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT621425	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621424	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621423	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621422	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT621421	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621420	hsa-miR-1976	HITS-CLIP	23824327
MIRT621419	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT621418	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT621417	hsa-miR-4279	HITS-CLIP	23824327
MIRT519493	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT519492	hsa-miR-4524b-3p	PAR-CLIP	23446348
MIRT519482	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT519491	hsa-miR-1228-3p	PAR-CLIP	23446348
MIRT519490	hsa-miR-6765-3p	PAR-CLIP	23446348
MIRT519489	hsa-miR-6823-5p	PAR-CLIP	23446348
MIRT519488	hsa-miR-4735-5p	PAR-CLIP	23446348
MIRT519487	hsa-miR-4794	PAR-CLIP	23446348
MIRT519486	hsa-miR-664a-5p	PAR-CLIP	23446348
MIRT519485	hsa-miR-4524a-3p	PAR-CLIP	23446348
MIRT519484	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT519483	hsa-miR-4775	PAR-CLIP	23446348
MIRT519482	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT519481	hsa-miR-197-3p	PAR-CLIP	23446348
MIRT519480	hsa-miR-5096	PAR-CLIP	23446348
MIRT519479	hsa-miR-2113	PAR-CLIP	23446348
MIRT519478	hsa-miR-5010-3p	PAR-CLIP	23446348
MIRT519477	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT1245421	hsa-miR-1343	CLIP-seq
MIRT1245422	hsa-miR-26a	CLIP-seq
MIRT1245423	hsa-miR-26b	CLIP-seq
MIRT1245424	hsa-miR-3614-3p	CLIP-seq
MIRT1245425	hsa-miR-4297	CLIP-seq
MIRT2072603	hsa-miR-1254	CLIP-seq
MIRT2072604	hsa-miR-1257	CLIP-seq
MIRT2072605	hsa-miR-1281	CLIP-seq
MIRT1245421	hsa-miR-1343	CLIP-seq
MIRT2072606	hsa-miR-146b-3p	CLIP-seq
MIRT2072607	hsa-miR-216a	CLIP-seq
MIRT1245422	hsa-miR-26a	CLIP-seq
MIRT1245423	hsa-miR-26b	CLIP-seq
MIRT2072608	hsa-miR-3116	CLIP-seq
MIRT2072609	hsa-miR-3149	CLIP-seq
MIRT2072610	hsa-miR-3173-5p	CLIP-seq
MIRT2072611	hsa-miR-365	CLIP-seq
MIRT2072612	hsa-miR-4656	CLIP-seq
MIRT2072613	hsa-miR-4704-5p	CLIP-seq
MIRT2072614	hsa-miR-4781-3p	CLIP-seq
MIRT2072615	hsa-miR-637	CLIP-seq
MIRT2072616	hsa-miR-661	CLIP-seq
MIRT2072617	hsa-miR-874	CLIP-seq
MIRT2072603	hsa-miR-1254	CLIP-seq
MIRT2072604	hsa-miR-1257	CLIP-seq
MIRT2072605	hsa-miR-1281	CLIP-seq
MIRT1245421	hsa-miR-1343	CLIP-seq
MIRT2072606	hsa-miR-146b-3p	CLIP-seq
MIRT2072607	hsa-miR-216a	CLIP-seq
MIRT1245422	hsa-miR-26a	CLIP-seq
MIRT1245423	hsa-miR-26b	CLIP-seq
MIRT2299761	hsa-miR-28-3p	CLIP-seq
MIRT2072608	hsa-miR-3116	CLIP-seq
MIRT2072610	hsa-miR-3173-5p	CLIP-seq
MIRT1245424	hsa-miR-3614-3p	CLIP-seq
MIRT2072611	hsa-miR-365	CLIP-seq
MIRT2299762	hsa-miR-4637	CLIP-seq
MIRT2072612	hsa-miR-4656	CLIP-seq
MIRT2072613	hsa-miR-4704-5p	CLIP-seq
MIRT2072615	hsa-miR-637	CLIP-seq
MIRT2072616	hsa-miR-661	CLIP-seq
MIRT2072617	hsa-miR-874	CLIP-seq
MIRT2072603	hsa-miR-1254	CLIP-seq
MIRT2072604	hsa-miR-1257	CLIP-seq
MIRT2072606	hsa-miR-146b-3p	CLIP-seq
MIRT2299761	hsa-miR-28-3p	CLIP-seq
MIRT2072608	hsa-miR-3116	CLIP-seq
MIRT2072610	hsa-miR-3173-5p	CLIP-seq
MIRT2072611	hsa-miR-365	CLIP-seq
MIRT2072612	hsa-miR-4656	CLIP-seq
MIRT2072613	hsa-miR-4704-5p	CLIP-seq
MIRT2072615	hsa-miR-637	CLIP-seq
MIRT2072616	hsa-miR-661	CLIP-seq
MIRT2072617	hsa-miR-874	CLIP-seq
MIRT2072605	hsa-miR-1281	CLIP-seq
MIRT1245421	hsa-miR-1343	CLIP-seq
MIRT1245422	hsa-miR-26a	CLIP-seq
MIRT1245423	hsa-miR-26b	CLIP-seq
MIRT1245424	hsa-miR-3614-3p	CLIP-seq
MIRT1245425	hsa-miR-4297	CLIP-seq
MIRT2596446	hsa-miR-1236	CLIP-seq
MIRT2596447	hsa-miR-1260	CLIP-seq
MIRT2596448	hsa-miR-1260b	CLIP-seq
MIRT2072605	hsa-miR-1281	CLIP-seq
MIRT1245421	hsa-miR-1343	CLIP-seq
MIRT2596449	hsa-miR-1470	CLIP-seq
MIRT2596450	hsa-miR-188-3p	CLIP-seq
MIRT2596451	hsa-miR-2110	CLIP-seq
MIRT2596452	hsa-miR-2682	CLIP-seq
MIRT1245422	hsa-miR-26a	CLIP-seq
MIRT1245423	hsa-miR-26b	CLIP-seq
MIRT2596453	hsa-miR-3127-3p	CLIP-seq
MIRT2596454	hsa-miR-3130-3p	CLIP-seq
MIRT2596455	hsa-miR-3144-5p	CLIP-seq
MIRT2072609	hsa-miR-3149	CLIP-seq
MIRT2596456	hsa-miR-3150a-3p	CLIP-seq
MIRT2596457	hsa-miR-3156-3p	CLIP-seq
MIRT2596458	hsa-miR-3191	CLIP-seq
MIRT2596459	hsa-miR-34a	CLIP-seq
MIRT2596460	hsa-miR-34c-5p	CLIP-seq
MIRT1245424	hsa-miR-3614-3p	CLIP-seq
MIRT2596461	hsa-miR-411	CLIP-seq
MIRT2596462	hsa-miR-4271	CLIP-seq
MIRT1245425	hsa-miR-4297	CLIP-seq
MIRT2596463	hsa-miR-449a	CLIP-seq
MIRT2596464	hsa-miR-449b	CLIP-seq
MIRT2596465	hsa-miR-449c	CLIP-seq
MIRT2596466	hsa-miR-450b-3p	CLIP-seq
MIRT2596467	hsa-miR-4514	CLIP-seq
MIRT2596468	hsa-miR-4652-5p	CLIP-seq
MIRT2596469	hsa-miR-4654	CLIP-seq
MIRT2596470	hsa-miR-4667-3p	CLIP-seq
MIRT2596471	hsa-miR-4692	CLIP-seq
MIRT2596472	hsa-miR-4713-3p	CLIP-seq
MIRT2596473	hsa-miR-4725-3p	CLIP-seq
MIRT2596474	hsa-miR-4753-3p	CLIP-seq
MIRT2596475	hsa-miR-4769-5p	CLIP-seq
MIRT2596476	hsa-miR-4795-5p	CLIP-seq
MIRT2596477	hsa-miR-501-3p	CLIP-seq
MIRT2596478	hsa-miR-502-3p	CLIP-seq
MIRT2596479	hsa-miR-635	CLIP-seq
MIRT2596480	hsa-miR-638	CLIP-seq
MIRT2596481	hsa-miR-642a	CLIP-seq
MIRT2596482	hsa-miR-767-5p	CLIP-seq
MIRT2596483	hsa-miR-769-3p	CLIP-seq
MIRT2596446	hsa-miR-1236	CLIP-seq
MIRT2596447	hsa-miR-1260	CLIP-seq
MIRT2596448	hsa-miR-1260b	CLIP-seq
MIRT2072605	hsa-miR-1281	CLIP-seq
MIRT1245421	hsa-miR-1343	CLIP-seq
MIRT2596449	hsa-miR-1470	CLIP-seq
MIRT2596450	hsa-miR-188-3p	CLIP-seq
MIRT2596451	hsa-miR-2110	CLIP-seq
MIRT2596452	hsa-miR-2682	CLIP-seq
MIRT1245422	hsa-miR-26a	CLIP-seq
MIRT1245423	hsa-miR-26b	CLIP-seq
MIRT2596453	hsa-miR-3127-3p	CLIP-seq
MIRT2596454	hsa-miR-3130-3p	CLIP-seq
MIRT2596455	hsa-miR-3144-5p	CLIP-seq
MIRT2072609	hsa-miR-3149	CLIP-seq
MIRT2596456	hsa-miR-3150a-3p	CLIP-seq
MIRT2596457	hsa-miR-3156-3p	CLIP-seq
MIRT2596458	hsa-miR-3191	CLIP-seq
MIRT2596459	hsa-miR-34a	CLIP-seq
MIRT2596460	hsa-miR-34c-5p	CLIP-seq
MIRT1245424	hsa-miR-3614-3p	CLIP-seq
MIRT2596462	hsa-miR-4271	CLIP-seq
MIRT1245425	hsa-miR-4297	CLIP-seq
MIRT2596463	hsa-miR-449a	CLIP-seq
MIRT2596464	hsa-miR-449b	CLIP-seq
MIRT2596465	hsa-miR-449c	CLIP-seq
MIRT2596466	hsa-miR-450b-3p	CLIP-seq
MIRT2596467	hsa-miR-4514	CLIP-seq
MIRT2596468	hsa-miR-4652-5p	CLIP-seq
MIRT2596469	hsa-miR-4654	CLIP-seq
MIRT2596470	hsa-miR-4667-3p	CLIP-seq
MIRT2596471	hsa-miR-4692	CLIP-seq
MIRT2596472	hsa-miR-4713-3p	CLIP-seq
MIRT2596473	hsa-miR-4725-3p	CLIP-seq
MIRT2596474	hsa-miR-4753-3p	CLIP-seq
MIRT2596475	hsa-miR-4769-5p	CLIP-seq
MIRT2596476	hsa-miR-4795-5p	CLIP-seq
MIRT2596477	hsa-miR-501-3p	CLIP-seq
MIRT2596478	hsa-miR-502-3p	CLIP-seq
MIRT2596479	hsa-miR-635	CLIP-seq
MIRT2596480	hsa-miR-638	CLIP-seq
MIRT2596481	hsa-miR-642a	CLIP-seq
MIRT2596482	hsa-miR-767-5p	CLIP-seq
MIRT2596483	hsa-miR-769-3p	CLIP-seq

Show/Hide all(50)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001676	Process	Long-chain fatty acid metabolic process	IDA	22560221
GO:0001676	Process	Long-chain fatty acid metabolic process	IEA
GO:0003841	Function	1-acylglycerol-3-phosphate O-acyltransferase activity	IDA	22560221
GO:0003841	Function	1-acylglycerol-3-phosphate O-acyltransferase activity	IEA
GO:0004465	Function	Lipoprotein lipase activity	TAS
GO:0004623	Function	Phospholipase A2 activity	IDA	15364929
GO:0004623	Function	Phospholipase A2 activity	IEA
GO:0004806	Function	Triacylglycerol lipase activity	IBA
GO:0004806	Function	Triacylglycerol lipase activity	IDA	15364929, 20034933, 22560221
GO:0004806	Function	Triacylglycerol lipase activity	IEA
GO:0004806	Function	Triacylglycerol lipase activity	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005811	Component	Lipid droplet	IBA
GO:0005811	Component	Lipid droplet	IDA	20034933, 22560221, 23398201
GO:0005811	Component	Lipid droplet	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006650	Process	Glycerophospholipid metabolic process	IDA	22560221
GO:0006654	Process	Phosphatidic acid biosynthetic process	IDA	22560221
GO:0006654	Process	Phosphatidic acid biosynthetic process	IEA
GO:0008654	Process	Phospholipid biosynthetic process	IEA
GO:0009744	Process	Response to sucrose	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IDA	22560221
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	ISS
GO:0016042	Process	Lipid catabolic process	IEA
GO:0016411	Function	Acylglycerol O-acyltransferase activity	TAS
GO:0016740	Function	Transferase activity	IEA
GO:0016746	Function	Acyltransferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019432	Process	Triglyceride biosynthetic process	IDA	15364929, 22560221
GO:0019432	Process	Triglyceride biosynthetic process	IEA
GO:0019433	Process	Triglyceride catabolic process	IBA
GO:0019433	Process	Triglyceride catabolic process	IDA	15364929, 22560221
GO:0019433	Process	Triglyceride catabolic process	IEA
GO:0032869	Process	Cellular response to insulin stimulus	IEA
GO:0034389	Process	Lipid droplet organization	IMP	23398201
GO:0035727	Function	Lysophosphatidic acid binding	IDA	22560221
GO:0035727	Function	Lysophosphatidic acid binding	IEA
GO:0036042	Function	Long-chain fatty acyl-CoA binding	IDA	22560221
GO:0036042	Function	Long-chain fatty acyl-CoA binding	IEA
GO:0036153	Process	Triglyceride acyl-chain remodeling	IDA	24511104
GO:0036155	Process	Acylglycerol acyl-chain remodeling	TAS
GO:0042171	Function	Lysophosphatidic acid acyltransferase activity	IDA	22560221
GO:0050872	Process	White fat cell differentiation	IEA
GO:0051264	Function	Mono-olein transacylation activity	IDA	15364929
GO:0051265	Function	Diolein transacylation activity	IDA	15364929
GO:0055088	Process	Lipid homeostasis	IBA
GO:1905243	Process	Cellular response to 3,3',5-triiodo-L-thyronine	IEA

MIM	HGNC	e!Ensembl
609567	18590	ENSG00000100344

Protein

UniProt ID

Q9NST1

Protein name

1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (EC 2.3.1.51) (Acylglycerol transacylase) (Adiponutrin) (ADPN) (Calcium-independent phospholipase A2-epsilon) (iPLA2-epsilon) (EC 3.1.1.4) (Lysophosphatidic acid acyltransferase) (Patatin-like phospholip

Protein function

Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerop

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01734	Patatin	10 → 179	Patatin-like phospholipase	Family

Sequence

MYDAERGWSLSFAGCGFLGFYHVGATRCLSEHAPHLLRDARMLFGASAGALHCVGVLSGI
PLEQTLQVLSDLVRKARSRNIGIFHPSFNLSKFLRQGLCKCLPANVHQLISGKIGISLTR
VSDGENVLVSDFRSKDEVVDALVCSCFIPFYSGLIPPSFRGVRYVDGGVSDNVPFIDAKT
TITVSPFYGEYDICPKVKSTNFLHVDITKLSLRLCTGNLYLLSRAFVPPDLKVLGEICLR
GYLDAFRFLEEKGICNRPQPGLKSSSEGMDPEVAMPSWANMSLDSSPESAALAVRLEGDE
LLDHLRLSILPWDESILDTLSPRLATALSEEMKDKGGYMSKICNLLPIRIMSYVMLPCTL
PVESAIAIVQRLVTWLPDMPDDVLWLQWVTSQVFTRVLMCLLPASRSQMPVSSQQASPCT
PEQDWPCWTPCSPKGCPAETKAEATPRSILRSSLNFFLGNKVPAGAEGLSTFPSFSLEKS
L

Sequence length

481

Interactions

View interactions

	KEGG		Reactome
	Glycerolipid metabolism Metabolic pathways		Acyl chain remodeling of DAG and TAG

Show/Hide Unknown Diseases (10)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Acne	acne vulgaris	N/A	N/A	GWAS
Cholelithiasis	Cholelithiasis	N/A	N/A	GWAS
Cirrhosis	Cirrhosis	N/A	N/A	GWAS
Coronary artery disease	Coronary artery disease	N/A	N/A	GWAS
Diabetes	Type 2 diabetes with ophthalmic manifestations (PheCode 250.23), Type 2 diabetes (PheCode 250.2), Type 2 diabetes, Type 2 diabetes (adjusted for BMI)	N/A	N/A	GWAS
Fatty Liver	Fatty liver	N/A	N/A	GWAS
Gout	Gout	N/A	N/A	GWAS
Hypertension	Portal hypertension (PheCode 571.81)	N/A	N/A	GWAS
Hypogonadism	Hypogonadism	N/A	N/A	GWAS
Non-alcoholic Fatty Liver Disease	Nonalcoholic steatohepatitis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (100)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Alcoholism	Associate	23032985, 24114820, 31630428, 33279778, 36190732
Asthma	Associate	36233078
Atherosclerosis	Associate	36079710
Brain Infarction	Associate	32592869
Carcinoma Hepatocellular	Associate	22087248, 22869157, 22898488, 23776098, 24155878, 24670599, 24763554, 25171251, 25504078, 26219465, 26745088, 26854475, 27888630, 28674415, 28928439 View all (27 more)
Carcinoma Lobular	Associate	20684021
Cardiomyopathy Familial Hypertrophic 1	Associate	30218427
Cardiovascular Diseases	Associate	34798835, 35085396
Carotid Artery Diseases	Associate	24069270, 32592869
Carotid Stenosis	Associate	24069270
Celiac Disease	Associate	30189691
Cell Transformation Neoplastic	Associate	31637480
Cerebrovascular Disorders	Associate	32592869
Chemical and Drug Induced Liver Injury	Associate	21176169, 22087248, 22140488, 22719190, 22724004, 22898488, 23394097, 23418085, 24152445, 26355465, 30487694, 33024398, 34198853, 37581274
Cholangitis Sclerosing	Associate	36454904
Chronic Kidney Disease Mineral and Bone Disorder	Associate	36947711
Chronobiology Disorders	Associate	28695131
Constriction Pathologic	Associate	36454904
Conversion Disorder	Associate	26200108
Coronary Artery Disease	Inhibit	29083408
Coronary Disease	Associate	32093693
COVID 19	Associate	35276911
Death	Associate	23776098, 24155878, 36190732
Diabetes Gestational	Associate	25646328
Diabetes Mellitus	Associate	21665509, 23776098, 23859071, 24069270, 29474507, 32987175, 33348109, 34656649, 35696400, 38360269, 38632349, 39427597
Diabetes Mellitus Type 1	Associate	23418085
Diabetes Mellitus Type 2	Associate	21665509, 22724004, 26634513, 35630668, 38145725, 40090039
Disease Models Animal	Associate	23418085
Dyslipidemias	Associate	31826069
Embolism Fat	Associate	19738004, 20962157, 22629460, 26457389
End Stage Liver Disease	Associate	31527889, 33616244
Fat Necrosis	Associate	22869157, 32143931, 32762045, 36028802
Fatty Liver	Associate	19224197, 19651814, 19738004, 20648472, 20684021, 20803499, 21533024, 21665509, 22087248, 22105854, 22543885, 22546774, 22629460, 22719190, 22724004 View all (85 more)
Fatty Liver Alcoholic	Associate	22258181, 23394097, 23512881, 26599080, 26745088, 26845607, 27128907, 27596100, 28626169, 30487694, 34106646, 34609305, 36166317, 36555467, 36611868, 37298640, 40065199 View all (2 more)
Fibrosis	Associate	20684021, 21176169, 22258181, 22719190, 22719876, 22869157, 22978414, 23535911, 23594525, 23776098, 24081230, 24102786, 24123231, 24155878, 24349054 View all (64 more)
Fractures Spontaneous	Associate	36028802
Glucose Intolerance	Associate	31826069
Gout	Associate	31311600
HAIR AN syndrome	Associate	36881106
Heart Failure	Associate	29956823, 37149016
Helicobacter Infections	Associate	39312529
Hemochromatosis	Associate	22719190, 32680469
Hepatic Encephalopathy	Associate	34808618
Hepatitis Alcoholic	Associate	28161471, 28776448, 33616244
Hepatitis Autoimmune	Associate	34949757
Hepatitis B	Associate	32349377, 36881106
Hepatitis B Chronic	Associate	26229402, 28695131, 36233078
Hepatitis C	Associate	22543885, 22978414, 24349054, 26389885, 27973562, 30139224, 30218427, 31527889, 31642820, 37400794
Hepatitis C Chronic	Associate	22898488, 24123231, 24553484, 25171251, 25801076, 26139292, 26389885, 26854475, 28427234, 28797039, 29089161, 30246767, 31642820
Hepatitis E	Associate	22869157
Hepatitis Viral Human	Associate	30161167
HIV Infections	Associate	26599080, 27973562, 30139224, 30218427
Hyperbilirubinemia	Associate	36580335
Hyperinsulinism	Associate	22471940
Hypertension	Associate	23226254, 40306283
Hypertension Portal	Associate	26599080, 29150621, 29956823
Hypertriglyceridemia	Associate	21274868, 23226254
Hypoglycemia	Associate	23859071
Idiopathic Noncirrhotic Portal Hypertension	Associate	29089161, 38365182
Infections	Associate	25171251
Inflammation	Associate	18820647, 20684021, 23512881, 23594525, 29150621, 30032630, 31637480, 31793207, 32871288, 33218077, 33279778, 35349726
Inflammation	Stimulate	34879108
Inflammatory Bowel Diseases	Associate	26355465
Insulin Resistance	Associate	19651814, 21274868, 22724004, 22978414, 23418085, 23859071, 25646328, 25681381, 26962819, 28555633, 28695131, 29055919, 30218427, 30227635, 31826069, 37111057 View all (1 more)
Intrahepatic Cholestasis of Pregnancy	Associate	25297933
Kidney Diseases	Associate	26200108, 36947711, 37400794
Kidney Neoplasms	Associate	39427597
Leukoencephalopathies	Associate	32592869
Liver Cirrhosis	Associate	23418085, 24152445, 24556216, 24670599, 24978903, 25171251, 26229402, 26389885, 26599080, 27742777, 27973562, 28338112, 29055919, 29258449, 29956823 View all (23 more)
Liver Cirrhosis Alcoholic	Associate	22087248, 22276112, 24102786, 24114820, 26482880, 28776448, 31630428, 31637480, 32871288, 34656649
Liver Cirrhosis Biliary	Associate	25297933
Liver Diseases	Associate	18940312, 19542081, 22863562, 24155878, 24670599, 24763554, 26219465, 26355465, 26599080, 27752939, 28427234, 29055919, 29562163, 29578593, 30912093 View all (29 more)
Liver Diseases Alcoholic	Associate	21893698, 22087248, 22869157, 24155878, 26599080, 29474507, 30161167, 30589442, 30978214, 31630428, 31637480, 33279778
Liver Failure	Associate	19738004, 21281435, 22140488, 22546774, 24152445, 27836992, 27973562, 28776448, 29562163, 30161167, 31527889, 32871288, 33922278, 36924053, 36947711, 37149016, 39312529 View all (2 more)
Malignant hyperthermia susceptibility type 4	Associate	29385134
Metabolic Diseases	Associate	24680680, 30161167, 33622266, 36947711, 37400794, 39312529, 40090039
Metabolic Syndrome	Associate	29578593, 31826069, 32247823, 32463622, 33622266, 38360269, 39638042
Mitochondrial Diseases	Associate	24763554, 37298640, 37909034, 38365182
Myotonic Dystrophy	Associate	32544194
Neoplasms	Associate	29116096, 35338048, 36233078, 40065199
Neoplasms Adipose Tissue	Associate	28436986, 32247823
Non alcoholic Fatty Liver Disease	Associate	18820647, 19542081, 19738004, 20648472, 20684021, 21176169, 21281435, 21665509, 21878620, 21893698, 22258181, 22719876, 22869157, 22898488, 22959976 View all (151 more)
Obesity	Stimulate	17609260
Obesity	Associate	19224197, 19542081, 19729411, 20803499, 22105854, 22140488, 22724004, 23032985, 23226254, 23334462, 23418085, 23512881, 23859071, 24069270, 24477042 View all (16 more)
Overweight	Associate	20962157, 22719190, 25171251, 26136587, 26485523, 27752939, 29307798, 29469042
Pancreatitis Chronic	Associate	22276112
Pneumonia Lipid	Associate	25171251
Polycystic Ovary Syndrome	Associate	37537636
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	28090653
Prediabetic State	Associate	31826069
Pruritus	Associate	25297933
Psoriasis	Associate	38360269
Renal Insufficiency Chronic	Associate	34798835, 37400794, 39427597
Rosacea	Associate	39272052
Spherocytosis Type 1	Associate	28695131
Vascular System Injuries	Associate	27627804
Virus Diseases	Associate	24927606, 30161167
Vitamin A Deficiency	Associate	34063790
Weight Gain	Associate	26485523, 35276911
Weight Loss	Associate	22648723

PNPLA3 (patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase)