Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	80332
Gene name Gene Name - the full gene name approved by the HGNC.	ADAM metallopeptidase domain 33
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ADAM33
Synonyms (NCBI Gene) Gene synonyms aliases	C20orf153, DJ964F7.1
Chromosome Chromosome number	20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	20p13
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes

Show/Hide all(129)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019258	hsa-miR-148b-3p	Microarray	17612493
MIRT529187	hsa-miR-8485	PAR-CLIP	22012620
MIRT529185	hsa-miR-6892-3p	PAR-CLIP	22012620
MIRT529186	hsa-miR-2276-5p	PAR-CLIP	22012620
MIRT529184	hsa-miR-642a-5p	PAR-CLIP	22012620
MIRT529183	hsa-miR-6819-3p	PAR-CLIP	22012620
MIRT529187	hsa-miR-8485	PAR-CLIP	22012620
MIRT529185	hsa-miR-6892-3p	PAR-CLIP	22012620
MIRT529186	hsa-miR-2276-5p	PAR-CLIP	22012620
MIRT529184	hsa-miR-642a-5p	PAR-CLIP	22012620
MIRT529183	hsa-miR-6819-3p	PAR-CLIP	22012620
MIRT766167	hsa-miR-1182	CLIP-seq
MIRT766168	hsa-miR-122	CLIP-seq
MIRT766169	hsa-miR-1227	CLIP-seq
MIRT766170	hsa-miR-193a-5p	CLIP-seq
MIRT766171	hsa-miR-2467-3p	CLIP-seq
MIRT766172	hsa-miR-3135b	CLIP-seq
MIRT766173	hsa-miR-3194-3p	CLIP-seq
MIRT766174	hsa-miR-3194-5p	CLIP-seq
MIRT766175	hsa-miR-3652	CLIP-seq
MIRT766176	hsa-miR-3678-3p	CLIP-seq
MIRT766177	hsa-miR-431	CLIP-seq
MIRT766178	hsa-miR-4430	CLIP-seq
MIRT766179	hsa-miR-4715-3p	CLIP-seq
MIRT766180	hsa-miR-4755-3p	CLIP-seq
MIRT766168	hsa-miR-122	CLIP-seq
MIRT766169	hsa-miR-1227	CLIP-seq
MIRT766172	hsa-miR-3135b	CLIP-seq
MIRT766175	hsa-miR-3652	CLIP-seq
MIRT766178	hsa-miR-4430	CLIP-seq
MIRT766179	hsa-miR-4715-3p	CLIP-seq
MIRT766168	hsa-miR-122	CLIP-seq
MIRT1925772	hsa-miR-22	CLIP-seq
MIRT766172	hsa-miR-3135b	CLIP-seq
MIRT1925773	hsa-miR-4274	CLIP-seq
MIRT1925774	hsa-miR-4290	CLIP-seq
MIRT1925775	hsa-miR-4530	CLIP-seq
MIRT766168	hsa-miR-122	CLIP-seq
MIRT766169	hsa-miR-1227	CLIP-seq
MIRT766172	hsa-miR-3135b	CLIP-seq
MIRT766175	hsa-miR-3652	CLIP-seq
MIRT766178	hsa-miR-4430	CLIP-seq
MIRT766179	hsa-miR-4715-3p	CLIP-seq
MIRT766172	hsa-miR-3135b	CLIP-seq
MIRT766167	hsa-miR-1182	CLIP-seq
MIRT766168	hsa-miR-122	CLIP-seq
MIRT766170	hsa-miR-193a-5p	CLIP-seq
MIRT766172	hsa-miR-3135b	CLIP-seq
MIRT766173	hsa-miR-3194-3p	CLIP-seq
MIRT766175	hsa-miR-3652	CLIP-seq
MIRT766177	hsa-miR-431	CLIP-seq
MIRT766178	hsa-miR-4430	CLIP-seq
MIRT766167	hsa-miR-1182	CLIP-seq
MIRT2469687	hsa-miR-1200	CLIP-seq
MIRT766168	hsa-miR-122	CLIP-seq
MIRT766169	hsa-miR-1227	CLIP-seq
MIRT2469688	hsa-miR-1245	CLIP-seq
MIRT2469689	hsa-miR-1245b-5p	CLIP-seq
MIRT766170	hsa-miR-193a-5p	CLIP-seq
MIRT2469690	hsa-miR-1976	CLIP-seq
MIRT766172	hsa-miR-3135b	CLIP-seq
MIRT2469691	hsa-miR-3142	CLIP-seq
MIRT2469692	hsa-miR-3155	CLIP-seq
MIRT2469693	hsa-miR-3155b	CLIP-seq
MIRT2469694	hsa-miR-3157-5p	CLIP-seq
MIRT766173	hsa-miR-3194-3p	CLIP-seq
MIRT2469695	hsa-miR-329	CLIP-seq
MIRT2469696	hsa-miR-3545-3p	CLIP-seq
MIRT2469697	hsa-miR-362-3p	CLIP-seq
MIRT766175	hsa-miR-3652	CLIP-seq
MIRT2469698	hsa-miR-370	CLIP-seq
MIRT2469699	hsa-miR-3941	CLIP-seq
MIRT2469700	hsa-miR-3977	CLIP-seq
MIRT766177	hsa-miR-431	CLIP-seq
MIRT2469701	hsa-miR-4324	CLIP-seq
MIRT2469702	hsa-miR-4418	CLIP-seq
MIRT766178	hsa-miR-4430	CLIP-seq
MIRT2469703	hsa-miR-4468	CLIP-seq
MIRT2469704	hsa-miR-4680-5p	CLIP-seq
MIRT766179	hsa-miR-4715-3p	CLIP-seq
MIRT2469705	hsa-miR-4735-5p	CLIP-seq
MIRT2469706	hsa-miR-4775	CLIP-seq
MIRT2469707	hsa-miR-484	CLIP-seq
MIRT2469708	hsa-miR-509-3-5p	CLIP-seq
MIRT2469709	hsa-miR-509-5p	CLIP-seq
MIRT2469710	hsa-miR-510	CLIP-seq
MIRT2469711	hsa-miR-544b	CLIP-seq
MIRT2469712	hsa-miR-552	CLIP-seq
MIRT2469713	hsa-miR-590-3p	CLIP-seq
MIRT2469714	hsa-miR-603	CLIP-seq
MIRT2469715	hsa-miR-646	CLIP-seq
MIRT2469716	hsa-miR-653	CLIP-seq
MIRT766167	hsa-miR-1182	CLIP-seq
MIRT2469687	hsa-miR-1200	CLIP-seq
MIRT766168	hsa-miR-122	CLIP-seq
MIRT766169	hsa-miR-1227	CLIP-seq
MIRT2469688	hsa-miR-1245	CLIP-seq
MIRT2469689	hsa-miR-1245b-5p	CLIP-seq
MIRT766170	hsa-miR-193a-5p	CLIP-seq
MIRT2469690	hsa-miR-1976	CLIP-seq
MIRT766172	hsa-miR-3135b	CLIP-seq
MIRT2469691	hsa-miR-3142	CLIP-seq
MIRT2469692	hsa-miR-3155	CLIP-seq
MIRT2469693	hsa-miR-3155b	CLIP-seq
MIRT2469694	hsa-miR-3157-5p	CLIP-seq
MIRT766173	hsa-miR-3194-3p	CLIP-seq
MIRT2469695	hsa-miR-329	CLIP-seq
MIRT2469696	hsa-miR-3545-3p	CLIP-seq
MIRT2469697	hsa-miR-362-3p	CLIP-seq
MIRT766175	hsa-miR-3652	CLIP-seq
MIRT2469698	hsa-miR-370	CLIP-seq
MIRT2469699	hsa-miR-3941	CLIP-seq
MIRT2469700	hsa-miR-3977	CLIP-seq
MIRT766177	hsa-miR-431	CLIP-seq
MIRT2469701	hsa-miR-4324	CLIP-seq
MIRT2469702	hsa-miR-4418	CLIP-seq
MIRT766178	hsa-miR-4430	CLIP-seq
MIRT2469703	hsa-miR-4468	CLIP-seq
MIRT2469704	hsa-miR-4680-5p	CLIP-seq
MIRT766179	hsa-miR-4715-3p	CLIP-seq
MIRT2469707	hsa-miR-484	CLIP-seq
MIRT2469708	hsa-miR-509-3-5p	CLIP-seq
MIRT2469709	hsa-miR-509-5p	CLIP-seq
MIRT2469710	hsa-miR-510	CLIP-seq
MIRT2469711	hsa-miR-544b	CLIP-seq
MIRT2469712	hsa-miR-552	CLIP-seq
MIRT2469714	hsa-miR-603	CLIP-seq
MIRT2469715	hsa-miR-646	CLIP-seq
MIRT2469716	hsa-miR-653	CLIP-seq

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0004222	Function	Metalloendopeptidase activity	NAS	11814695
GO:0005515	Function	Protein binding	IPI	25416956
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	NAS	11814695
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008270	Function	Zinc ion binding	NAS	11814695
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	11814695
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
607114	15478	ENSG00000149451

Protein

UniProt ID

Q9BZ11

Protein name

Disintegrin and metalloproteinase domain-containing protein 33 (ADAM 33) (EC 3.4.24.-)

PDB

1R54 , 1R55

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01562	Pep_M12B_propep	39 → 167	Reprolysin family propeptide	Family
PF01421	Reprolysin	210 → 409	Reprolysin (M12B) family zinc metalloprotease	Domain
PF00200	Disintegrin	426 → 498	Disintegrin	Domain
PF08516	ADAM_CR	503 → 619	ADAM cysteine-rich	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in all tissues, except liver, with high expression in placenta, lung, spleen and veins. {ECO:0000269|PubMed:11814695}.

Sequence

MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV
SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV
RGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG
HRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEV
ANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQL
LTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGC
CVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALC
GNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMG
DCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEA
CFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLD
GQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSH
GVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGL
AWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPE
NSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW

Sequence length

813

Interactions

View interactions

ADAM33 (ADAM metallopeptidase domain 33)