Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	80332
Gene name	ADAM metallopeptidase domain 33
Gene symbol	ADAM33
Synonyms (NCBI Gene)	C20orf153DJ964F7.1
Chromosome	20
Chromosome location	20p13
Summary	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes

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Show/Hide all (129)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019258	hsa-miR-148b-3p	Microarray	17612493
MIRT529187	hsa-miR-8485	PAR-CLIP	22012620
MIRT529185	hsa-miR-6892-3p	PAR-CLIP	22012620
MIRT529186	hsa-miR-2276-5p	PAR-CLIP	22012620
MIRT529184	hsa-miR-642a-5p	PAR-CLIP	22012620
MIRT529183	hsa-miR-6819-3p	PAR-CLIP	22012620
MIRT529187	hsa-miR-8485	PAR-CLIP	22012620
MIRT529185	hsa-miR-6892-3p	PAR-CLIP	22012620
MIRT529186	hsa-miR-2276-5p	PAR-CLIP	22012620
MIRT529184	hsa-miR-642a-5p	PAR-CLIP	22012620
MIRT529183	hsa-miR-6819-3p	PAR-CLIP	22012620
MIRT766167	hsa-miR-1182	CLIP-seq
MIRT766168	hsa-miR-122	CLIP-seq
MIRT766169	hsa-miR-1227	CLIP-seq
MIRT766170	hsa-miR-193a-5p	CLIP-seq
MIRT766171	hsa-miR-2467-3p	CLIP-seq
MIRT766172	hsa-miR-3135b	CLIP-seq
MIRT766173	hsa-miR-3194-3p	CLIP-seq
MIRT766174	hsa-miR-3194-5p	CLIP-seq
MIRT766175	hsa-miR-3652	CLIP-seq
MIRT766176	hsa-miR-3678-3p	CLIP-seq
MIRT766177	hsa-miR-431	CLIP-seq
MIRT766178	hsa-miR-4430	CLIP-seq
MIRT766179	hsa-miR-4715-3p	CLIP-seq
MIRT766180	hsa-miR-4755-3p	CLIP-seq
MIRT766168	hsa-miR-122	CLIP-seq
MIRT766169	hsa-miR-1227	CLIP-seq
MIRT766172	hsa-miR-3135b	CLIP-seq
MIRT766175	hsa-miR-3652	CLIP-seq
MIRT766178	hsa-miR-4430	CLIP-seq
MIRT766179	hsa-miR-4715-3p	CLIP-seq
MIRT766168	hsa-miR-122	CLIP-seq
MIRT1925772	hsa-miR-22	CLIP-seq
MIRT766172	hsa-miR-3135b	CLIP-seq
MIRT1925773	hsa-miR-4274	CLIP-seq
MIRT1925774	hsa-miR-4290	CLIP-seq
MIRT1925775	hsa-miR-4530	CLIP-seq
MIRT766168	hsa-miR-122	CLIP-seq
MIRT766169	hsa-miR-1227	CLIP-seq
MIRT766172	hsa-miR-3135b	CLIP-seq
MIRT766175	hsa-miR-3652	CLIP-seq
MIRT766178	hsa-miR-4430	CLIP-seq
MIRT766179	hsa-miR-4715-3p	CLIP-seq
MIRT766172	hsa-miR-3135b	CLIP-seq
MIRT766167	hsa-miR-1182	CLIP-seq
MIRT766168	hsa-miR-122	CLIP-seq
MIRT766170	hsa-miR-193a-5p	CLIP-seq
MIRT766172	hsa-miR-3135b	CLIP-seq
MIRT766173	hsa-miR-3194-3p	CLIP-seq
MIRT766175	hsa-miR-3652	CLIP-seq
MIRT766177	hsa-miR-431	CLIP-seq
MIRT766178	hsa-miR-4430	CLIP-seq
MIRT766167	hsa-miR-1182	CLIP-seq
MIRT2469687	hsa-miR-1200	CLIP-seq
MIRT766168	hsa-miR-122	CLIP-seq
MIRT766169	hsa-miR-1227	CLIP-seq
MIRT2469688	hsa-miR-1245	CLIP-seq
MIRT2469689	hsa-miR-1245b-5p	CLIP-seq
MIRT766170	hsa-miR-193a-5p	CLIP-seq
MIRT2469690	hsa-miR-1976	CLIP-seq
MIRT766172	hsa-miR-3135b	CLIP-seq
MIRT2469691	hsa-miR-3142	CLIP-seq
MIRT2469692	hsa-miR-3155	CLIP-seq
MIRT2469693	hsa-miR-3155b	CLIP-seq
MIRT2469694	hsa-miR-3157-5p	CLIP-seq
MIRT766173	hsa-miR-3194-3p	CLIP-seq
MIRT2469695	hsa-miR-329	CLIP-seq
MIRT2469696	hsa-miR-3545-3p	CLIP-seq
MIRT2469697	hsa-miR-362-3p	CLIP-seq
MIRT766175	hsa-miR-3652	CLIP-seq
MIRT2469698	hsa-miR-370	CLIP-seq
MIRT2469699	hsa-miR-3941	CLIP-seq
MIRT2469700	hsa-miR-3977	CLIP-seq
MIRT766177	hsa-miR-431	CLIP-seq
MIRT2469701	hsa-miR-4324	CLIP-seq
MIRT2469702	hsa-miR-4418	CLIP-seq
MIRT766178	hsa-miR-4430	CLIP-seq
MIRT2469703	hsa-miR-4468	CLIP-seq
MIRT2469704	hsa-miR-4680-5p	CLIP-seq
MIRT766179	hsa-miR-4715-3p	CLIP-seq
MIRT2469705	hsa-miR-4735-5p	CLIP-seq
MIRT2469706	hsa-miR-4775	CLIP-seq
MIRT2469707	hsa-miR-484	CLIP-seq
MIRT2469708	hsa-miR-509-3-5p	CLIP-seq
MIRT2469709	hsa-miR-509-5p	CLIP-seq
MIRT2469710	hsa-miR-510	CLIP-seq
MIRT2469711	hsa-miR-544b	CLIP-seq
MIRT2469712	hsa-miR-552	CLIP-seq
MIRT2469713	hsa-miR-590-3p	CLIP-seq
MIRT2469714	hsa-miR-603	CLIP-seq
MIRT2469715	hsa-miR-646	CLIP-seq
MIRT2469716	hsa-miR-653	CLIP-seq
MIRT766167	hsa-miR-1182	CLIP-seq
MIRT2469687	hsa-miR-1200	CLIP-seq
MIRT766168	hsa-miR-122	CLIP-seq
MIRT766169	hsa-miR-1227	CLIP-seq
MIRT2469688	hsa-miR-1245	CLIP-seq
MIRT2469689	hsa-miR-1245b-5p	CLIP-seq
MIRT766170	hsa-miR-193a-5p	CLIP-seq
MIRT2469690	hsa-miR-1976	CLIP-seq
MIRT766172	hsa-miR-3135b	CLIP-seq
MIRT2469691	hsa-miR-3142	CLIP-seq
MIRT2469692	hsa-miR-3155	CLIP-seq
MIRT2469693	hsa-miR-3155b	CLIP-seq
MIRT2469694	hsa-miR-3157-5p	CLIP-seq
MIRT766173	hsa-miR-3194-3p	CLIP-seq
MIRT2469695	hsa-miR-329	CLIP-seq
MIRT2469696	hsa-miR-3545-3p	CLIP-seq
MIRT2469697	hsa-miR-362-3p	CLIP-seq
MIRT766175	hsa-miR-3652	CLIP-seq
MIRT2469698	hsa-miR-370	CLIP-seq
MIRT2469699	hsa-miR-3941	CLIP-seq
MIRT2469700	hsa-miR-3977	CLIP-seq
MIRT766177	hsa-miR-431	CLIP-seq
MIRT2469701	hsa-miR-4324	CLIP-seq
MIRT2469702	hsa-miR-4418	CLIP-seq
MIRT766178	hsa-miR-4430	CLIP-seq
MIRT2469703	hsa-miR-4468	CLIP-seq
MIRT2469704	hsa-miR-4680-5p	CLIP-seq
MIRT766179	hsa-miR-4715-3p	CLIP-seq
MIRT2469707	hsa-miR-484	CLIP-seq
MIRT2469708	hsa-miR-509-3-5p	CLIP-seq
MIRT2469709	hsa-miR-509-5p	CLIP-seq
MIRT2469710	hsa-miR-510	CLIP-seq
MIRT2469711	hsa-miR-544b	CLIP-seq
MIRT2469712	hsa-miR-552	CLIP-seq
MIRT2469714	hsa-miR-603	CLIP-seq
MIRT2469715	hsa-miR-646	CLIP-seq
MIRT2469716	hsa-miR-653	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0004222	Function	Metalloendopeptidase activity	NAS	11814695
GO:0005515	Function	Protein binding	IPI	25416956
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	NAS	11814695
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008270	Function	Zinc ion binding	NAS	11814695
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	11814695
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
607114	15478	ENSG00000149451

Q9BZ11

Protein name

Disintegrin and metalloproteinase domain-containing protein 33 (ADAM 33) (EC 3.4.24.-)

PDB

1R54 , 1R55

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01562	Pep_M12B_propep	39 → 167	Reprolysin family propeptide	Family
PF01421	Reprolysin	210 → 409	Reprolysin (M12B) family zinc metalloprotease	Domain
PF00200	Disintegrin	426 → 498	Disintegrin	Domain
PF08516	ADAM_CR	503 → 619	ADAM cysteine-rich	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in all tissues, except liver, with high expression in placenta, lung, spleen and veins. {ECO:0000269|PubMed:11814695}.

Sequence

MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV
SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV
RGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG
HRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEV
ANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQL
LTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGC
CVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALC
GNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMG
DCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEA
CFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLD
GQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSH
GVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGL
AWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPE
NSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW

Sequence length

813

Interactions

View interactions

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Colon adenocarcinoma	Benign	rs17548837	RCV005869429
Malignant lymphoma, large B-cell, diffuse	Benign	rs17548837	RCV005869433
Malignant tumor of esophagus	Benign	rs17548837	RCV005869430
Nonpapillary renal cell carcinoma	Benign	rs17548837	RCV005869431
Uveal melanoma	Benign	rs17548837	RCV005869432

Show/Hide Text Mining Associations (42)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Airway Remodeling	Associate	23640557
Arthritis Psoriatic	Associate	16519819
Arthritis Rheumatoid	Associate	16519819
Asthma	Associate	12401189, 16024651, 16784537, 17088949, 17640346, 17878941, 18560587, 18778489, 19317339, 19951440, 20003279, 20513247, 21103062, 22227561, 22660217 View all (24 more)
Atherosclerosis	Associate	23861802
Breast Neoplasms	Associate	19267929, 28294120
Bronchial Hyperreactivity	Associate	23640030
Bronchitis	Associate	27624002
Carcinoma Lobular	Associate	19267929
Castleman Disease	Associate	34686774
CD59 Deficiency	Associate	16519819
Conversion Disorder	Associate	24253534
Coronary Artery Disease	Associate	24699314
COVID 19	Associate	38345545
Eczema	Associate	27624002
Familial Primary Pulmonary Hypertension	Associate	25840998
Fractures Stress	Associate	27624002
Glioma	Associate	23525950
Graves Disease	Associate	16519819
Hereditary Breast and Ovarian Cancer Syndrome	Associate	19267929
Hypersensitivity Immediate	Associate	24141861
Ige Responsiveness Atopic	Associate	24039878
Immune System Diseases	Associate	17878941
Inflammation	Associate	17090574, 17878941, 25369941, 27624002, 34848800
Lung Injury	Associate	20003279
Lupus Erythematosus Systemic	Associate	16519819
Multiple Sclerosis	Associate	16519819
Neoplasm Metastasis	Associate	28294120
Neoplasms	Inhibit	19267929
Neoplasms	Associate	36977901
Pancreatic Neoplasms	Associate	32907841
Psoriasis	Associate	17878941, 18560587
Pulmonary Disease Chronic Obstructive	Associate	17090574, 20003279, 20156753, 23861802, 24191661, 24253534, 25369941, 27323020, 34848800, 38345545
Respiratory Hypersensitivity	Associate	17090574, 31719298
Respiratory Sounds	Associate	27624002
Rhinitis	Associate	18778489
Rhinitis Allergic	Associate	18778489
Status Asthmaticus	Associate	19317339, 22227417, 22227561, 22871616, 23245479, 23640030, 23640557, 31586488
Thyroid Neoplasms	Associate	36977901
Tobacco Use Disorder	Associate	37372959
Triple Negative Breast Neoplasms	Associate	28294120
Vascular Remodeling	Associate	33982767

ADAM33 (ADAM metallopeptidase domain 33)