Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	80328
Gene name	UL16 binding protein 2
Gene symbol	ULBP2
Synonyms (NCBI Gene)	ALCAN-alphaN2DL2NKG2DL2RAET1HRAET1L
Chromosome	6
Chromosome location	6q25.1
Summary	This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activa

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Show/Hide all (145)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006286	hsa-miR-34a-5p	FlowLuciferase reporter assayWestern blot	22102694
MIRT006287	hsa-miR-34c-5p	FlowLuciferase reporter assayWestern blot	22102694
MIRT006286	hsa-miR-34a-5p	FlowLuciferase reporter assayWestern blot	22102694
MIRT006286	hsa-miR-34a-5p	FlowLuciferase reporter assayWestern blot	22102694
MIRT438756	hsa-miR-182-5p	Luciferase reporter assayqRT-PCRWestern blot	23956116
MIRT438756	hsa-miR-182-5p	Luciferase reporter assayqRT-PCRWestern blot	23956116
MIRT316341	hsa-miR-29a-3p	PAR-CLIP	23592263
MIRT316344	hsa-miR-29b-3p	PAR-CLIP	23592263
MIRT316345	hsa-miR-29c-3p	PAR-CLIP	23592263
MIRT488440	hsa-miR-6871-3p	PAR-CLIP	23592263
MIRT488439	hsa-miR-6884-3p	PAR-CLIP	23592263
MIRT316354	hsa-miR-5682	PAR-CLIP	23592263
MIRT488438	hsa-miR-153-3p	PAR-CLIP	23592263
MIRT488437	hsa-miR-448	PAR-CLIP	23592263
MIRT488438	hsa-miR-153-3p	PAR-CLIP	26701625
MIRT488438	hsa-miR-153-3p	PAR-CLIP	26701625
MIRT488438	hsa-miR-153-3p	PAR-CLIP	26701625
MIRT488438	hsa-miR-153-3p	PAR-CLIP	26701625
MIRT488438	hsa-miR-153-3p	PAR-CLIP	26701625
MIRT488438	hsa-miR-153-3p	PAR-CLIP	26701625
MIRT488438	hsa-miR-153-3p	PAR-CLIP	26701625
MIRT488438	hsa-miR-153-3p	PAR-CLIP	26701625
MIRT488438	hsa-miR-153-3p	PAR-CLIP	26701625
MIRT316341	hsa-miR-29a-3p	PAR-CLIP	26701625
MIRT316341	hsa-miR-29a-3p	PAR-CLIP	26701625
MIRT316341	hsa-miR-29a-3p	PAR-CLIP	26701625
MIRT316341	hsa-miR-29a-3p	PAR-CLIP	26701625
MIRT316341	hsa-miR-29a-3p	PAR-CLIP	26701625
MIRT316341	hsa-miR-29a-3p	PAR-CLIP	26701625
MIRT316341	hsa-miR-29a-3p	PAR-CLIP	26701625
MIRT316341	hsa-miR-29a-3p	PAR-CLIP	26701625
MIRT316341	hsa-miR-29a-3p	PAR-CLIP	26701625
MIRT316344	hsa-miR-29b-3p	PAR-CLIP	26701625
MIRT316344	hsa-miR-29b-3p	PAR-CLIP	26701625
MIRT316344	hsa-miR-29b-3p	PAR-CLIP	26701625
MIRT316344	hsa-miR-29b-3p	PAR-CLIP	26701625
MIRT316344	hsa-miR-29b-3p	PAR-CLIP	26701625
MIRT316344	hsa-miR-29b-3p	PAR-CLIP	26701625
MIRT316344	hsa-miR-29b-3p	PAR-CLIP	26701625
MIRT316344	hsa-miR-29b-3p	PAR-CLIP	26701625
MIRT316344	hsa-miR-29b-3p	PAR-CLIP	26701625
MIRT316345	hsa-miR-29c-3p	PAR-CLIP	26701625
MIRT316345	hsa-miR-29c-3p	PAR-CLIP	26701625
MIRT316345	hsa-miR-29c-3p	PAR-CLIP	26701625
MIRT316345	hsa-miR-29c-3p	PAR-CLIP	26701625
MIRT316345	hsa-miR-29c-3p	PAR-CLIP	26701625
MIRT316345	hsa-miR-29c-3p	PAR-CLIP	26701625
MIRT316345	hsa-miR-29c-3p	PAR-CLIP	26701625
MIRT316345	hsa-miR-29c-3p	PAR-CLIP	26701625
MIRT316345	hsa-miR-29c-3p	PAR-CLIP	26701625
MIRT006286	hsa-miR-34a-5p	PAR-CLIP	26701625
MIRT006286	hsa-miR-34a-5p	PAR-CLIP	26701625
MIRT006286	hsa-miR-34a-5p	PAR-CLIP	26701625
MIRT006286	hsa-miR-34a-5p	PAR-CLIP	26701625
MIRT006286	hsa-miR-34a-5p	PAR-CLIP	26701625
MIRT006286	hsa-miR-34a-5p	PAR-CLIP	26701625
MIRT006286	hsa-miR-34a-5p	PAR-CLIP	26701625
MIRT006286	hsa-miR-34a-5p	PAR-CLIP	26701625
MIRT006286	hsa-miR-34a-5p	PAR-CLIP	26701625
MIRT006287	hsa-miR-34c-5p	PAR-CLIP	26701625
MIRT006287	hsa-miR-34c-5p	PAR-CLIP	26701625
MIRT006287	hsa-miR-34c-5p	PAR-CLIP	26701625
MIRT006287	hsa-miR-34c-5p	PAR-CLIP	26701625
MIRT006287	hsa-miR-34c-5p	PAR-CLIP	26701625
MIRT006287	hsa-miR-34c-5p	PAR-CLIP	26701625
MIRT006287	hsa-miR-34c-5p	PAR-CLIP	26701625
MIRT006287	hsa-miR-34c-5p	PAR-CLIP	26701625
MIRT006287	hsa-miR-34c-5p	PAR-CLIP	26701625
MIRT488437	hsa-miR-448	PAR-CLIP	26701625
MIRT488437	hsa-miR-448	PAR-CLIP	26701625
MIRT488437	hsa-miR-448	PAR-CLIP	26701625
MIRT488437	hsa-miR-448	PAR-CLIP	26701625
MIRT488437	hsa-miR-448	PAR-CLIP	26701625
MIRT488437	hsa-miR-448	PAR-CLIP	26701625
MIRT488437	hsa-miR-448	PAR-CLIP	26701625
MIRT488437	hsa-miR-448	PAR-CLIP	26701625
MIRT488437	hsa-miR-448	PAR-CLIP	26701625
MIRT316354	hsa-miR-5682	PAR-CLIP	26701625
MIRT316354	hsa-miR-5682	PAR-CLIP	26701625
MIRT316354	hsa-miR-5682	PAR-CLIP	26701625
MIRT316354	hsa-miR-5682	PAR-CLIP	26701625
MIRT316354	hsa-miR-5682	PAR-CLIP	26701625
MIRT316354	hsa-miR-5682	PAR-CLIP	26701625
MIRT316354	hsa-miR-5682	PAR-CLIP	26701625
MIRT316354	hsa-miR-5682	PAR-CLIP	26701625
MIRT316354	hsa-miR-5682	PAR-CLIP	26701625
MIRT488440	hsa-miR-6871-3p	PAR-CLIP	26701625
MIRT488440	hsa-miR-6871-3p	PAR-CLIP	26701625
MIRT488440	hsa-miR-6871-3p	PAR-CLIP	26701625
MIRT488440	hsa-miR-6871-3p	PAR-CLIP	26701625
MIRT488440	hsa-miR-6871-3p	PAR-CLIP	26701625
MIRT488440	hsa-miR-6871-3p	PAR-CLIP	26701625
MIRT488440	hsa-miR-6871-3p	PAR-CLIP	26701625
MIRT488440	hsa-miR-6871-3p	PAR-CLIP	26701625
MIRT488440	hsa-miR-6871-3p	PAR-CLIP	26701625
MIRT488439	hsa-miR-6884-3p	PAR-CLIP	26701625
MIRT488439	hsa-miR-6884-3p	PAR-CLIP	26701625
MIRT488439	hsa-miR-6884-3p	PAR-CLIP	26701625
MIRT488439	hsa-miR-6884-3p	PAR-CLIP	26701625
MIRT488439	hsa-miR-6884-3p	PAR-CLIP	26701625
MIRT488439	hsa-miR-6884-3p	PAR-CLIP	26701625
MIRT488439	hsa-miR-6884-3p	PAR-CLIP	26701625
MIRT488439	hsa-miR-6884-3p	PAR-CLIP	26701625
MIRT488439	hsa-miR-6884-3p	PAR-CLIP	26701625
MIRT316341	hsa-miR-29a-3p	PAR-CLIP	23592263
MIRT316344	hsa-miR-29b-3p	PAR-CLIP	23592263
MIRT316345	hsa-miR-29c-3p	PAR-CLIP	23592263
MIRT488440	hsa-miR-6871-3p	PAR-CLIP	23592263
MIRT488439	hsa-miR-6884-3p	PAR-CLIP	23592263
MIRT316354	hsa-miR-5682	PAR-CLIP	23592263
MIRT488438	hsa-miR-153-3p	PAR-CLIP	23592263
MIRT488437	hsa-miR-448	PAR-CLIP	23592263
MIRT2363202	hsa-miR-3074-3p	CLIP-seq
MIRT2363203	hsa-miR-4311	CLIP-seq
MIRT2363204	hsa-miR-450b-5p	CLIP-seq
MIRT2363205	hsa-miR-4696	CLIP-seq
MIRT2657121	hsa-miR-1178	CLIP-seq
MIRT2657122	hsa-miR-1207-3p	CLIP-seq
MIRT2657123	hsa-miR-1253	CLIP-seq
MIRT2657124	hsa-miR-1324	CLIP-seq
MIRT2657125	hsa-miR-3154	CLIP-seq
MIRT2657126	hsa-miR-338-5p	CLIP-seq
MIRT2657127	hsa-miR-3677-3p	CLIP-seq
MIRT2363203	hsa-miR-4311	CLIP-seq
MIRT2657128	hsa-miR-4435	CLIP-seq
MIRT2657129	hsa-miR-4440	CLIP-seq
MIRT2363204	hsa-miR-450b-5p	CLIP-seq
MIRT2657130	hsa-miR-4649-5p	CLIP-seq
MIRT2363205	hsa-miR-4696	CLIP-seq
MIRT2657131	hsa-miR-513a-5p	CLIP-seq
MIRT2657132	hsa-miR-579	CLIP-seq
MIRT2657121	hsa-miR-1178	CLIP-seq
MIRT2657122	hsa-miR-1207-3p	CLIP-seq
MIRT2657124	hsa-miR-1324	CLIP-seq
MIRT2657125	hsa-miR-3154	CLIP-seq
MIRT2657126	hsa-miR-338-5p	CLIP-seq
MIRT2657127	hsa-miR-3677-3p	CLIP-seq
MIRT2363203	hsa-miR-4311	CLIP-seq
MIRT2657128	hsa-miR-4435	CLIP-seq
MIRT2657129	hsa-miR-4440	CLIP-seq
MIRT2363204	hsa-miR-450b-5p	CLIP-seq
MIRT2657130	hsa-miR-4649-5p	CLIP-seq
MIRT2363205	hsa-miR-4696	CLIP-seq
MIRT2657131	hsa-miR-513a-5p	CLIP-seq
MIRT2657132	hsa-miR-579	CLIP-seq

Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001916	Process	Positive regulation of T cell mediated cytotoxicity	IBA
GO:0002376	Process	Immune system process	IEA
GO:0002476	Process	Antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA
GO:0002486	Process	Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA
GO:0005515	Function	Protein binding	IPI	19424970, 28559451, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	18676862
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005886	Component	Plasma membrane	IDA	11239445
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006955	Process	Immune response	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0009897	Component	External side of plasma membrane	IBA
GO:0009986	Component	Cell surface	IDA	18676862
GO:0016020	Component	Membrane	IEA
GO:0030101	Process	Natural killer cell activation	IDA	11239445
GO:0034235	Function	GPI anchor binding	IDA	37684232
GO:0042267	Process	Natural killer cell mediated cytotoxicity	IDA	17562706
GO:0042267	Process	Natural killer cell mediated cytotoxicity	IDA	11239445, 37774496
GO:0046703	Function	Natural killer cell lectin-like receptor binding	IDA	11239445
GO:0048018	Function	Receptor ligand activity	IDA	11777960
GO:0098552	Component	Side of membrane	IEA

MIM	HGNC	e!Ensembl
605698	14894	ENSG00000131015

Q9BZM5

Protein name

UL16-binding protein 2 (ALCAN-alpha) (NKG2D ligand 2) (N2DL-2) (NKG2DL2) (Retinoic acid early transcript 1H)

Protein function

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

PDB

8IMX , 8IMY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00129	MHC_I	29 → 205	Class I Histocompatibility antigen, domains alpha 1 and 2	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. {ECO:0000269|PubMed:11444831}.

Sequence

MAAAAATKILLCLPLLLLLSGWSRAGRADPHSLCYDITVIPKFRPGPRWCAVQGQVDEKT
FLHYDCGNKTVTPVSPLGKKLNVTTAWKAQNPVLREVVDILTEQLRDIQLENYTPKEPLT
LQARMSCEQKAEGHSSGSWQFSFDGQIFLLFDSEKRMWTTVHPGARKMKEKWENDKVVAM
SFHYFSMGDCIGWLEDFLMGMDSTLEPSAGAPLAMSSGTTQLRATATTLILCCLLIILPC
FILPGI

Sequence length

246

Interactions

View interactions

	KEGG		Reactome
	Natural killer cell mediated cytotoxicity		Post-translational modification: synthesis of GPI-anchored proteins

ULBP2 (UL16 binding protein 2)