Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	80323
Gene name Gene Name - the full gene name approved by the HGNC.	Coiled-coil domain containing 68
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CCDC68
Synonyms (NCBI Gene) Gene synonyms aliases	SE57-1
Chromosome Chromosome number	18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	18q21.2

Show/Hide all(62)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022785	hsa-miR-124-3p	Microarray	18668037
MIRT628349	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT628348	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT628347	hsa-miR-940	HITS-CLIP	23824327
MIRT628346	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT628345	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT628344	hsa-miR-1827	HITS-CLIP	23824327
MIRT628343	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT628342	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT628341	hsa-miR-665	HITS-CLIP	23824327
MIRT628349	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT628348	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT628347	hsa-miR-940	HITS-CLIP	23824327
MIRT628346	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT628345	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT628344	hsa-miR-1827	HITS-CLIP	23824327
MIRT628343	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT628342	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT628341	hsa-miR-665	HITS-CLIP	23824327
MIRT869641	hsa-miR-106a	CLIP-seq
MIRT869642	hsa-miR-106b	CLIP-seq
MIRT869643	hsa-miR-147	CLIP-seq
MIRT869644	hsa-miR-17	CLIP-seq
MIRT869645	hsa-miR-1914	CLIP-seq
MIRT869646	hsa-miR-20a	CLIP-seq
MIRT869647	hsa-miR-20b	CLIP-seq
MIRT869648	hsa-miR-3177-5p	CLIP-seq
MIRT869649	hsa-miR-3609	CLIP-seq
MIRT869650	hsa-miR-3611	CLIP-seq
MIRT869651	hsa-miR-3653	CLIP-seq
MIRT869652	hsa-miR-3929	CLIP-seq
MIRT869653	hsa-miR-409-5p	CLIP-seq
MIRT869654	hsa-miR-4316	CLIP-seq
MIRT869655	hsa-miR-4419b	CLIP-seq
MIRT869656	hsa-miR-4427	CLIP-seq
MIRT869657	hsa-miR-4478	CLIP-seq
MIRT869658	hsa-miR-4710	CLIP-seq
MIRT869659	hsa-miR-4777-3p	CLIP-seq
MIRT869660	hsa-miR-4792	CLIP-seq
MIRT869661	hsa-miR-4796-3p	CLIP-seq
MIRT869662	hsa-miR-485-5p	CLIP-seq
MIRT869663	hsa-miR-513c	CLIP-seq
MIRT869664	hsa-miR-514b-5p	CLIP-seq
MIRT869665	hsa-miR-519d	CLIP-seq
MIRT869666	hsa-miR-548ah	CLIP-seq
MIRT869667	hsa-miR-548u	CLIP-seq
MIRT869668	hsa-miR-552	CLIP-seq
MIRT869669	hsa-miR-599	CLIP-seq
MIRT869670	hsa-miR-93	CLIP-seq
MIRT869671	hsa-miR-3161	CLIP-seq
MIRT869672	hsa-miR-3646	CLIP-seq
MIRT869652	hsa-miR-3929	CLIP-seq
MIRT869673	hsa-miR-3942-3p	CLIP-seq
MIRT869655	hsa-miR-4419b	CLIP-seq
MIRT869657	hsa-miR-4478	CLIP-seq
MIRT869674	hsa-miR-4760-5p	CLIP-seq
MIRT869675	hsa-miR-4775	CLIP-seq
MIRT2385665	hsa-miR-3607-3p	CLIP-seq
MIRT2385666	hsa-miR-3686	CLIP-seq
MIRT2385667	hsa-miR-4719	CLIP-seq
MIRT2385668	hsa-miR-4768-5p	CLIP-seq
MIRT2385669	hsa-miR-4797-3p	CLIP-seq

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 28422092, 28514442, 31515488, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005814	Component	Centriole	IBA
GO:0005814	Component	Centriole	IDA	28422092
GO:0005814	Component	Centriole	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0008104	Process	Intracellular protein localization	IMP	28422092
GO:0034454	Process	Microtubule anchoring at centrosome	IBA
GO:0034454	Process	Microtubule anchoring at centrosome	IGI	28422092
GO:0034454	Process	Microtubule anchoring at centrosome	IMP	28422092
GO:0120103	Component	Centriolar subdistal appendage	IDA	28422092

MIM	HGNC	e!Ensembl
616909	24350	ENSG00000166510

Protein

UniProt ID

Q9H2F9

Protein name

Coiled-coil domain-containing protein 68 (Cutaneous T-cell lymphoma-associated antigen se57-1) (CTCL-associated antigen se57-1)

Protein function

Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC120, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical su

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Expressed in bone marrow, colon, small intestine, spleen, testis, trachea and cutaneous T-cell lymphoma (CTCL). {ECO:0000269|PubMed:11149944, ECO:0000269|PubMed:15142679}.

Sequence

MTTVTVTTEIPPRDKMEDNSALYESTSAHIIEETEYVKKIRTTLQKIRTQMFKDEIRHDS
TNHKLDAKHCGNLQQGSDSEMDPSCCSLDLLMKKIKGKDLQLLEMNKENEVLKIKLQASR
EAGAAALRNVAQRLFENYQTQSEEVRKKQEDSKQLLQVNKLEKEQKLKQHVENLNQVAEK
LEEKHSQITELENLVQRMEKEKRTLLERKLSLENKLLQLKSSATYGKSCQDLQREISILQ
EQISHLQFVIHSQHQNLRSVIQEMEGLKNNLKEQDKRIENLREKVNILEAQNKELKTQVA
LSSETPRTKVSKAVSTSELKTEGVSPYLMLIRLRK

Sequence length

335

Interactions

View interactions

Show/Hide Unknown Diseases (6)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Insomnia	Insomnia	N/A	N/A	GWAS
Mental Depression	Major depressive disorder	N/A	N/A	GWAS
Neuroticism	Neuroticism	N/A	N/A	GWAS
Pancreatic cancer	Pancreatic cancer	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Colorectal Neoplasms	Associate	19359472
Neoplasms	Inhibit	19359472

CCDC68 (coiled-coil domain containing 68)