CCDC68 (coiled-coil domain containing 68)

Gene

• Entrez ID: 80323
• Gene name: Coiled-coil domain containing 68
• Gene symbol: CCDC68
• Synonyms (NCBI Gene): SE57-1
• Chromosome: 18
• Chromosome location: 18q21.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022785	hsa-miR-124-3p	Microarray	18668037
MIRT628349	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT628348	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT628347	hsa-miR-940	HITS-CLIP	23824327
MIRT628346	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT628345	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT628344	hsa-miR-1827	HITS-CLIP	23824327
MIRT628343	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT628342	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT628341	hsa-miR-665	HITS-CLIP	23824327
MIRT628349	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT628348	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT628347	hsa-miR-940	HITS-CLIP	23824327
MIRT628346	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT628345	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT628344	hsa-miR-1827	HITS-CLIP	23824327
MIRT628343	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT628342	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT628341	hsa-miR-665	HITS-CLIP	23824327
MIRT869641	hsa-miR-106a	CLIP-seq
MIRT869642	hsa-miR-106b	CLIP-seq
MIRT869643	hsa-miR-147	CLIP-seq
MIRT869644	hsa-miR-17	CLIP-seq
MIRT869645	hsa-miR-1914	CLIP-seq
MIRT869646	hsa-miR-20a	CLIP-seq
MIRT869647	hsa-miR-20b	CLIP-seq
MIRT869648	hsa-miR-3177-5p	CLIP-seq
MIRT869649	hsa-miR-3609	CLIP-seq
MIRT869650	hsa-miR-3611	CLIP-seq
MIRT869651	hsa-miR-3653	CLIP-seq
MIRT869652	hsa-miR-3929	CLIP-seq
MIRT869653	hsa-miR-409-5p	CLIP-seq
MIRT869654	hsa-miR-4316	CLIP-seq
MIRT869655	hsa-miR-4419b	CLIP-seq
MIRT869656	hsa-miR-4427	CLIP-seq
MIRT869657	hsa-miR-4478	CLIP-seq
MIRT869658	hsa-miR-4710	CLIP-seq
MIRT869659	hsa-miR-4777-3p	CLIP-seq
MIRT869660	hsa-miR-4792	CLIP-seq
MIRT869661	hsa-miR-4796-3p	CLIP-seq
MIRT869662	hsa-miR-485-5p	CLIP-seq
MIRT869663	hsa-miR-513c	CLIP-seq
MIRT869664	hsa-miR-514b-5p	CLIP-seq
MIRT869665	hsa-miR-519d	CLIP-seq
MIRT869666	hsa-miR-548ah	CLIP-seq
MIRT869667	hsa-miR-548u	CLIP-seq
MIRT869668	hsa-miR-552	CLIP-seq
MIRT869669	hsa-miR-599	CLIP-seq
MIRT869670	hsa-miR-93	CLIP-seq
MIRT869671	hsa-miR-3161	CLIP-seq
MIRT869672	hsa-miR-3646	CLIP-seq
MIRT869652	hsa-miR-3929	CLIP-seq
MIRT869673	hsa-miR-3942-3p	CLIP-seq
MIRT869655	hsa-miR-4419b	CLIP-seq
MIRT869657	hsa-miR-4478	CLIP-seq
MIRT869674	hsa-miR-4760-5p	CLIP-seq
MIRT869675	hsa-miR-4775	CLIP-seq
MIRT2385665	hsa-miR-3607-3p	CLIP-seq
MIRT2385666	hsa-miR-3686	CLIP-seq
MIRT2385667	hsa-miR-4719	CLIP-seq
MIRT2385668	hsa-miR-4768-5p	CLIP-seq
MIRT2385669	hsa-miR-4797-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 28422092, 28514442, 31515488, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005814	Component	Centriole	IBA
GO:0005814	Component	Centriole	IDA	28422092
GO:0005814	Component	Centriole	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0008104	Process	Intracellular protein localization	IMP	28422092
GO:0034454	Process	Microtubule anchoring at centrosome	IBA
GO:0034454	Process	Microtubule anchoring at centrosome	IGI	28422092
GO:0034454	Process	Microtubule anchoring at centrosome	IMP	28422092
GO:0120103	Component	Centriolar subdistal appendage	IDA	28422092

Other IDs

• MIM: 616909
• HGNC: 24350
• e!Ensembl: ENSG00000166510

Protein

• UniProt ID: Q9H2F9
• Protein name: Coiled-coil domain-containing protein 68 (Cutaneous T-cell lymphoma-associated antigen se57-1) (CTCL-associated antigen se57-1)
• Protein function: Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC120, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical su
• Tissue specificity: TISSUE SPECIFICITY: Expressed in bone marrow, colon, small intestine, spleen, testis, trachea and cutaneous T-cell lymphoma (CTCL). {ECO:0000269|PubMed:11149944, ECO:0000269|PubMed:15142679}.
• Sequence:

  MTTVTVTTEIPPRDKMEDNSALYESTSAHIIEETEYVKKIRTTLQKIRTQMFKDEIRHDS
  TNHKLDAKHCGNLQQGSDSEMDPSCCSLDLLMKKIKGKDLQLLEMNKENEVLKIKLQASR
  EAGAAALRNVAQRLFENYQTQSEEVRKKQEDSKQLLQVNKLEKEQKLKQHVENLNQVAEK
  LEEKHSQITELENLVQRMEKEKRTLLERKLSLENKLLQLKSSATYGKSCQDLQREISILQ
  EQISHLQFVIHSQHQNLRSVIQEMEGLKNNLKEQDKRIENLREKVNILEAQNKELKTQVA
  LSSETPRTKVSKAVSTSELKTEGVSPYLMLIRLRK

• Sequence length: 335

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Recurrent spontaneous abortion	Likely pathogenic	rs2044011378	RCV001250896

Associations from Text Mining
Disease Name	Relationship Type	References
Colorectal Neoplasms	Associate	19359472
Neoplasms	Inhibit	19359472