Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8031
Gene name Gene Name - the full gene name approved by the HGNC.
Nuclear receptor coactivator 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NCOA4
Synonyms (NCBI Gene) Gene synonyms aliases
ARA70, ELE1, PTC3, RFG
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q11.22
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gen
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT044019 hsa-miR-365a-3p CLASH 23622248
MIRT041830 hsa-miR-484 CLASH 23622248
MIRT038845 hsa-miR-93-3p CLASH 23622248
MIRT328260 hsa-miR-6507-5p PAR-CLIP 21572407
MIRT328258 hsa-miR-3668 PAR-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003713 Function Transcription coactivator activity IEA
GO:0005634 Component Nucleus TAS 8643607
GO:0006622 Process Protein targeting to lysosome IDA 25327288
GO:0006879 Process Cellular iron ion homeostasis IEA
GO:0008584 Process Male gonad development TAS 8643607
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601984 7671 ENSG00000266412
Protein
UniProt ID Q13772
Protein name Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ferritin cargo receptor NCOA4) (Ret-activating protein EL
Protein function Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis (PubMed:25327288, PubMed:26436293). Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation o
PDB 1T5Z , 8QU9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12489 ARA70 34 147 Nuclear coactivator Family
PF12489 ARA70 199 328 Nuclear coactivator Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta is only expressed in testis.
Sequence
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHL
ECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSV
CLERLGSLTLKPEDSTVLLFEADTITL
RQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQTS
SRACNFFNNVGGNLKGLENWLLKSEKSSYQKCNSHSTTSSFSIEMEKVGDQELPDQDEMD
LSDWLVTPQESHKLRKPENGSRETSEKF
KLLFQSYNVNDWLVKTDSCTNCQGNQPKGVEI
ENLGNLKCLNDHLEAKKPLSTPSMVTEDWLVQNHQDPCKVEEVCRANEPCTSFAECVCDE
NCEKEALYKWLLKKEGKDKNGMPVEPKPEPEKHKDSLNMWLCPRKEVIEQTKAPKAMTPS
RIADSFQVIKNSPLSEWLIRPPYKEGSPKEVPGTEDRAGKQKFKSPMNTSWCSFNTADWV
LPGKKMGNLSQLSSGEDKWLLRKKAQEVLLNSPLQEEHNFPPDHYGLPAVCDLFACMQLK
VDKEKWLYRTPLQM
Sequence length 614
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Ferroptosis
Pathways in cancer
Thyroid cancer
 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Papillary thyroid carcinoma Papillary thyroid carcinoma rs751409106 8290261, 25407564
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 21261984
Adenoma Associate 32638211
Adenomatous Polyposis Coli Associate 9916927
Androgen Insensitivity Syndrome Associate 9576916
Brain Injuries Traumatic Associate 37979398
Carcinogenesis Associate 30467698
Carcinoma Intraductal Noninfiltrating Associate 29443014, 31162284, 32661669, 33991527, 34985683
Carcinoma Pancreatic Ductal Associate 31162284
Carcinoma Papillary Associate 10646883
Carcinoma Renal Cell Associate 32688345, 33402128, 34370716