NCOA4 (nuclear receptor coactivator 4)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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8031 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Nuclear receptor coactivator 4 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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NCOA4 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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ARA70, ELE1, PTC3, RFG |
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Chromosome
Chromosome number
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10 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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10q11.22 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gen |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||
| UniProt ID | Q13772 | |||||||||||||||
| Protein name | Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ferritin cargo receptor NCOA4) (Ret-activating protein EL | |||||||||||||||
| Protein function | Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis (PubMed:25327288, PubMed:26436293). Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation o | |||||||||||||||
| PDB | 1T5Z , 8QU9 | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta is only expressed in testis. | |||||||||||||||
| Sequence |
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| Sequence length | 614 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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