Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	80309
Gene name Gene Name - the full gene name approved by the HGNC.	SPHK1 interactor, AKAP domain containing
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SPHKAP
Synonyms (NCBI Gene) Gene synonyms aliases	SKIP
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q36.3

Show/Hide all(27)

miRTarBase ID	miRNA	Experiments
MIRT1383939	hsa-miR-1305	CLIP-seq
MIRT1383940	hsa-miR-3160-5p	CLIP-seq
MIRT1383941	hsa-miR-4753-3p	CLIP-seq
MIRT1383942	hsa-miR-4768-5p	CLIP-seq
MIRT1383943	hsa-miR-651	CLIP-seq
MIRT1383944	hsa-miR-1292	CLIP-seq
MIRT1383945	hsa-miR-23a	CLIP-seq
MIRT1383946	hsa-miR-23b	CLIP-seq
MIRT1383947	hsa-miR-23c	CLIP-seq
MIRT1383948	hsa-miR-4282	CLIP-seq
MIRT1383949	hsa-miR-4471	CLIP-seq
MIRT1383950	hsa-miR-4796-3p	CLIP-seq
MIRT1383951	hsa-miR-488	CLIP-seq
MIRT1383952	hsa-miR-649	CLIP-seq
MIRT2337607	hsa-miR-1279	CLIP-seq
MIRT2337608	hsa-miR-15a	CLIP-seq
MIRT2337609	hsa-miR-15b	CLIP-seq
MIRT2337610	hsa-miR-16	CLIP-seq
MIRT2337611	hsa-miR-195	CLIP-seq
MIRT2337612	hsa-miR-424	CLIP-seq
MIRT2337613	hsa-miR-4524	CLIP-seq
MIRT2337614	hsa-miR-497	CLIP-seq
MIRT2337615	hsa-miR-503	CLIP-seq
MIRT2337616	hsa-miR-646	CLIP-seq
MIRT2433496	hsa-miR-3669	CLIP-seq
MIRT2433497	hsa-miR-548c-3p	CLIP-seq
MIRT2433498	hsa-miR-944	CLIP-seq

Show/Hide all(5)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	12080051
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005739	Component	Mitochondrion	IBA	21873635
GO:0051018	Function	Protein kinase A binding	IBA	21873635
GO:0051018	Function	Protein kinase A binding	IDA	20394097

MIM	HGNC	e!Ensembl
611646	30619	ENSG00000153820

Protein

UniProt ID

Q2M3C7

Protein name

A-kinase anchor protein SPHKAP (SPHK1-interactor and AKAP domain-containing protein) (Sphingosine kinase type 1-interacting protein)

Protein function

Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signalin

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05716	AKAP_110	1587 → 1699	A-kinase anchor protein 110 kDa (AKAP 110)	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in heart. Both isoforms abundantly expressed in ventricle. Also expressed in spleen, ovary and brain. {ECO:0000269|PubMed:12080051, ECO:0000269|PubMed:20394097}.

Sequence

MDGNSLLSVPSNLESSRMYDVLEPQQGRGCGSSGSGPGNSITACKKVLRSNSLLESTDYW
LQNQRMPCQIGFVEDKSENCASVCFVNLDVNKDECSTEHLQQKLVNVSPDLPKLISSMNV
QQPKENEIVVLSGLASGNLQADFEVSQCPWLPDICLVQCARGNRPNSTNCIIFEINKFLI
GLELVQERQLHLETNILKLEDDTNCSLSSIEEDFLTASEHLEEESEVDESRNDYENINVS
ANVLESKQLKGATQVEWNCNKEKWLYALEDKYINKYPTPLIKTERSPENLTKNTALQSLD
PSAKPSQWKREAVGNGRQATHYYHSEAFKGQMEKSQALYIPKDAYFSMMDKDVPSACAVA
EQRSNLNPGDHEDTRNALPPRQDGEVTTGKYATNLAESVLQDAFIRLSQSQSTLPQESAV
SVSVGSSLLPSCYSTKDTVVSRSWNELPKIVVVQSPDGSDAAPQPGISSWPEMEVSVETS
SILSGENSSRQPQSALEVALACAATVIGTISSPQATERLKMEQVVSNFPPGSSGALQTQA
PQGLKEPSINEYSFPSALCGMTQVASAVAVCGLGEREEVTCSVAPSGSLPPAAEASEAMP
PLCGLASMELGKEAIAKGLLKEAALVLTRPNTYSSIGDFLDSMNRRIMETASKSQTLCSE
NVVRNELAHTLSNVILRHSIDEVHHKNMIIDPNDNRHSSEILDTLMESTNQLLLDVICFT
FKKMSHIVRLGECPAVLSKETIRRRETEPSCQPSDPGASQAWTKATESSSSSPLSNSHNT
SLVINNLVDGMYSKQDKGGVRPGLFKNPTLQSQLSRSHRVPDSSTATTSSKEIYLKGIAG
EDTKSPHHSENECRASSEGQRSPTVSQSRSGSQEAEESIHPNTQEKYNCATSRINEVQVN
LSLLGDDLLLPAQSTLQTKHPDIYCITDFAEELADTVVSMATEIAAICLDNSSGKQPWFC
AWKRGSEFLMTPNVPCRSLKRKKESQGSGTAVRKHKPPRLSEIKRKTDEHPELKEKLMNR
VVDESMNLEDVPDSVNLFANEVAAKIMNLTEFSMVDGMWQAQGYPRNRLLSGDRWSRLKA
SSCESIPEEDSEARAYVNSLGLMSTLSQPVSRASSVSKQSSCESITDEFSRFMVNQMENE
GRGFELLLDYYAGKNASSILNSAMQQACRKSDHLSVRPSCPSKQSSTESITEEFYRYMLR
DIERDSRESASSRRSSQDWTAGLLSPSLRSPVCHRQSSMPDSRSPCSRLTVNVPIKANSL
DGFAQNCPQDFLSVQPVSSASSSGLCKSDSCLYRRGGTDHITNMLIHETWASSIEALMRK
NKIIVDDAEEADTEPVSGGSPSQAEKCANRLAASRMCSGPTLLVQESLDCPRKDSVTECK
QPPVSSLSKTASLTNHSPLDSKKETSSCQDPVPINHKRRSLCSREVPLIQIETDQREACA
GEPEPFLSKSSLLEEAEGHSNDKNIPDVVRGGDTAVSACQIHSDSLDTRDVPEAEASTEA
RAPDEAPNPPSSSEESTGSWTQLANEEDNPDDTSSFLQLSERSMSNGNSSATSSLGIMDL
DIYQESMPSSPMINELVEEKKILKGQSESTEAPASGPPTGTASPQRSLLVINFDLEPECP
DAELRATLQWIAASELGIPTIYFKKSQENRIEKFLDVVQLVHRKSWKVGDIFHAVVQYCK
MHEEQKDGRLSLFDWLLELG

Sequence length

1700

Interactions

View interactions

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237 View all (293 more)	30054458
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	31374203, 26198764

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Diabetes	Diabetes	GWAS
Metabolic Syndrome	Metabolic Syndrome	GWAS

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining
Endometrial Neoplasms	Associate	22277765
Esophageal Squamous Cell Carcinoma	Associate	28694483
Leukemia Myeloid Acute	Inhibit	22479372
Leukemia Myeloid Acute	Associate	32161116
Pancreatic Intraductal Neoplasms	Associate	22355676
Schizophrenia	Associate	30285260

SPHKAP (SPHK1 interactor, AKAP domain containing)