Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	80274
Gene name	Signal peptide, CUB domain and EGF like domain containing 1
Gene symbol	SCUBE1
Synonyms (NCBI Gene)	-
Chromosome	22
Chromosome location	22q13.2
Summary	This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB do

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miRTarBase ID	miRNA	Experiments	Reference
MIRT513272	hsa-miR-449b-3p	PAR-CLIP	22012620
MIRT513271	hsa-miR-34c-3p	PAR-CLIP	22012620
MIRT513270	hsa-miR-3189-3p	PAR-CLIP	22012620
MIRT513269	hsa-miR-4786-3p	PAR-CLIP	22012620
MIRT513268	hsa-miR-671-5p	PAR-CLIP	22012620
MIRT513267	hsa-miR-4747-5p	PAR-CLIP	22012620
MIRT513266	hsa-miR-5196-5p	PAR-CLIP	22012620
MIRT513265	hsa-miR-181b-2-3p	PAR-CLIP	22012620
MIRT513264	hsa-miR-181b-3p	PAR-CLIP	22012620
MIRT513262	hsa-miR-4420	PAR-CLIP	22012620
MIRT513263	hsa-miR-450a-1-3p	PAR-CLIP	22012620
MIRT513272	hsa-miR-449b-3p	PAR-CLIP	23446348
MIRT513271	hsa-miR-34c-3p	PAR-CLIP	23446348
MIRT513270	hsa-miR-3189-3p	PAR-CLIP	23446348
MIRT513269	hsa-miR-4786-3p	PAR-CLIP	23446348
MIRT513268	hsa-miR-671-5p	PAR-CLIP	23446348
MIRT513267	hsa-miR-4747-5p	PAR-CLIP	23446348
MIRT513266	hsa-miR-5196-5p	PAR-CLIP	23446348
MIRT513265	hsa-miR-181b-2-3p	PAR-CLIP	23446348
MIRT513264	hsa-miR-181b-3p	PAR-CLIP	23446348
MIRT513262	hsa-miR-4420	PAR-CLIP	23446348
MIRT513263	hsa-miR-450a-1-3p	PAR-CLIP	23446348
MIRT513272	hsa-miR-449b-3p	PAR-CLIP	22012620
MIRT513271	hsa-miR-34c-3p	PAR-CLIP	22012620
MIRT513270	hsa-miR-3189-3p	PAR-CLIP	22012620
MIRT513269	hsa-miR-4786-3p	PAR-CLIP	22012620
MIRT513268	hsa-miR-671-5p	PAR-CLIP	22012620
MIRT513267	hsa-miR-4747-5p	PAR-CLIP	22012620
MIRT513266	hsa-miR-5196-5p	PAR-CLIP	22012620
MIRT513265	hsa-miR-181b-2-3p	PAR-CLIP	22012620
MIRT513264	hsa-miR-181b-3p	PAR-CLIP	22012620
MIRT513262	hsa-miR-4420	PAR-CLIP	22012620
MIRT513263	hsa-miR-450a-1-3p	PAR-CLIP	22012620
MIRT513272	hsa-miR-449b-3p	PAR-CLIP	23446348
MIRT513271	hsa-miR-34c-3p	PAR-CLIP	23446348
MIRT513270	hsa-miR-3189-3p	PAR-CLIP	23446348
MIRT513269	hsa-miR-4786-3p	PAR-CLIP	23446348
MIRT513268	hsa-miR-671-5p	PAR-CLIP	23446348
MIRT513267	hsa-miR-4747-5p	PAR-CLIP	23446348
MIRT513266	hsa-miR-5196-5p	PAR-CLIP	23446348
MIRT513265	hsa-miR-181b-2-3p	PAR-CLIP	23446348
MIRT513264	hsa-miR-181b-3p	PAR-CLIP	23446348
MIRT513262	hsa-miR-4420	PAR-CLIP	23446348
MIRT513263	hsa-miR-450a-1-3p	PAR-CLIP	23446348
MIRT1330951	hsa-miR-1321	CLIP-seq
MIRT1330952	hsa-miR-1827	CLIP-seq
MIRT1330953	hsa-miR-2467-3p	CLIP-seq
MIRT1330954	hsa-miR-3188	CLIP-seq
MIRT1330955	hsa-miR-3202	CLIP-seq
MIRT1330956	hsa-miR-3612	CLIP-seq
MIRT1330957	hsa-miR-4419a	CLIP-seq
MIRT1330958	hsa-miR-4510	CLIP-seq
MIRT1330959	hsa-miR-4728-5p	CLIP-seq
MIRT1330960	hsa-miR-4739	CLIP-seq
MIRT1330961	hsa-miR-4756-5p	CLIP-seq
MIRT1330962	hsa-miR-615-5p	CLIP-seq
MIRT1330963	hsa-miR-650	CLIP-seq
MIRT1921824	hsa-miR-3155	CLIP-seq
MIRT1921825	hsa-miR-3155b	CLIP-seq
MIRT1921826	hsa-miR-361-3p	CLIP-seq
MIRT1921827	hsa-miR-484	CLIP-seq
MIRT1921824	hsa-miR-3155	CLIP-seq
MIRT1921825	hsa-miR-3155b	CLIP-seq
MIRT1921826	hsa-miR-361-3p	CLIP-seq
MIRT1921827	hsa-miR-484	CLIP-seq
MIRT2322380	hsa-miR-3156-3p	CLIP-seq
MIRT2322381	hsa-miR-3616-3p	CLIP-seq
MIRT2322382	hsa-miR-3665	CLIP-seq
MIRT2322383	hsa-miR-4301	CLIP-seq
MIRT2322384	hsa-miR-4318	CLIP-seq
MIRT2322385	hsa-miR-4436b-3p	CLIP-seq
MIRT2322386	hsa-miR-4736	CLIP-seq
MIRT2322387	hsa-miR-532-3p	CLIP-seq
MIRT2322388	hsa-miR-764	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005509	Function	Calcium ion binding	TAS	12270931
GO:0005515	Function	Protein binding	IPI	12270931
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	12270931
GO:0005886	Component	Plasma membrane	IDA	12270931
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006954	Process	Inflammatory response	NAS	12270931
GO:0007165	Process	Signal transduction	IBA
GO:0007512	Process	Adult heart development	NAS	12270931
GO:0007596	Process	Blood coagulation	NAS	12270931
GO:0009791	Process	Post-embryonic development	NAS	12270931
GO:0009897	Component	External side of plasma membrane	IDA	12270931
GO:0009986	Component	Cell surface	IBA
GO:0009986	Component	Cell surface	IDA	12270931
GO:0016020	Component	Membrane	IEA
GO:0042802	Function	Identical protein binding	IDA	12270931
GO:0042802	Function	Identical protein binding	IPI	12270931
GO:0045446	Process	Endothelial cell differentiation	NAS	12270931
GO:0045880	Process	Positive regulation of smoothened signaling pathway	IEA

MIM	HGNC	e!Ensembl
611746	13441	ENSG00000159307

Q8IWY4

Protein name

Signal peptide, CUB and EGF-like domain-containing protein 1

Protein function

Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12947	EGF_3	37 → 72	EGF domain	Domain
PF12662	cEGF	97 → 120	Complement Clr-like EGF-like	Domain
PF14670	FXa_inhibition	121 → 156		Domain
PF14670	FXa_inhibition	245 → 280		Domain
PF14670	FXa_inhibition	286 → 321		Domain
PF07645	EGF_CA	362 → 407	Calcium-binding EGF domain	Domain
PF07699	Ephrin_rec_like	636 → 683	Putative ephrin-receptor like	Family
PF07699	Ephrin_rec_like	690 → 737	Putative ephrin-receptor like	Family
PF07699	Ephrin_rec_like	746 → 793	Putative ephrin-receptor like	Family
PF00431	CUB	798 → 907	CUB domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in endothelial cells. Highly expressed in platelets. Stored in platelet alpha granules, and transferred to the cell surface upon activation and aggregation. A smaller form, probably produced by limited proteolysis, after being

Sequence

MGAAAVRWHLCVLLALGTRGRLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCL
CKPGYKGEGKQCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDE
CQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRET
PKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRT
CIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNT
VGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGTTHC
GDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLS
CSKAGGVESCFLSCPAHTLFVPDSENSYVLSCGVPGPQGKALQKRNGTSSGLGPSCSDAP
TTPIKQKARFKIRDAKCHLRPHSQARAKETARQPLLDHCHVTFVTLKCDSSKKRRRGRKS
PSKEVSHITAEFEIETKMEEASDTCEADCLRKRAEQSLQAAIKTLRKSIGRQQFYVQVSG
TEYEVAQRPAKALEGQGACGAGQVLQDSKCVACGPGTHFGGELGQCVSCMPGTYQDMEGQ
LSCTPCPSSDGLGLPGARNVSECGGQCSPGFFSADGFKPCQACPVGTYQPEPGRTGCFPC
GGGLLTKHEGTTSFQDCEAKVHCSPGHHYNTTTHRCIRCPVGTYQPEFGQNHCITCPGNT
STDFDGSTNVTHCKNQHCGGELGDYTGYIESPNYPGDYPANAECVWHIAPPPKRRILIVV
PEIFLPIEDECGDVLVMRKSASPTSITTYETCQTYERPIAFTSRSRKLWIQFKSNEGNSG
KGFQVPYVTYDEDYQQLIEDIVRDGRLYASENHQEILKDKKLIKALFDVLAHPQNYFKYT
AQESKEMFPRSFIKLLRSKVSRFLRPYK

Sequence length

988

Interactions

View interactions

	Reactome
			Degradation of the extracellular matrix

SCUBE1 (signal peptide, CUB domain and EGF like domain containing 1)