SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1)

Gene

• Entrez ID: 80176
• Gene name: SplA/ryanodine receptor domain and SOCS box containing 1
• Gene symbol: SPSB1
• Synonyms (NCBI Gene): SSB-1, SSB1
• Chromosome: 1
• Chromosome location: 1p36.22

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017474	hsa-miR-335-5p	Microarray	18185580
MIRT509604	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT509603	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT520963	hsa-miR-656-3p	HITS-CLIP	21572407
MIRT509602	hsa-miR-567	HITS-CLIP	21572407
MIRT509601	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509600	hsa-miR-3924	HITS-CLIP	21572407
MIRT509599	hsa-miR-297	HITS-CLIP	21572407
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT520963	hsa-miR-656-3p	PAR-CLIP	20371350
MIRT509602	hsa-miR-567	PAR-CLIP	20371350
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT509600	hsa-miR-3924	PAR-CLIP	20371350
MIRT509599	hsa-miR-297	PAR-CLIP	20371350
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT520963	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT509602	hsa-miR-567	PAR-CLIP	21572407
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509600	hsa-miR-3924	PAR-CLIP	21572407
MIRT509599	hsa-miR-297	PAR-CLIP	21572407
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509602	hsa-miR-567	PAR-CLIP	21572407
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509600	hsa-miR-3924	PAR-CLIP	21572407
MIRT509599	hsa-miR-297	PAR-CLIP	21572407
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT520963	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT509602	hsa-miR-567	PAR-CLIP	21572407
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509600	hsa-miR-3924	PAR-CLIP	21572407
MIRT509599	hsa-miR-297	PAR-CLIP	21572407
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT520963	hsa-miR-656-3p	PAR-CLIP	23446348
MIRT509602	hsa-miR-567	PAR-CLIP	23446348
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509600	hsa-miR-3924	PAR-CLIP	23446348
MIRT509599	hsa-miR-297	PAR-CLIP	23446348
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509602	hsa-miR-567	PAR-CLIP	23446348
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509600	hsa-miR-3924	PAR-CLIP	23446348
MIRT509599	hsa-miR-297	PAR-CLIP	23446348
MIRT483927	hsa-miR-583	PAR-CLIP	23592263
MIRT483925	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT483924	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT483923	hsa-miR-3179	PAR-CLIP	23592263
MIRT483922	hsa-miR-219b-5p	PAR-CLIP	23592263
MIRT489366	hsa-miR-8075	PAR-CLIP	23592263
MIRT483921	hsa-miR-3202	PAR-CLIP	23592263
MIRT483920	hsa-miR-3153	PAR-CLIP	23592263
MIRT483919	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT483918	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT483917	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT483916	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT483915	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT483914	hsa-miR-425-3p	PAR-CLIP	23592263
MIRT483927	hsa-miR-583	PAR-CLIP	23592263
MIRT483925	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT483924	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT483923	hsa-miR-3179	PAR-CLIP	23592263
MIRT483922	hsa-miR-219b-5p	PAR-CLIP	23592263
MIRT483921	hsa-miR-3202	PAR-CLIP	23592263
MIRT483920	hsa-miR-3153	PAR-CLIP	23592263
MIRT483919	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT483918	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT483917	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT483916	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT483915	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT483914	hsa-miR-425-3p	PAR-CLIP	23592263
MIRT509604	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT509603	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT520963	hsa-miR-656-3p	HITS-CLIP	21572407
MIRT509602	hsa-miR-567	HITS-CLIP	21572407
MIRT509601	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509600	hsa-miR-3924	HITS-CLIP	21572407
MIRT509599	hsa-miR-297	HITS-CLIP	21572407
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT520963	hsa-miR-656-3p	PAR-CLIP	20371350
MIRT509602	hsa-miR-567	PAR-CLIP	20371350
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT509600	hsa-miR-3924	PAR-CLIP	20371350
MIRT509599	hsa-miR-297	PAR-CLIP	20371350
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT520963	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT509602	hsa-miR-567	PAR-CLIP	21572407
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509600	hsa-miR-3924	PAR-CLIP	21572407
MIRT509599	hsa-miR-297	PAR-CLIP	21572407
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509602	hsa-miR-567	PAR-CLIP	21572407
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509600	hsa-miR-3924	PAR-CLIP	21572407
MIRT509599	hsa-miR-297	PAR-CLIP	21572407
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT520963	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT509602	hsa-miR-567	PAR-CLIP	21572407
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509600	hsa-miR-3924	PAR-CLIP	21572407
MIRT509599	hsa-miR-297	PAR-CLIP	21572407
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT520963	hsa-miR-656-3p	PAR-CLIP	23446348
MIRT509602	hsa-miR-567	PAR-CLIP	23446348
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509600	hsa-miR-3924	PAR-CLIP	23446348
MIRT509599	hsa-miR-297	PAR-CLIP	23446348
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509602	hsa-miR-567	PAR-CLIP	23446348
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509600	hsa-miR-3924	PAR-CLIP	23446348
MIRT509599	hsa-miR-297	PAR-CLIP	23446348
MIRT483927	hsa-miR-583	PAR-CLIP	23592263
MIRT483925	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT483924	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT483923	hsa-miR-3179	PAR-CLIP	23592263
MIRT483922	hsa-miR-219b-5p	PAR-CLIP	23592263
MIRT489366	hsa-miR-8075	PAR-CLIP	23592263
MIRT483921	hsa-miR-3202	PAR-CLIP	23592263
MIRT483920	hsa-miR-3153	PAR-CLIP	23592263
MIRT483919	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT483918	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT483917	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT483916	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT483915	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT483914	hsa-miR-425-3p	PAR-CLIP	23592263
MIRT483927	hsa-miR-583	PAR-CLIP	23592263
MIRT483925	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT483924	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT483923	hsa-miR-3179	PAR-CLIP	23592263
MIRT483922	hsa-miR-219b-5p	PAR-CLIP	23592263
MIRT483921	hsa-miR-3202	PAR-CLIP	23592263
MIRT483920	hsa-miR-3153	PAR-CLIP	23592263
MIRT483919	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT483918	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT483917	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT483916	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT483915	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT483914	hsa-miR-425-3p	PAR-CLIP	23592263
MIRT1386535	hsa-miR-1229	CLIP-seq
MIRT1386536	hsa-miR-1237	CLIP-seq
MIRT1386537	hsa-miR-1248	CLIP-seq
MIRT1386538	hsa-miR-1249	CLIP-seq
MIRT1386539	hsa-miR-125a-5p	CLIP-seq
MIRT1386540	hsa-miR-125b	CLIP-seq
MIRT1386541	hsa-miR-1271	CLIP-seq
MIRT1386542	hsa-miR-1305	CLIP-seq
MIRT1386543	hsa-miR-150	CLIP-seq
MIRT1386544	hsa-miR-181a	CLIP-seq
MIRT1386545	hsa-miR-181b	CLIP-seq
MIRT1386546	hsa-miR-181c	CLIP-seq
MIRT1386547	hsa-miR-181d	CLIP-seq
MIRT1386548	hsa-miR-2113	CLIP-seq
MIRT1386549	hsa-miR-218	CLIP-seq
MIRT1386550	hsa-miR-2964a-5p	CLIP-seq
MIRT1386551	hsa-miR-3130-5p	CLIP-seq
MIRT1386552	hsa-miR-3184	CLIP-seq
MIRT1386553	hsa-miR-423-5p	CLIP-seq
MIRT1386554	hsa-miR-4257	CLIP-seq
MIRT1386555	hsa-miR-4261	CLIP-seq
MIRT1386556	hsa-miR-4262	CLIP-seq
MIRT1386557	hsa-miR-4287	CLIP-seq
MIRT1386558	hsa-miR-4290	CLIP-seq
MIRT1386559	hsa-miR-4319	CLIP-seq
MIRT1386560	hsa-miR-4469	CLIP-seq
MIRT1386561	hsa-miR-4482	CLIP-seq
MIRT1386562	hsa-miR-4648	CLIP-seq
MIRT1386563	hsa-miR-4654	CLIP-seq
MIRT1386564	hsa-miR-4685-3p	CLIP-seq
MIRT1386565	hsa-miR-4711-3p	CLIP-seq
MIRT1386566	hsa-miR-4713-5p	CLIP-seq
MIRT1386567	hsa-miR-4732-3p	CLIP-seq
MIRT1386568	hsa-miR-4769-5p	CLIP-seq
MIRT1386569	hsa-miR-494	CLIP-seq
MIRT1386570	hsa-miR-511	CLIP-seq
MIRT1386571	hsa-miR-532-3p	CLIP-seq
MIRT1386572	hsa-miR-543	CLIP-seq
MIRT1386573	hsa-miR-544b	CLIP-seq
MIRT1386574	hsa-miR-607	CLIP-seq
MIRT1386575	hsa-miR-624	CLIP-seq
MIRT1386576	hsa-miR-625	CLIP-seq
MIRT1386577	hsa-miR-636	CLIP-seq
MIRT1386578	hsa-miR-670	CLIP-seq
MIRT1386579	hsa-miR-96	CLIP-seq
MIRT2115689	hsa-miR-3199	CLIP-seq
MIRT2115690	hsa-miR-3663-5p	CLIP-seq
MIRT2115691	hsa-miR-4268	CLIP-seq
MIRT2115692	hsa-miR-4448	CLIP-seq
MIRT2115693	hsa-miR-4522	CLIP-seq
MIRT2115694	hsa-miR-4652-5p	CLIP-seq
MIRT2115695	hsa-miR-4740-5p	CLIP-seq
MIRT2115696	hsa-miR-4773	CLIP-seq
MIRT2115697	hsa-miR-767-3p	CLIP-seq
MIRT2338324	hsa-miR-1207-5p	CLIP-seq
MIRT2338325	hsa-miR-1914	CLIP-seq
MIRT2338326	hsa-miR-2467-5p	CLIP-seq
MIRT2338327	hsa-miR-298	CLIP-seq
MIRT2338328	hsa-miR-3145-5p	CLIP-seq
MIRT2338329	hsa-miR-3188	CLIP-seq
MIRT2338330	hsa-miR-3646	CLIP-seq
MIRT2338331	hsa-miR-3665	CLIP-seq
MIRT2338332	hsa-miR-3944-5p	CLIP-seq
MIRT2338333	hsa-miR-3975	CLIP-seq
MIRT2338334	hsa-miR-4316	CLIP-seq
MIRT2338335	hsa-miR-4505	CLIP-seq
MIRT2338336	hsa-miR-4699-3p	CLIP-seq
MIRT2338337	hsa-miR-4731-5p	CLIP-seq
MIRT2338338	hsa-miR-4736	CLIP-seq
MIRT2338339	hsa-miR-4763-3p	CLIP-seq
MIRT2338340	hsa-miR-485-5p	CLIP-seq
MIRT2338341	hsa-miR-508-5p	CLIP-seq
MIRT2338342	hsa-miR-764	CLIP-seq
MIRT2395111	hsa-miR-1294	CLIP-seq
MIRT2338334	hsa-miR-4316	CLIP-seq
MIRT2395112	hsa-miR-4677-3p	CLIP-seq
MIRT2395113	hsa-miR-4679	CLIP-seq
MIRT2631904	hsa-miR-1264	CLIP-seq
MIRT2631905	hsa-miR-1321	CLIP-seq
MIRT2631906	hsa-miR-4419a	CLIP-seq
MIRT2631907	hsa-miR-4459	CLIP-seq
MIRT2631908	hsa-miR-4510	CLIP-seq
MIRT2631909	hsa-miR-4739	CLIP-seq
MIRT2631910	hsa-miR-4756-5p	CLIP-seq
MIRT2631911	hsa-miR-4779	CLIP-seq
MIRT1386569	hsa-miR-494	CLIP-seq
MIRT2631912	hsa-miR-548n	CLIP-seq
MIRT2631913	hsa-miR-548t	CLIP-seq
MIRT2631914	hsa-miR-600	CLIP-seq
MIRT2631905	hsa-miR-1321	CLIP-seq
MIRT2631906	hsa-miR-4419a	CLIP-seq
MIRT2631907	hsa-miR-4459	CLIP-seq
MIRT2631908	hsa-miR-4510	CLIP-seq
MIRT2631909	hsa-miR-4739	CLIP-seq
MIRT2631910	hsa-miR-4756-5p	CLIP-seq
MIRT2631911	hsa-miR-4779	CLIP-seq
MIRT2631912	hsa-miR-548n	CLIP-seq
MIRT2631913	hsa-miR-548t	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	20561531, 21199876, 23455924, 25203322, 28931592, 32296183, 32814053
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	21199876
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IDA	21199876
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0016567	Process	Protein ubiquitination	IDA	21199876
GO:0016567	Process	Protein ubiquitination	IEA
GO:0019005	Component	SCF ubiquitin ligase complex	IBA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IEA
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IPI	21199876

Other IDs

• MIM: 611657
• HGNC: 30628
• e!Ensembl: ENSG00000171621

Protein

• UniProt ID: Q96BD6
• Protein name: SPRY domain-containing SOCS box protein 1 (SSB-1)
• Protein function: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199
• PDB: 2JK9, 3F2O
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00622	SPRY	97 → 228	SPRY domain	Family
  PF07525	SOCS_box	234 → 272	SOCS box	Domain

• Sequence:

  MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMPPVSYDVQLLHSWNNND
  RSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATA
  DAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVA
  LDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDL
  CRRSVRLALGRERLGEIHTLPLPASLKAYLLYQ

• Sequence length: 273

Pathways

Reactome:

Neddylation
Antigen processing: Ubiquitination & Proteasome degradation