EDC3 (enhancer of mRNA decapping 3)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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80153 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Enhancer of mRNA decapping 3 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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EDC3 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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LSM16, MRT50, YJDC, YJEFN2, hYjeF_N2-15q23 |
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Chromosome
Chromosome number
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15 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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15q24.1 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a protein that is important in mRNA degradation. The encoded protein is a component of a decapping complex that promotes efficient removal of the monomethylguanosine (m7G) cap from mRNAs, as part of the 5` to 3` mRNA decay pathway. Mutat |
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SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||||||||||||
| UniProt ID | Q96F86 | |||||||||||||||||||||||||
| Protein name | Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1) | |||||||||||||||||||||||||
| Protein function | Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis. {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:17533573, ECO:0000269|PubM | |||||||||||||||||||||||||
| PDB | 2VC8 , 2WAX , 2WAY , 3D3J , 3D3K , 6S8S | |||||||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in theca and granulosa cells in ovary, and in spermatids of the meiotic division part II and apical membrane of Sertoli cells in testis (at protein level). Also expressed in brain and mammary gland. {ECO:0000269|PubMed:175335 | |||||||||||||||||||||||||
| Sequence | ||||||||||||||||||||||||||
| Sequence length | 508 | |||||||||||||||||||||||||
| Interactions | View interactions | |||||||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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