Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	80150
Gene name	Asparaginase and isoaspartyl peptidase 1
Gene symbol	ASRGL1
Synonyms (NCBI Gene)	ALPALP1CRASH
Chromosome	11
Chromosome location	11q12.3

Show/Hide all (80)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024570	hsa-miR-215-5p	Microarray	19074876
MIRT026301	hsa-miR-192-5p	Microarray	19074876
MIRT030736	hsa-miR-21-5p	Microarray	18591254
MIRT803198	hsa-miR-1	CLIP-seq
MIRT803199	hsa-miR-129-5p	CLIP-seq
MIRT803200	hsa-miR-206	CLIP-seq
MIRT803201	hsa-miR-224	CLIP-seq
MIRT803202	hsa-miR-3154	CLIP-seq
MIRT803203	hsa-miR-3673	CLIP-seq
MIRT803204	hsa-miR-3918	CLIP-seq
MIRT803205	hsa-miR-3919	CLIP-seq
MIRT803206	hsa-miR-4321	CLIP-seq
MIRT803207	hsa-miR-4446-3p	CLIP-seq
MIRT803208	hsa-miR-4512	CLIP-seq
MIRT803209	hsa-miR-4539	CLIP-seq
MIRT803210	hsa-miR-4656	CLIP-seq
MIRT803211	hsa-miR-4717-3p	CLIP-seq
MIRT803212	hsa-miR-4728-3p	CLIP-seq
MIRT803213	hsa-miR-4756-3p	CLIP-seq
MIRT803214	hsa-miR-4802-3p	CLIP-seq
MIRT803215	hsa-miR-613	CLIP-seq
MIRT803216	hsa-miR-628-5p	CLIP-seq
MIRT1937206	hsa-miR-1299	CLIP-seq
MIRT1937207	hsa-miR-4666-3p	CLIP-seq
MIRT1937208	hsa-miR-621	CLIP-seq
MIRT1937209	hsa-miR-875-3p	CLIP-seq
MIRT2176863	hsa-miR-122	CLIP-seq
MIRT2176864	hsa-miR-1297	CLIP-seq
MIRT1937206	hsa-miR-1299	CLIP-seq
MIRT2176865	hsa-miR-26a	CLIP-seq
MIRT2176866	hsa-miR-26b	CLIP-seq
MIRT2176867	hsa-miR-3124-3p	CLIP-seq
MIRT2176868	hsa-miR-3135b	CLIP-seq
MIRT2176869	hsa-miR-3180-5p	CLIP-seq
MIRT2176870	hsa-miR-3652	CLIP-seq
MIRT2176871	hsa-miR-3660	CLIP-seq
MIRT2176872	hsa-miR-378g	CLIP-seq
MIRT2176873	hsa-miR-4293	CLIP-seq
MIRT2176874	hsa-miR-4423-5p	CLIP-seq
MIRT2176875	hsa-miR-4430	CLIP-seq
MIRT2176876	hsa-miR-4437	CLIP-seq
MIRT2176877	hsa-miR-4465	CLIP-seq
MIRT2176878	hsa-miR-4526	CLIP-seq
MIRT1937207	hsa-miR-4666-3p	CLIP-seq
MIRT2176879	hsa-miR-4674	CLIP-seq
MIRT2176880	hsa-miR-4792	CLIP-seq
MIRT2176881	hsa-miR-500a	CLIP-seq
MIRT2176882	hsa-miR-520a-5p	CLIP-seq
MIRT2176883	hsa-miR-525-5p	CLIP-seq
MIRT2176884	hsa-miR-548ad	CLIP-seq
MIRT1937208	hsa-miR-621	CLIP-seq
MIRT1937209	hsa-miR-875-3p	CLIP-seq
MIRT803198	hsa-miR-1	CLIP-seq
MIRT2176863	hsa-miR-122	CLIP-seq
MIRT2480289	hsa-miR-149	CLIP-seq
MIRT803200	hsa-miR-206	CLIP-seq
MIRT2176868	hsa-miR-3135b	CLIP-seq
MIRT2176870	hsa-miR-3652	CLIP-seq
MIRT803203	hsa-miR-3673	CLIP-seq
MIRT803206	hsa-miR-4321	CLIP-seq
MIRT2176874	hsa-miR-4423-5p	CLIP-seq
MIRT2176875	hsa-miR-4430	CLIP-seq
MIRT803211	hsa-miR-4717-3p	CLIP-seq
MIRT803214	hsa-miR-4802-3p	CLIP-seq
MIRT803215	hsa-miR-613	CLIP-seq
MIRT803198	hsa-miR-1	CLIP-seq
MIRT2480289	hsa-miR-149	CLIP-seq
MIRT803200	hsa-miR-206	CLIP-seq
MIRT2675537	hsa-miR-24	CLIP-seq
MIRT2675538	hsa-miR-3591-3p	CLIP-seq
MIRT2675539	hsa-miR-3612	CLIP-seq
MIRT803203	hsa-miR-3673	CLIP-seq
MIRT2675540	hsa-miR-4284	CLIP-seq
MIRT803206	hsa-miR-4321	CLIP-seq
MIRT2675541	hsa-miR-4443	CLIP-seq
MIRT803211	hsa-miR-4717-3p	CLIP-seq
MIRT803214	hsa-miR-4802-3p	CLIP-seq
MIRT2675542	hsa-miR-485-5p	CLIP-seq
MIRT803215	hsa-miR-613	CLIP-seq
MIRT2675543	hsa-miR-650	CLIP-seq

Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001917	Component	Photoreceptor inner segment	IEA
GO:0001917	Component	Photoreceptor inner segment	ISS
GO:0003948	Function	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity	IDA	19839645
GO:0004067	Function	Asparaginase activity	IDA	19839645
GO:0004067	Function	Asparaginase activity	IEA
GO:0004067	Function	Asparaginase activity	IMP	27106100
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	27106100
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008798	Function	Beta-aspartyl-peptidase activity	IDA	19839645
GO:0008798	Function	Beta-aspartyl-peptidase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0033345	Process	L-asparagine catabolic process via L-aspartate	IBA
GO:0033345	Process	L-asparagine catabolic process via L-aspartate	IDA	19839645
GO:0033345	Process	L-asparagine catabolic process via L-aspartate	ISS

MIM	HGNC	e!Ensembl
609212	16448	ENSG00000162174

Q7L266

Protein name

Isoaspartyl peptidase/L-asparaginase (EC 3.4.19.5) (EC 3.5.1.1) (Asparaginase-like protein 1) (Beta-aspartyl-peptidase) (Isoaspartyl dipeptidase) (L-asparagine amidohydrolase) [Cleaved into: Isoaspartyl peptidase/L-asparaginase alpha chain; Isoaspartyl pe

Protein function

Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has ca

PDB

3TKJ , 4ET0 , 4O0C , 4O0D , 4O0E , 4O0F , 4O0G , 4O0H , 4OSX , 4OSY , 4PVP , 4PVQ , 4PVR , 4PVS , 4ZM9

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01112	Asparaginase_2	3 → 296	Asparaginase	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain, kidney, testis and tissues of the gastrointestinal tract. Present in sperm (at protein level). Over-expressed in uterine, mammary, prostatic and ovarian carcinoma. {ECO:0000269|PubMed:11984834, ECO:0000269|PubMed:14

Sequence

MNPIVVVHGGGAGPISKDRKERVHQGMVRAATVGYGILREGGSAVDAVEGAVVALEDDPE
FNAGCGSVLNTNGEVEMDASIMDGKDLSAGAVSAVQCIANPIKLARLVMEKTPHCFLTDQ
GAAQFAAAMGVPEIPGEKLVTERNKKRLEKEKHEKGAQKTDCQKNLGTVGAVALDCKGNV
AYATSTGGIVNKMVGRVGDSPCLGAGGYADNDIGAVSTTGHGESILKVNLARLTLFHIEQ
GKTVEEAADLSLGYMKSRVKGLGGLIVVSKTGDWVAKWTSTSMPWAAAKDGKLHFGIDPD
DTTITDLP

Sequence length

308

Interactions

View interactions

	KEGG		Reactome
	Alanine, aspartate and glutamate metabolism Metabolic pathways		Phenylalanine metabolism

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
ASRGL1-related disorder	Likely benign; Benign	rs140693977, rs765843116, rs115409110, rs3741244, rs149188142, rs151164229, rs145379105, rs3741245	RCV003938739 RCV003956027 RCV003931144 RCV003980539 RCV003931108 RCV003921145 RCV003908854 RCV003974393
Familial cancer of breast	Benign	rs558946011	RCV005867138
Retinal dystrophy	Uncertain significance	rs751865225	RCV005370258

Show/Hide Text Mining Associations (31)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Arthritis Rheumatoid	Associate	36012429
Asthenozoospermia	Associate	30544396
Breast Neoplasms	Associate	29767260
Carcinogenesis	Associate	30696738, 36572570
Carcinoma Hepatocellular	Associate	36572570
Colitis Ulcerative	Associate	39596612
Collagen Diseases	Associate	36012429
Colonic Neoplasms	Associate	33646276, 34850851
Colorectal Neoplasms	Associate	36769302
Death	Associate	27625572
Digestive System Diseases	Associate	33646276
Drug Hypersensitivity	Stimulate	30052638
Drug Related Side Effects and Adverse Reactions	Stimulate	36191335
Emphysema	Associate	28459279
Hemostatic Disorders	Stimulate	30052638
Immunologic Deficiency Syndromes	Associate	36191335
Leukemia	Associate	24362429, 30052638
Leukemia Myeloid Acute	Inhibit	30052638
Lymphoma Non Hodgkin	Inhibit	30052638
Multiple Myeloma	Associate	32915979
Neoplasm Metastasis	Associate	33646276
Neoplasms	Associate	36191335
Neoplasms	Stimulate	36572570
Neoplasms	Inhibit	36769302
Ovarian Neoplasms	Associate	29767260
Pancreatitis	Stimulate	30052638
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	28003999, 32915979
Precursor Cell Lymphoblastic Leukemia Lymphoma	Inhibit	30052638, 30819925, 31806048, 32786406, 34504186, 37446393
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Inhibit	36191335
Uterine Cervical Neoplasms	Associate	29767260
Uterine Cervicitis	Associate	30696738

ASRGL1 (asparaginase and isoaspartyl peptidase 1)