Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	80146
Gene name	UDP-glucuronate decarboxylase 1
Gene symbol	UXS1
Synonyms (NCBI Gene)	SDR6E1UGDhUXShUXS1
Chromosome	2
Chromosome location	2q12.2
Summary	This gene encodes an enzyme found in the perinuclear Golgi which catalyzes the synthesis of UDP-xylose used in glycosaminoglycan (GAG) synthesis on proteoglycans. The GAG chains are covalently attached to proteoglycans which participate in signaling pathw

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019956	hsa-miR-375	Microarray	20215506
MIRT439318	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT439319	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439318	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT726154	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT726152	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT726153	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT726151	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT439319	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT1481522	hsa-miR-106a	CLIP-seq
MIRT1481523	hsa-miR-106b	CLIP-seq
MIRT1481524	hsa-miR-1184	CLIP-seq
MIRT1481525	hsa-miR-1205	CLIP-seq
MIRT1481526	hsa-miR-1264	CLIP-seq
MIRT1481527	hsa-miR-129-5p	CLIP-seq
MIRT1481528	hsa-miR-1304	CLIP-seq
MIRT1481529	hsa-miR-130a	CLIP-seq
MIRT1481530	hsa-miR-130b	CLIP-seq
MIRT1481531	hsa-miR-17	CLIP-seq
MIRT1481532	hsa-miR-1913	CLIP-seq
MIRT1481533	hsa-miR-200b	CLIP-seq
MIRT1481534	hsa-miR-200c	CLIP-seq
MIRT1481535	hsa-miR-20a	CLIP-seq
MIRT1481536	hsa-miR-20b	CLIP-seq
MIRT1481537	hsa-miR-2113	CLIP-seq
MIRT1481538	hsa-miR-301a	CLIP-seq
MIRT1481539	hsa-miR-301b	CLIP-seq
MIRT1481540	hsa-miR-3148	CLIP-seq
MIRT1481541	hsa-miR-3158-5p	CLIP-seq
MIRT1481542	hsa-miR-3184	CLIP-seq
MIRT1481543	hsa-miR-324-3p	CLIP-seq
MIRT1481544	hsa-miR-3613-3p	CLIP-seq
MIRT1481545	hsa-miR-3622a-3p	CLIP-seq
MIRT1481546	hsa-miR-3622a-5p	CLIP-seq
MIRT1481547	hsa-miR-3622b-3p	CLIP-seq
MIRT1481548	hsa-miR-3647-3p	CLIP-seq
MIRT1481549	hsa-miR-3666	CLIP-seq
MIRT1481550	hsa-miR-3978	CLIP-seq
MIRT1481551	hsa-miR-409-3p	CLIP-seq
MIRT1481552	hsa-miR-423-5p	CLIP-seq
MIRT1481553	hsa-miR-429	CLIP-seq
MIRT1481554	hsa-miR-4295	CLIP-seq
MIRT1481555	hsa-miR-4300	CLIP-seq
MIRT1481556	hsa-miR-4311	CLIP-seq
MIRT1481557	hsa-miR-4313	CLIP-seq
MIRT1481558	hsa-miR-4326	CLIP-seq
MIRT1481559	hsa-miR-4328	CLIP-seq
MIRT1481560	hsa-miR-4423-3p	CLIP-seq
MIRT1481561	hsa-miR-4427	CLIP-seq
MIRT1481562	hsa-miR-4449	CLIP-seq
MIRT1481563	hsa-miR-454	CLIP-seq
MIRT1481564	hsa-miR-4646-3p	CLIP-seq
MIRT1481565	hsa-miR-4680-3p	CLIP-seq
MIRT1481566	hsa-miR-4708-3p	CLIP-seq
MIRT1481567	hsa-miR-4714-5p	CLIP-seq
MIRT1481568	hsa-miR-4756-3p	CLIP-seq
MIRT1481569	hsa-miR-519a	CLIP-seq
MIRT1481570	hsa-miR-519b-3p	CLIP-seq
MIRT1481571	hsa-miR-519c-3p	CLIP-seq
MIRT1481572	hsa-miR-519d	CLIP-seq
MIRT1481573	hsa-miR-548ae	CLIP-seq
MIRT1481574	hsa-miR-548aj	CLIP-seq
MIRT1481575	hsa-miR-548am	CLIP-seq
MIRT1481576	hsa-miR-548t	CLIP-seq
MIRT1481577	hsa-miR-548x	CLIP-seq
MIRT1481578	hsa-miR-920	CLIP-seq
MIRT1481579	hsa-miR-93	CLIP-seq
MIRT1481580	hsa-miR-939	CLIP-seq
MIRT1557274	hsa-miR-4477a	CLIP-seq
MIRT1481526	hsa-miR-1264	CLIP-seq
MIRT1481532	hsa-miR-1913	CLIP-seq
MIRT2365207	hsa-miR-3120-3p	CLIP-seq
MIRT1481543	hsa-miR-324-3p	CLIP-seq
MIRT2365208	hsa-miR-342-3p	CLIP-seq
MIRT1481557	hsa-miR-4313	CLIP-seq
MIRT2365209	hsa-miR-451b	CLIP-seq
MIRT2365210	hsa-miR-4704-3p	CLIP-seq
MIRT2365211	hsa-miR-505	CLIP-seq
MIRT2365212	hsa-miR-548a-3p	CLIP-seq
MIRT2365213	hsa-miR-548e	CLIP-seq
MIRT2365214	hsa-miR-548f	CLIP-seq
MIRT2365215	hsa-miR-548g	CLIP-seq
MIRT2365216	hsa-miR-577	CLIP-seq
MIRT1481526	hsa-miR-1264	CLIP-seq
MIRT2658991	hsa-miR-1290	CLIP-seq
MIRT2658992	hsa-miR-153	CLIP-seq
MIRT1481533	hsa-miR-200b	CLIP-seq
MIRT1481534	hsa-miR-200c	CLIP-seq
MIRT2365207	hsa-miR-3120-3p	CLIP-seq
MIRT2658993	hsa-miR-3159	CLIP-seq
MIRT2365208	hsa-miR-342-3p	CLIP-seq
MIRT1481544	hsa-miR-3613-3p	CLIP-seq
MIRT1481548	hsa-miR-3647-3p	CLIP-seq
MIRT1481553	hsa-miR-429	CLIP-seq
MIRT1481556	hsa-miR-4311	CLIP-seq
MIRT1557274	hsa-miR-4477a	CLIP-seq
MIRT2365209	hsa-miR-451b	CLIP-seq
MIRT2658994	hsa-miR-4708-5p	CLIP-seq
MIRT2658995	hsa-miR-4729	CLIP-seq
MIRT1481568	hsa-miR-4756-3p	CLIP-seq
MIRT2658996	hsa-miR-491-3p	CLIP-seq
MIRT1481573	hsa-miR-548ae	CLIP-seq
MIRT1481574	hsa-miR-548aj	CLIP-seq
MIRT1481575	hsa-miR-548am	CLIP-seq
MIRT1481576	hsa-miR-548t	CLIP-seq
MIRT1481577	hsa-miR-548x	CLIP-seq
MIRT2365216	hsa-miR-577	CLIP-seq
MIRT2658997	hsa-miR-586	CLIP-seq
MIRT1481526	hsa-miR-1264	CLIP-seq
MIRT2658991	hsa-miR-1290	CLIP-seq
MIRT1481527	hsa-miR-129-5p	CLIP-seq
MIRT2658992	hsa-miR-153	CLIP-seq
MIRT1481533	hsa-miR-200b	CLIP-seq
MIRT1481534	hsa-miR-200c	CLIP-seq
MIRT2365207	hsa-miR-3120-3p	CLIP-seq
MIRT2658993	hsa-miR-3159	CLIP-seq
MIRT2694884	hsa-miR-3163	CLIP-seq
MIRT2365208	hsa-miR-342-3p	CLIP-seq
MIRT1481544	hsa-miR-3613-3p	CLIP-seq
MIRT1481548	hsa-miR-3647-3p	CLIP-seq
MIRT1481553	hsa-miR-429	CLIP-seq
MIRT2694885	hsa-miR-4304	CLIP-seq
MIRT1481556	hsa-miR-4311	CLIP-seq
MIRT1557274	hsa-miR-4477a	CLIP-seq
MIRT2365209	hsa-miR-451b	CLIP-seq
MIRT2694886	hsa-miR-4668-3p	CLIP-seq
MIRT2658994	hsa-miR-4708-5p	CLIP-seq
MIRT2658995	hsa-miR-4729	CLIP-seq
MIRT1481568	hsa-miR-4756-3p	CLIP-seq
MIRT2658996	hsa-miR-491-3p	CLIP-seq
MIRT1481573	hsa-miR-548ae	CLIP-seq
MIRT1481574	hsa-miR-548aj	CLIP-seq
MIRT1481575	hsa-miR-548am	CLIP-seq
MIRT1481577	hsa-miR-548x	CLIP-seq
MIRT2365216	hsa-miR-577	CLIP-seq
MIRT2658997	hsa-miR-586	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005794	Component	Golgi apparatus	IEA
GO:0016020	Component	Membrane	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0016831	Function	Carboxy-lyase activity	IEA
GO:0032580	Component	Golgi cisterna membrane	IEA
GO:0033320	Process	UDP-D-xylose biosynthetic process	IDA	22810237, 25521717
GO:0033320	Process	UDP-D-xylose biosynthetic process	IEA
GO:0042732	Process	D-xylose metabolic process	IEA
GO:0042802	Function	Identical protein binding	IPI	23656592
GO:0042803	Function	Protein homodimerization activity	IDA	23656592
GO:0048040	Function	UDP-glucuronate decarboxylase activity	IBA
GO:0048040	Function	UDP-glucuronate decarboxylase activity	IDA	22810237, 23072385, 23656592, 25521717
GO:0048040	Function	UDP-glucuronate decarboxylase activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:0070403	Function	NAD+ binding	IBA
GO:0070403	Function	NAD+ binding	IDA	22810237, 23072385, 25521717
GO:0070403	Function	NAD+ binding	IEA
GO:1902494	Component	Catalytic complex	IDA	23656592

MIM	HGNC	e!Ensembl
609749	17729	ENSG00000115652

Q8NBZ7

Protein name

UDP-glucuronic acid decarboxylase 1 (EC 4.1.1.35) (UDP-glucuronate decarboxylase 1) (UGD) (UXS-1) (hUXS) (hUXS1)

Protein function

Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose (PubMed:22810237, PubMed:23656592, PubMed:25521717). Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (PubMed:22810237,

PDB

2B69 , 4GLL , 4LK3 , 4M55

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF11803	UXS1_N	4 → 78	UDP-glucuronate decarboxylase N-terminal	Family
PF16363	GDP_Man_Dehyd	92 → 387	GDP-mannose 4,6 dehydratase	Domain

Sequence

MVSKALLRLVSAVNRRRMKLLLGIALLAYVASVWGNFVNMRSIQENGELKIESKIEEMVE
PLREKIRDLEKSFTQKYPPVKFLSEKDRKRILITGGAGFVGSHLTDKLMMDGHEVTVVDN
FFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLASPASPPNYMYNPIKTLKTNT
IGTLNMLGLAKRVGARLLLASTSEVYGDPEVHPQSEDYWGHVNPIGPRACYDEGKRVAET
MCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSNFILQALQGEPLTVYGSGSQTRAFQ
YVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFLSEAQDDPQK
RKPDIKKAKLMLGWEPVVPLEEGLNKAIHYFRKELEYQANNQYIPKPKPARIKKGRTRHS

Sequence length

420

Interactions

View interactions

	KEGG
	Amino sugar and nucleotide sugar metabolism Metabolic pathways Biosynthesis of nucleotide sugars

UXS1 (UDP-glucuronate decarboxylase 1)