Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	80146
Gene name Gene Name - the full gene name approved by the HGNC.	UDP-glucuronate decarboxylase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	UXS1
Synonyms (NCBI Gene) Gene synonyms aliases	SDR6E1, UGD, hUXS, hUXS1
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q12.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes an enzyme found in the perinuclear Golgi which catalyzes the synthesis of UDP-xylose used in glycosaminoglycan (GAG) synthesis on proteoglycans. The GAG chains are covalently attached to proteoglycans which participate in signaling pathw

Show/Hide all(136)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019956	hsa-miR-375	Microarray	20215506
MIRT439318	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT439319	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439318	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT726154	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT726152	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT726153	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT726151	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT439319	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT1481522	hsa-miR-106a	CLIP-seq
MIRT1481523	hsa-miR-106b	CLIP-seq
MIRT1481524	hsa-miR-1184	CLIP-seq
MIRT1481525	hsa-miR-1205	CLIP-seq
MIRT1481526	hsa-miR-1264	CLIP-seq
MIRT1481527	hsa-miR-129-5p	CLIP-seq
MIRT1481528	hsa-miR-1304	CLIP-seq
MIRT1481529	hsa-miR-130a	CLIP-seq
MIRT1481530	hsa-miR-130b	CLIP-seq
MIRT1481531	hsa-miR-17	CLIP-seq
MIRT1481532	hsa-miR-1913	CLIP-seq
MIRT1481533	hsa-miR-200b	CLIP-seq
MIRT1481534	hsa-miR-200c	CLIP-seq
MIRT1481535	hsa-miR-20a	CLIP-seq
MIRT1481536	hsa-miR-20b	CLIP-seq
MIRT1481537	hsa-miR-2113	CLIP-seq
MIRT1481538	hsa-miR-301a	CLIP-seq
MIRT1481539	hsa-miR-301b	CLIP-seq
MIRT1481540	hsa-miR-3148	CLIP-seq
MIRT1481541	hsa-miR-3158-5p	CLIP-seq
MIRT1481542	hsa-miR-3184	CLIP-seq
MIRT1481543	hsa-miR-324-3p	CLIP-seq
MIRT1481544	hsa-miR-3613-3p	CLIP-seq
MIRT1481545	hsa-miR-3622a-3p	CLIP-seq
MIRT1481546	hsa-miR-3622a-5p	CLIP-seq
MIRT1481547	hsa-miR-3622b-3p	CLIP-seq
MIRT1481548	hsa-miR-3647-3p	CLIP-seq
MIRT1481549	hsa-miR-3666	CLIP-seq
MIRT1481550	hsa-miR-3978	CLIP-seq
MIRT1481551	hsa-miR-409-3p	CLIP-seq
MIRT1481552	hsa-miR-423-5p	CLIP-seq
MIRT1481553	hsa-miR-429	CLIP-seq
MIRT1481554	hsa-miR-4295	CLIP-seq
MIRT1481555	hsa-miR-4300	CLIP-seq
MIRT1481556	hsa-miR-4311	CLIP-seq
MIRT1481557	hsa-miR-4313	CLIP-seq
MIRT1481558	hsa-miR-4326	CLIP-seq
MIRT1481559	hsa-miR-4328	CLIP-seq
MIRT1481560	hsa-miR-4423-3p	CLIP-seq
MIRT1481561	hsa-miR-4427	CLIP-seq
MIRT1481562	hsa-miR-4449	CLIP-seq
MIRT1481563	hsa-miR-454	CLIP-seq
MIRT1481564	hsa-miR-4646-3p	CLIP-seq
MIRT1481565	hsa-miR-4680-3p	CLIP-seq
MIRT1481566	hsa-miR-4708-3p	CLIP-seq
MIRT1481567	hsa-miR-4714-5p	CLIP-seq
MIRT1481568	hsa-miR-4756-3p	CLIP-seq
MIRT1481569	hsa-miR-519a	CLIP-seq
MIRT1481570	hsa-miR-519b-3p	CLIP-seq
MIRT1481571	hsa-miR-519c-3p	CLIP-seq
MIRT1481572	hsa-miR-519d	CLIP-seq
MIRT1481573	hsa-miR-548ae	CLIP-seq
MIRT1481574	hsa-miR-548aj	CLIP-seq
MIRT1481575	hsa-miR-548am	CLIP-seq
MIRT1481576	hsa-miR-548t	CLIP-seq
MIRT1481577	hsa-miR-548x	CLIP-seq
MIRT1481578	hsa-miR-920	CLIP-seq
MIRT1481579	hsa-miR-93	CLIP-seq
MIRT1481580	hsa-miR-939	CLIP-seq
MIRT1557274	hsa-miR-4477a	CLIP-seq
MIRT1481526	hsa-miR-1264	CLIP-seq
MIRT1481532	hsa-miR-1913	CLIP-seq
MIRT2365207	hsa-miR-3120-3p	CLIP-seq
MIRT1481543	hsa-miR-324-3p	CLIP-seq
MIRT2365208	hsa-miR-342-3p	CLIP-seq
MIRT1481557	hsa-miR-4313	CLIP-seq
MIRT2365209	hsa-miR-451b	CLIP-seq
MIRT2365210	hsa-miR-4704-3p	CLIP-seq
MIRT2365211	hsa-miR-505	CLIP-seq
MIRT2365212	hsa-miR-548a-3p	CLIP-seq
MIRT2365213	hsa-miR-548e	CLIP-seq
MIRT2365214	hsa-miR-548f	CLIP-seq
MIRT2365215	hsa-miR-548g	CLIP-seq
MIRT2365216	hsa-miR-577	CLIP-seq
MIRT1481526	hsa-miR-1264	CLIP-seq
MIRT2658991	hsa-miR-1290	CLIP-seq
MIRT2658992	hsa-miR-153	CLIP-seq
MIRT1481533	hsa-miR-200b	CLIP-seq
MIRT1481534	hsa-miR-200c	CLIP-seq
MIRT2365207	hsa-miR-3120-3p	CLIP-seq
MIRT2658993	hsa-miR-3159	CLIP-seq
MIRT2365208	hsa-miR-342-3p	CLIP-seq
MIRT1481544	hsa-miR-3613-3p	CLIP-seq
MIRT1481548	hsa-miR-3647-3p	CLIP-seq
MIRT1481553	hsa-miR-429	CLIP-seq
MIRT1481556	hsa-miR-4311	CLIP-seq
MIRT1557274	hsa-miR-4477a	CLIP-seq
MIRT2365209	hsa-miR-451b	CLIP-seq
MIRT2658994	hsa-miR-4708-5p	CLIP-seq
MIRT2658995	hsa-miR-4729	CLIP-seq
MIRT1481568	hsa-miR-4756-3p	CLIP-seq
MIRT2658996	hsa-miR-491-3p	CLIP-seq
MIRT1481573	hsa-miR-548ae	CLIP-seq
MIRT1481574	hsa-miR-548aj	CLIP-seq
MIRT1481575	hsa-miR-548am	CLIP-seq
MIRT1481576	hsa-miR-548t	CLIP-seq
MIRT1481577	hsa-miR-548x	CLIP-seq
MIRT2365216	hsa-miR-577	CLIP-seq
MIRT2658997	hsa-miR-586	CLIP-seq
MIRT1481526	hsa-miR-1264	CLIP-seq
MIRT2658991	hsa-miR-1290	CLIP-seq
MIRT1481527	hsa-miR-129-5p	CLIP-seq
MIRT2658992	hsa-miR-153	CLIP-seq
MIRT1481533	hsa-miR-200b	CLIP-seq
MIRT1481534	hsa-miR-200c	CLIP-seq
MIRT2365207	hsa-miR-3120-3p	CLIP-seq
MIRT2658993	hsa-miR-3159	CLIP-seq
MIRT2694884	hsa-miR-3163	CLIP-seq
MIRT2365208	hsa-miR-342-3p	CLIP-seq
MIRT1481544	hsa-miR-3613-3p	CLIP-seq
MIRT1481548	hsa-miR-3647-3p	CLIP-seq
MIRT1481553	hsa-miR-429	CLIP-seq
MIRT2694885	hsa-miR-4304	CLIP-seq
MIRT1481556	hsa-miR-4311	CLIP-seq
MIRT1557274	hsa-miR-4477a	CLIP-seq
MIRT2365209	hsa-miR-451b	CLIP-seq
MIRT2694886	hsa-miR-4668-3p	CLIP-seq
MIRT2658994	hsa-miR-4708-5p	CLIP-seq
MIRT2658995	hsa-miR-4729	CLIP-seq
MIRT1481568	hsa-miR-4756-3p	CLIP-seq
MIRT2658996	hsa-miR-491-3p	CLIP-seq
MIRT1481573	hsa-miR-548ae	CLIP-seq
MIRT1481574	hsa-miR-548aj	CLIP-seq
MIRT1481575	hsa-miR-548am	CLIP-seq
MIRT1481577	hsa-miR-548x	CLIP-seq
MIRT2365216	hsa-miR-577	CLIP-seq
MIRT2658997	hsa-miR-586	CLIP-seq

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005794	Component	Golgi apparatus	IEA
GO:0016020	Component	Membrane	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0016831	Function	Carboxy-lyase activity	IEA
GO:0032580	Component	Golgi cisterna membrane	IEA
GO:0033320	Process	UDP-D-xylose biosynthetic process	IDA	22810237, 25521717
GO:0033320	Process	UDP-D-xylose biosynthetic process	IEA
GO:0042732	Process	D-xylose metabolic process	IEA
GO:0042802	Function	Identical protein binding	IPI	23656592
GO:0042803	Function	Protein homodimerization activity	IDA	23656592
GO:0048040	Function	UDP-glucuronate decarboxylase activity	IBA
GO:0048040	Function	UDP-glucuronate decarboxylase activity	IDA	22810237, 23072385, 23656592, 25521717
GO:0048040	Function	UDP-glucuronate decarboxylase activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:0070403	Function	NAD+ binding	IBA
GO:0070403	Function	NAD+ binding	IDA	22810237, 23072385, 25521717
GO:0070403	Function	NAD+ binding	IEA
GO:1902494	Component	Catalytic complex	IDA	23656592

MIM	HGNC	e!Ensembl
609749	17729	ENSG00000115652

Protein

UniProt ID

Q8NBZ7

Protein name

UDP-glucuronic acid decarboxylase 1 (EC 4.1.1.35) (UDP-glucuronate decarboxylase 1) (UGD) (UXS-1) (hUXS) (hUXS1)

Protein function

Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose (PubMed:22810237, PubMed:23656592, PubMed:25521717). Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (PubMed:22810237,

PDB

2B69 , 4GLL , 4LK3 , 4M55

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF11803	UXS1_N	4 → 78	UDP-glucuronate decarboxylase N-terminal	Family
PF16363	GDP_Man_Dehyd	92 → 387	GDP-mannose 4,6 dehydratase	Domain

Sequence

MVSKALLRLVSAVNRRRMKLLLGIALLAYVASVWGNFVNMRSIQENGELKIESKIEEMVE
PLREKIRDLEKSFTQKYPPVKFLSEKDRKRILITGGAGFVGSHLTDKLMMDGHEVTVVDN
FFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLASPASPPNYMYNPIKTLKTNT
IGTLNMLGLAKRVGARLLLASTSEVYGDPEVHPQSEDYWGHVNPIGPRACYDEGKRVAET
MCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSNFILQALQGEPLTVYGSGSQTRAFQ
YVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFLSEAQDDPQK
RKPDIKKAKLMLGWEPVVPLEEGLNKAIHYFRKELEYQANNQYIPKPKPARIKKGRTRHS

Sequence length

420

Interactions

View interactions

	KEGG
	Amino sugar and nucleotide sugar metabolism Metabolic pathways Biosynthesis of nucleotide sugars

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Glioblastoma	Glioblastoma	N/A	N/A	GWAS
Skeletal Dysplasia	skeletal dysplasia	N/A	N/A	GenCC

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Neoplasms	Associate	37880368

UXS1 (UDP-glucuronate decarboxylase 1)